{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T03:14:52Z","timestamp":1791256492273,"version":"4.1.0"},"reference-count":81,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,8,11]],"date-time":"2025-08-11T00:00:00Z","timestamp":1754870400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100020655","name":"European Health and Digital Executive Agency","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100020655","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004569","name":"Ministerstwo Edukacji i Nauki","doi-asserted-by":"publisher","award":["2022\/WK\/05"],"award-info":[{"award-number":["2022\/WK\/05"]}],"id":[{"id":"10.13039\/501100004569","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004281","name":"Narodowe Centrum Nauki","doi-asserted-by":"publisher","award":["2019\/33\/B\/NZ1\/01556"],"award-info":[{"award-number":["2019\/33\/B\/NZ1\/01556"]}],"id":[{"id":"10.13039\/501100004281","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Reports"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1016\/j.celrep.2025.116222","type":"journal-article","created":{"date-parts":[[2025,9,3]],"date-time":"2025-09-03T22:19:38Z","timestamp":1756937978000},"page":"116222","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"title":["Hypoxic stress dysregulates functions of glioma-associated myeloid cells through epigenomic and transcriptional programs"],"prefix":"10.1016","volume":"44","author":[{"given":"Monika","family":"Dzwigonska","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrycja","family":"Rosa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Szymon","family":"Lipiec","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomasz","family":"Obrebski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela","family":"Smyk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beata","family":"Kaza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salwador","family":"Cyranowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksandra","family":"Ellert-Miklaszewska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agata","family":"Kominek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna R.","family":"Malik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katarzyna","family":"Piwocka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jakub","family":"Mieczkowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bozena","family":"Kaminska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3504-1553","authenticated-orcid":false,"given":"Katarzyna B.","family":"Leszczynska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.celrep.2025.116222_bib1","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1093\/neuonc\/noab106","article-title":"The 2021 WHO classification of tumors of the central nervous system: A summary","volume":"23","author":"Louis","year":"2021","journal-title":"Neuro Oncol."},{"key":"10.1016\/j.celrep.2025.116222_bib2","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1016\/j.cell.2019.06.024","article-title":"An Integrative Model of Cellular States, Plasticity, and Genetics for Glioblastoma","volume":"178","author":"Neftel","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2025.116222_bib3","doi-asserted-by":"crossref","DOI":"10.1172\/JCI163446","article-title":"Macrophages and microglia in glioblastoma: heterogeneity, plasticity, and therapy","volume":"133","author":"Khan","year":"2023","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.celrep.2025.116222_bib4","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/j.ccell.2017.02.009","article-title":"The Microenvironmental Landscape of Brain Tumors","volume":"31","author":"Quail","year":"2017","journal-title":"Cancer Cell"},{"key":"10.1016\/j.celrep.2025.116222_bib5","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1016\/j.ccell.2024.03.013","article-title":"Identification of hypoxic macrophages in glioblastoma with therapeutic potential for vasculature normalization","volume":"42","author":"Wang","year":"2024","journal-title":"Cancer Cell"},{"key":"10.1016\/j.celrep.2025.116222_bib6","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1038\/s41467-021-21407-w","article-title":"Single-cell RNA sequencing reveals functional heterogeneity of glioma-associated brain macrophages","volume":"12","author":"Ochocka","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2025.116222_bib7","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1038\/s41593-020-00789-y","article-title":"Single-cell profiling of myeloid cells in glioblastoma across species and disease stage reveals macrophage competition and specialization","volume":"24","author":"Pombo Antunes","year":"2021","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.celrep.2025.116222_bib8","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1038\/s41591-023-02673-1","article-title":"Multiomic spatial landscape of innate immune cells at human central nervous system borders","volume":"30","author":"Sankowski","year":"2024","journal-title":"Nat. Med."},{"key":"10.1016\/j.celrep.2025.116222_bib9","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1186\/s13073-024-01321-8","article-title":"Glioblastoma-instructed microglia transition to heterogeneous phenotypic states with phagocytic and dendritic cell-like features in patient tumors and patient-derived orthotopic xenografts","volume":"16","author":"Yabo","year":"2024","journal-title":"Genome Med."},{"key":"10.1016\/j.celrep.2025.116222_bib10","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/j.ccell.2022.05.009","article-title":"Spatially resolved multi-omics deciphers bidirectional tumor-host interdependence in glioblastoma","volume":"40","author":"Ravi","year":"2022","journal-title":"Cancer Cell"},{"key":"10.1016\/j.celrep.2025.116222_bib11","doi-asserted-by":"crossref","first-page":"5336","DOI":"10.1016\/j.cell.2024.07.030","article-title":"Macrophage-mediated myelin recycling fuels brain cancer malignancy","volume":"187","author":"Kloosterman","year":"2024","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2025.116222_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.111971","article-title":"Specialized functions and sexual dimorphism explain the functional diversity of the myeloid populations during glioma progression","volume":"42","author":"Ochocka","year":"2023","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2025.116222_bib13","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1016\/j.ccell.2021.05.002","article-title":"Interactions between cancer cells and immune cells drive transitions to mesenchymal-like states in glioblastoma","volume":"39","author":"Hara","year":"2021","journal-title":"Cancer Cell"},{"key":"10.1016\/j.celrep.2025.116222_bib14","doi-asserted-by":"crossref","first-page":"1825","DOI":"10.1016\/j.immuni.2023.06.017","article-title":"Hypoxic niches attract and sequester tumor-associated macrophages and cytotoxic T cells and reprogram them for immunosuppression","volume":"56","author":"Sattiraju","year":"2023","journal-title":"Immunity"},{"key":"10.1016\/j.celrep.2025.116222_bib15","doi-asserted-by":"crossref","first-page":"2485","DOI":"10.1016\/j.cell.2024.03.029","article-title":"Integrative spatial analysis reveals a multi-layered organization of glioblastoma","volume":"187","author":"Greenwald","year":"2024","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2025.116222_bib16","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.clon.2014.02.002","article-title":"The Meaning, Measurement and Modification of Hypoxia in the Laboratory and the Clinic","volume":"26","author":"Hammond","year":"2014","journal-title":"Clin. Oncol."},{"key":"10.1016\/j.celrep.2025.116222_bib17","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.1016\/j.ajpath.2020.04.003","article-title":"Understanding the Oxygen-Sensing Pathway and Its Therapeutic Implications in Diseases","volume":"190","author":"Liao","year":"2020","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.celrep.2025.116222_bib18","doi-asserted-by":"crossref","first-page":"3672","DOI":"10.1172\/JCI84427","article-title":"The impact of hypoxia on tumor-associated macrophages","volume":"126","author":"Henze","year":"2016","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.celrep.2025.116222_bib19","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2024.1360629","article-title":"High hypoxia status in pancreatic cancer is associated with multiple hallmarks of an immunosuppressive tumor microenvironment","volume":"15","author":"Sadozai","year":"2024","journal-title":"Front. Immunol."},{"key":"10.1016\/j.celrep.2025.116222_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2020.173637","article-title":"Hypoxia contributes to galectin-3 expression in renal carcinoma cells","volume":"890","author":"Gu","year":"2021","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.celrep.2025.116222_bib22","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/S0092-8674(01)00507-4","article-title":"C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation","volume":"107","author":"Epstein","year":"2001","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2025.116222_bib21","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1126\/science.aaf2666","article-title":"An anatomic transcriptional atlas of human glioblastoma","volume":"360","author":"Puchalski","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.celrep.2025.116222_bib23","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1093\/brain\/awl263","article-title":"The invasion promoting effect of microglia on glioblastoma cells is inhibited by cyclosporin A","volume":"130","author":"Sliwa","year":"2007","journal-title":"Brain"},{"key":"10.1016\/j.celrep.2025.116222_bib24","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0240769","article-title":"Glyoxal fixation facilitates transcriptome analysis after antigen staining and cell sorting by flow cytometry","volume":"16","author":"Channathodiyil","year":"2021","journal-title":"PLoS One"},{"key":"10.1016\/j.celrep.2025.116222_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.111652","article-title":"Pan-cancer analysis of tissue and single-cell HIF-pathway activation using a conserved gene signature","volume":"41","author":"Lombardi","year":"2022","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2025.116222_bib26","doi-asserted-by":"crossref","first-page":"492","DOI":"10.4161\/cbt.3.6.1010","article-title":"Regulation of transcription and translation by hypoxia","volume":"3","author":"Liu","year":"2004","journal-title":"Cancer Biol. Ther."},{"key":"10.1016\/j.celrep.2025.116222_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.114661","article-title":"The role of KLF transcription factor in the regulation of cancer progression","volume":"162","author":"Li","year":"2023","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.celrep.2025.116222_bib28","doi-asserted-by":"crossref","first-page":"4424","DOI":"10.1038\/onc.2010.191","article-title":"Regulation of autophagy by ATF4 in response to severe hypoxia","volume":"29","author":"Rzymski","year":"2010","journal-title":"Oncogene"},{"key":"10.1016\/j.celrep.2025.116222_bib29","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1038\/sj.onc.1209781","article-title":"Induction of activating transcription factor 3 by anoxia is independent of p53 and the hypoxic HIF signalling pathway","volume":"26","author":"Ameri","year":"2007","journal-title":"Oncogene"},{"key":"10.1016\/j.celrep.2025.116222_bib30","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1002\/1878-0261.13431","article-title":"Hypoxia-mediated regulation of DDX5 through decreased chromatin accessibility and post-translational targeting restricts R-loop accumulation","volume":"17","author":"Leszczynska","year":"2023","journal-title":"Mol. Oncol."},{"key":"10.1016\/j.celrep.2025.116222_bib31","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1158\/0008-5472.CAN-09-2715","article-title":"Effects of acute versus chronic hypoxia on DNA damage responses and genomic instability","volume":"70","author":"Pires","year":"2010","journal-title":"Cancer Res."},{"key":"10.1016\/j.celrep.2025.116222_bib32","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.2002623","article-title":"Transcriptome analysis of hypoxic cancer cells uncovers intron retention in EIF2B5 as a mechanism to inhibit translation","volume":"15","author":"Brady","year":"2017","journal-title":"PLoS Biol."},{"key":"10.1016\/j.celrep.2025.116222_bib33","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1126\/science.aau5870","article-title":"Hypoxia induces rapid changes to histone methylation and reprograms chromatin","volume":"363","author":"Batie","year":"2019","journal-title":"Science"},{"key":"10.1016\/j.celrep.2025.116222_bib34","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1126\/science.aaw1026","article-title":"Histone demethylase KDM6A directly senses oxygen to control chromatin and cell fate","volume":"363","author":"Chakraborty","year":"2019","journal-title":"Science"},{"key":"10.1016\/j.celrep.2025.116222_bib35","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1038\/onc.2015.134","article-title":"H3K9me3 facilitates hypoxia-induced p53-dependent apoptosis through repression of APAK","volume":"35","author":"Olcina","year":"2016","journal-title":"Oncogene"},{"key":"10.1016\/j.celrep.2025.116222_bib36","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1038\/nature19081","article-title":"Tumour hypoxia causes DNA hypermethylation by reducing TET activity","volume":"537","author":"Thienpont","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2025.116222_bib37","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1042\/BCJ20220008","article-title":"Regulation of chromatin accessibility by hypoxia and HIF","volume":"479","author":"Batie","year":"2022","journal-title":"Biochem. J."},{"key":"10.1016\/j.celrep.2025.116222_bib38","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1038\/nmeth.4031","article-title":"ATAC-see reveals the accessible genome by transposase-mediated imaging and sequencing","volume":"13","author":"Chen","year":"2016","journal-title":"Nat. Methods"},{"key":"10.1016\/j.celrep.2025.116222_bib39","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1007\/s00066-007-1664-7","article-title":"Differential expression of Egr1 and activation of microglia following irradiation in the rat brain","volume":"183","author":"Vollmann","year":"2007","journal-title":"Strahlentherapie und Onkol"},{"key":"10.1016\/j.celrep.2025.116222_bib40","doi-asserted-by":"crossref","first-page":"21271","DOI":"10.1074\/jbc.M116.738617","article-title":"Kruppel-like factor 6 promotes macrophage-mediated inflammation by suppressing B cell leukemia\/lymphoma 6 expression","volume":"291","author":"Kim","year":"2016","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.celrep.2025.116222_bib41","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2022.109191","article-title":"Crosstalk between PI3K\/AKT\/KLF4 signaling and microglia M1\/M2 polarization as a novel mechanistic approach towards flibanserin repositioning in parkinson\u2019s disease","volume":"112","author":"El-Deeb","year":"2022","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.celrep.2025.116222_bib42","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1016\/j.molcel.2014.01.033","article-title":"Nrf2 amplifies oxidative stress via induction of Klf9","volume":"53","author":"Zucker","year":"2014","journal-title":"Mol. Cell"},{"key":"10.1016\/j.celrep.2025.116222_bib43","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.neuroscience.2024.02.014","article-title":"Sp1 Regulates the M1 Polarization of Microglia Through the HuR\/NF-\u03baB Axis after Spinal Cord Injury","volume":"544","author":"Guo","year":"2024","journal-title":"Neuroscience"},{"key":"10.1016\/j.celrep.2025.116222_bib44","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1002\/glia.22343","article-title":"TGF-\u03b2 signaling through SMAD2\/3 induces the quiescent microglial phenotype within the CNS environment","volume":"60","author":"Abutbul","year":"2012","journal-title":"Glia"},{"key":"10.1016\/j.celrep.2025.116222_bib45","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1186\/s40478-024-01754-7","article-title":"Tumor associated microglia\/macrophages utilize GPNMB to promote tumor growth and alter immune cell infiltration in glioma","volume":"12","author":"Yalcin","year":"2024","journal-title":"Acta Neuropathol. Commun."},{"key":"10.1016\/j.celrep.2025.116222_bib46","doi-asserted-by":"crossref","first-page":"52294","DOI":"10.18632\/oncotarget.10561","article-title":"TGF-\u03b2 induces M2-like macrophage polarization via SNAILmediated suppression of a pro-inflammatory phenotype","volume":"7","author":"Zhang","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.celrep.2025.116222_bib47","doi-asserted-by":"crossref","first-page":"556","DOI":"10.3389\/fendo.2020.00556","article-title":"Master Regulator Activating Transcription Factor 3 (ATF3) in Metabolic Homeostasis and Cancer","volume":"11","author":"Ku","year":"2020","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.celrep.2025.116222_bib48","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/s41232-022-00201-1","article-title":"Single transcription factor efficiently leads human induced pluripotent stem cells to functional microglia","volume":"42","author":"Sonn","year":"2022","journal-title":"Inflamm. Regen."},{"key":"10.1016\/j.celrep.2025.116222_bib49","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1038\/s41583-018-0057-5","article-title":"Microglial signatures and their role in health and disease","volume":"19","author":"Butovsky","year":"2018","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.celrep.2025.116222_bib50","article-title":"Transcriptional and epigenetic regulation of microglia in maintenance of brain homeostasis and neurodegeneration","volume":"15","author":"Maurya","year":"2022","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.celrep.2025.116222_bib51","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.abb.2019.05.011","article-title":"STAT1 drives M1 microglia activation and neuroinflammation under hypoxia","volume":"669","author":"Butturini","year":"2019","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.celrep.2025.116222_bib52","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1186\/1742-2094-8-187","article-title":"Interferon regulatory factor 3 plays an anti-inflammatory role in microglia by activating the PI3K\/Akt pathway","volume":"8","author":"Tarassishin","year":"2011","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.celrep.2025.116222_bib53","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1038\/s41419-024-06903-3","article-title":"ID2-ETS2 axis regulates the transcriptional acquisition of pro-tumoral microglia phenotype in glioma","volume":"15","author":"V\u00e1zquez-Cabrera","year":"2024","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.celrep.2025.116222_bib54","doi-asserted-by":"crossref","DOI":"10.1016\/j.cellsig.2023.110660","article-title":"Functional crosstalk between chromatin and hypoxia signalling","volume":"106","author":"Collier","year":"2023","journal-title":"Cell. Signal."},{"key":"10.1016\/j.celrep.2025.116222_bib55","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1038\/s41416-019-0451-4","article-title":"Lipid metabolism in cancer cells under metabolic stress","volume":"120","author":"Munir","year":"2019","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.celrep.2025.116222_bib56","doi-asserted-by":"crossref","DOI":"10.1016\/j.canlet.2024.216879","article-title":"Galectin-3 depletion tames pro-tumoural microglia and restrains cancer cells growth","volume":"591","author":"Rivera-Ramos","year":"2024","journal-title":"Cancer Lett."},{"key":"10.1016\/j.celrep.2025.116222_bib57","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2020.114113","article-title":"Galectin-3 expression and secretion by tumor-associated macrophages in hypoxia promotes breast cancer progression","volume":"178","author":"Wang","year":"2020","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.celrep.2025.116222_bib58","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1038\/s41581-022-00587-8","article-title":"The effect of HIF on metabolism and immunity","volume":"18","author":"Taylor","year":"2022","journal-title":"Nat. Rev. Nephrol."},{"key":"10.1016\/j.celrep.2025.116222_bib59","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1016\/j.molcel.2022.01.023","article-title":"HiCAR is a robust and sensitive method to analyze open-chromatin-associated genome organization","volume":"82","author":"Wei","year":"2022","journal-title":"Mol. Cell"},{"key":"10.1016\/j.celrep.2025.116222_bib60","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1038\/nbt.3192","article-title":"Spatial reconstruction of single-cell gene expression data","volume":"33","author":"Satija","year":"2015","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.celrep.2025.116222_bib61","doi-asserted-by":"crossref","first-page":"2114","DOI":"10.1093\/bioinformatics\/btu170","article-title":"Trimmomatic: A flexible trimmer for Illumina sequence data","volume":"30","author":"Bolger","year":"2014","journal-title":"Bioinformatics"},{"key":"10.1016\/j.celrep.2025.116222_bib62","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1093\/bioinformatics\/bts635","article-title":"STAR: Ultrafast universal RNA-seq aligner","volume":"29","author":"Dobin","year":"2013","journal-title":"Bioinformatics"},{"key":"10.1016\/j.celrep.2025.116222_bib63","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1093\/bioinformatics\/btu638","article-title":"HTSeq-A Python framework to work with high-throughput sequencing data","volume":"31","author":"Anders","year":"2015","journal-title":"Bioinformatics"},{"key":"10.1016\/j.celrep.2025.116222_bib64","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/nmeth.1923","article-title":"Fast gapped-read alignment with Bowtie 2","volume":"9","author":"Langmead","year":"2012","journal-title":"Nat. Methods"},{"key":"10.1016\/j.celrep.2025.116222_bib65","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/nmeth.3317","article-title":"HISAT: A fast spliced aligner with low memory requirements","volume":"12","author":"Kim","year":"2015","journal-title":"Nat. Methods"},{"key":"10.1016\/j.celrep.2025.116222_bib66","doi-asserted-by":"crossref","DOI":"10.1186\/gb-2008-9-9-r137","article-title":"Model-based analysis of ChIP-Seq (MACS)","volume":"9","author":"Zhang","year":"2008","journal-title":"Genome Biol."},{"key":"10.1016\/j.celrep.2025.116222_bib67","doi-asserted-by":"crossref","first-page":"W160","DOI":"10.1093\/nar\/gkw257","article-title":"deepTools2: a next generation web server for deep-sequencing data analysis","volume":"44","author":"Ram\u00edrez","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.celrep.2025.116222_bib68","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0021800","article-title":"Revigo summarizes and visualizes long lists of gene ontology terms","volume":"6","author":"Supek","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.celrep.2025.116222_bib69","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1038\/nbt.1754","article-title":"Integrative genomics viewer","volume":"29","author":"Robinson","year":"2011","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.celrep.2025.116222_bib70","doi-asserted-by":"crossref","DOI":"10.1016\/j.xpro.2020.100246","article-title":"Preparation and culture of bone marrow-derived macrophages from mice for functional analysis","volume":"2","author":"Toda","year":"2021","journal-title":"STAR Protoc."},{"key":"10.1016\/j.celrep.2025.116222_bib71","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2024.113707","article-title":"H2A.Z histone variants facilitate HDACi-dependent removal of H3.3K27M mutant protein in pediatric high-grade glioma cells","volume":"43","author":"Leszczynska","year":"2024","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2025.116222_bib72","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.3389\/fimmu.2018.01329","article-title":"In search for reliable markers of glioma-induced polarization of microglia","volume":"9","author":"Walentynowicz","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.celrep.2025.116222_bib73","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1002\/0471142727.mb2129s109","article-title":"ATAC-seq: A method for assaying chromatin accessibility genome-wide","volume":"109","author":"Buenrostro","year":"2015","journal-title":"Curr. Protoc. Mol. Biol."},{"key":"10.1016\/j.celrep.2025.116222_bib74","doi-asserted-by":"crossref","first-page":"2485","DOI":"10.1093\/bioinformatics\/btab003","article-title":"Nebulosa recovers single-cell gene expression signals by kernel density estimation","volume":"37","author":"Alquicira-Hernandez","year":"2021","journal-title":"Bioinformatics"},{"key":"10.1016\/j.celrep.2025.116222_bib75","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol."},{"key":"10.1016\/j.celrep.2025.116222_bib76","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1089\/omi.2011.0118","article-title":"ClusterProfiler: An R package for comparing biological themes among gene clusters","volume":"16","author":"Yu","year":"2012","journal-title":"Omi. A J. Integr. Biol."},{"key":"10.1016\/j.celrep.2025.116222_bib77","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1186\/1471-2105-11-237","article-title":"ChIPpeakAnno: A Bioconductor package to annotate ChIP-seq and ChIP-chip data","volume":"11","author":"Zhu","year":"2010","journal-title":"BMC Bioinf."},{"key":"10.1016\/j.celrep.2025.116222_bib78","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.1003118","article-title":"Software for Computing and Annotating Genomic Ranges","volume":"9","author":"Lawrence","year":"2013","journal-title":"PLoS Comput. Biol."},{"key":"10.1016\/j.celrep.2025.116222_bib79","doi-asserted-by":"crossref","first-page":"2382","DOI":"10.1093\/bioinformatics\/btv145","article-title":"ChIP seeker: An R\/Bioconductor package for ChIP peak annotation, comparison and visualization","volume":"31","author":"Yu","year":"2015","journal-title":"Bioinformatics"},{"key":"10.1016\/j.celrep.2025.116222_bib80","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1038\/nprot.2009.97","article-title":"Mapping identifiers for the integration of genomic datasets with the R\/Bioconductor package biomaRt","volume":"4","author":"Durinck","year":"2009","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.celrep.2025.116222_bib81","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1093\/bioinformatics\/btr064","article-title":"FIMO: Scanning for occurrences of a given motif","volume":"27","author":"Grant","year":"2011","journal-title":"Bioinformatics"}],"container-title":["Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124725009933?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124725009933?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T04:26:49Z","timestamp":1790137609000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211124725009933"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":81,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["S2211124725009933"],"URL":"https:\/\/doi.org\/10.1016\/j.celrep.2025.116222","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2024.09.12.612769","asserted-by":"object"}]},"ISSN":["2211-1247"],"issn-type":[{"value":"2211-1247","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hypoxic stress dysregulates functions of glioma-associated myeloid cells through epigenomic and transcriptional programs","name":"articletitle","label":"Article Title"},{"value":"Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.celrep.2025.116222","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"116222"}}