{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T05:06:58Z","timestamp":1790140018957,"version":"4.0.1"},"reference-count":81,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,8,13]],"date-time":"2025-08-13T00:00:00Z","timestamp":1755043200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000024","name":"CIHR","doi-asserted-by":"publisher","award":["PJT-159731"],"award-info":[{"award-number":["PJT-159731"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001804","name":"Canada Research Chairs Program","doi-asserted-by":"publisher","award":["CRC-2021-00482"],"award-info":[{"award-number":["CRC-2021-00482"]}],"id":[{"id":"10.13039\/501100001804","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010318","name":"University of Manitoba","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010318","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100019416","name":"Manitoba Centre for Health Policy, University of Manitoba","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100019416","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Reports"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1016\/j.celrep.2025.116245","type":"journal-article","created":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T15:56:06Z","timestamp":1757519766000},"page":"116245","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"title":["Integrative analysis of taste genetics and the dental plaque microbiome in early childhood caries"],"prefix":"10.1016","volume":"44","author":[{"given":"Mohd Wasif","family":"Khan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivianne","family":"Cruz de Jesus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Betty-Anne","family":"Mittermuller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert J.","family":"Schroth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pingzhao","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1129-7957","authenticated-orcid":false,"given":"Prashen","family":"Chelikani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.celrep.2025.116245_bib1","series-title":"Policy on Early Childhood Caries ECC: Consequences and Preventive Strategies. The Reference Manual of Pediatric Dentistry","first-page":"89","year":"2024"},{"key":"10.1016\/j.celrep.2025.116245_bib2","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1111\/ipd.12484","article-title":"Early childhood caries epidemiology, aetiology, risk assessment, societal burden, management, education, and policy: Global perspective","volume":"29","author":"Tinanoff","year":"2019","journal-title":"Int. J. Paediatr. Dent."},{"key":"10.1016\/j.celrep.2025.116245_bib3","doi-asserted-by":"crossref","DOI":"10.3389\/fpubh.2019.00328","article-title":"The Burden of Early Childhood Caries in Canadian Children and Associated Risk Factors","volume":"7","author":"Pierce","year":"2019","journal-title":"Front. Public Health"},{"key":"10.1016\/j.celrep.2025.116245_bib4","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1101\/gr.265645.120","article-title":"Deep metagenomics examines the oral microbiome during dental caries, revealing novel taxa and co-occurrences with host molecules","volume":"31","author":"Baker","year":"2021","journal-title":"Genome Res."},{"key":"10.1016\/j.celrep.2025.116245_bib5","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1111\/adj.12262","article-title":"Genetic factors affecting dental caries risk","volume":"60","author":"Opal","year":"2015","journal-title":"Aust. Dent. J."},{"key":"10.1016\/j.celrep.2025.116245_bib6","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.1128\/JCM.02427-10","article-title":"Cultivable anaerobic microbiota of severe early childhood caries","volume":"49","author":"Tanner","year":"2011","journal-title":"J. Clin. Microbiol."},{"key":"10.1016\/j.celrep.2025.116245_bib7","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2017.02244","article-title":"Profiling of Oral Microbiota in Early Childhood Caries Using Single-Molecule Real-Time Sequencing","volume":"8","author":"Wang","year":"2017","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.celrep.2025.116245_bib8","first-page":"41","article-title":"Analysis of Nutritional Status and Oral Veillonella With Caries Status in Preschool Children in Manitoba","volume":"47","author":"Lee","year":"2025","journal-title":"Pediatr. Dent."},{"key":"10.1016\/j.celrep.2025.116245_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2024.114635","article-title":"Role of socioeconomic factors and interkingdom crosstalk in the dental plaque microbiome in early childhood caries","volume":"43","author":"Khan","year":"2024","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2025.116245_bib10","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1111\/j.1365-263X.2011.01186.x","article-title":"Environmental, maternal, and child factors which contribute to early childhood caries: a unifying conceptual model: A unifying conceptual model for early childhood caries","volume":"22","author":"Seow","year":"2012","journal-title":"Int. J. Paediatr. Dent."},{"key":"10.1016\/j.celrep.2025.116245_bib11","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1097\/00003727-200504000-00008","article-title":"The independent impact of household- and neighborhood-based social determinants on early childhood caries: A cross-sectional study of inner-city children","volume":"28","author":"Willems","year":"2005","journal-title":"Fam. Commun. Health"},{"key":"10.1016\/j.celrep.2025.116245_bib12","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1111\/ipd.13140","article-title":"A systematic review of caries risk in children <6 years of age","volume":"34","author":"Khan","year":"2024","journal-title":"Int. J. Paediatr. Dent."},{"key":"10.1016\/j.celrep.2025.116245_bib13","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1177\/0022034519897910","article-title":"Heritability of Caries Scores, Trajectories, and Disease Subtypes","volume":"99","author":"Haworth","year":"2020","journal-title":"J. Dent. Res."},{"key":"10.1016\/j.celrep.2025.116245_bib14","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1177\/0022034514534688","article-title":"Genetic association of MPPED2 and ACTN2 with dental caries","volume":"93","author":"Stanley","year":"2014","journal-title":"J. Dent. Res."},{"key":"10.1016\/j.celrep.2025.116245_bib15","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1093\/hmg\/ddv506","article-title":"Genome-wide association study of dental caries in the Hispanic Communities Health Study\/Study of Latinos (HCHS\/SOL)","volume":"25","author":"Morrison","year":"2016","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.celrep.2025.116245_bib16","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-019-10630-1","article-title":"Genome-wide analysis of dental caries and periodontitis combining clinical and self-reported data","volume":"10","author":"Shungin","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2025.116245_bib17","doi-asserted-by":"crossref","DOI":"10.1186\/s12903-021-01623-y","article-title":"Replication of GWAS significant loci in a sub-Saharan African Cohort with early childhood caries: a pilot study","volume":"21","author":"Olatosi","year":"2021","journal-title":"BMC Oral Health"},{"key":"10.1016\/j.celrep.2025.116245_bib18","doi-asserted-by":"crossref","DOI":"10.1186\/s12864-017-4008-8","article-title":"Genetic influences on the human oral microbiome","volume":"18","author":"Demmitt","year":"2017","journal-title":"BMC Genom."},{"key":"10.1016\/j.celrep.2025.116245_bib19","doi-asserted-by":"crossref","DOI":"10.1186\/s13059-015-0759-1","article-title":"Host genetic variation impacts microbiome composition across human body sites","volume":"16","author":"Blekhman","year":"2015","journal-title":"Genome Biol."},{"key":"10.1016\/j.celrep.2025.116245_bib20","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.chom.2017.08.013","article-title":"Host Genetic Control of the Oral Microbiome in Health and Disease","volume":"22","author":"Gomez","year":"2017","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.celrep.2025.116245_bib21","doi-asserted-by":"crossref","DOI":"10.1186\/s13073-018-0515-8","article-title":"Host genetic variation and its microbiome interactions within the Human Microbiome Project","volume":"10","author":"Kolde","year":"2018","journal-title":"Genome Med."},{"key":"10.1016\/j.celrep.2025.116245_bib22","doi-asserted-by":"crossref","DOI":"10.1128\/IAI.00309-21","article-title":"Loss of neutrophil homing to the periodontal tissues modulates the composition and disease potential of the oral Microbiota","volume":"89","author":"Hashim","year":"2021","journal-title":"Infect. Immun."},{"key":"10.1016\/j.celrep.2025.116245_bib23","doi-asserted-by":"crossref","DOI":"10.1038\/s41421-021-00356-0","article-title":"Metagenome-genome-wide association studies reveal human genetic impact on the oral microbiome","volume":"7","author":"Liu","year":"2021","journal-title":"Cell Discov."},{"key":"10.1016\/j.celrep.2025.116245_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2022.105489","article-title":"Genetic variants in taste genes play a role in oral microbial composition and severe early childhood caries","volume":"25","author":"de Jesus","year":"2022","journal-title":"iScience"},{"key":"10.1016\/j.celrep.2025.116245_bib25","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/S0092-8674(00)80706-0","article-title":"T2Rs function as bitter taste receptors","volume":"100","author":"Chandrashekar","year":"2000","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2025.116245_bib26","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1126\/science.1204076","article-title":"A gustotopic map of taste qualities in the mammalian brain","volume":"333","author":"Chen","year":"2011","journal-title":"Science"},{"key":"10.1016\/j.celrep.2025.116245_bib27","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1159\/000430958","article-title":"GLUT2 and TAS1R2 polymorphisms and susceptibility to dental caries","volume":"49","author":"Izakovicova Holla","year":"2015","journal-title":"Caries Res."},{"key":"10.1016\/j.celrep.2025.116245_bib28","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-019-40374-3","article-title":"New insights into the relationship between taste perception and oral microbiota composition","volume":"9","author":"Cattaneo","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.celrep.2025.116245_bib29","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1080\/00016357.2020.1832253","article-title":"Single nucleotide polymorphisms of taste genes and caries: a systematic review and meta-analysis","volume":"79","author":"Chisini","year":"2021","journal-title":"Acta Odontol. Scand."},{"key":"10.1016\/j.celrep.2025.116245_bib30","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1177\/00220345241291528","article-title":"Multiancestry genome-wide association study of early childhood caries","volume":"104","author":"Shrestha","year":"2025","journal-title":"J. Dent. Res."},{"key":"10.1016\/j.celrep.2025.116245_bib31","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202000208R","article-title":"Bitter taste receptor T2R14 detects quorum sensing molecules from cariogenic Streptococcus mutans and mediates innate immune responses in gingival epithelial cells","volume":"35","author":"Medapati","year":"2021","journal-title":"FASEB J."},{"key":"10.1016\/j.celrep.2025.116245_bib32","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1159\/000345652","article-title":"Association of GLUT2 and TAS1R2 genotypes with risk for dental caries","volume":"47","author":"Kulkarni","year":"2013","journal-title":"Caries Res."},{"key":"10.1016\/j.celrep.2025.116245_bib33","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.3390\/cimb43030103","article-title":"Association of bitter taste receptor T2R38 polymorphisms, oral Microbiota, and rheumatoid arthritis","volume":"43","author":"de Jesus","year":"2021","journal-title":"Curr. Issues Mol. Biol."},{"key":"10.1016\/j.celrep.2025.116245_bib34","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1101\/gr.107524.110","article-title":"The Genome Analysis Toolkit: a MapReduce framework for analyzing next-generation DNA sequencing data","volume":"20","author":"McKenna","year":"2010","journal-title":"Genome Res."},{"key":"10.1016\/j.celrep.2025.116245_bib35","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1086\/519795","article-title":"PLINK: a tool set for whole-genome association and population-based linkage analyses","volume":"81","author":"Purcell","year":"2007","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.celrep.2025.116245_bib36","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.ajhg.2012.06.007","article-title":"Optimal unified approach for rare-variant association testing with application to small-sample case-control whole-exome sequencing studies","volume":"91","author":"Lee","year":"2012","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.celrep.2025.116245_bib37","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.ajhg.2011.05.029","article-title":"Rare-variant association testing for sequencing data with the sequence kernel association test","volume":"89","author":"Wu","year":"2011","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.celrep.2025.116245_bib38","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.1009442","article-title":"Multivariable association discovery in population-scale meta-omics studies","volume":"17","author":"Mallick","year":"2021","journal-title":"PLoS Comput. Biol."},{"key":"10.1016\/j.celrep.2025.116245_bib39","doi-asserted-by":"crossref","first-page":"3173","DOI":"10.1093\/bioinformatics\/btac310","article-title":"A new approach to testing mediation of the microbiome at both the community and individual taxon levels","volume":"38","author":"Yue","year":"2022","journal-title":"Bioinformatics"},{"key":"10.1016\/j.celrep.2025.116245_bib40","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.1177\/0022034517718819","article-title":"Microbiome Associated with Severe Caries in Canadian First Nations Children","volume":"96","author":"Agnello","year":"2017","journal-title":"J. Dent. Res."},{"key":"10.1016\/j.celrep.2025.116245_bib41","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.chom.2015.08.005","article-title":"Prediction of early childhood caries via spatial-temporal variations of oral microbiota","volume":"18","author":"Teng","year":"2015","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.celrep.2025.116245_bib42","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-78057-z","article-title":"Bacterial diversity and functional analysis of severe early childhood caries and recurrence in India","volume":"10","author":"Kalpana","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.celrep.2025.116245_bib43","doi-asserted-by":"crossref","DOI":"10.3390\/genes14010059","article-title":"Association of Early Childhood Caries with Bitter Taste Receptors: A Meta-Analysis of Genome-Wide Association Studies and Transcriptome-Wide Association Study","volume":"14","author":"Orlova","year":"2022","journal-title":"Genes"},{"key":"10.1016\/j.celrep.2025.116245_bib44","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0051571","article-title":"Meta-analysis of 125 rheumatoid arthritis-related single nucleotide polymorphisms studied in the past two decades","volume":"7","author":"Jiang","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.celrep.2025.116245_bib45","doi-asserted-by":"crossref","DOI":"10.1002\/brb3.471","article-title":"Genetic variation and cognitive dysfunction in opioid-treated patients with cancer","volume":"6","author":"Kurita","year":"2016","journal-title":"Brain Behav."},{"key":"10.1016\/j.celrep.2025.116245_bib46","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-64747-1","article-title":"Longitudinal study of oral microbiome variation in twins","volume":"10","author":"Freire","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.celrep.2025.116245_bib47","doi-asserted-by":"crossref","DOI":"10.1186\/s40168-020-00986-8","article-title":"Acquisition of oral microbiota is driven by environment, not host genetics","volume":"9","author":"Mukherjee","year":"2021","journal-title":"Microbiome"},{"key":"10.1016\/j.celrep.2025.116245_bib48","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1038\/s41586-020-2308-7","article-title":"The mutational constraint spectrum quantified from variation in 141,456 humans","volume":"581","author":"Karczewski","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2025.116245_bib49","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1177\/00220345221077989","article-title":"Role of taste receptors in innate immunity and oral health","volume":"101","author":"Xi","year":"2022","journal-title":"J. Dent. Res."},{"key":"10.1016\/j.celrep.2025.116245_bib50","doi-asserted-by":"crossref","DOI":"10.3390\/microorganisms11051295","article-title":"Interkingdom detection of bacterial quorum-sensing molecules by mammalian taste receptors","volume":"11","author":"Kouakou","year":"2023","journal-title":"Microorganisms"},{"key":"10.1016\/j.celrep.2025.116245_bib51","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22189920","article-title":"Bitter taste receptor T2R14 modulates gram-positive bacterial internalization and survival in gingival epithelial cells","volume":"22","author":"Medapati","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.celrep.2025.116245_bib52","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/978-3-030-96881-6_6","article-title":"Fungi-A component of the oral microbiome involved in periodontal diseases","volume":"1373","author":"Karkowska-Kuleta","year":"2022","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.celrep.2025.116245_bib53","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/S0966-842X(02)00034-3","article-title":"Bacterial coaggregation: an integral process in the development of multi-species biofilms","volume":"11","author":"Rickard","year":"2003","journal-title":"Trends Microbiol."},{"key":"10.1016\/j.celrep.2025.116245_bib54","doi-asserted-by":"crossref","DOI":"10.3389\/fdmed.2022.875953","article-title":"Oral microbiome dental caries associated genotypes analysis of 6- to 19-year-old individuals shows novel associations","volume":"3","author":"Vieira","year":"2022","journal-title":"Front. Dent. Med."},{"key":"10.1016\/j.celrep.2025.116245_bib55","doi-asserted-by":"crossref","DOI":"10.3390\/genes12040462","article-title":"Prediction of early childhood caries based on single nucleotide polymorphisms using neural networks","volume":"12","author":"Zaorska","year":"2021","journal-title":"Genes"},{"key":"10.1016\/j.celrep.2025.116245_bib56","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1177\/00220345231175356","article-title":"Bacterial Community Modifies Host Genetics Effect on Early Childhood Caries","volume":"102","author":"Blostein","year":"2023","journal-title":"J. Dent. Res."},{"key":"10.1016\/j.celrep.2025.116245_bib57","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1007\/978-1-4939-9012-2_40","article-title":"The Supragingival Biofilm in Early Childhood Caries: Clinical and Laboratory Protocols and Bioinformatics Pipelines Supporting Metagenomics, Metatranscriptomics, and Metabolomics Studies of the Oral Microbiome","volume":"1922","author":"Divaris","year":"2019","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.celrep.2025.116245_bib58","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1111\/cdoe.12795","article-title":"Subtypes of early childhood caries predict future caries experience","volume":"51","author":"Gormley","year":"2023","journal-title":"Commun. Dent. Oral Epidemiol."},{"key":"10.1016\/j.celrep.2025.116245_bib59","article-title":"Evidence for clinical subtypes of early childhood caries","author":"Simancas-Pallares","year":"2023","journal-title":"Research Square"},{"key":"10.1016\/j.celrep.2025.116245_bib60","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.2105\/AJPH.2018.304466","article-title":"Prevalence and Data Availability of Early Childhood Caries in 193 United Nations Countries, 2007-2017","volume":"108","author":"El Tantawi","year":"2018","journal-title":"Am. J. Public Health"},{"key":"10.1016\/j.celrep.2025.116245_bib61","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1111\/ipd.12783","article-title":"The global prevalence of early childhood caries: A systematic review with meta-analysis using the WHO diagnostic criteria","volume":"31","author":"Uribe","year":"2021","journal-title":"Int. J. Paediatr. Dent."},{"key":"10.1016\/j.celrep.2025.116245_bib62","doi-asserted-by":"crossref","DOI":"10.1080\/19490976.2023.2297860","article-title":"Multi-omic approaches for host-microbiome data integration","volume":"16","author":"Chetty","year":"2024","journal-title":"Gut Microbes"},{"key":"10.1016\/j.celrep.2025.116245_bib74","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1038\/s41587-019-0209-9","article-title":"Reproducible, interactive, scalable and extensible microbiome data science using QIIME 2","volume":"37","author":"Bolyen","year":"2019","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.celrep.2025.116245_bib63","doi-asserted-by":"crossref","DOI":"10.1128\/msystems.00187-18","article-title":"New Insights into Human Nostril Microbiome from the Expanded Human Oral Microbiome Database (eHOMD): a Resource for the Microbiome of the Human Aerodigestive Tract","volume":"3","author":"Escapa","year":"2018","journal-title":"mSystems"},{"key":"10.1016\/j.celrep.2025.116245_bib64","doi-asserted-by":"crossref","first-page":"D259","DOI":"10.1093\/nar\/gky1022","article-title":"The UNITE database for molecular identification of fungi: handling dark taxa and parallel taxonomic classifications","volume":"47","author":"Nilsson","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.celrep.2025.116245_bib65","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0061217","article-title":"phyloseq: an R package for reproducible interactive analysis and graphics of microbiome census data","volume":"8","author":"McMurdie","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.celrep.2025.116245_bib66","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1111\/j.1654-1103.2003.tb02228.x","article-title":"VEGAN, A Package of R Functions for Community Ecology","volume":"14","author":"Dixon","year":"2003","journal-title":"J. Veg. Sci."},{"key":"10.1016\/j.celrep.2025.116245_bib67","series-title":"R: A Language and Environment for Statistical Computing","year":"2023"},{"key":"10.1016\/j.celrep.2025.116245_bib68","series-title":"ggplot2: Elegant Graphics for Data Analysis","author":"Wickham","year":"2016"},{"key":"10.1016\/j.celrep.2025.116245_bib70","doi-asserted-by":"crossref","first-page":"1","DOI":"10.18637\/jss.v045.i03","article-title":"mice: Multivariate Imputation by Chained Equations in R","volume":"45","author":"Buuren","year":"2011","journal-title":"J. Stat. Softw."},{"key":"10.1016\/j.celrep.2025.116245_bib76","doi-asserted-by":"crossref","first-page":"1754","DOI":"10.1093\/bioinformatics\/btp324","article-title":"Fast and accurate short read alignment with Burrows-Wheeler transform","volume":"25","author":"Li","year":"2009","journal-title":"Bioinformatics"},{"key":"10.1016\/j.celrep.2025.116245_bib81","doi-asserted-by":"crossref","first-page":"2156","DOI":"10.1093\/bioinformatics\/btr330","article-title":"The variant call format and VCFtools","volume":"27","author":"Danecek","year":"2011","journal-title":"Bioinformatics"},{"key":"10.1016\/j.celrep.2025.116245_bib69","unstructured":"Kuhn, M., and Wickham, H. (2020). Tidymodels: a collection of packages for modeling and machine learning using tidyverse principles. https:\/\/www.tidymodels.org."},{"key":"10.1016\/j.celrep.2025.116245_bib71","series-title":"Composite Measures\/Indices of Health and Health System Performance","author":"Metge","year":"2009"},{"key":"10.1016\/j.celrep.2025.116245_bib72","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1177\/0022034520908595","article-title":"Sex-Based Diverse Plaque Microbiota in Children with Severe Caries","volume":"99","author":"de Jesus","year":"2020","journal-title":"J. Dent. Res."},{"key":"10.1016\/j.celrep.2025.116245_bib73","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2021.683685","article-title":"Characterization of Supragingival Plaque and Oral Swab Microbiomes in Children With Severe Early Childhood Caries","volume":"12","author":"de Jesus","year":"2021","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.celrep.2025.116245_bib75","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2017.02224","article-title":"Microbiome Datasets Are Compositional: And This Is Not Optional","volume":"8","author":"Gloor","year":"2017","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.celrep.2025.116245_bib77","doi-asserted-by":"crossref","DOI":"10.1186\/s12864-018-4933-1","article-title":"Elimination of PCR duplicates in RNA-seq and small RNA-seq using unique molecular identifiers","volume":"19","author":"Fu","year":"2018","journal-title":"BMC Genom."},{"key":"10.1016\/j.celrep.2025.116245_bib78","doi-asserted-by":"crossref","DOI":"10.1186\/s12859-016-1097-3","article-title":"Evaluating the necessity of PCR duplicate removal from next-generation sequencing data and a comparison of approaches","volume":"17","author":"Ebbert","year":"2016","journal-title":"BMC Bioinf."},{"key":"10.1016\/j.celrep.2025.116245_bib79","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2024.110447","article-title":"A cross-cohort analysis of dental plaque microbiome in early childhood caries","volume":"27","author":"Khan","year":"2024","journal-title":"iScience"},{"key":"10.1016\/j.celrep.2025.116245_bib80","doi-asserted-by":"crossref","first-page":"2759","DOI":"10.1038\/s41596-020-0353-1","article-title":"Tutorial: a guide to performing polygenic risk score analyses","volume":"15","author":"Choi","year":"2020","journal-title":"Nat. Protoc."}],"container-title":["Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124725010162?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124725010162?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T04:43:48Z","timestamp":1790138628000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211124725010162"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":81,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["S2211124725010162"],"URL":"https:\/\/doi.org\/10.1016\/j.celrep.2025.116245","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2025.03.10.642456","asserted-by":"object"}]},"ISSN":["2211-1247"],"issn-type":[{"value":"2211-1247","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Integrative analysis of taste genetics and the dental plaque microbiome in early childhood caries","name":"articletitle","label":"Article Title"},{"value":"Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.celrep.2025.116245","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"116245"}}