{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T16:43:28Z","timestamp":1790959408496,"version":"4.1.0"},"reference-count":85,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,8,25]],"date-time":"2025-08-25T00:00:00Z","timestamp":1756080000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000957","name":"Alzheimer's Association","doi-asserted-by":"publisher","award":["AARFD-22-926379"],"award-info":[{"award-number":["AARFD-22-926379"]}],"id":[{"id":"10.13039\/100000957","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AG069475"],"award-info":[{"award-number":["AG069475"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["NS077239"],"award-info":[{"award-number":["NS077239"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AG032611"],"award-info":[{"award-number":["AG032611"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Reports"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1016\/j.celrep.2025.116291","type":"journal-article","created":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T00:53:31Z","timestamp":1758070411000},"page":"116291","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["Clearing truncated tau protein restores neuronal function and prevents microglia activation in tauopathy mice"],"prefix":"10.1016","volume":"44","author":[{"given":"Alejandro","family":"Mart\u00edn-\u00c1vila","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Swananda R.","family":"Modak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hameetha B.","family":"Rajamohamedsait","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andie","family":"Dodge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dov B.","family":"Shamir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Senthilkumar","family":"Krishnaswamy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leslie A.","family":"Sandusky-Beltran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marilyn","family":"Walker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin E.","family":"Congdon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1451-0952","authenticated-orcid":false,"given":"Einar M.","family":"Sigurdsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.celrep.2025.116291_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.jalz.2006.05.141","article-title":"Tau-based Immunotherapy for Dementia","volume":"2","author":"Asuni","year":"2006","journal-title":"Alzheimer's Dement."},{"key":"10.1016\/j.celrep.2025.116291_bib2","doi-asserted-by":"crossref","first-page":"9115","DOI":"10.1523\/JNEUROSCI.2361-07.2007","article-title":"Immunotherapy targeting pathological tau conformers in a tangle mouse model reduces brain pathology with associated functional improvements","volume":"27","author":"Asuni","year":"2007","journal-title":"J. Neurosci."},{"key":"10.1016\/j.celrep.2025.116291_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.jalz.2010.05.1970","article-title":"Passive tau immunotherapy diminishes functional decline and clears tau aggregates in a mouse model of tauopathy","volume":"6","author":"Boutajangout","year":"2010","journal-title":"Alzheimer's Dement."},{"key":"10.1016\/j.celrep.2025.116291_bib4","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1111\/j.1471-4159.2011.07337.x","article-title":"Passive immunization targeting pathological phospho-tau protein in a mouse model reduces functional decline and clears tau aggregates from the brain","volume":"118","author":"Boutajangout","year":"2011","journal-title":"J. Neurochem."},{"key":"10.1016\/j.celrep.2025.116291_bib5","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1038\/s41582-023-00883-2","article-title":"Tau-targeting therapies for Alzheimer disease: current status and future directions","volume":"19","author":"Congdon","year":"2023","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.celrep.2025.116291_bib6","doi-asserted-by":"crossref","first-page":"S129","DOI":"10.3233\/JAD-231238","article-title":"Tau Immunotherapies for Alzheimer's Disease and Related Tauopathies: Status of Trials and Insights from Preclinical Studies","volume":"101","author":"Sigurdsson","year":"2024","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.celrep.2025.116291_bib7","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1093\/jnen\/64.2.104","article-title":"The role of caspase cleavage of tau in Alzheimer disease neuropathology","volume":"64","author":"Cotman","year":"2005","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.celrep.2025.116291_bib8","doi-asserted-by":"crossref","first-page":"733","DOI":"10.2741\/2097","article-title":"The role of tau phosphorylation and cleavage in neuronal cell death","volume":"12","author":"Chun","year":"2007","journal-title":"Front. Biosci."},{"key":"10.1016\/j.celrep.2025.116291_bib9","doi-asserted-by":"crossref","first-page":"123","DOI":"10.2353\/ajpath.2008.070627","article-title":"Analysis of tau phosphorylation and truncation in a mouse model of human tauopathy","volume":"172","author":"Delobel","year":"2008","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.celrep.2025.116291_bib10","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1038\/nature08890","article-title":"Caspase activation precedes and leads to tangles","volume":"464","author":"de Calignon","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2025.116291_bib11","doi-asserted-by":"crossref","first-page":"1699","DOI":"10.1016\/j.cell.2020.10.029","article-title":"Tau PTM Profiles Identify Patient Heterogeneity and Stages of Alzheimer's Disease","volume":"183","author":"Wesseling","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2025.116291_bib12","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1186\/s13024-016-0126-z","article-title":"Affinity of Tau antibodies for solubilized pathological Tau species but not their immunogen or insoluble Tau aggregates predicts in vivo and ex vivo efficacy","volume":"11","author":"Congdon","year":"2016","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.celrep.2025.116291_bib13","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.ebiom.2018.08.041","article-title":"Dynamic assessment of tau immunotherapies in the brains of live animals by two-photon imaging","volume":"35","author":"Wu","year":"2018","journal-title":"EBioMedicine"},{"key":"10.1016\/j.celrep.2025.116291_bib14","doi-asserted-by":"crossref","first-page":"105165","DOI":"10.1016\/j.nbd.2020.105165","article-title":"Increased neuronal activity in motor cortex reveals prominent calcium dyshomeostasis in tauopathy mice","volume":"147","author":"Wu","year":"2021","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.celrep.2025.116291_bib15","doi-asserted-by":"crossref","first-page":"7954","DOI":"10.1002\/alz.14273","article-title":"Neuronal hypofunction and network dysfunction in a mouse model at an early stage of tauopathy","volume":"20","author":"Ji","year":"2024","journal-title":"Alzheimer's Dement."},{"key":"10.1016\/j.celrep.2025.116291_bib16","first-page":"14","article-title":"Antibodies targeting truncated tau protein reduce tau pathology in primary neuronal and mixed cortical cultures","volume":"579","author":"Modak","year":"2015","journal-title":"Soc. Neurosci. Abstr."},{"key":"10.1016\/j.celrep.2025.116291_bib17","first-page":"19","article-title":"Antibodies targeting truncated Asp421 tau protein clear human Alzheimer's tau and prevent its toxicity in primary neuronal and mixed cortical cultures","volume":"478","author":"Modak","year":"2017","journal-title":"Soc. Neurosci. Abstr."},{"key":"10.1016\/j.celrep.2025.116291_bib18","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1016\/j.ajpath.2017.01.022","article-title":"Tau Antibody Targeting Pathological Species Blocks Neuronal Uptake and Interneuron Propagation of Tau in Vitro","volume":"187","author":"Nobuhara","year":"2017","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.celrep.2025.116291_bib19","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0177914","article-title":"Characterization of TauC3 antibody and demonstration of its potential to block tau propagation","volume":"12","author":"Nicholls","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.celrep.2025.116291_bib20","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1146\/annurev-biochem-061516-045049","article-title":"Propagation of Protein Aggregation in Neurodegenerative Diseases","volume":"88","author":"Vaquer-Alicea","year":"2019","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.celrep.2025.116291_bib21","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1001\/jamaneurol.2018.2505","article-title":"Mechanisms of Cell-to-Cell Transmission of Pathological Tau: A Review","volume":"76","author":"Gibbons","year":"2019","journal-title":"JAMA Neurol."},{"key":"10.1016\/j.celrep.2025.116291_bib22","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a024372","article-title":"The Prion-Like Behavior of Assembled Tau in Transgenic Mice","volume":"7","author":"Clavaguera","year":"2017","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"10.1016\/j.celrep.2025.116291_bib23","doi-asserted-by":"crossref","first-page":"59","DOI":"10.3389\/fpsyt.2011.00059","article-title":"Mechanistic Studies of Antibody-Mediated Clearance of Tau Aggregates Using an ex vivo Brain Slice Model","volume":"2","author":"Krishnamurthy","year":"2011","journal-title":"Front. Psychiatry"},{"key":"10.1016\/j.celrep.2025.116291_bib24","doi-asserted-by":"crossref","first-page":"35452","DOI":"10.1074\/jbc.M113.491001","article-title":"Antibody Uptake into Neurons Occurs Primarily via Clathrin-dependent Fcgamma Receptor Endocytosis and Is a Prerequisite for Acute Tau Protein Clearance","volume":"288","author":"Congdon","year":"2013","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.celrep.2025.116291_bib25","doi-asserted-by":"crossref","first-page":"33081","DOI":"10.1074\/jbc.M113.494922","article-title":"Two novel Tau antibodies targeting the 396\/404 region are primarily taken up by neurons and reduce Tau protein pathology","volume":"288","author":"Gu","year":"2013","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.celrep.2025.116291_bib26","doi-asserted-by":"crossref","first-page":"16835","DOI":"10.1523\/JNEUROSCI.2755-14.2014","article-title":"Antibody-derived in vivo imaging of tau pathology","volume":"34","author":"Krishnaswamy","year":"2014","journal-title":"J. Neurosci."},{"key":"10.1016\/j.celrep.2025.116291_bib27","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1016\/j.jalz.2016.01.013","article-title":"Internalization of tau antibody and pathological tau protein detected with a flow cytometry multiplexing approach","volume":"12","author":"Shamir","year":"2016","journal-title":"Alzheimer's Dement."},{"key":"10.1016\/j.celrep.2025.116291_bib28","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1038\/nature14658","article-title":"Antibody against early driver of neurodegeneration cis P-tau blocks brain injury and tauopathy","volume":"523","author":"Kondo","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2025.116291_bib29","doi-asserted-by":"crossref","first-page":"2834","DOI":"10.1093\/brain\/awu213","article-title":"Neuronal uptake of tau\/pS422 antibody and reduced progression of tau pathology in a mouse model of Alzheimer's disease","volume":"137","author":"Collin","year":"2014","journal-title":"Brain"},{"key":"10.1016\/j.celrep.2025.116291_bib30","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1073\/pnas.1607215114","article-title":"Cytosolic Fc receptor TRIM21 inhibits seeded tau aggregation","volume":"114","author":"McEwan","year":"2017","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2025.116291_bib31","doi-asserted-by":"crossref","first-page":"602292","DOI":"10.3389\/fneur.2020.602292","article-title":"Dynamics of internalization and intracellular interaction of tau antibodies and human pathological tau protein in a human neuron-like model","volume":"11","author":"Shamir","year":"2020","journal-title":"Front. Neurol."},{"key":"10.1016\/j.celrep.2025.116291_bib32","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.ebiom.2019.03.033","article-title":"Tau antibody chimerization alters its charge and binding, thereby reducing its cellular uptake and efficacy","volume":"42","author":"Congdon","year":"2019","journal-title":"EBioMedicine"},{"key":"10.1016\/j.celrep.2025.116291_bib33","article-title":"Novel antibody against low-n oligomers of tau protein promotes clearance of tau in cells via lysosomes","volume":"6","author":"Chandupatla","year":"2020","journal-title":"Alzheimer's Dement."},{"key":"10.1016\/j.celrep.2025.116291_bib34","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.1126\/science.abn1366","article-title":"Cytosolic antibody receptor TRIM21 is required for effective tau immunotherapy in mouse models","volume":"379","author":"Mukadam","year":"2023","journal-title":"Science"},{"key":"10.1016\/j.celrep.2025.116291_bib35","doi-asserted-by":"crossref","first-page":"1676","DOI":"10.1016\/j.neuron.2024.02.017","article-title":"P-tau217 correlates with neurodegeneration in Alzheimer's disease, and targeting p-tau217 with immunotherapy ameliorates murine tauopathy","volume":"112","author":"Zhang","year":"2024","journal-title":"Neuron"},{"key":"10.1016\/j.celrep.2025.116291_bib36","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1038\/s41541-019-0118-4","article-title":"Qss Virus-like particle-based vaccine induces robust immunity and protects against tauopathy","volume":"4","author":"Maphis","year":"2019","journal-title":"NPJ. Vaccines"},{"key":"10.1016\/j.celrep.2025.116291_bib37","doi-asserted-by":"crossref","first-page":"4260","DOI":"10.1523\/JNEUROSCI.3192-13.2014","article-title":"Passive Immunization with Tau Oligomer Monoclonal Antibody Reverses Tauopathy Phenotypes without Affecting Hyperphosphorylated Neurofibrillary Tangles","volume":"34","author":"Castillo-Carranza","year":"2014","journal-title":"J. Neurosci."},{"key":"10.1016\/j.celrep.2025.116291_bib38","article-title":"Passive Immunization in JNPL3 Transgenic Mice Using an Array of Phospho-Tau Specific Antibodies","volume":"10","author":"d'Abramo","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.celrep.2025.116291_bib39","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1002\/acn3.176","article-title":"Anti-tau antibody reduces insoluble tau and decreases brain atrophy","volume":"2","author":"Yanamandra","year":"2015","journal-title":"Ann. Clin. Transl. Neurol."},{"key":"10.1016\/j.celrep.2025.116291_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2020.108104","article-title":"Tau immunotherapies: Lessons learned, current status and future considerations","volume":"175","author":"Sandusky-Beltran","year":"2020","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.celrep.2025.116291_bib41","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.semcdb.2021.12.002","article-title":"Targeting tau only extracellularly is likely to be less efficacious than targeting it both intra- and extracellularly","volume":"126","author":"Congdon","year":"2022","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.celrep.2025.116291_bib42","doi-asserted-by":"crossref","first-page":"1690","DOI":"10.1016\/j.celrep.2016.06.099","article-title":"Antibody-Mediated Targeting of Tau In Vivo Does Not Require Effector Function and Microglial Engagement","volume":"16","author":"Lee","year":"2016","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2025.116291_bib43","article-title":"Microglial internalization and degradation of pathological tau is enhanced by an anti-tau monoclonal antibody","volume":"5","author":"Luo","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.celrep.2025.116291_bib44","doi-asserted-by":"crossref","first-page":"4658","DOI":"10.1038\/s41598-019-41105-4","article-title":"Antibody-mediated clearance of tau in primary mouse microglial cultures requires Fcgamma-receptor binding and functional lysosomes","volume":"9","author":"Andersson","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.celrep.2025.116291_bib45","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1186\/s40478-020-00948-z","article-title":"Humanized tau antibodies promote tau uptake by human microglia without any increase of inflammation","volume":"8","author":"Zilkova","year":"2020","journal-title":"Acta Neuropathol. Commun."},{"key":"10.1016\/j.celrep.2025.116291_bib46","first-page":"8816","article-title":"Untangling Tau: Molecular Insights into Neuroinflammation, Pathophysiology, and Emerging Immunotherapies. Curr. Issues Mol","volume":"45","author":"Davidson","year":"2023","journal-title":"Biol"},{"key":"10.1016\/j.celrep.2025.116291_bib47","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1146\/annurev-immunol-101921-035222","article-title":"Immune Activation in Alzheimer Disease","volume":"42","author":"Mary","year":"2024","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.celrep.2025.116291_bib48","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0169-328X(98)00040-0","article-title":"Microglia-specific localisation of a novel calcium binding protein","volume":"57","author":"Ito","year":"1998","journal-title":"Brain Res. Mol. Brain Res."},{"key":"10.1016\/j.celrep.2025.116291_bib49","doi-asserted-by":"crossref","first-page":"16559","DOI":"10.1523\/JNEUROSCI.4363-10.2010","article-title":"Immunotherapy targeting pathological tau prevents cognitive decline in a new tangle mouse model","volume":"30","author":"Boutajangout","year":"2010","journal-title":"J. Neurosci."},{"key":"10.1016\/j.celrep.2025.116291_bib50","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-17313-1","article-title":"Prophylactic Active Tau Immunization Leads to Sustained Reduction in Both Tau and Amyloid-beta Pathologies in 3xTg Mice","volume":"7","author":"Rajamohamedsait","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.celrep.2025.116291_bib51","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/j.trci.2018.09.005","article-title":"Highly specific and selective anti-pS396-tau antibody C10.2 targets seeding-competent tau","volume":"4","author":"Rosenqvist","year":"2018","journal-title":"Alzheimer's Dement."},{"key":"10.1016\/j.celrep.2025.116291_bib52","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2020.104770","article-title":"Neuronally expressed anti-tau scFv prevents tauopathy-induced phenotypes in Drosophila models","volume":"137","author":"Krishnaswamy","year":"2020","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.celrep.2025.116291_bib53","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1007\/978-1-4939-7816-8_22","article-title":"Live Imaging of Pathological Tau Protein and Tau Antibodies in a Neuron-Like Cellular Model","volume":"1779","author":"Shamir","year":"2018","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.celrep.2025.116291_bib54","doi-asserted-by":"crossref","DOI":"10.1126\/science.1260419","article-title":"Proteomics. Tissue-based map of the human proteome","volume":"347","author":"Uhlen","year":"2015","journal-title":"Science"},{"key":"10.1016\/j.celrep.2025.116291_bib55","doi-asserted-by":"crossref","first-page":"11929","DOI":"10.1523\/JNEUROSCI.1860-14.2014","article-title":"An RNA-sequencing transcriptome and splicing database of glia, neurons, and vascular cells of the cerebral cortex","volume":"34","author":"Zhang","year":"2014","journal-title":"J. Neurosci."},{"key":"10.1016\/j.celrep.2025.116291_bib56","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1038\/s41582-020-00435-y","article-title":"Neuroinflammation and microglial activation in Alzheimer disease: where do we go from here?","volume":"17","author":"Leng","year":"2021","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.celrep.2025.116291_bib57","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1038\/s41593-023-01494-2","article-title":"TFEB-vacuolar ATPase signaling regulates lysosomal function and microglial activation in tauopathy","volume":"27","author":"Wang","year":"2024","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.celrep.2025.116291_bib58","doi-asserted-by":"crossref","first-page":"1969","DOI":"10.1038\/s41467-022-29552-6","article-title":"Microglial NF-kappaB drives tau spreading and toxicity in a mouse model of tauopathy","volume":"13","author":"Wang","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2025.116291_bib59","doi-asserted-by":"crossref","first-page":"4985","DOI":"10.1002\/alz.14078","article-title":"Inpp5d haplodeficiency alleviates tau pathology in the PS19 mouse model of Tauopathy","volume":"20","author":"Soni","year":"2024","journal-title":"Alzheimer's Dement."},{"key":"10.1016\/j.celrep.2025.116291_bib60","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1093\/cei\/uxae023","article-title":"Quantifying microglial morphology: an insight into function","volume":"216","author":"Green","year":"2024","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.celrep.2025.116291_bib61","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.jalz.2016.12.006","article-title":"Calcium Hypothesis of Alzheimer's disease and brain aging: A framework for integrating new evidence into a comprehensive theory of pathogenesis","volume":"13","year":"2017","journal-title":"Alzheimer's Dement."},{"key":"10.1016\/j.celrep.2025.116291_bib62","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1016\/j.tins.2008.06.005","article-title":"Neuronal calcium mishandling and the pathogenesis of Alzheimer's disease","volume":"31","author":"Bezprozvanny","year":"2008","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.celrep.2025.116291_bib63","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1046\/j.1471-4159.2003.02020.x","article-title":"Alteration in calcium channel properties is responsible for the neurotoxic action of a familial frontotemporal dementia tau mutation","volume":"87","author":"Furukawa","year":"2003","journal-title":"J. Neurochem."},{"key":"10.1016\/j.celrep.2025.116291_bib64","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/0896-6273(90)90447-N","article-title":"Antigenic changes similar to those seen in neurofibrillary tangles are elicited by glutamate and Ca2+ influx in cultured hippocampal neurons","volume":"4","author":"Mattson","year":"1990","journal-title":"Neuron"},{"key":"10.1016\/j.celrep.2025.116291_bib65","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1097\/00005072-199001000-00006","article-title":"Hippocampal neurons predisposed to neurofibrillary tangle formation are enriched in type II calcium\/calmodulin-dependent protein kinase","volume":"49","author":"McKee","year":"1990","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.celrep.2025.116291_bib66","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/S1568-1637(03)00029-1","article-title":"The calpains in aging and aging-related diseases","volume":"2","author":"Nixon","year":"2003","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.celrep.2025.116291_bib67","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1093\/brain\/awz035","article-title":"In vivo imaging reveals reduced activity of neuronal circuits in a mouse tauopathy model","volume":"142","author":"Marinkovic","year":"2019","journal-title":"Brain"},{"key":"10.1016\/j.celrep.2025.116291_bib68","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/j.neuroscience.2015.08.068","article-title":"Differential calcium alterations in animal models of neurodegenerative disease: Reversal by FK506","volume":"310","author":"Overk","year":"2015","journal-title":"Neuroscience"},{"key":"10.1016\/j.celrep.2025.116291_bib69","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1038\/s41593-018-0289-8","article-title":"Tau impairs neural circuits, dominating amyloid-beta effects, in Alzheimer models in vivo","volume":"22","author":"Busche","year":"2019","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.celrep.2025.116291_bib70","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/s40478-015-0193-3","article-title":"Pro-aggregant Tau impairs mossy fiber plasticity due to structural changes and Ca(++) dysregulation","volume":"3","author":"Decker","year":"2015","journal-title":"Acta Neuropathol. Commun"},{"key":"10.1016\/j.celrep.2025.116291_bib71","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0080834","article-title":"Tau causes synapse loss without disrupting calcium homeostasis in the rTg4510 model of tauopathy","volume":"8","author":"Kopeikina","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.celrep.2025.116291_bib72","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1073\/pnas.1318807111","article-title":"Neurofibrillary tangle-bearing neurons are functionally integrated in cortical circuits in vivo","volume":"111","author":"Kuchibhotla","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2025.116291_bib73","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1038\/78078","article-title":"Neurofibrillary tangles, amyotrophy and progressive motor disturbance in mice expressing mutant (P301L) tau protein","volume":"25","author":"Lewis","year":"2000","journal-title":"Nat. Genet."},{"key":"10.1016\/j.celrep.2025.116291_bib74","doi-asserted-by":"crossref","DOI":"10.1016\/j.jneumeth.2019.108535","article-title":"Imaging neuronal activity in the central and peripheral nervous systems using new Thy1.2-GCaMP6 transgenic mouse lines","volume":"334","author":"Cichon","year":"2020","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.celrep.2025.116291_bib75","doi-asserted-by":"crossref","first-page":"104249","DOI":"10.1016\/j.ebiom.2022.104249","article-title":"Single domain antibodies targeting pathological tau protein: Influence of four IgG subclasses on efficacy and toxicity","volume":"84","author":"Congdon","year":"2022","journal-title":"EBioMedicine"},{"key":"10.1016\/j.celrep.2025.116291_bib76","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1007\/978-1-61779-551-0_28","article-title":"Histological Staining of Amyloid and Pre-amyloid Peptides and Proteins in Mouse Tissue","volume":"849","author":"Rajamohamedsait","year":"2012","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.celrep.2025.116291_bib77","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/S0076-6879(99)09008-4","article-title":"Purification of paired helical filament tau and normal tau from human brain tissue","volume":"309","author":"Lee","year":"1999","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.celrep.2025.116291_bib78","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1038\/22124","article-title":"Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse","volume":"400","author":"Schenk","year":"1999","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2025.116291_bib79","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1186\/s13024-017-0228-2","article-title":"Abnormal dendritic calcium activity and synaptic depotentiation occur early in a mouse model of Alzheimer's disease","volume":"12","author":"Bai","year":"2017","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.celrep.2025.116291_bib80","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1038\/nature14251","article-title":"Branch-specific dendritic Ca(2+) spikes cause persistent synaptic plasticity","volume":"520","author":"Cichon","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2025.116291_bib81","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1038\/nn.4479","article-title":"REM sleep selectively prunes and maintains new synapses in development and learning","volume":"20","author":"Li","year":"2017","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.celrep.2025.116291_bib82","doi-asserted-by":"crossref","first-page":"9445","DOI":"10.1073\/pnas.1703084114","article-title":"Voltage-gated calcium flux mediates Escherichia coli mechanosensation","volume":"114","author":"Bruni","year":"2017","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2025.116291_bib83","doi-asserted-by":"crossref","first-page":"9992","DOI":"10.1523\/JNEUROSCI.1270-12.2012","article-title":"In vivo alterations in calcium buffering capacity in transgenic mouse model of synucleinopathy","volume":"32","author":"Reznichenko","year":"2012","journal-title":"J. Neurosci."},{"key":"10.1016\/j.celrep.2025.116291_bib84","doi-asserted-by":"crossref","DOI":"10.1038\/srep40740","article-title":"High-throughput screen detects calcium signaling dysfunction in typical sporadic autism spectrum disorder","volume":"7","author":"Schmunk","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.celrep.2025.116291_bib85","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1109\/83.650848","article-title":"A pyramid approach to subpixel registration based on intensity","volume":"7","author":"Thevenaz","year":"1998","journal-title":"IEEE Trans. Image Process."}],"container-title":["Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124725010629?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124725010629?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T13:07:30Z","timestamp":1790600850000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211124725010629"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":85,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["S2211124725010629"],"URL":"https:\/\/doi.org\/10.1016\/j.celrep.2025.116291","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2024.05.21.595198","asserted-by":"object"}]},"ISSN":["2211-1247"],"issn-type":[{"value":"2211-1247","type":"print"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Clearing truncated tau protein restores neuronal function and prevents microglia activation in tauopathy mice","name":"articletitle","label":"Article Title"},{"value":"Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.celrep.2025.116291","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"116291"}}