{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T13:55:54Z","timestamp":1790603754213,"version":"4.1.0"},"reference-count":92,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T00:00:00Z","timestamp":1756425600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR-11-IDEX-0003-02"],"award-info":[{"award-number":["ANR-11-IDEX-0003-02"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR-10-INBS-04\/FranceBioImaging"],"award-info":[{"award-number":["ANR-10-INBS-04\/FranceBioImaging"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Reports"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1016\/j.celrep.2025.116320","type":"journal-article","created":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T05:17:05Z","timestamp":1758604625000},"page":"116320","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["Seipin Governs caveolin-1 trafficking through modulating sphingolipid-glycerolipid balance"],"prefix":"10.1016","volume":"44","author":[{"given":"Maxime","family":"Carpentier","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohyeddine","family":"Omrane","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rola","family":"Shaaban","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennica","family":"Tr\u00e4ger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na\u00efma","family":"El Khallouki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soazig","family":"Le Lay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Patat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Palard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehdi","family":"Zouiouich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoann","family":"Combot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Harayama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corinne","family":"Vigouroux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristine","family":"Schauer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Giordano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"Prieur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdou Rachid","family":"Thiam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.celrep.2025.116320_bib1","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1038\/s42255-021-00384-w","article-title":"Reciprocal regulation of cellular mechanics and metabolism","volume":"3","author":"Evers","year":"2021","journal-title":"Nat. Metab."},{"key":"10.1016\/j.celrep.2025.116320_bib2","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1152\/physrev.00003.2009","article-title":"Membrane Fatty Acid Transporters as Regulators of Lipid Metabolism: Implications for Metabolic Disease","volume":"90","author":"Glatz","year":"2010","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.celrep.2025.116320_bib3","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/9761539","article-title":"Role of caveolin-1 in diabetes and its complications","volume":"2020","author":"Haddad","year":"2020","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.celrep.2025.116320_bib4","doi-asserted-by":"crossref","first-page":"367","DOI":"10.4103\/2319-4170.164229","article-title":"Caveolae and cancer: A new mechanical perspective","volume":"38","author":"Lamaze","year":"2015","journal-title":"Biomed. J."},{"key":"10.1016\/j.celrep.2025.116320_bib5","doi-asserted-by":"crossref","first-page":"1628","DOI":"10.1126\/science.1130773","article-title":"Caveolin-1 is essential for liver regeneration","volume":"313","author":"Fern\u00e1ndez","year":"2006","journal-title":"Science"},{"key":"10.1016\/j.celrep.2025.116320_bib6","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1530\/EJE-21-0915","article-title":"Biallelic CAV1 null variants induce congenital generalized lipodystrophy with achalasia","volume":"185","author":"Karhan","year":"2021","journal-title":"Eur. J. Endocrinol."},{"key":"10.1016\/j.celrep.2025.116320_bib7","doi-asserted-by":"crossref","first-page":"1796","DOI":"10.1002\/ajmg.a.37115","article-title":"Whole exome sequencing identifies de novo heterozygous CAV1 mutations associated with a novel neonatal onset lipodystrophy syndrome","volume":"167A","author":"Garg","year":"2015","journal-title":"Am. J. Med. Genet."},{"key":"10.1016\/j.celrep.2025.116320_bib8","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/j.cell.2010.12.031","article-title":"Cells respond to mechanical stress by rapid disassembly of caveolae","volume":"144","author":"Sinha","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2025.116320_bib9","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1111\/j.1600-0854.2011.01259.x","article-title":"Mitochondrial Cholesterol: A Connection Between Caveolin, Metabolism, and Disease","volume":"12","author":"Bosch","year":"2011","journal-title":"Traffic"},{"key":"10.1016\/j.celrep.2025.116320_bib10","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.ceb.2020.02.001","article-title":"Caveolae: Formation, dynamics, and function","volume":"65","author":"Parton","year":"2020","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.celrep.2025.116320_bib11","doi-asserted-by":"crossref","first-page":"L1179","DOI":"10.1152\/ajplung.00242.2003","article-title":"Caveolin regulation of endothelial function","volume":"285","author":"Minshall","year":"2003","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"10.1016\/j.celrep.2025.116320_bib12","doi-asserted-by":"crossref","first-page":"41295","DOI":"10.1074\/jbc.R200020200","article-title":"Multiple functions of caveolin-1","volume":"277","author":"Liu","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.celrep.2025.116320_bib13","doi-asserted-by":"crossref","DOI":"10.1083\/jcb.201905071","article-title":"Caveolae and lipid sorting: Shaping the cellular response to stress","volume":"219","author":"Parton","year":"2020","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.celrep.2025.116320_bib14","doi-asserted-by":"crossref","first-page":"jcs241562","DOI":"10.1242\/jcs.241562","article-title":"Non-caveolar caveolins-duties outside the caves","volume":"133","author":"Pol","year":"2020","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.celrep.2025.116320_bib15","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1083\/jcb.152.5.1079","article-title":"Caveolin-2 is targeted to lipid droplets, a new \u201cmembrane domain\u201d in the cell","volume":"152","author":"Fujimoto","year":"2001","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.celrep.2025.116320_bib16","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1083\/jcb.152.5.1071","article-title":"Accumulation of Caveolin in the Endoplasmic Reticulum Redirects the Protein to Lipid Storage Droplets","volume":"152","author":"Ostermeyer","year":"2001","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.celrep.2025.116320_bib17","article-title":"Early proteostasis of caveolins synchronizes trafficking, degradation, and oligomerization to prevent toxic aggregation","volume":"222","author":"Morales-Paytuv\u00ed","year":"2023","journal-title":"JCB (J. Cell Biol.)"},{"key":"10.1016\/j.celrep.2025.116320_bib18","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1016\/j.bbalip.2008.10.008","article-title":"Filling up adipocytes with lipids. Lessons from caveolin-1 deficiency","volume":"1791","author":"Le Lay","year":"2009","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.celrep.2025.116320_bib19","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1111\/j.1600-0854.2006.00406.x","article-title":"Cholesterol-induced caveolin targeting to lipid droplets in adipocytes: a role for caveolar endocytosis","volume":"7","author":"Le Lay","year":"2006","journal-title":"Traffic"},{"key":"10.1016\/j.celrep.2025.116320_bib20","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.tem.2011.04.001","article-title":"Fat caves: caveolae, lipid trafficking and lipid metabolism in adipocytes","volume":"22","author":"Pilch","year":"2011","journal-title":"Trends Endocrinol. Metab."},{"key":"10.1016\/j.celrep.2025.116320_bib21","doi-asserted-by":"crossref","first-page":"10683","DOI":"10.1074\/jbc.M208563200","article-title":"The adipocyte plasma membrane caveolin functional\/structural organization is necessary for the efficient endocytosis of GLUT4","volume":"278","author":"Shigematsu","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.celrep.2025.116320_bib22","first-page":"1","article-title":"The effect of caveolin-1 (Cav-1) on fatty acid uptake and CD36 localization and lipotoxicity in vascular smooth muscle (VSM) cells","volume":"1","author":"Mattern","year":"2009","journal-title":"Int. J. Physiol. Pathophysiol. Pharmacol."},{"key":"10.1016\/j.celrep.2025.116320_bib23","doi-asserted-by":"crossref","first-page":"12050","DOI":"10.1073\/pnas.211341698","article-title":"Lipid rafts are required for GLUT4 internalization in adipose cells","volume":"98","author":"Ros-Bar\u00f3","year":"2001","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2025.116320_bib24","doi-asserted-by":"crossref","first-page":"3493","DOI":"10.1210\/en.2008-1520","article-title":"Caveolin-1 loss of function accelerates glucose transporter 4 and insulin receptor degradation in 3T3-L1 adipocytes","volume":"150","author":"Gonzalez-Munoz","year":"2009","journal-title":"Endocrinology"},{"key":"10.1016\/j.celrep.2025.116320_bib25","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1016\/j.bbalip.2006.03.016","article-title":"Caveolin-1 is required for fatty acid translocase (FAT\/CD36) localization and function at the plasma membrane of mouse embryonic fibroblasts","volume":"1761","author":"Ring","year":"2006","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.celrep.2025.116320_bib26","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1111\/cas.13448","article-title":"ASC amino acid transporter 2, defined by enzyme-mediated activation of radical sources, enhances malignancy of GD2-positive small-cell lung cancer","volume":"109","author":"Esaki","year":"2018","journal-title":"Cancer Sci."},{"key":"10.1016\/j.celrep.2025.116320_bib27","doi-asserted-by":"crossref","DOI":"10.1126\/scisignal.aal2005","article-title":"Caveolin-1-mediated internalization of the vitamin C transporter SVCT2 in microglia triggers an inflammatory phenotype","volume":"10","author":"Portugal","year":"2017","journal-title":"Sci. Signal."},{"key":"10.1016\/j.celrep.2025.116320_bib28","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1210\/jc.2007-1328","article-title":"Association of a homozygous nonsense caveolin-1 mutation with Berardinelli-Seip congenital lipodystrophy","volume":"93","author":"Kim","year":"2008","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.celrep.2025.116320_bib29","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1194\/jlr.R023754","article-title":"Seipin: from human disease to molecular mechanism","volume":"53","author":"Cartwright","year":"2012","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.celrep.2025.116320_bib30","doi-asserted-by":"crossref","first-page":"2939","DOI":"10.1038\/s41467-018-05278-2","article-title":"Seipin and the membrane-shaping protein Pex30 cooperate in organelle budding from the endoplasmic reticulum","volume":"9","author":"Wang","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2025.116320_bib31","article-title":"Dynamics and functions of lipid droplets","volume":"1","author":"Olzmann","year":"2018","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.celrep.2025.116320_bib32","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1038\/ng585","article-title":"Identification of the gene altered in Berardinelli-Seip congenital lipodystrophy on chromosome 11q13","volume":"28","author":"Magr\u00e9","year":"2001","journal-title":"Nat. Genet."},{"key":"10.1016\/j.celrep.2025.116320_bib33","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.devcel.2018.09.010","article-title":"Human SEIPIN binds anionic phospholipids","volume":"47","author":"Yan","year":"2018","journal-title":"Dev. Cell"},{"key":"10.1016\/j.celrep.2025.116320_bib34","doi-asserted-by":"crossref","first-page":"4080","DOI":"10.1083\/jcb.201809067","article-title":"Cryo-electron microscopy structure of the lipid droplet-formation protein seipin","volume":"217","author":"Sui","year":"2018","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.celrep.2025.116320_bib35","article-title":"Adipogenin Dictates Adipose Tissue Expansion by Facilitating the Assembly of a Dodecameric Seipin Complex","author":"Li","year":"2024","journal-title":"bioRxiv"},{"key":"10.1016\/j.celrep.2025.116320_bib36","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1038\/s41594-021-00718-y","article-title":"Seipin forms a flexible cage at lipid droplet formation sites","volume":"29","author":"Arlt","year":"2022","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.celrep.2025.116320_bib37","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1016\/j.devcel.2019.05.016","article-title":"Seipin facilitates triglyceride flow to lipid droplet and counteracts droplet ripening via endoplasmic reticulum contact","volume":"50","author":"Salo","year":"2019","journal-title":"Dev. Cell"},{"key":"10.1016\/j.celrep.2025.116320_bib38","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.16582","article-title":"Seipin is required for converting nascent to mature lipid droplets","volume":"5","author":"Wang","year":"2016","journal-title":"eLife"},{"key":"10.1016\/j.celrep.2025.116320_bib39","article-title":"Steric Repulsion Counteracts ER-to-Lipid Droplet Protein Movement","author":"Damm","year":"2024","journal-title":"bioRxiv"},{"key":"10.1016\/j.celrep.2025.116320_bib40","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.1038\/s41556-022-00974-0","article-title":"Identification of two pathways mediating protein targeting from ER to lipid droplets","volume":"24","author":"Song","year":"2022","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.celrep.2025.116320_bib41","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1016\/j.bbalip.2013.05.001","article-title":"Intestinal caveolin-1 is important for dietary fatty acid absorption","volume":"1831","author":"Siddiqi","year":"2013","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.celrep.2025.116320_bib42","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.tem.2011.02.004","article-title":"Seipin, adipogenesis and lipid droplets","volume":"22","author":"Fei","year":"2011","journal-title":"Trends Endocrinol. Metab."},{"key":"10.1016\/j.celrep.2025.116320_bib43","doi-asserted-by":"crossref","first-page":"20890","DOI":"10.1073\/pnas.0704154104","article-title":"The lipodystrophy protein seipin is found at endoplasmic reticulum lipid droplet junctions and is important for droplet morphology","volume":"104","author":"Szymanski","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2025.116320_bib44","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1016\/S0955-0674(96)80033-0","article-title":"Caveolae and caveolins","volume":"8","author":"Parton","year":"1996","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.celrep.2025.116320_bib45","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.tcb.2012.04.007","article-title":"Stressing caveolae new role in cell mechanics","volume":"22","author":"Nassoy","year":"2012","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.celrep.2025.116320_bib46","article-title":"Energy and dynamics of caveolae trafficking","volume":"8","author":"Matthaeus","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.celrep.2025.116320_bib47","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1038\/nmeth.1928","article-title":"Synchronization of secretory protein traffic in populations of cells","volume":"9","author":"Boncompain","year":"2012","journal-title":"Nat. Methods"},{"key":"10.1016\/j.celrep.2025.116320_bib48","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.semcdb.2020.04.001","article-title":"Direct trafficking pathways from the Golgi apparatus to the plasma membrane","volume":"107","author":"Stalder","year":"2020","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.celrep.2025.116320_bib49","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.ceb.2021.02.005","article-title":"Sending out molecules from the TGN","volume":"71","author":"Ramazanov","year":"2021","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.celrep.2025.116320_bib50","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1016\/j.cell.2013.09.056","article-title":"A four-step cycle driven by PI (4) P hydrolysis directs sterol\/PI (4) P exchange by the ER-Golgi tether OSBP","volume":"155","author":"Mesmin","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2025.116320_bib51","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1038\/nature02188","article-title":"Molecular machinery for non-vesicular trafficking of ceramide","volume":"426","author":"Hanada","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2025.116320_bib52","doi-asserted-by":"crossref","first-page":"3156","DOI":"10.15252\/embj.201796687","article-title":"Sterol transfer, PI 4P consumption, and control of membrane lipid order by endogenous OSBP","volume":"36","author":"Mesmin","year":"2017","journal-title":"EMBO J."},{"key":"10.1016\/j.celrep.2025.116320_bib53","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1021\/acs.accounts.2c00586","article-title":"Fluorescent Probes for Lipid Membranes: From the Cell Surface to Organelles","volume":"56","author":"Klymchenko","year":"2023","journal-title":"Acc. Chem. Res."},{"key":"10.1016\/j.celrep.2025.116320_bib54","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1021\/jacs.0c10972","article-title":"Targeted solvatochromic fluorescent probes for imaging lipid order in organelles under oxidative and mechanical stress","volume":"143","author":"Danylchuk","year":"2021","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.celrep.2025.116320_bib55","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1038\/s41467-023-36375-6","article-title":"Cholesterol esters form supercooled lipid droplets whose nucleation is facilitated by triacylglycerols","volume":"14","author":"Dumesnil","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2025.116320_bib56","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1111\/j.1365-2184.2011.00761.x","article-title":"Serine palmitoyltransferase inhibitor myriocin induces growth inhibition of B16F10 melanoma cells through G2\/M phase arrest: Myriocin inhibits B16F10 melanoma cell growth","volume":"44","author":"Lee","year":"2011","journal-title":"Cell Prolif."},{"key":"10.1016\/j.celrep.2025.116320_bib57","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/j.bbalip.2013.08.011","article-title":"Ceramide synthesis in the epidermis","volume":"1841","author":"Rabionet","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.celrep.2025.116320_bib58","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1038\/nrm.2017.138","article-title":"Understanding the diversity of membrane lipid composition","volume":"19","author":"Harayama","year":"2018","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.celrep.2025.116320_bib59","article-title":"Stearoyl-CoA desaturase-1 mediated cell apoptosis in colorectal cancer by promoting ceramide synthesis","volume":"6","author":"Chen","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.celrep.2025.116320_bib60","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1016\/j.biochi.2009.01.011","article-title":"Seipin deficiency alters fatty acid \u03949 desaturation and lipid droplet formation in Berardinelli-Seip congenital lipodystrophy","volume":"91","author":"Boutet","year":"2009","journal-title":"Biochimie"},{"key":"10.1016\/j.celrep.2025.116320_bib61","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1007\/s11745-016-4210-5","article-title":"Hepatic BSCL2 (Seipin) Deficiency Disrupts Lipid Droplet Homeostasis and Increases Lipid Metabolism via SCD1 Activity","volume":"52","author":"Lounis","year":"2017","journal-title":"Lipids"},{"key":"10.1016\/j.celrep.2025.116320_bib62","doi-asserted-by":"crossref","first-page":"1546","DOI":"10.1016\/j.celrep.2016.10.037","article-title":"SEIPIN regulates lipid droplet expansion and adipocyte development by modulating the activity of glycerol-3-phosphate acyltransferase","volume":"17","author":"Pagac","year":"2016","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2025.116320_bib63","doi-asserted-by":"crossref","first-page":"3663","DOI":"10.1083\/jcb.201902072","article-title":"Seipin negatively regulates sphingolipid production at the ER-LD contact site","volume":"218","author":"Su","year":"2019","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.celrep.2025.116320_bib64","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/j.cmet.2014.03.028","article-title":"Seipin promotes adipose tissue fat storage through the ER Ca2+-ATPase SERCA","volume":"19","author":"Bi","year":"2014","journal-title":"Cell Metab."},{"key":"10.1016\/j.celrep.2025.116320_bib65","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.tcb.2020.11.006","article-title":"Lipid Droplet Nucleation","volume":"31","author":"Thiam","year":"2020","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.celrep.2025.116320_bib66","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.88049","article-title":"Mice lacking triglyceride synthesis enzymes in adipose tissue are resistant to diet-induced obesity","volume":"12","author":"Chitraju","year":"2023","journal-title":"eLife"},{"key":"10.1016\/j.celrep.2025.116320_bib67","doi-asserted-by":"crossref","first-page":"1928","DOI":"10.1194\/jlr.M600172-JLR200","article-title":"Colocalization of SCD1 and DGAT2: implying preference for endogenous monounsaturated fatty acids in triglyceride synthesis","volume":"47","author":"Man","year":"2006","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.celrep.2025.116320_bib68","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.molmet.2014.12.013","article-title":"Seipin oligomers can interact directly with AGPAT2 and lipin 1, physically scaffolding critical regulators of adipogenesis","volume":"4","author":"Talukder","year":"2015","journal-title":"Mol. Metab."},{"key":"10.1016\/j.celrep.2025.116320_bib69","doi-asserted-by":"crossref","DOI":"10.1083\/jcb.201910177","article-title":"Seipin and Nem1 establish discrete ER subdomains to initiate yeast lipid droplet biogenesis","volume":"219","author":"Choudhary","year":"2020","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.celrep.2025.116320_bib70","doi-asserted-by":"crossref","DOI":"10.1083\/jcb.202112107","article-title":"ORP5 and ORP8 orchestrate lipid droplet biogenesis and maintenance at ER-mitochondria contact sites","volume":"221","author":"Guyard","year":"2022","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.celrep.2025.116320_bib71","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1016\/j.molcel.2019.09.011","article-title":"MIGA2 links mitochondria, the ER, and lipid droplets and promotes de novo lipogenesis in adipocytes","volume":"76","author":"Freyre","year":"2019","journal-title":"Mol. Cell"},{"key":"10.1016\/j.celrep.2025.116320_bib72","doi-asserted-by":"crossref","DOI":"10.26508\/lsa.202101278","article-title":"Serine palmitoyltransferase assembles at ER-mitochondria contact sites","volume":"5","author":"Aaltonen","year":"2022","journal-title":"Life Sci. Alliance"},{"key":"10.1016\/j.celrep.2025.116320_bib73","doi-asserted-by":"crossref","first-page":"7471","DOI":"10.1073\/pnas.1918415117","article-title":"EHD2-mediated restriction of caveolar dynamics regulates cellular fatty acid uptake","volume":"117","author":"Matthaeus","year":"2020","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2025.116320_bib74","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.molmet.2016.05.004","article-title":"AGPAT2 is essential for postnatal development and maintenance of white and brown adipose tissue","volume":"5","author":"Cautivo","year":"2016","journal-title":"Mol. Metab."},{"key":"10.1016\/j.celrep.2025.116320_bib75","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1007\/s00125-018-4590-6","article-title":"Ceramide stearic to palmitic acid ratio predicts incident diabetes","volume":"61","author":"Hilvo","year":"2018","journal-title":"Diabetologia"},{"key":"10.1016\/j.celrep.2025.116320_bib76","doi-asserted-by":"crossref","first-page":"D640","DOI":"10.1093\/nar\/gkad1045","article-title":"MetaboLights: open data repository for metabolomics","volume":"52","author":"Yurekten","year":"2024","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.celrep.2025.116320_bib86","doi-asserted-by":"crossref","first-page":"6512","DOI":"10.1021\/acs.analchem.0c00023","article-title":"Polarity mapping of cells and embryos by improved fluorescent solvatochromic pyrene probe","volume":"92","author":"Valanciunaite","year":"2020","journal-title":"Anal. Chem."},{"key":"10.1016\/j.celrep.2025.116320_bib78","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1002\/dvg.20665","article-title":"Tamoxifen-inducible Cre-mediated recombination in adipocytes","volume":"48","author":"Sassmann","year":"2010","journal-title":"Genesis"},{"key":"10.1016\/j.celrep.2025.116320_bib90","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1111\/j.1600-0854.2009.01023.x","article-title":"Biogenesis of caveolae: stepwise assembly of large caveolin and cavin complexes","volume":"11","author":"Hayer","year":"2010","journal-title":"Traffic"},{"key":"10.1016\/j.celrep.2025.116320_bib91","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1083\/jcb.145.7.1443","article-title":"Molecular characterization of caveolin association with the Golgi complex: identification of a cis-Golgi targeting domain in the caveolin molecule","volume":"145","author":"Luetterforst","year":"1999","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.celrep.2025.116320_bib92","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1038\/s41592-019-0512-x","article-title":"An efficient auxin-inducible degron system with low basal degradation in human cells","volume":"16","author":"Li","year":"2019","journal-title":"Nat. Methods"},{"key":"10.1016\/j.celrep.2025.116320_bib82","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1186\/s12859-021-04344-9","article-title":"CellProfiler 4: improvements in speed, utility and usability","volume":"22","author":"Stirling","year":"2021","journal-title":"BMC Bioinf."},{"key":"10.1016\/j.celrep.2025.116320_bib83","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.2005970","article-title":"CellProfiler 3.0: Next-generation image processing for biology","volume":"16","author":"McQuin","year":"2018","journal-title":"PLoS Biol."},{"key":"10.1016\/j.celrep.2025.116320_bib84","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1093\/bioinformatics\/btr095","article-title":"Improved structure, function and compatibility for CellProfiler: modular high-throughput image analysis software","volume":"27","author":"Kamentsky","year":"2011","journal-title":"Bioinformatics"},{"key":"10.1016\/j.celrep.2025.116320_bib85","doi-asserted-by":"crossref","DOI":"10.1186\/gb-2006-7-10-r100","article-title":"CellProfiler: image analysis software for identifying and quantifying cell phenotypes","volume":"7","author":"Carpenter","year":"2006","journal-title":"Genome Biol."},{"key":"10.1016\/j.celrep.2025.116320_bib77","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1002\/dvg.20826","article-title":"Highly-efficient, fluorescent, locus directed cre and FlpO deleter mice on a pure C57BL\/6N genetic background","volume":"50","author":"Birling","year":"2012","journal-title":"Genesis"},{"key":"10.1016\/j.celrep.2025.116320_bib79","doi-asserted-by":"crossref","first-page":"3767","DOI":"10.1038\/s41467-024-48086-7","article-title":"Giant organelle vesicles to uncover intracellular membrane mechanics and plasticity","volume":"15","author":"Santinho","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2025.116320_bib80","doi-asserted-by":"crossref","first-page":"2276","DOI":"10.1038\/s41467-021-22518-0","article-title":"Democratising deep learning for microscopy with ZeroCostDL4Mic","volume":"12","author":"von Chamier","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2025.116320_bib81","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1038\/s41592-020-01018-x","article-title":"Cellpose: a generalist algorithm for cellular segmentation","volume":"18","author":"Stringer","year":"2021","journal-title":"Nat. Methods"},{"key":"10.1016\/j.celrep.2025.116320_bib87","first-page":"1266","article-title":"LC3B is lipidated to large lipid droplets during prolonged starvation for noncanonical autophagy","volume":"58","author":"Omrane","year":"2023","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2025.116320_bib88","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/S0021-9258(18)64849-5","article-title":"A simple method for the isolation and purification of total lipids from animal tissues","volume":"226","author":"Folch","year":"1957","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.celrep.2025.116320_bib89","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1109\/TSMC.1979.4310076","article-title":"A threshold selection method from gray-level histograms","volume":"9","author":"Otsu","year":"1979","journal-title":"IEEE Trans. Syst. Man Cybern."}],"container-title":["Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124725010915?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124725010915?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T13:04:17Z","timestamp":1790600657000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211124725010915"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":92,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["S2211124725010915"],"URL":"https:\/\/doi.org\/10.1016\/j.celrep.2025.116320","relation":{},"ISSN":["2211-1247"],"issn-type":[{"value":"2211-1247","type":"print"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Seipin Governs caveolin-1 trafficking through modulating sphingolipid-glycerolipid balance","name":"articletitle","label":"Article Title"},{"value":"Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.celrep.2025.116320","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"116320"}}