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R package version 2.5.3 (Northwestern University, Evanston, Illinois)"},{"key":"10.1016\/j.celrep.2025.116379_bib118","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.1093\/bioinformatics\/btr167","article-title":"Bismark: a flexible aligner and methylation caller for Bisulfite-Seq applications","volume":"27","author":"Krueger","year":"2011","journal-title":"Bioinformatics"},{"key":"10.1016\/j.celrep.2025.116379_bib119","doi-asserted-by":"crossref","first-page":"R83","DOI":"10.1186\/gb-2012-13-10-r83","article-title":"BSmooth: from whole genome bisulfite sequencing reads to differentially methylated regions","volume":"13","author":"Hansen","year":"2012","journal-title":"Genome Biol."},{"key":"10.1016\/j.celrep.2025.116379_bib94","doi-asserted-by":"crossref","first-page":"2414","DOI":"10.1093\/bioinformatics\/btu339","article-title":"MethylSig: a whole genome DNA methylation analysis pipeline","volume":"30","author":"Park","year":"2014","journal-title":"Bioinformatics"},{"key":"10.1016\/j.celrep.2025.116379_bib95","doi-asserted-by":"crossref","first-page":"W39","DOI":"10.1093\/nar\/gkv416","article-title":"The MEME Suite","volume":"43","author":"Bailey","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.celrep.2025.116379_bib96","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1038\/s41587-020-0439-x","article-title":"The nf-core framework for community-curated bioinformatics pipelines","volume":"38","author":"Ewels","year":"2020","journal-title":"Nat. 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