{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T03:05:01Z","timestamp":1791947101286,"version":"4.3.4"},"reference-count":57,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T00:00:00Z","timestamp":1759449600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004731","name":"Zhejiang Province Natural Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017594","name":"Medical Science and Technology Project of Zhejiang Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100017594","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Reports"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.celrep.2025.116473","type":"journal-article","created":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T02:39:52Z","timestamp":1761187192000},"page":"116473","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"title":["PreTA-mediated metabolism of 5-fluorouracil by intratumoral Citrobacter freundii drives chemoresistance in pancreatic cancer"],"prefix":"10.1016","volume":"44","author":[{"given":"Weiben","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiying","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengqian","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shujing","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linwei","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangyu","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhajun","family":"Zhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lulu","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhua","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Canming","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengqin","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liefeng","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Libin","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luo","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.celrep.2025.116473_bib1","first-page":"229","article-title":"Global cancer statistics 2022: Globocan estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"74","author":"Bray","year":"2024","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.celrep.2025.116473_bib2","doi-asserted-by":"crossref","first-page":"439","DOI":"10.6004\/jnccn.2021.0017","article-title":"Pancreatic adenocarcinoma, version 2.2021, nccn clinical practice guidelines in oncology","volume":"19","author":"Tempero","year":"2021","journal-title":"J. Natl. Compr. Canc. Netw."},{"key":"10.1016\/j.celrep.2025.116473_bib3","doi-asserted-by":"crossref","first-page":"3217","DOI":"10.1200\/JCO.20.01364","article-title":"Metastatic pancreatic cancer: Asco guideline update","volume":"38","author":"Sohal","year":"2020","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.celrep.2025.116473_bib4","first-page":"2289","article-title":"The oral fluoropyrimidines in cancer chemotherapy","volume":"5","author":"Lamont","year":"1999","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.celrep.2025.116473_bib5","doi-asserted-by":"crossref","first-page":"15682","DOI":"10.3748\/wjg.v20.i42.15682","article-title":"Recent studies of 5-fluorouracil resistance in pancreatic cancer","volume":"20","author":"Wang","year":"2014","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.celrep.2025.116473_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2021.111285","article-title":"5-fluorouracil (5-fu) resistance and the new strategy to enhance the sensitivity against cancer: Implication of DNA repair inhibition","volume":"137","author":"Sethy","year":"2021","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.celrep.2025.116473_bib7","first-page":"12","article-title":"Cancer statistics, 2024","volume":"74","author":"Siegel","year":"2024","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.celrep.2025.116473_bib8","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1126\/science.aay9189","article-title":"The human tumor microbiome is composed of tumor type-specific intracellular bacteria","volume":"368","author":"Nejman","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.celrep.2025.116473_bib9","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1016\/j.cell.2022.02.027","article-title":"Tumor-resident intracellular microbiota promotes metastatic colonization in breast cancer","volume":"185","author":"Fu","year":"2022","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2025.116473_bib10","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1038\/s41586-022-05435-0","article-title":"Effect of the intratumoral microbiota on spatial and cellular heterogeneity in cancer","volume":"611","author":"Galeano Ni\u00f1o","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2025.116473_bib11","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1158\/2159-8290.CD-17-1134","article-title":"The pancreatic cancer microbiome promotes oncogenesis by induction of innate and adaptive immune suppression","volume":"8","author":"Pushalkar","year":"2018","journal-title":"Cancer Discov."},{"key":"10.1016\/j.celrep.2025.116473_bib12","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1186\/s40168-018-0483-7","article-title":"Pharmacomicrobiomics: Exploiting the drug-microbiota interactions in anticancer therapies","volume":"6","author":"Panebianco","year":"2018","journal-title":"Microbiome"},{"key":"10.1016\/j.celrep.2025.116473_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.111625","article-title":"The cancer chemotherapeutic 5-fluorouracil is a potent fusobacterium nucleatum inhibitor and its activity is modified by intratumoral microbiota","volume":"41","author":"LaCourse","year":"2022","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2025.116473_bib14","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1038\/s41564-022-01226-5","article-title":"Host and gut bacteria share metabolic pathways for anti-cancer drug metabolism","volume":"7","author":"Spanogiannopoulos","year":"2022","journal-title":"Nat. Microbiol."},{"key":"10.1016\/j.celrep.2025.116473_bib15","doi-asserted-by":"crossref","first-page":"1945","DOI":"10.1016\/j.ccell.2023.09.012","article-title":"Tumor-resident lactobacillus iners confer chemoradiation resistance through lactate-induced metabolic rewiring","volume":"41","author":"Colbert","year":"2023","journal-title":"Cancer Cell"},{"key":"10.1016\/j.celrep.2025.116473_bib16","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1126\/science.aah5043","article-title":"Potential role of intratumor bacteria in mediating tumor resistance to the chemotherapeutic drug gemcitabine","volume":"357","author":"Geller","year":"2017","journal-title":"Science"},{"key":"10.1016\/j.celrep.2025.116473_bib17","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1016\/j.ejca.2003.12.004","article-title":"Dihydropyrimidine dehydrogenase and the efficacy and toxicity of 5-fluorouracil","volume":"40","author":"van Kuilenburg","year":"2004","journal-title":"Eur. J. Cancer"},{"key":"10.1016\/j.celrep.2025.116473_bib18","first-page":"XE01","article-title":"Current development of anti-cancer drug s-1","volume":"10","author":"Chhetri","year":"2016","journal-title":"J. Clin. Diagn. Res."},{"key":"10.1016\/j.celrep.2025.116473_bib19","doi-asserted-by":"crossref","first-page":"15110","DOI":"10.3748\/wjg.v20.i41.15110","article-title":"S-1 in the treatment of pancreatic cancer","volume":"20","author":"Sudo","year":"2014","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.celrep.2025.116473_bib20","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1097\/00001813-199607000-00010","article-title":"Development of a novel form of an oral 5-fluorouracil derivative (s-1) directed to the potentiation of the tumor selective cytotoxicity of 5-fluorouracil by two biochemical modulators","volume":"7","author":"Shirasaka","year":"1996","journal-title":"Anti Cancer Drugs"},{"key":"10.1016\/j.celrep.2025.116473_bib21","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/S0140-6736(16)30583-9","article-title":"Adjuvant chemotherapy of s-1 versus gemcitabine for resected pancreatic cancer: A phase 3, open-label, randomised, non-inferiority trial (jaspac 01)","volume":"388","author":"Uesaka","year":"2016","journal-title":"Lancet"},{"key":"10.1016\/j.celrep.2025.116473_bib22","doi-asserted-by":"crossref","first-page":"8529","DOI":"10.1021\/jacs.1c10998","article-title":"Real-time monitoring of host-gut microbial interspecies interaction in anticancer drug metabolism","volume":"144","author":"Nguyen","year":"2022","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.celrep.2025.116473_bib23","doi-asserted-by":"crossref","first-page":"e55","DOI":"10.1002\/imt2.55","article-title":"Ipga: A handy integrated prokaryotes genome and pan-genome analysis web service","volume":"1","author":"Liu","year":"2022","journal-title":"Imeta"},{"key":"10.1016\/j.celrep.2025.116473_bib24","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1128\/JB.01178-10","article-title":"Escherichia coli dihydropyrimidine dehydrogenase is a novel nad-dependent heterotetramer essential for the production of 5,6-dihydrouracil","volume":"193","author":"Hidese","year":"2011","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.celrep.2025.116473_bib25","article-title":"Multiple protein structure alignment at scale with foldmason","author":"Gilchrist","year":"2024","journal-title":"bioRxiv"},{"key":"10.1016\/j.celrep.2025.116473_bib26","first-page":"1239","article-title":"Attenuation of the antitumor activity of 5-fluorouracil by (r)-5-fluoro-5,6-dihydrouracil","volume":"55","author":"Spector","year":"1995","journal-title":"Cancer Res."},{"key":"10.1016\/j.celrep.2025.116473_bib27","first-page":"5553","article-title":"Effects of uridine and thymidine on the degradation of 5-fluorouracil, uracil, and thymine by rat liver dihydropyrimidine dehydrogenase","volume":"45","author":"Tuchman","year":"1985","journal-title":"Cancer Res."},{"key":"10.1016\/j.celrep.2025.116473_bib28","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1158\/1078-0432.CCR-07-1225","article-title":"Can inhibiting dihydropyrimidine dehydrogenase limit hand-foot syndrome caused by fluoropyrimidines?","volume":"14","author":"Yen-Revollo","year":"2008","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.celrep.2025.116473_bib29","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1200\/JCO.2002.20.6.1519","article-title":"Randomized, open-label, phase iii study of a 28-day oral regimen of eniluracil plus fluorouracil versus intravenous fluorouracil plus leucovorin as first-line therapy in patients with metastatic\/advanced colorectal cancer","volume":"20","author":"Schilsky","year":"2002","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.celrep.2025.116473_bib30","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/j.cell.2019.07.008","article-title":"Tumor microbiome diversity and composition influence pancreatic cancer outcomes","volume":"178","author":"Riquelme","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2025.116473_bib31","article-title":"Current understanding of the intratumoral microbiome in various tumors","volume":"4","author":"Xue","year":"2023","journal-title":"Cell Rep. Med."},{"key":"10.1016\/j.celrep.2025.116473_bib32","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1038\/s41568-023-00594-2","article-title":"Bacteria in cancer initiation, promotion and progression","volume":"23","author":"El Tekle","year":"2023","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.celrep.2025.116473_bib33","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202200470","article-title":"Microbiota in tumors: From understanding to application","volume":"9","author":"Xie","year":"2022","journal-title":"Adv. Sci."},{"key":"10.1016\/j.celrep.2025.116473_bib34","doi-asserted-by":"crossref","first-page":"9909","DOI":"10.1158\/0008-5472.CAN-08-1551","article-title":"Enterococcus faecalis induces aneuploidy and tetraploidy in colonic epithelial cells through a bystander effect","volume":"68","author":"Wang","year":"2008","journal-title":"Cancer Res."},{"key":"10.1016\/j.celrep.2025.116473_bib35","doi-asserted-by":"crossref","DOI":"10.1126\/science.aar7785","article-title":"The human gut bacterial genotoxin colibactin alkylates DNA","volume":"363","author":"Wilson","year":"2019","journal-title":"Science"},{"key":"10.1016\/j.celrep.2025.116473_bib36","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1158\/2159-8290.CD-21-0912","article-title":"Bacterial genotoxin accelerates transient infection-driven murine colon tumorigenesis","volume":"12","author":"Liu","year":"2022","journal-title":"Cancer Discov."},{"key":"10.1016\/j.celrep.2025.116473_bib37","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1136\/gutjnl-2023-330941","article-title":"Oral bacteria accelerate pancreatic cancer development in mice","volume":"73","author":"Saba","year":"2024","journal-title":"Gut"},{"key":"10.1016\/j.celrep.2025.116473_bib38","doi-asserted-by":"crossref","DOI":"10.1128\/spectrum.04254-23","article-title":"Investigation of citrobacter freundii clinical isolates in a chinese hospital during 2020-2022 revealed genomic characterization of an extremely drug-resistant c. Freundii st257 clinical strain gmu8049 co-carrying bla(ndm-1) and a novel bla(cmy) variant","volume":"12","author":"Zhang","year":"2024","journal-title":"Microbiol. Spectr."},{"key":"10.1016\/j.celrep.2025.116473_bib39","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.cmet.2023.11.019","article-title":"Targeting gut microbial nitrogen recycling and cellular uptake of ammonium to improve bortezomib resistance in multiple myeloma","volume":"36","author":"Zhu","year":"2024","journal-title":"Cell Metab."},{"key":"10.1016\/j.celrep.2025.116473_bib40","doi-asserted-by":"crossref","first-page":"4123","DOI":"10.1038\/s41380-022-01569-9","article-title":"Multi-omics analyses of serum metabolome, gut microbiome and brain function reveal dysregulated microbiota-gut-brain axis in bipolar depression","volume":"27","author":"Li","year":"2022","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.celrep.2025.116473_bib41","doi-asserted-by":"crossref","DOI":"10.1080\/19490976.2021.1983101","article-title":"Isolation of pancreatic microbiota from cystic precursors of pancreatic cancer with intracellular growth and DNA damaging properties","volume":"13","author":"Halimi","year":"2021","journal-title":"Gut Microbes"},{"key":"10.1016\/j.celrep.2025.116473_bib42","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1038\/nrmicro.2016.17","article-title":"The microbial pharmacists within us: A metagenomic view of xenobiotic metabolism","volume":"14","author":"Spanogiannopoulos","year":"2016","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.celrep.2025.116473_bib43","series-title":"Medical Genetics Summaries","article-title":"Fluorouracil therapy and dpyd genotype","author":"Dean","year":"2012"},{"key":"10.1016\/j.celrep.2025.116473_bib44","doi-asserted-by":"crossref","first-page":"1712","DOI":"10.1111\/j.1349-7006.2011.02004.x","article-title":"Gimeracil, an inhibitor of dihydropyrimidine dehydrogenase, inhibits the early step in homologous recombination","volume":"102","author":"Sakata","year":"2011","journal-title":"Cancer Sci."},{"key":"10.1016\/j.celrep.2025.116473_bib45","doi-asserted-by":"crossref","first-page":"3006","DOI":"10.1016\/0006-2952(82)90279-9","article-title":"Metabolic activation of ftorafur [r,s-1-(tetrahydro-2-furanyl)-5-fluorouracil]: The microsomal oxidative pathway","volume":"31","author":"El Sayed","year":"1982","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.celrep.2025.116473_bib46","doi-asserted-by":"crossref","first-page":"2772","DOI":"10.1200\/JCO.2000.18.14.2772","article-title":"Phase i clinical and pharmacokinetic study of oral s-1 in patients with advanced solid tumors","volume":"18","author":"van Groeningen","year":"2000","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.celrep.2025.116473_bib47","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1186\/s12866-024-03384-4","article-title":"Prebiotic fibre mixtures counteract the manifestation of gut microbial dysbiosis induced by the chemotherapeutic 5-fluorouracil (5-fu) in a validated in vitro model of the colon","volume":"24","author":"Ziemons","year":"2024","journal-title":"BMC Microbiol."},{"key":"10.1016\/j.celrep.2025.116473_bib48","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.adq8870","article-title":"Expansion of a bacterial operon during cancer treatment ameliorates fluoropyrimidine toxicity","volume":"17","author":"Trepka","year":"2025","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.celrep.2025.116473_bib49","doi-asserted-by":"crossref","first-page":"2915","DOI":"10.1093\/annonc\/mdx411","article-title":"Dpyd genotype-guided dose individualization to improve patient safety of fluoropyrimidine therapy: Call for a drug label update","volume":"28","author":"Henricks","year":"2017","journal-title":"Ann. Oncol."},{"key":"10.1016\/j.celrep.2025.116473_bib50","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1038\/s41587-019-0209-9","article-title":"Reproducible, interactive, scalable and extensible microbiome data science using qiime 2","volume":"37","author":"Bolyen","year":"2019","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.celrep.2025.116473_bib51","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1089\/cmb.2012.0021","article-title":"Spades: A new genome assembly algorithm and its applications to single-cell sequencing","volume":"19","author":"Bankevich","year":"2012","journal-title":"J. Comput. Biol."},{"key":"10.1016\/j.celrep.2025.116473_bib52","doi-asserted-by":"crossref","first-page":"2068","DOI":"10.1093\/bioinformatics\/btu153","article-title":"Prokka: Rapid prokaryotic genome annotation","volume":"30","author":"Seemann","year":"2014","journal-title":"Bioinformatics"},{"key":"10.1016\/j.celrep.2025.116473_bib53","doi-asserted-by":"crossref","DOI":"10.1128\/JCM.01769-21","article-title":"The clinical utility of two high-throughput 16s rrna gene sequencing workflows for taxonomic assignment of unidentifiable bacterial pathogens in matrix-assisted laser desorption ionization-time of flight mass spectrometry","volume":"60","author":"Lao","year":"2022","journal-title":"J. Clin. Microbiol."},{"key":"10.1016\/j.celrep.2025.116473_bib54","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/s40168-017-0396-x","article-title":"Combining 16s rrna gene variable regions enables high-resolution microbial community profiling","volume":"6","author":"Fuks","year":"2018","journal-title":"Microbiome"},{"key":"10.1016\/j.celrep.2025.116473_bib55","doi-asserted-by":"crossref","DOI":"10.1128\/JCM.00568-18","article-title":"Fishing mycobacterium tuberculosis complex by use of a rpob DNA probe bait","volume":"56","author":"Loukil","year":"2018","journal-title":"J. Clin. Microbiol."},{"key":"10.1016\/j.celrep.2025.116473_bib56","doi-asserted-by":"crossref","first-page":"3811","DOI":"10.1038\/s41467-020-17512-x","article-title":"Purine metabolism regulates DNA repair and therapy resistance in glioblastoma","volume":"11","author":"Zhou","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2025.116473_bib57","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.ccell.2022.11.013","article-title":"Gut microbiota-mediated nucleotide synthesis attenuates the response to neoadjuvant chemoradiotherapy in rectal cancer","volume":"41","author":"Teng","year":"2023","journal-title":"Cancer Cell"}],"container-title":["Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124725012446?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124725012446?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T04:27:30Z","timestamp":1776918450000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211124725012446"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":57,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["S2211124725012446"],"URL":"https:\/\/doi.org\/10.1016\/j.celrep.2025.116473","relation":{},"ISSN":["2211-1247"],"issn-type":[{"value":"2211-1247","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"PreTA-mediated metabolism of 5-fluorouracil by intratumoral Citrobacter freundii drives chemoresistance in pancreatic cancer","name":"articletitle","label":"Article Title"},{"value":"Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.celrep.2025.116473","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"116473"}}