{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T19:23:47Z","timestamp":1778613827345,"version":"3.51.4"},"reference-count":120,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T00:00:00Z","timestamp":1759449600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MR\/N013166\/1"],"award-info":[{"award-number":["MR\/N013166\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006306","name":"Sigrid Jus\u00e9liuksen S\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006306","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["105570\/Z\/14\/A"],"award-info":[{"award-number":["105570\/Z\/14\/A"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["219542\/Z\/19\/Z"],"award-info":[{"award-number":["219542\/Z\/19\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["100104\/Z\/12\/Z"],"award-info":[{"award-number":["100104\/Z\/12\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000289","name":"Cancer Research UK","doi-asserted-by":"publisher","award":["C38363\/A26931"],"award-info":[{"award-number":["C38363\/A26931"]}],"id":[{"id":"10.13039\/501100000289","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000289","name":"Cancer Research UK","doi-asserted-by":"publisher","award":["PRCBTP-Nov23\/100002"],"award-info":[{"award-number":["PRCBTP-Nov23\/100002"]}],"id":[{"id":"10.13039\/501100000289","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000288","name":"Royal Society","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000288","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011713","name":"Worldwide Cancer Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011713","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010046","name":"University of Essex","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010046","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100019142","name":"International Seafood Sustainability Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100019142","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000321","name":"World Cancer Research Fund","doi-asserted-by":"publisher","award":["19-0238"],"award-info":[{"award-number":["19-0238"]}],"id":[{"id":"10.13039\/501100000321","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Reports"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.celrep.2025.116478","type":"journal-article","created":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T04:10:23Z","timestamp":1761365423000},"page":"116478","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["Oncogenic Ras activation in permissive somatic cells triggers rapid-onset phenotypic plasticity and elicits a tumor-promoting neutrophil response"],"prefix":"10.1016","volume":"44","author":[{"given":"Abigail M.","family":"Elliot","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabel","family":"Ribeiro Bravo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yiyi","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhuorui","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeanette","family":"Astorga Johansson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esme","family":"Hutton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Cunningham","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henna","family":"Myllym\u00e4ki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kai Yee","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Justyna","family":"Cholewa-Waclaw","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa","family":"Kelly","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariana","family":"Beltran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amy","family":"Lewis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip M.","family":"Elks","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carsten Gram","family":"Hansen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neil C.","family":"Henderson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8021-7776","authenticated-orcid":false,"given":"Yi","family":"Feng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.celrep.2025.116478_bib1","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1038\/s41568-018-0076-6","article-title":"A model for RAS mutation patterns in cancers: finding the sweet spot","volume":"18","author":"Li","year":"2018","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.celrep.2025.116478_bib2","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1126\/science.aaa6806","article-title":"High burden and pervasive positive selection of somatic mutations in normal human skin","volume":"348","author":"Martincorena","year":"2015","journal-title":"Science"},{"key":"10.1016\/j.celrep.2025.116478_bib3","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1038\/s41568-021-00335-3","article-title":"Clonal expansion in non-cancer tissues","volume":"21","author":"Kakiuchi","year":"2021","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.celrep.2025.116478_bib4","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1007\/BF00429714","article-title":"Diaplacental carcinogenesis: initiation with the carcinogens dimethylbenzanthracene (DMBA) and urethane during fetal life and postnatal promotion with the phorbol ester TPA in a modified 2-stage Berenblum\/Mottram experiment","volume":"372","author":"Goerttler","year":"1976","journal-title":"Virchows Arch. A Pathol. Anat. Histol."},{"key":"10.1016\/j.celrep.2025.116478_bib5","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1007\/s10654-022-00933-x","article-title":"Peto\u2019s paradox revisited: black box vs mechanistic approaches to understanding the roles of mutations and promoting factors in cancer","volume":"38","author":"Balmain","year":"2023","journal-title":"Eur. J. Epidemiol."},{"key":"10.1016\/j.celrep.2025.116478_bib6","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.ccr.2007.01.012","article-title":"Chronic Pancreatitis Is Essential for Induction of Pancreatic Ductal Adenocarcinoma by K-Ras Oncogenes in Adult Mice","volume":"11","author":"Guerra","year":"2007","journal-title":"Cancer Cell"},{"key":"10.1016\/j.celrep.2025.116478_bib7","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1016\/0092-8674(90)90115-U","article-title":"Skin hyperkeratosis and papilloma formation in transgenic mice expressing a ras oncogene from a suprabasal keratin promoter","volume":"62","author":"Bailleul","year":"1990","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2025.116478_bib8","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/0092-8674(86)90665-3","article-title":"v-ras genes from Harvey and BALB murine sarcoma viruses can act as initiators of two-stage mouse skin carcinogenesis","volume":"46","author":"Brown","year":"1986","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2025.116478_bib9","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1038\/10552","article-title":"Mice deficient in tumor necrosis factor-\u03b1 are resistant to skin carcinogenesis","volume":"5","author":"Moore","year":"1999","journal-title":"Nat. Med."},{"key":"10.1016\/j.celrep.2025.116478_bib10","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.3390\/cells9041018","article-title":"Inflammatory Responses during Tumour Initiation: From Zebrafish Transgenic Models of Cancer to Evidence from Mouse and Man","volume":"9","author":"Elliot","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.celrep.2025.116478_bib11","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.immuni.2014.06.010","article-title":"Tumor-associated macrophages: from mechanisms to therapy","volume":"41","author":"Noy","year":"2014","journal-title":"Immunity"},{"key":"10.1016\/j.celrep.2025.116478_bib12","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1038\/nrc.2016.52","article-title":"Neutrophils in cancer: neutral no more","volume":"16","author":"Coffelt","year":"2016","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.celrep.2025.116478_bib13","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.1000562","article-title":"Live Imaging of Innate Immune Cell Sensing of Transformed Cells in Zebrafish Larvae: Parallels between Tumor Initiation and Wound Inflammation","volume":"8","author":"Feng","year":"2010","journal-title":"PLoS Biol."},{"key":"10.1016\/j.celrep.2025.116478_bib14","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1016\/j.jhep.2015.03.024","article-title":"Stimulation of hepatocarcinogenesis by neutrophils upon induction of oncogenic kras expression in transgenic zebrafish","volume":"63","author":"Yan","year":"2015","journal-title":"J. Hepatol."},{"key":"10.1016\/j.celrep.2025.116478_bib15","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1158\/2159-8290.CD-21-1059","article-title":"Hallmarks of Cancer: New Dimensions","volume":"12","author":"Hanahan","year":"2022","journal-title":"Cancer Discov."},{"key":"10.1016\/j.celrep.2025.116478_bib16","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1038\/s41588-020-0624-3","article-title":"Spatial competition shapes the dynamic mutational landscape of normal esophageal epithelium","volume":"52","author":"Colom","year":"2020","journal-title":"Nat. Genet."},{"key":"10.1016\/j.celrep.2025.116478_bib17","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/j.stem.2018.08.017","article-title":"Epidermal Tissue Adapts to Restrain Progenitors Carrying Clonal p53 Mutations","volume":"23","author":"Murai","year":"2018","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.celrep.2025.116478_bib18","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1126\/science.1243148","article-title":"Defining stem cell dynamics in models of intestinal tumor initiation","volume":"342","author":"Vermeulen","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.celrep.2025.116478_bib19","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1038\/s41588-022-01088-x","article-title":"Single-cell analyses define a continuum of cell state and composition changes in the malignant transformation of polyps to colorectal cancer","volume":"54","author":"Becker","year":"2022","journal-title":"Nat. Genet."},{"key":"10.1016\/j.celrep.2025.116478_bib20","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.ccell.2020.06.012","article-title":"Emergence of a High-Plasticity Cell State during Lung Cancer Evolution","volume":"38","author":"Marjanovic","year":"2020","journal-title":"Cancer Cell"},{"key":"10.1016\/j.celrep.2025.116478_bib21","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.ccell.2020.06.006","article-title":"Epigenomic State Transitions Characterize Tumor Progression in Mouse Lung Adenocarcinoma","volume":"38","author":"LaFave","year":"2020","journal-title":"Cancer Cell"},{"key":"10.1016\/j.celrep.2025.116478_bib22","doi-asserted-by":"crossref","first-page":"6582","DOI":"10.1158\/1078-0432.CCR-14-1768","article-title":"Mutational landscape of aggressive cutaneous squamous cell carcinoma","volume":"20","author":"Pickering","year":"2014","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.celrep.2025.116478_bib23","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1038\/303072a0","article-title":"Mouse skin carcinomas induced in vivo by chemical carcinogens have a transforming Harvey-ras oncogene","volume":"303","author":"Balmain","year":"1983","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2025.116478_bib24","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2021.684036","article-title":"Metabolic Alterations in Preneoplastic Development Revealed by Untargeted Metabolomic Analysis","volume":"9","author":"Myllym\u00e4ki","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.celrep.2025.116478_bib25","article-title":"Basal Keratinocytes Contribute to All Strata of the Adult Zebrafish Epidermis","volume":"9","author":"Lee","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.celrep.2025.116478_bib26","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.ydbio.2011.01.002","article-title":"Transgenerational analysis of transcriptional silencing in zebrafish","volume":"352","author":"Akitake","year":"2011","journal-title":"Dev. Biol."},{"key":"10.1016\/j.celrep.2025.116478_bib27","doi-asserted-by":"crossref","DOI":"10.3791\/52107-v","article-title":"Live Imaging of Innate Immune and Preneoplastic Cell Interactions Using an Inducible Gal4\/UAS Expression System in Larval Zebrafish Skin","author":"Ramezani","year":"2015","journal-title":"J. Vis. Exp."},{"key":"10.1016\/j.celrep.2025.116478_bib28","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1038\/s41580-020-0255-7","article-title":"ERK signalling: a master regulator of cell behaviour, life and fate","volume":"21","author":"Lavoie","year":"2020","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.celrep.2025.116478_bib29","doi-asserted-by":"crossref","first-page":"4055","DOI":"10.2147\/OTT.S198542","article-title":"TPM4 promotes cell migration by modulating F-actin formation in lung cancer","volume":"12","author":"Zhao","year":"2019","journal-title":"OncoTargets Ther."},{"key":"10.1016\/j.celrep.2025.116478_bib30","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2020.573859","article-title":"Transgelins: Cytoskeletal Associated Proteins Implicated in the Metastasis of Colorectal Cancer","volume":"8","author":"Liu","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.celrep.2025.116478_bib31","doi-asserted-by":"crossref","first-page":"4243","DOI":"10.1038\/s41598-017-03470-w","article-title":"Intracellular targeting of annexin A2 inhibits tumor cell adhesion, migration, and in vivo grafting","volume":"7","author":"Staquicini","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.celrep.2025.116478_bib32","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1016\/j.jid.2019.10.013","article-title":"Overexpression of MYB in the Skin Induces Alopecia and Epidermal Hyperplasia","volume":"140","author":"Hu","year":"2020","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.celrep.2025.116478_bib33","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.aba2084","article-title":"Cellular diversity of the regenerating caudal fin","volume":"6","author":"Hou","year":"2020","journal-title":"Sci. Adv."},{"key":"10.1016\/j.celrep.2025.116478_bib34","doi-asserted-by":"crossref","first-page":"3439","DOI":"10.1534\/g3.119.400402","article-title":"Tissue-Specific Transcriptomes Reveal Gene Expression Trajectories in Two Maturing Skin Epithelial Layers in Zebrafish Embryos","volume":"9","author":"Cokus","year":"2019","journal-title":"G3 (Bethesda)"},{"key":"10.1016\/j.celrep.2025.116478_bib35","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1038\/nrm2636","article-title":"Epidermal homeostasis: a balancing act of stem cells in the skin","volume":"10","author":"Blanpain","year":"2009","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.celrep.2025.116478_bib39","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1126\/science.aar4362","article-title":"Single-cell mapping of gene expression landscapes and lineage in the zebrafish embryo","volume":"360","author":"Wagner","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.celrep.2025.116478_bib40","doi-asserted-by":"crossref","first-page":"3049","DOI":"10.1038\/s41467-019-11121-z","article-title":"Pioneer and repressive functions of p63 during zebrafish embryonic ectoderm specification","volume":"10","author":"Santos-Pereira","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2025.116478_bib36","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/B978-0-12-814085-7.00010-6","article-title":"Transcriptional and epigenetic regulatory mechanisms in glioblastoma stem cells","author":"Bressan","year":"2020","journal-title":"Stem Cell Epigenet."},{"key":"10.1016\/j.celrep.2025.116478_bib37","doi-asserted-by":"crossref","first-page":"2638","DOI":"10.1158\/2159-8290.CD-20-1637","article-title":"Cancer cells retrace a stepwise differentiation program during malignant progression","volume":"11","author":"Saghafinia","year":"2021","journal-title":"Cancer Discov."},{"key":"10.1016\/j.celrep.2025.116478_bib38","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.stem.2011.12.018","article-title":"A mammary stem cell population identified and characterized in late embryogenesis reveals similarities to human breast cancer","volume":"10","author":"Spike","year":"2012","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.celrep.2025.116478_bib41","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1146\/annurev.cellbio.23.090506.123357","article-title":"Mechanisms Regulating Epithelial Stratification","volume":"23","author":"Koster","year":"2007","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"10.1016\/j.celrep.2025.116478_bib42","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a015263","article-title":"Epigenetic Regulation of Epidermal Differentiation","volume":"4","author":"Perdigoto","year":"2014","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"10.1016\/j.celrep.2025.116478_bib43","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.stem.2012.12.014","article-title":"ACTL6a enforces the epidermal progenitor state by suppressing SWI\/SNF-dependent induction of KLF4","volume":"12","author":"Bao","year":"2013","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.celrep.2025.116478_bib44","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1038\/ncb2520","article-title":"Diverse epigenetic strategies interact to control epidermal differentiation","volume":"14","author":"Mulder","year":"2012","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.celrep.2025.116478_bib45","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.tcb.2018.12.001","article-title":"EMT Transition States during Tumor Progression and Metastasis","volume":"29","author":"Pastushenko","year":"2019","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.celrep.2025.116478_bib46","article-title":"The Role of CD276 in Cancers","volume":"11","author":"Liu","year":"2021","journal-title":"Front. Oncol."},{"key":"10.1016\/j.celrep.2025.116478_bib47","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2018961118","article-title":"Targeting the tetraspanin CD81 reduces cancer invasion and metastasis","volume":"118","author":"Vences-Catal\u00e1n","year":"2021","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2025.116478_bib48","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0101931","article-title":"Neuropilin-1 promotes epithelial-to-mesenchymal transition by stimulating nuclear factor-kappa B and is associated with poor prognosis in human oral squamous cell carcinoma","volume":"9","author":"Chu","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.celrep.2025.116478_bib49","doi-asserted-by":"crossref","first-page":"138","DOI":"10.3389\/fmolb.2020.00138","article-title":"Slug and E-Cadherin: Stealth Accomplices?","volume":"7","author":"Sterneck","year":"2020","journal-title":"Front. Mol. Biosci."},{"key":"10.1016\/j.celrep.2025.116478_bib50","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1159\/000512520","article-title":"A Computational Systems Biology Approach Identifies SLUG as a Mediator of Partial Epithelial-Mesenchymal Transition (EMT)","volume":"211","author":"Subbalakshmi","year":"2022","journal-title":"Cells Tissues Organs"},{"key":"10.1016\/j.celrep.2025.116478_bib51","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1038\/nrclinonc.2017.44","article-title":"EMT, CSCs, and drug resistance: the mechanistic link and clinical implications","volume":"14","author":"Shibue","year":"2017","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.celrep.2025.116478_bib52","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1038\/s41392-020-00430-1","article-title":"Targeting cancer stem cells for reversing therapy resistance: mechanism, signaling, and prospective agents","volume":"6","author":"Zhou","year":"2021","journal-title":"Signal Transduct. Targeted Ther."},{"key":"10.1016\/j.celrep.2025.116478_bib53","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1038\/s41586-022-05475-6","article-title":"Ras drives malignancy through stem cell crosstalk with the microenvironment","volume":"612","author":"Yuan","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2025.116478_bib54","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.1016\/j.cell.2020.08.043","article-title":"Multimodal Analysis of Composition and Spatial Architecture in Human Squamous Cell Carcinoma","volume":"182","author":"Ji","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2025.116478_bib55","doi-asserted-by":"crossref","first-page":"1873","DOI":"10.1016\/j.cell.2019.05.006","article-title":"Single-Cell Multi-omic Integration Compares and Contrasts Features of Brain Cell Identity","volume":"177","author":"Welch","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2025.116478_bib56","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-018-31675-0","article-title":"Cxcr1 mediates recruitment of neutrophils and supports proliferation of tumor-initiating astrocytes in vivo","volume":"8","author":"Powell","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.celrep.2025.116478_bib57","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1080\/14728222.2020.1799350","article-title":"Activin A: an emerging target for improving cancer treatment?","volume":"24","author":"Ries","year":"2020","journal-title":"Expert Opin. Ther. Targets"},{"key":"10.1016\/j.celrep.2025.116478_bib58","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1016\/j.immuni.2019.03.024","article-title":"Transforming Grown Factor-\u03b2 Signaling in Immunity and Cancer","volume":"50","author":"Batlle","year":"2019","journal-title":"Immunity"},{"key":"10.1016\/j.celrep.2025.116478_bib59","doi-asserted-by":"crossref","first-page":"2803","DOI":"10.1182\/blood-2010-03-276972","article-title":"Live imaging of neutrophil motility in a zebrafish model of WHIM syndrome","volume":"116","author":"Walters","year":"2010","journal-title":"Blood"},{"key":"10.1016\/j.celrep.2025.116478_bib60","doi-asserted-by":"crossref","first-page":"17304","DOI":"10.1073\/pnas.1004640107","article-title":"Essential role of c-myb in definitive hematopoiesis is evolutionarily conserved","volume":"107","author":"Soza-Ried","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2025.116478_bib61","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1182\/blood-2015-12-686147","article-title":"c-Myb acts in parallel and cooperatively with Cebp1 to regulate neutrophil maturation in zebrafish","volume":"128","author":"Jin","year":"2016","journal-title":"Blood"},{"key":"10.1016\/j.celrep.2025.116478_bib62","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1038\/nri3660","article-title":"Emergency granulopoiesis","volume":"14","author":"Manz","year":"2014","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.celrep.2025.116478_bib63","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1038\/ni1354","article-title":"C\/EBPbeta is required for \u2018emergency\u2019 granulopoiesis","volume":"7","author":"Hirai","year":"2006","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.celrep.2025.116478_bib64","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/j.immuni.2018.02.002","article-title":"Developmental Analysis of Bone Marrow Neutrophils Reveals Populations Specialized in Expansion, Trafficking, and Effector Functions","volume":"48","author":"Evrard","year":"2018","journal-title":"Immunity"},{"key":"10.1016\/j.celrep.2025.116478_bib65","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.ccr.2009.06.017","article-title":"Polarization of Tumor-Associated Neutrophil Phenotype by TGF-\u03b2: \u2018N1\u2019 versus \u2018N2\u2019 TAN","volume":"16","author":"Fridlender","year":"2009","journal-title":"Cancer Cell"},{"key":"10.1016\/j.celrep.2025.116478_bib66","doi-asserted-by":"crossref","first-page":"6254","DOI":"10.3390\/ijms20246254","article-title":"Prostaglandin E2\/EP Signaling in the Tumor Microenvironment of Colorectal Cancer","volume":"20","author":"Mizuno","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.celrep.2025.116478_bib67","doi-asserted-by":"crossref","first-page":"4316","DOI":"10.1111\/febs.14524","article-title":"Cancer-related circulating and tumor-associated neutrophils \u2013 subtypes, sources and function","volume":"285","author":"Shaul","year":"2018","journal-title":"FEBS J."},{"key":"10.1016\/j.celrep.2025.116478_bib68","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1038\/nri3175","article-title":"Coordinated regulation of myeloid cells by tumours","volume":"12","author":"Gabrilovich","year":"2012","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.celrep.2025.116478_bib69","doi-asserted-by":"crossref","DOI":"10.1242\/dmm.049966","article-title":"An arginase 2 promoter transgenic line illuminates immune cell polarisation in zebrafish","volume":"16","author":"Hammond","year":"2023","journal-title":"Dis. Model. Mech."},{"key":"10.1016\/j.celrep.2025.116478_bib70","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1182\/blood-2005-10-4162","article-title":"G-CSF down-regulation of CXCR4 expression identified as a mechanism for mobilization of myeloid cells","volume":"108","author":"Hyun","year":"2006","journal-title":"Blood"},{"key":"10.1016\/j.celrep.2025.116478_bib71","doi-asserted-by":"crossref","first-page":"21248","DOI":"10.1073\/pnas.1015855107","article-title":"Granulocyte-colony stimulating factor promotes lung metastasis through mobilization of Ly6G+Ly6C+ granulocytes","volume":"107","author":"Kowanetz","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2025.116478_bib72","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1189\/jlb.0708405","article-title":"Transgenic zebrafish reporter lines reveal conserved Toll-like receptor signaling potential in embryonic myeloid leukocytes and adult immune cell lineages","volume":"85","author":"Hall","year":"2009","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.celrep.2025.116478_bib73","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1084\/jem.20220011","article-title":"Cancer Focus: Neutrophil phenotypes and functions in cancer: A consensus statement","volume":"219","author":"Quail","year":"2022","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.celrep.2025.116478_bib74","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1016\/j.cub.2012.05.010","article-title":"Live Imaging of Tumor Initiation in Zebrafish Larvae Reveals a Trophic Role for Leukocyte-Derived PGE2","volume":"22","author":"Feng","year":"2012","journal-title":"Curr. Biol."},{"key":"10.1016\/j.celrep.2025.116478_bib75","doi-asserted-by":"crossref","first-page":"5166","DOI":"10.1038\/s41467-019-13107-3","article-title":"Chemokine receptor trafficking coordinates neutrophil clustering and dispersal at wounds in zebrafish","volume":"10","author":"Coombs","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2025.116478_bib76","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1038\/s41586-022-05242-7","article-title":"A cellular hierarchy in melanoma uncouples growth and metastasis","volume":"610","author":"Karras","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2025.116478_bib77","doi-asserted-by":"crossref","first-page":"2837","DOI":"10.1016\/j.celrep.2019.05.029","article-title":"Proteolytic and Opportunistic Breaching of the Basement Membrane Zone by Immune Cells during Tumor Initiation","volume":"27","author":"van den Berg","year":"2019","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2025.116478_bib78","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1038\/nature20609","article-title":"Mechanism of early dissemination and metastasis in Her2+ mammary cancer","volume":"540","author":"Harper","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2025.116478_bib79","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1016\/j.trecan.2022.04.007","article-title":"Cellular and molecular mechanisms of plasticity in cancer","volume":"8","author":"Torborg","year":"2022","journal-title":"Trends Cancer"},{"key":"10.1016\/j.celrep.2025.116478_bib80","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1016\/j.cell.2015.01.043","article-title":"TGF-\u03b2 Promotes Heterogeneity and Drug Resistance in Squamous Cell Carcinoma","volume":"160","author":"Oshimori","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2025.116478_bib81","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1038\/nature11393","article-title":"Distinct contribution of stem and progenitor cells to epidermal maintenance","volume":"489","author":"Mascr\u00e9","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2025.116478_bib82","article-title":"Transit-Amplifying Cells in the Fast Lane from Stem Cells towards Differentiation","volume":"2017","author":"Rangel-Huerta","year":"2017","journal-title":"Stem Cell. Int."},{"key":"10.1016\/j.celrep.2025.116478_bib83","doi-asserted-by":"crossref","DOI":"10.1126\/science.add5327","article-title":"Epigenetic plasticity cooperates with cell-cell interactions to direct pancreatic tumorigenesis","volume":"380","author":"Burdziak","year":"2023","journal-title":"Science"},{"key":"10.1016\/j.celrep.2025.116478_bib84","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1016\/j.ccell.2016.04.014","article-title":"CXCR2 Inhibition Profoundly Suppresses Metastases and Augments Immunotherapy in Pancreatic Ductal Adenocarcinoma","volume":"29","author":"Steele","year":"2016","journal-title":"Cancer Cell"},{"key":"10.1016\/j.celrep.2025.116478_bib85","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0112183","article-title":"Live Imaging and Gene Expression Analysis in Zebrafish Identifies a Link between Neutrophils and Epithelial to Mesenchymal Transition","volume":"9","author":"Freisinger","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.celrep.2025.116478_bib86","doi-asserted-by":"crossref","first-page":"E566","DOI":"10.1073\/pnas.1424927112","article-title":"Invasive breast cancer reprograms early myeloid differentiation in the bone marrow to generate immunosuppressive neutrophils","volume":"112","author":"Casbon","year":"2015","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2025.116478_bib87","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1016\/j.ccell.2025.04.007","article-title":"Understanding and reversing mammary tumor-driven reprogramming of myelopoiesis to reduce metastatic spread","volume":"43","author":"Garner","year":"2025","journal-title":"Cancer Cell"},{"key":"10.1016\/j.celrep.2025.116478_bib88","doi-asserted-by":"crossref","DOI":"10.1126\/science.adf6493","article-title":"Deterministic reprogramming of neutrophils within tumors","volume":"383","author":"Ng","year":"2024","journal-title":"Science"},{"key":"10.1016\/j.celrep.2025.116478_bib89","doi-asserted-by":"crossref","DOI":"10.1080\/2162402X.2024.2384674","article-title":"CXCR1\/2 antagonism inhibits neutrophil function and not recruitment in cancer","volume":"13","author":"Kwak","year":"2024","journal-title":"OncoImmunology"},{"key":"10.1016\/j.celrep.2025.116478_bib90","doi-asserted-by":"crossref","first-page":"2038","DOI":"10.1002\/ijc.25562","article-title":"Interleukin-8 is associated with proliferation, migration, angiogenesis and chemosensitivity in vitro and in vivo in colon cancer cell line models","volume":"128","author":"Ning","year":"2011","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.celrep.2025.116478_bib91","first-page":"275","article-title":"IL-8 promotes cell proliferation and migration through metalloproteinase-cleavage proHB-EGF in human colon carcinoma cells","volume":"29","author":"Itoh","year":"2005","journal-title":"Cytokine"},{"key":"10.1016\/j.celrep.2025.116478_bib92","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejca.2025.115267","article-title":"The role of IL-8 in cancer development and its impact on immunotherapy resistance","volume":"218","author":"Meier","year":"2025","journal-title":"Eur. J. Cancer"},{"key":"10.1016\/j.celrep.2025.116478_bib110","doi-asserted-by":"crossref","first-page":"D650","DOI":"10.1093\/nar\/gkz813","article-title":"Alliance of Genome Resources Portal: unified model organism research platform","volume":"48","author":"Agapite","year":"2020","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.celrep.2025.116478_bib111","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1002\/glia.24154","article-title":"Wasl is crucial to maintain microglial core activities during glioblastoma initiation stages","volume":"70","author":"Mazzolini","year":"2022","journal-title":"Glia"},{"key":"10.1016\/j.celrep.2025.116478_bib112","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/1471-213X-7-42","article-title":"The zebrafish lysozyme C promoter drives myeloid-specific expression in transgenic fish","volume":"7","author":"Hall","year":"2007","journal-title":"BMC Dev. Biol."},{"key":"10.1016\/j.celrep.2025.116478_bib113","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1016\/j.cub.2020.11.014","article-title":"PTPN21\/Pez Is a Novel and Evolutionarily Conserved Key Regulator of Inflammation In Vivo","volume":"31","author":"Campbell","year":"2021","journal-title":"Curr. Biol."},{"key":"10.1016\/j.celrep.2025.116478_bib114","doi-asserted-by":"crossref","first-page":"e49","DOI":"10.1182\/blood-2010-10-314120","article-title":"mpeg1 promoter transgenes direct macrophage-lineage expression in zebrafish","volume":"117","author":"Ellett","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.celrep.2025.116478_bib115","doi-asserted-by":"crossref","first-page":"3976","DOI":"10.1182\/blood-2006-05-024075","article-title":"Atransgenic zebrafish model of neutrophilic inflammation","volume":"108","author":"Renshaw","year":"2006","journal-title":"Blood"},{"key":"10.1016\/j.celrep.2025.116478_bib116","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/nmeth.2019","article-title":"Fiji: An open-source platform for biological-image analysis","volume":"9","author":"Schindelin","year":"2012","journal-title":"Nat. Methods"},{"key":"10.1016\/j.celrep.2025.116478_bib97","doi-asserted-by":"crossref","DOI":"10.1093\/gigascience\/giaa151","article-title":"SoupX removes ambient RNA contamination from droplet-based single-cell RNA sequencing data","volume":"9","author":"Young","year":"2020","journal-title":"GigaScience"},{"key":"10.1016\/j.celrep.2025.116478_bib98","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.cels.2018.11.005","article-title":"Computational Identification of Cell Doublets in Single-Cell Transcriptomic Data","volume":"8","author":"Wolock","year":"2019","journal-title":"Cell Syst."},{"key":"10.1016\/j.celrep.2025.116478_bib99","doi-asserted-by":"crossref","first-page":"1718","DOI":"10.1016\/j.celrep.2019.09.082","article-title":"DoubletDecon: Deconvoluting Doublets from Single-Cell RNA-Sequencing Data","volume":"29","author":"DePasquale","year":"2019","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2025.116478_bib102","first-page":"2122","article-title":"A step-by-step workflow for low-level analysis of single-cell RNA-seq data with Bioconductor","volume":"5","author":"Lun","year":"2016","journal-title":"F1000Res."},{"key":"10.1016\/j.celrep.2025.116478_bib117","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1038\/nbt.4096","article-title":"Integrating single-cell transcriptomic data across different conditions, technologies, and species","volume":"36","author":"Butler","year":"2018","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.celrep.2025.116478_bib100","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1186\/s13059-019-1874-1","article-title":"Normalization and variance stabilization of single-cell RNA-seq data using regularized negative binomial regression","volume":"20","author":"Hafemeister","year":"2019","journal-title":"Genome Biol."},{"key":"10.1016\/j.celrep.2025.116478_bib118","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1093\/bioinformatics\/btp616","article-title":"edgeR: a Bioconductor package for differential expression analysis of digital gene expression data","volume":"26","author":"Robinson","year":"2010","journal-title":"Bioinformatics"},{"key":"10.1016\/j.celrep.2025.116478_bib119","doi-asserted-by":"crossref","first-page":"15545","DOI":"10.1073\/pnas.0506580102","article-title":"Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles","volume":"102","author":"Subramanian","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2025.116478_bib120","article-title":"Fast gene set enrichment analysis","author":"Korotkevich","year":"2021","journal-title":"bioRxiv"},{"key":"10.1016\/j.celrep.2025.116478_bib104","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1038\/s41586-019-0969-x","article-title":"The single-cell transcriptional landscape of mammalian organogenesis","volume":"566","author":"Cao","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2025.116478_bib105","doi-asserted-by":"crossref","first-page":"3632","DOI":"10.1038\/s41596-020-0391-8","article-title":"Jointly defining cell types from multiple single-cell datasets using LIGER","volume":"15","author":"Liu","year":"2020","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.celrep.2025.116478_bib101","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1038\/s41592-019-0619-0","article-title":"Fast, sensitive and accurate integration of single-cell data with Harmony","volume":"16","author":"Korsunsky","year":"2019","journal-title":"Nat. Methods"},{"key":"10.1016\/j.celrep.2025.116478_bib109","article-title":"Continuous Biomarker Assessment by Exhaustive Survival Analysis","author":"Pearce","year":"2018","journal-title":"bioRxiv"},{"key":"10.1016\/j.celrep.2025.116478_bib93","series-title":"The Zebrafish Book: A Guide for the Laboratory Use of Zebrafish (Danio Rerio)","author":"Westerfield","year":"2000"},{"key":"10.1016\/j.celrep.2025.116478_bib94","doi-asserted-by":"crossref","unstructured":"Myllymaki, H., Elliot, A. & Feng, Y. Wholemount Edu Staining (Zebrafish Larvae). (2023) doi:https:\/\/doi.org\/10.17504\/PROTOCOLS.IO.N92LD9429G5B\/V1.","DOI":"10.17504\/protocols.io.n92ld9429g5b\/v1"},{"key":"10.1016\/j.celrep.2025.116478_bib95","doi-asserted-by":"crossref","unstructured":"Elliot, A. & Feng, Y. Zebrafish larvae dissociation for FACs sorting cells expressing fluorescent proteins. (2023) doi:https:\/\/doi.org\/10.17504\/protocols.io.yxmvmk819g3p\/v1.","DOI":"10.17504\/protocols.io.yxmvmk819g3p\/v1"},{"key":"10.1016\/j.celrep.2025.116478_bib96","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1038\/nprot.2014.006","article-title":"Full-length RNA-seq from single cells using Smart-seq2","volume":"9","author":"Picelli","year":"2014","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.celrep.2025.116478_bib103","unstructured":"Cs\u00e1rdi, G. & Nepusz, T. The igraph software package for complex network research. (2006)."},{"key":"10.1016\/j.celrep.2025.116478_bib106","unstructured":"The Cancer Genome Atlas Program (TCGA) - NCI. https:\/\/www.cancer.gov\/ccg\/research\/genome-sequencing\/tcga."},{"key":"10.1016\/j.celrep.2025.116478_bib107","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1242\/jcs.182873","article-title":"RAS isoforms and mutations in cancer at a glance","volume":"129","author":"Hobbs","year":"2016","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.celrep.2025.116478_bib108","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1471-2105-14-7","article-title":"GSVA: Gene set variation analysis for microarray and RNA-Seq data","volume":"14","author":"H\u00e4nzelmann","year":"2013","journal-title":"BMC Bioinf."}],"container-title":["Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124725012495?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124725012495?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T04:40:21Z","timestamp":1776919221000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211124725012495"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":120,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["S2211124725012495"],"URL":"https:\/\/doi.org\/10.1016\/j.celrep.2025.116478","relation":{},"ISSN":["2211-1247"],"issn-type":[{"value":"2211-1247","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Oncogenic Ras activation in permissive somatic cells triggers rapid-onset phenotypic plasticity and elicits a tumor-promoting neutrophil response","name":"articletitle","label":"Article Title"},{"value":"Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.celrep.2025.116478","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"116478"}}