{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T10:53:51Z","timestamp":1793012031981,"version":"4.5.0"},"reference-count":58,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T00:00:00Z","timestamp":1759968000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100018540","name":"Science Fund for Distinguished Young Scholars of Guangdong Province","doi-asserted-by":"publisher","award":["2024B1515020086"],"award-info":[{"award-number":["2024B1515020086"]}],"id":[{"id":"10.13039\/501100018540","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009659","name":"Guangzhou Medical University","doi-asserted-by":"publisher","award":["1600153"],"award-info":[{"award-number":["1600153"]}],"id":[{"id":"10.13039\/100009659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2022B1515120024"],"award-info":[{"award-number":["2022B1515120024"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82472195"],"award-info":[{"award-number":["82472195"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82130063"],"award-info":[{"award-number":["82130063"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82202379"],"award-info":[{"award-number":["82202379"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82241061"],"award-info":[{"award-number":["82241061"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82272194"],"award-info":[{"award-number":["82272194"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Reports"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.celrep.2025.116497","type":"journal-article","created":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T19:01:16Z","timestamp":1761850876000},"page":"116497","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"title":["Circulating FABP5 released by dying macrophages function as a DAMP to exacerbate septic inflammation"],"prefix":"10.1016","volume":"44","author":[{"given":"Rong","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunong","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaochan","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing-Ming","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuyu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanshan","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ze","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengzheng","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weidong","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenhua","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhe-Xiong","family":"Lian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi-Bin","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shenhai","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.celrep.2025.116497_bib1","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1038\/nri.2017.36","article-title":"The immunopathology of sepsis and potential therapeutic targets","volume":"17","author":"van der Poll","year":"2017","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.celrep.2025.116497_bib2","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1164\/rccm.201504-0781OC","article-title":"Assessment of Global Incidence and Mortality of Hospital-treated Sepsis. Current Estimates and Limitations","volume":"193","author":"Fleischmann","year":"2016","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.celrep.2025.116497_bib3","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/S0140-6736(19)32989-7","article-title":"Global, regional, and national sepsis incidence and mortality, 1990-2017: analysis for the Global Burden of Disease Study","volume":"395","author":"Rudd","year":"2020","journal-title":"Lancet"},{"key":"10.1016\/j.celrep.2025.116497_bib4","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/S0140-6736(21)02724-0","article-title":"Global burden of bacterial antimicrobial resistance in 2019: a systematic analysis","volume":"399","year":"2022","journal-title":"Lancet"},{"key":"10.1016\/j.celrep.2025.116497_bib5","doi-asserted-by":"crossref","first-page":"864","DOI":"10.15585\/mmwr.mm6533e1","article-title":"Vital Signs: Epidemiology of Sepsis: Prevalence of Health Care Factors and Opportunities for Prevention","volume":"65","author":"Novosad","year":"2016","journal-title":"MMWR Morb. Mortal. Wkly. Rep."},{"key":"10.1016\/j.celrep.2025.116497_bib6","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1097\/00003246-200107000-00002","article-title":"Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care","volume":"29","author":"Angus","year":"2001","journal-title":"Crit. Care Med."},{"key":"10.1016\/j.celrep.2025.116497_bib7","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1182\/blood-2010-08-265892","article-title":"Cytokine release from innate immune cells: association with diverse membrane trafficking pathways","volume":"118","author":"Lacy","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.celrep.2025.116497_bib8","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1038\/s41392-021-00687-0","article-title":"Pattern recognition receptors in health and diseases","volume":"6","author":"Li","year":"2021","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.celrep.2025.116497_bib9","first-page":"56","article-title":"Sepsis-induced immunosuppression: mechanisms, diagnosis and current treatment options","volume":"9","author":"Liu","year":"2022","journal-title":"Mil. Med. Res."},{"key":"10.1016\/j.celrep.2025.116497_bib10","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1038\/s41577-019-0215-7","article-title":"DAMP-sensing receptors in sterile inflammation and inflammatory diseases","volume":"20","author":"Gong","year":"2020","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.celrep.2025.116497_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2022.104363","article-title":"Immunopathophysiology of human sepsis","volume":"86","author":"Wiersinga","year":"2022","journal-title":"EBioMedicine"},{"key":"10.1016\/j.celrep.2025.116497_bib12","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1007\/s10495-021-01663-3","article-title":"Release mechanisms of major DAMPs","volume":"26","author":"Murao","year":"2021","journal-title":"Apoptosis"},{"key":"10.1016\/j.celrep.2025.116497_bib13","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1038\/s41577-023-00894-6","article-title":"The multifunctional protein HMGB1: 50 years of discovery","volume":"23","author":"Tang","year":"2023","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.celrep.2025.116497_bib14","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1186\/s13054-014-0543-8","article-title":"Impact of plasma histones in human sepsis and their contribution to cellular injury and inflammation","volume":"18","author":"Ekaney","year":"2014","journal-title":"Crit. Care"},{"key":"10.1016\/j.celrep.2025.116497_bib15","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.945603","article-title":"Serum concentration of extracellular cold-inducible RNA-binding protein is associated with respiratory failure in COVID-19","volume":"13","author":"Schagatay","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.celrep.2025.116497_bib16","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1007\/s00134-021-06506-y","article-title":"Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021","volume":"47","author":"Evans","year":"2021","journal-title":"Intensive Care Med."},{"key":"10.1016\/j.celrep.2025.116497_bib17","doi-asserted-by":"crossref","first-page":"7094","DOI":"10.1038\/s41467-021-27428-9","article-title":"Oxidative stress-induced FABP5 S-glutathionylation protects against acute lung injury by suppressing inflammation in macrophages","volume":"12","author":"Guo","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2025.116497_bib18","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1038\/nrendo.2015.122","article-title":"Metabolic functions of FABPs--mechanisms and therapeutic implications","volume":"11","author":"Hotamisligil","year":"2015","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.celrep.2025.116497_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.111668","article-title":"FABP5 controls macrophage alternative activation and allergic asthma by selectively programming long-chain unsaturated fatty acid metabolism","volume":"41","author":"Hou","year":"2022","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2025.116497_bib20","first-page":"433","article-title":"Spatially resolved expression landscape and gene-regulatory network of human gastric corpus epithelium","volume":"14","author":"Dong","year":"2023","journal-title":"Protein Cell"},{"key":"10.1016\/j.celrep.2025.116497_bib21","doi-asserted-by":"crossref","first-page":"3115","DOI":"10.7150\/ijbs.85285","article-title":"FABP5 suppresses colorectal cancer progression via mTOR-mediated autophagy by decreasing FASN expression","volume":"19","author":"Ye","year":"2023","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.celrep.2025.116497_bib22","doi-asserted-by":"crossref","first-page":"L64","DOI":"10.1152\/ajplung.00276.2012","article-title":"FABP5 deficiency enhances susceptibility to H1N1 influenza A virus-induced lung inflammation","volume":"305","author":"Gally","year":"2013","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"10.1016\/j.celrep.2025.116497_bib23","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/s40169-019-0227-8","article-title":"Impact of fatty acid binding protein 5-deficiency on COPD exacerbations and cigarette smoke-induced inflammatory response to bacterial infection","volume":"8","author":"Rao","year":"2019","journal-title":"Clin. Transl. Med."},{"key":"10.1016\/j.celrep.2025.116497_bib24","doi-asserted-by":"crossref","DOI":"10.1186\/cc12498","article-title":"Serum adipocyte fatty acid-binding protein levels in patients with critical illness are associated with insulin resistance and predict mortality","volume":"17","author":"Huang","year":"2013","journal-title":"Crit. Care"},{"key":"10.1016\/j.celrep.2025.116497_bib25","doi-asserted-by":"crossref","first-page":"4421","DOI":"10.1007\/s11033-021-06461-3","article-title":"Serum fatty acid binding protein 5 (FABP5) as a potential biomarker of inflammation in psoriasis","volume":"48","author":"Kozlowska","year":"2021","journal-title":"Mol. Biol. Rep."},{"key":"10.1016\/j.celrep.2025.116497_bib26","doi-asserted-by":"crossref","first-page":"2181","DOI":"10.4049\/jimmunol.2200182","article-title":"FABP5 Deficiency Impaired Macrophage Inflammation by Regulating AMPK\/NF-kappaB Signaling Pathway","volume":"209","author":"Hou","year":"2022","journal-title":"J. Immunol."},{"key":"10.1016\/j.celrep.2025.116497_bib27","doi-asserted-by":"crossref","first-page":"e66","DOI":"10.1038\/emm.2013.97","article-title":"Recognition of lipopolysaccharide pattern by TLR4 complexes","volume":"45","author":"Park","year":"2013","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.celrep.2025.116497_bib28","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1126\/science.1087262","article-title":"Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway","volume":"301","author":"Yamamoto","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.celrep.2025.116497_bib29","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1016\/j.immuni.2019.11.009","article-title":"Toll-like Receptor Signaling Rewires Macrophage Metabolism and Promotes Histone Acetylation via ATP-Citrate Lyase","volume":"51","author":"Lauterbach","year":"2019","journal-title":"Immunity"},{"key":"10.1016\/j.celrep.2025.116497_bib30","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1186\/s12979-023-00383-3","article-title":"Toll-like receptor 4 (TLR4): new insight immune and aging","volume":"20","author":"Kim","year":"2023","journal-title":"Immun. Ageing"},{"key":"10.1016\/j.celrep.2025.116497_bib31","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1080\/10408398.2014.989958","article-title":"An updated review of dietary isoflavones: Nutrition, processing, bioavailability and impacts on human health","volume":"57","author":"Zaheer","year":"2017","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"10.1016\/j.celrep.2025.116497_bib32","doi-asserted-by":"crossref","first-page":"2554","DOI":"10.1001\/jama.2016.8012","article-title":"Use of Plant-Based Therapies and Menopausal Symptoms: A Systematic Review and Meta-analysis","volume":"315","author":"Franco","year":"2016","journal-title":"JAMA"},{"key":"10.1016\/j.celrep.2025.116497_bib33","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/j.immuni.2023.01.015","article-title":"Pregnancy-induced changes to the gut microbiota drive macrophage pyroptosis and exacerbate septic inflammation","volume":"56","author":"Chen","year":"2023","journal-title":"Immunity"},{"key":"10.1016\/j.celrep.2025.116497_bib34","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1016\/j.chom.2023.04.002","article-title":"Liberation of daidzein by gut microbial beta-galactosidase suppresses acetaminophen-induced hepatotoxicity in mice","volume":"31","author":"Zeng","year":"2023","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.celrep.2025.116497_bib35","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1016\/j.chom.2025.04.011","article-title":"Cohabitation facilitates microbiome shifts that promote isoflavone transformation to ameliorate liver injury","volume":"33","author":"Zeng","year":"2025","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.celrep.2025.116497_bib36","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1038\/s41467-017-00930-9","article-title":"NMI and IFP35 serve as proinflammatory DAMPs during cellular infection and injury","volume":"8","author":"Xiahou","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2025.116497_bib37","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.chom.2010.06.007","article-title":"Manipulation of host cell death pathways during microbial infections","volume":"8","author":"Lamkanfi","year":"2010","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.celrep.2025.116497_bib38","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/j.it.2007.08.004","article-title":"Inside, outside, upside down: damage-associated molecular-pattern molecules (DAMPs) and redox","volume":"28","author":"Rubartelli","year":"2007","journal-title":"Trends Immunol."},{"key":"10.1016\/j.celrep.2025.116497_bib39","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1038\/s41590-019-0539-2","article-title":"Endogenous oxidized phospholipids reprogram cellular metabolism and boost hyperinflammation","volume":"21","author":"Di Gioia","year":"2020","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.celrep.2025.116497_bib40","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.immuni.2008.05.013","article-title":"Induction of immunological tolerance by apoptotic cells requires caspase-dependent oxidation of high-mobility group box-1 protein","volume":"29","author":"Kazama","year":"2008","journal-title":"Immunity"},{"key":"10.1016\/j.celrep.2025.116497_bib41","doi-asserted-by":"crossref","DOI":"10.1080\/19490976.2022.2127446","article-title":"Dietary Isoflavones Alter Gut Microbiota and Lipopolysaccharide Biosynthesis to Reduce Inflammation","volume":"14","author":"Ghimire","year":"2022","journal-title":"Gut Microbes"},{"key":"10.1016\/j.celrep.2025.116497_bib42","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.19662","article-title":"Actin is an evolutionarily-conserved damage-associated molecular pattern that signals tissue injury in Drosophila melanogaster","volume":"5","author":"Srinivasan","year":"2016","journal-title":"eLife"},{"key":"10.1016\/j.celrep.2025.116497_bib43","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1038\/s41419-022-05155-3","article-title":"Chromatin-Associated Molecular Patterns (CAMPs) in sepsis","volume":"13","author":"Nofi","year":"2022","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.celrep.2025.116497_bib44","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.jcrc.2017.07.012","article-title":"Intestinal fatty acid-binding protein level as a predictor of 28-day mortality and bowel ischemia in patients with septic shock: A preliminary study","volume":"42","author":"Sekino","year":"2017","journal-title":"J. Crit. Care"},{"key":"10.1016\/j.celrep.2025.116497_bib45","doi-asserted-by":"crossref","first-page":"79","DOI":"10.4103\/1735-3327.326652","article-title":"Association of adipocyte fatty acid-binding protein and tumor necrosis factor alpha with periodontal health and disease: A cross-sectional investigation","volume":"18","author":"Soubiya","year":"2021","journal-title":"Dent. Res. J."},{"key":"10.1016\/j.celrep.2025.116497_bib46","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1080\/0886022X.2021.1943439","article-title":"Urinary liver-type fatty acid-binding protein variation as a predictive value of short-term mortality in intensive care unit patients","volume":"43","author":"Suzuki","year":"2021","journal-title":"Ren. Fail."},{"key":"10.1016\/j.celrep.2025.116497_bib47","doi-asserted-by":"crossref","first-page":"4561","DOI":"10.1038\/s41467-020-18443-3","article-title":"Indirect regulation of HMGB1 release by gasdermin D","volume":"11","author":"Volchuk","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2025.116497_bib48","doi-asserted-by":"crossref","first-page":"1576","DOI":"10.1038\/s41564-020-00795-7","article-title":"Extracellular SQSTM1 mediates bacterial septic death in mice through insulin receptor signalling","volume":"5","author":"Zhou","year":"2020","journal-title":"Nat. Microbiol."},{"key":"10.1016\/j.celrep.2025.116497_bib49","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1038\/s41392-023-01377-9","article-title":"Activation of immune signals during organ transplantation","volume":"8","author":"Li","year":"2023","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.celrep.2025.116497_bib50","doi-asserted-by":"crossref","first-page":"20699","DOI":"10.1073\/pnas.1320808110","article-title":"Conditional ablation of HMGB1 in mice reveals its protective function against endotoxemia and bacterial infection","volume":"110","author":"Yanai","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2025.116497_bib51","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1172\/JCI76344","article-title":"Cytosolic HMGB1 controls the cellular autophagy\/apoptosis checkpoint during inflammation","volume":"125","author":"Zhu","year":"2015","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.celrep.2025.116497_bib52","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1038\/cdd.2014.40","article-title":"Macrophage endocytosis of high-mobility group box 1 triggers pyroptosis","volume":"21","author":"Xu","year":"2014","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.celrep.2025.116497_bib53","first-page":"5696","article-title":"TLR4-dependent internalization of CX3CR1 aggravates sepsis-induced immunoparalysis","volume":"8","author":"Ge","year":"2016","journal-title":"Am. J. Transl. Res."},{"key":"10.1016\/j.celrep.2025.116497_bib54","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1093\/humupd\/dmp010","article-title":"Effects of soy protein and isoflavones on circulating hormone concentrations in pre- and post-menopausal women: a systematic review and meta-analysis","volume":"15","author":"Hooper","year":"2009","journal-title":"Hum. Reprod. Update"},{"key":"10.1016\/j.celrep.2025.116497_bib55","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1001\/jama.2016.0287","article-title":"The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)","volume":"315","author":"Singer","year":"2016","journal-title":"JAMA"},{"key":"10.1016\/j.celrep.2025.116497_bib56","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1038\/s41565-023-01374-7","article-title":"Neutrophil hitchhiking for drug delivery to the bone marrow","volume":"18","author":"Luo","year":"2023","journal-title":"Nat. Nanotechnol."},{"key":"10.1016\/j.celrep.2025.116497_bib57","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1038\/s41565-023-01455-7","article-title":"Cholesterol modulates the physiological response to nanoparticles by changing the composition of protein corona","volume":"18","author":"Tang","year":"2023","journal-title":"Nat. Nanotechnol."},{"key":"10.1016\/j.celrep.2025.116497_bib58","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1038\/nature20160","article-title":"Intronic polyadenylation of PDGFR\u03b1 in resident stem cells attenuates muscle fibrosis","volume":"540","author":"Mueller","year":"2016","journal-title":"Nature"}],"container-title":["Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124725012689?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124725012689?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T04:27:03Z","timestamp":1776918423000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211124725012689"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":58,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["S2211124725012689"],"URL":"https:\/\/doi.org\/10.1016\/j.celrep.2025.116497","relation":{},"ISSN":["2211-1247"],"issn-type":[{"value":"2211-1247","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Circulating FABP5 released by dying macrophages function as a DAMP to exacerbate septic inflammation","name":"articletitle","label":"Article Title"},{"value":"Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.celrep.2025.116497","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"116497"}}