{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T00:33:25Z","timestamp":1787272405660,"version":"build-2736575974"},"reference-count":57,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T00:00:00Z","timestamp":1761782400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100015796","name":"Shanghai Lingjun Program","doi-asserted-by":"publisher","award":["22YF1457200"],"award-info":[{"award-number":["22YF1457200"]}],"id":[{"id":"10.13039\/100015796","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100015796","name":"Shanghai Lingjun Program","doi-asserted-by":"publisher","award":["23YF1456800"],"award-info":[{"award-number":["23YF1456800"]}],"id":[{"id":"10.13039\/100015796","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["2019SHZDZX02"],"award-info":[{"award-number":["2019SHZDZX02"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004739","name":"Youth Innovation Promotion Association of the Chinese Academy of Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004739","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFC2703105"],"award-info":[{"award-number":["2022YFC2703105"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFA1800804"],"award-info":[{"award-number":["2023YFA1800804"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000148","name":"Canadian Anesthesiologists&apos; Society","doi-asserted-by":"publisher","award":["XDB1060402"],"award-info":[{"award-number":["XDB1060402"]}],"id":[{"id":"10.13039\/501100000148","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000148","name":"Canadian Anesthesiologists&apos; Society","doi-asserted-by":"publisher","award":["XDB37030103"],"award-info":[{"award-number":["XDB37030103"]}],"id":[{"id":"10.13039\/501100000148","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82373881"],"award-info":[{"award-number":["82373881"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82473981"],"award-info":[{"award-number":["82473981"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82121005"],"award-info":[{"award-number":["82121005"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32130022"],"award-info":[{"award-number":["32130022"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82273985"],"award-info":[{"award-number":["82273985"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010097","name":"China Association for Science and Technology","doi-asserted-by":"publisher","award":["2022QNRC001"],"award-info":[{"award-number":["2022QNRC001"]}],"id":[{"id":"10.13039\/100010097","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Reports"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.celrep.2025.116582","type":"journal-article","created":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T11:28:27Z","timestamp":1763638107000},"page":"116582","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["Mechanisms of chemokine recognition and receptor activation of chemokine receptor CCR7"],"prefix":"10.1016","volume":"44","author":[{"given":"Yinglong","family":"Cao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingning","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fenghui","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiufeng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongchun","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. Eric","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dehua","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3605-046X","authenticated-orcid":false,"given":"Jia","family":"Duan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.celrep.2025.116582_bib1","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S1074-7613(00)80165-X","article-title":"Chemokines: a new classification system and their role in immunity","volume":"12","author":"Zlotnik","year":"2000","journal-title":"Immunity"},{"key":"10.1016\/j.celrep.2025.116582_bib2","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/S0031-6997(24)01439-X","article-title":"International union of pharmacology. XXII. Nomenclature for chemokine receptors","volume":"52","author":"Murphy","year":"2000","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.celrep.2025.116582_bib3","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1146\/annurev.pharmtox.48.121806.154841","article-title":"Chemokines and their receptors: drug targets in immunity and inflammation","volume":"48","author":"Viola","year":"2008","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1016\/j.celrep.2025.116582_bib4","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1146\/annurev-immunol-032713-120145","article-title":"Chemokines and chemokine receptors: positioning cells for host defense and immunity","volume":"32","author":"Griffith","year":"2014","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.celrep.2025.116582_bib5","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1146\/annurev.immunol.18.1.217","article-title":"The biology of chemokines and their receptors","volume":"18","author":"Rossi","year":"2000","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.celrep.2025.116582_bib6","doi-asserted-by":"crossref","first-page":"2944","DOI":"10.1111\/febs.14466","article-title":"A guide to chemokines and their receptors","volume":"285","author":"Hughes","year":"2018","journal-title":"FEBS J."},{"key":"10.1016\/j.celrep.2025.116582_bib7","doi-asserted-by":"crossref","first-page":"13803","DOI":"10.1074\/jbc.272.21.13803","article-title":"Molecular cloning of a novel human CC chemokine EBI1-ligand chemokine that is a specific functional ligand for EBI1, CCR7","volume":"272","author":"Yoshida","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.celrep.2025.116582_bib8","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1038\/nri2297","article-title":"CCR7 and its ligands: balancing immunity and tolerance","volume":"8","author":"Forster","year":"2008","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.celrep.2025.116582_bib9","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.841687","article-title":"New Insights of CCR7 Signaling in Dendritic Cell Migration and Inflammatory Diseases","volume":"13","author":"Hong","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.celrep.2025.116582_bib10","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0092-8674(00)80059-8","article-title":"CCR7 coordinates the primary immune response by establishing functional microenvironments in secondary lymphoid organs","volume":"99","author":"Forster","year":"1999","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2025.116582_bib11","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.immuni.2004.06.014","article-title":"CCR7 governs skin dendritic cell migration under inflammatory and steady-state conditions","volume":"21","author":"Ohl","year":"2004","journal-title":"Immunity"},{"key":"10.1016\/j.celrep.2025.116582_bib12","doi-asserted-by":"crossref","first-page":"7346","DOI":"10.4049\/jimmunol.177.10.7346","article-title":"Induction of tolerance to innocuous inhaled antigen relies on a CCR7-dependent dendritic cell-mediated antigen transport to the bronchial lymph node","volume":"177","author":"Hintzen","year":"2006","journal-title":"J. Immunol."},{"key":"10.1016\/j.celrep.2025.116582_bib13","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1084\/jem.20040643","article-title":"CCR7 signals are essential for cortex-medulla migration of developing thymocytes","volume":"200","author":"Ueno","year":"2004","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.celrep.2025.116582_bib14","doi-asserted-by":"crossref","first-page":"17129","DOI":"10.1073\/pnas.0906956106","article-title":"CCR7-mediated migration of developing thymocytes to the medulla is essential for negative selection to tissue-restricted antigens","volume":"106","author":"Nitta","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2025.116582_bib15","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1038\/nri1781","article-title":"Journey through the thymus: stromal guides for T-cell development and selection","volume":"6","author":"Takahama","year":"2006","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.celrep.2025.116582_bib16","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1038\/s41423-018-0056-5","article-title":"The chemokine receptor CCR7 is a promising target for rheumatoid arthritis therapy","volume":"16","author":"Moschovakis","year":"2019","journal-title":"Cell. Mol. Immunol."},{"key":"10.1016\/j.celrep.2025.116582_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2023.110431","article-title":"CCL21\/CCR7 axis as a therapeutic target for autoimmune diseases","volume":"121","author":"Han","year":"2023","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.celrep.2025.116582_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbcan.2020.188499","article-title":"CCR7 as a therapeutic target in Cancer","volume":"1875","author":"Salem","year":"2021","journal-title":"Biochim. Biophys. Acta. Rev. Cancer"},{"key":"10.1016\/j.celrep.2025.116582_bib19","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1593\/tlo.10178","article-title":"Expression of the C-C chemokine receptor 7 mediates metastasis of breast cancer to the lymph nodes in mice","volume":"3","author":"Cunningham","year":"2010","journal-title":"Transl. Oncol."},{"key":"10.1016\/j.celrep.2025.116582_bib20","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1038\/nri3049","article-title":"Homeostatic chemokine receptors and organ-specific metastasis","volume":"11","author":"Zlotnik","year":"2011","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.celrep.2025.116582_bib21","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1002\/ijc.21123","article-title":"Prediction of lymph node metastasis in colorectal carcinoma by expressionof chemokine receptor CCR7","volume":"116","author":"Gunther","year":"2005","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.celrep.2025.116582_bib22","doi-asserted-by":"crossref","first-page":"12694","DOI":"10.1073\/pnas.97.23.12694","article-title":"Coexpression of the chemokines ELC and SLC by T zone stromal cells and deletion of the ELC gene in the plt\/plt mouse","volume":"97","author":"Luther","year":"2000","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2025.116582_bib23","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.1002\/(SICI)1521-4141(199905)29:05<1617::AID-IMMU1617>3.0.CO;2-3","article-title":"Distinct patterns and kinetics of chemokine production regulate dendritic cell function","volume":"29","author":"Sallusto","year":"1999","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.celrep.2025.116582_bib24","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1002\/JLB.2VMA0118-008R","article-title":"CCL19 with CCL21-tail displays enhanced glycosaminoglycan binding with retained chemotactic potency in dendritic cells","volume":"104","author":"Jorgensen","year":"2018","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.celrep.2025.116582_bib25","doi-asserted-by":"crossref","first-page":"2156","DOI":"10.3389\/fimmu.2019.02156","article-title":"Biased Signaling of CCL21 and CCL19 Does Not Rely on N-Terminal Differences, but Markedly on the Chemokine Core Domains and Extracellular Loop 2 of CCR7","volume":"10","author":"Jorgensen","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.celrep.2025.116582_bib26","doi-asserted-by":"crossref","first-page":"3291","DOI":"10.1002\/1521-4141(200111)31:11<3291::AID-IMMU3291>3.0.CO;2-Z","article-title":"The T cell chemokine receptor CCR7 is internalized on stimulation with ELC, but not with SLC","volume":"31","author":"Bardi","year":"2001","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.celrep.2025.116582_bib27","doi-asserted-by":"crossref","first-page":"23214","DOI":"10.1074\/jbc.M402125200","article-title":"Differential desensitization, receptor phosphorylation, beta-arrestin recruitment, and ERK1\/2 activation by the two endogenous ligands for the CC chemokine receptor 7","volume":"279","author":"Kohout","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.celrep.2025.116582_bib28","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1016\/j.cell.2019.07.028","article-title":"Structural Basis for Allosteric Ligand Recognition in the Human CC Chemokine Receptor 7","volume":"178","author":"Jaeger","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2025.116582_bib29","article-title":"Systematic Assessment of Chemokine Signaling at Chemokine Receptors CCR4, CCR7 and CCR10","volume":"22","author":"Lim","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.celrep.2025.116582_bib30","doi-asserted-by":"crossref","first-page":"568","DOI":"10.3389\/fimmu.2016.00568","article-title":"Differential CCR7 Targeting in Dendritic Cells by Three Naturally Occurring CC-Chemokines","volume":"7","author":"Hjorto","year":"2016","journal-title":"Front. Immunol."},{"key":"10.1016\/j.celrep.2025.116582_bib31","doi-asserted-by":"crossref","first-page":"4121","DOI":"10.1038\/s41467-020-17933-8","article-title":"Cryo-EM structure of an activated VIP1 receptor-G protein complex revealed by a NanoBiT tethering strategy","volume":"11","author":"Duan","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2025.116582_bib32","doi-asserted-by":"crossref","first-page":"21752","DOI":"10.1074\/jbc.273.34.21752","article-title":"The A326S mutant of Gialpha1 as an approximation of the receptor-bound state","volume":"273","author":"Posner","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.celrep.2025.116582_bib33","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1016\/S0969-2126(96)00136-0","article-title":"Structure of the GDP-Pi complex of Gly203-->Ala gialpha1: a mimic of the ternary product complex of galpha-catalyzed GTP hydrolysis","volume":"4","author":"Berghuis","year":"1996","journal-title":"Structure"},{"key":"10.1016\/j.celrep.2025.116582_bib34","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1038\/s41589-021-00918-z","article-title":"Identification and mechanism of G protein-biased ligands for chemokine receptor CCR1","volume":"18","author":"Shao","year":"2022","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.celrep.2025.116582_bib35","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/s41421-022-00403-4","article-title":"Molecular insights into ligand recognition and activation of chemokine receptors CCR2 and CCR3","volume":"8","author":"Shao","year":"2022","journal-title":"Cell Discov."},{"key":"10.1016\/j.celrep.2025.116582_bib36","doi-asserted-by":"crossref","first-page":"4151","DOI":"10.1038\/s41467-021-24438-5","article-title":"Structural basis for chemokine recognition and receptor activation of chemokine receptor CCR5","volume":"12","author":"Zhang","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2025.116582_bib37","doi-asserted-by":"crossref","first-page":"3031","DOI":"10.1038\/s41467-020-16820-6","article-title":"Structural basis for chemokine receptor CCR6 activation by the endogenous protein ligand CCL20","volume":"11","author":"Wasilko","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2025.116582_bib38","doi-asserted-by":"crossref","first-page":"4107","DOI":"10.1038\/s41467-023-39799-2","article-title":"Structural basis of CXC chemokine receptor 1 ligand binding and activation","volume":"14","author":"Ishimoto","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2025.116582_bib39","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1038\/s41586-020-2492-5","article-title":"Structural basis of CXC chemokine receptor 2 activation and signalling","volume":"585","author":"Liu","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2025.116582_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2024.114578","article-title":"Cryo-EM structure of monomeric CXCL12-bound CXCR4 in the active state","volume":"43","author":"Liu","year":"2024","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2025.116582_bib41","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1007\/s10540-006-9025-9","article-title":"Structural basis of chemokine receptor function--a model for binding affinity and ligand selectivity","volume":"26","author":"Rajagopalan","year":"2006","journal-title":"Biosci. Rep."},{"key":"10.1016\/j.celrep.2025.116582_bib42","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.bcp.2016.04.007","article-title":"New paradigms in chemokine receptor signal transduction: Moving beyond the two-site model","volume":"114","author":"Kleist","year":"2016","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.celrep.2025.116582_bib43","doi-asserted-by":"crossref","first-page":"19084","DOI":"10.1074\/jbc.271.32.19084","article-title":"The amino-terminal extracellular domain of the MCP-1 receptor, but not the RANTES\/MIP-1alpha receptor, confers chemokine selectivity. Evidence for a two-step mechanism for MCP-1 receptor activation","volume":"271","author":"Monteclaro","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.celrep.2025.116582_bib44","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2403217121","article-title":"Structural insights into KSHV-GPCR constitutive activation and CXCL1 chemokine recognition","volume":"121","author":"Liu","year":"2024","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2025.116582_bib45","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.1111\/j.1476-5381.2011.01551.x","article-title":"Pharmacological modulation of chemokine receptor function","volume":"165","author":"Scholten","year":"2012","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.celrep.2025.116582_bib46","doi-asserted-by":"crossref","first-page":"7070","DOI":"10.1021\/acs.jmedchem.3c00352","article-title":"Structural Insights into Molecular Recognition and Receptor Activation in Chemokine-Chemokine Receptor Complexes","volume":"66","author":"Urvas","year":"2023","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.celrep.2025.116582_bib47","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.50279","article-title":"Common activation mechanism of class A GPCRs","volume":"8","author":"Zhou","year":"2019","journal-title":"eLife"},{"key":"10.1016\/j.celrep.2025.116582_bib48","doi-asserted-by":"crossref","first-page":"8340","DOI":"10.3390\/ijms22158340","article-title":"Dendritic Cells and CCR7 Expression: An Important Factor for Autoimmune Diseases, Chronic Inflammation, and Cancer","volume":"22","author":"Brandum","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.celrep.2025.116582_bib49","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.jsb.2015.08.008","article-title":"CTFFIND4: Fast and accurate defocus estimation from electron micrographs","volume":"192","author":"Rohou","year":"2015","journal-title":"J. Struct. Biol."},{"key":"10.1016\/j.celrep.2025.116582_bib50","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1038\/nmeth.4169","article-title":"cryoSPARC: algorithms for rapid unsupervised cryo-EM structure determination","volume":"14","author":"Punjani","year":"2017","journal-title":"Nat. Methods"},{"key":"10.1016\/j.celrep.2025.116582_bib51","doi-asserted-by":"crossref","first-page":"2126","DOI":"10.1107\/S0907444904019158","article-title":"Coot: model-building tools for molecular graphics","volume":"60","author":"Emsley","year":"2004","journal-title":"Acta Crystallogr. D Biol. Crystallogr."},{"key":"10.1016\/j.celrep.2025.116582_bib52","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1107\/S2059798318002425","article-title":"ISOLDE: a physically realistic environment for model building into low-resolution electron-density maps","volume":"74","author":"Croll","year":"2018","journal-title":"Acta Crystallogr. D Struct. Biol."},{"key":"10.1016\/j.celrep.2025.116582_bib53","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1107\/S0907444909052925","article-title":"PHENIX: a comprehensive Python-based system for macromolecular structure solution","volume":"66","author":"Adams","year":"2010","journal-title":"Acta Crystallogr. D Biol. Crystallogr."},{"key":"10.1016\/j.celrep.2025.116582_bib54","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1002\/pro.3943","article-title":"UCSF ChimeraX: Structure visualization for researchers, educators, and developers","volume":"30","author":"Pettersen","year":"2021","journal-title":"Protein Sci."},{"key":"10.1016\/j.celrep.2025.116582_bib55","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1002\/JLB.2VMA1217-492R","article-title":"A unique signal sequence of the chemokine receptor CCR7 promotes package into COPII vesicles for efficient receptor trafficking","volume":"104","author":"Uetz-von Allmen","year":"2018","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.celrep.2025.116582_bib56","doi-asserted-by":"crossref","first-page":"2464","DOI":"10.1111\/febs.14143","article-title":"The nucleotide-free state of heterotrimeric G proteins alpha-subunit adopts a highly stable conformation","volume":"284","author":"Andhirka","year":"2017","journal-title":"FEBS J."},{"key":"10.1016\/j.celrep.2025.116582_bib57","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1107\/S2052252520000081","article-title":"Estimation of high-order aberrations and anisotropic magnification from cryo-EM data sets in RELION-3.1","volume":"7","author":"Zivanov","year":"2020","journal-title":"IUCrJ"}],"container-title":["Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124725013543?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124725013543?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T11:09:30Z","timestamp":1778843370000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211124725013543"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":57,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["S2211124725013543"],"URL":"https:\/\/doi.org\/10.1016\/j.celrep.2025.116582","relation":{},"ISSN":["2211-1247"],"issn-type":[{"value":"2211-1247","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mechanisms of chemokine recognition and receptor activation of chemokine receptor CCR7","name":"articletitle","label":"Article Title"},{"value":"Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.celrep.2025.116582","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"116582"}}