{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T13:01:19Z","timestamp":1790600479974,"version":"4.1.0"},"reference-count":57,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T00:00:00Z","timestamp":1762214400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002809","name":"Government of Catalonia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003030","name":"Ag\u00e8ncia de Gesti\u00f3 d'Ajuts Universitaris i de Recerca","doi-asserted-by":"publisher","award":["2021\/SGR 01509"],"award-info":[{"award-number":["2021\/SGR 01509"]}],"id":[{"id":"10.13039\/501100003030","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003030","name":"Ag\u00e8ncia de Gesti\u00f3 d'Ajuts Universitaris i de Recerca","doi-asserted-by":"publisher","award":["2017\/SGR 537"],"award-info":[{"award-number":["2017\/SGR 537"]}],"id":[{"id":"10.13039\/501100003030","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Carlos III Health Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003329","name":"Gobierno de Espa\u00f1a Ministerio de Ciencia e Innovaci\u00f3n","doi-asserted-by":"publisher","award":["RTC2019-007067-1"],"award-info":[{"award-number":["RTC2019-007067-1"]}],"id":[{"id":"10.13039\/501100003329","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003329","name":"Gobierno de Espa\u00f1a Ministerio de Ciencia e Innovaci\u00f3n","doi-asserted-by":"publisher","award":["PLEC2021-007959"],"award-info":[{"award-number":["PLEC2021-007959"]}],"id":[{"id":"10.13039\/501100003329","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000781","name":"European Research Council","doi-asserted-by":"publisher","award":["ERC-2023-ADG 101142260"],"award-info":[{"award-number":["ERC-2023-ADG 101142260"]}],"id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","award":["CPP2022-009808"],"award-info":[{"award-number":["CPP2022-009808"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008050","name":"Fundaci\u00f3n Cellex","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010663","name":"H2020 European Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004837","name":"Ministerio de Ciencia e Innovaci\u00f3n","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018779","name":"Fundaci\u00f3n Fero","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100018779","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Reports"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.celrep.2025.116604","type":"journal-article","created":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T23:06:59Z","timestamp":1763766419000},"page":"116604","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["MYC inhibition by Omomyc causes DNA damage and overcomes PARPi resistance in breast cancer"],"prefix":"10.1016","volume":"44","author":[{"given":"Fabio","family":"Giuntini","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00cd\u00f1igo","family":"Gonz\u00e1lez-Larreategui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Herencia-Ropero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Casacuberta-Serra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariano F.","family":"Zacar\u00edas-Fluck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magdalena","family":"Arnal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flaminia","family":"Pedretti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Mart\u00ednez-Mart\u00edn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hugo","family":"Thabussot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginia Castillo","family":"Cano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judit","family":"Grueso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laia","family":"Foradada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erika","family":"Serrano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio","family":"L\u00f3pez-Est\u00e9vez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga","family":"Rodriguez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Guzman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adela","family":"Rodriguez-Hernandez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fara","family":"Bras\u00f3-Maristany","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alba","family":"Llop-Guevara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith","family":"Balma\u00f1a","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lara","family":"Nonell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleix","family":"Prat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Violeta","family":"Serra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Eve","family":"Beaulieu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan R.","family":"Whitfield","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Mass\u00f3-Vall\u00e9s","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4750-7971","authenticated-orcid":false,"given":"Laura","family":"Soucek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.celrep.2025.116604_bib1","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1038\/nrc904","article-title":"c-MYC: more than just a matter of life and death","volume":"2","author":"Pelengaris","year":"2002","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.celrep.2025.116604_bib2","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.cell.2012.03.003","article-title":"MYC on the path to cancer","volume":"149","author":"Dang","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2025.116604_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2021.103756","article-title":"Therapeutic targeting of \u201cundruggable\u201d MYC","volume":"75","author":"Llombart","year":"2022","journal-title":"EBioMedicine"},{"key":"10.1016\/j.celrep.2025.116604_bib4","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/1747-1028-7-6","article-title":"Two sides of the Myc-induced DNA damage response: from tumor suppression to tumor maintenance","volume":"7","author":"Campaner","year":"2012","journal-title":"Cell Div."},{"key":"10.1016\/j.celrep.2025.116604_bib5","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1038\/nrc2640","article-title":"Facilitating replication under stress: an oncogenic function of MYC?","volume":"9","author":"Herold","year":"2009","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.celrep.2025.116604_bib6","doi-asserted-by":"crossref","first-page":"8748","DOI":"10.1158\/0008-5472.CAN-10-0944","article-title":"Tumor cell kill by c-MYC depletion: role of MYC-regulated genes that control DNA double-strand break repair","volume":"70","author":"Luoto","year":"2010","journal-title":"Cancer Res."},{"key":"10.1016\/j.celrep.2025.116604_bib7","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a014423","article-title":"MYC and the control of DNA replication","volume":"4","author":"Dominguez-Sola","year":"2014","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"10.1016\/j.celrep.2025.116604_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.ctrv.2021.102154","article-title":"MYC as a target for cancer treatment","volume":"94","author":"Duffy","year":"2021","journal-title":"Cancer Treat Rev."},{"key":"10.1016\/j.celrep.2025.116604_bib9","doi-asserted-by":"crossref","first-page":"4632","DOI":"10.1038\/ncomms5632","article-title":"Myc inhibition is effective against glioma and reveals a role for Myc in proficient mitosis","volume":"5","author":"Annibali","year":"2014","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2025.116604_bib10","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aar5012","article-title":"Intrinsic cell-penetrating activity propels Omomyc from proof of concept to viable anti-MYC therapy","volume":"11","author":"Beaulieu","year":"2019","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.celrep.2025.116604_bib11","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1158\/2767-9764.CRC-21-0103","article-title":"MYC Inhibition Halts Metastatic Breast Cancer Progression by Blocking Growth, Invasion, and Seeding","volume":"2","author":"Masso-Valles","year":"2022","journal-title":"Cancer Res. Commun."},{"key":"10.1016\/j.celrep.2025.116604_bib12","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1101\/gad.205542.112","article-title":"Inhibition of Myc family proteins eradicates KRas-driven lung cancer in mice","volume":"27","author":"Soucek","year":"2013","journal-title":"Genes Dev."},{"key":"10.1016\/j.celrep.2025.116604_bib13","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1101\/gad.350078.122","article-title":"Reducing MYC's transcriptional footprint unveils a good prognostic gene signature in melanoma","volume":"37","author":"Zacarias-Fluck","year":"2023","journal-title":"Genes Dev."},{"key":"10.1016\/j.celrep.2025.116604_bib14","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1038\/sj.cdd.4401443","article-title":"Omomyc expression in skin prevents Myc-induced papillomatosis","volume":"11","author":"Soucek","year":"2004","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.celrep.2025.116604_bib15","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1038\/nature07260","article-title":"Modelling Myc inhibition as a cancer therapy","volume":"455","author":"Soucek","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2025.116604_bib16","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1038\/s41591-024-02805-1","article-title":"MYC targeting by OMO-103 in solid tumors: a phase 1 trial","volume":"30","author":"Garralda","year":"2024","journal-title":"Nat. Med."},{"key":"10.1016\/j.celrep.2025.116604_bib17","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1177\/1947601910378691","article-title":"MYC and Breast Cancer","volume":"1","author":"Xu","year":"2010","journal-title":"Genes Cancer"},{"key":"10.1016\/j.celrep.2025.116604_bib18","doi-asserted-by":"crossref","first-page":"1938","DOI":"10.1056\/NEJMra1001389","article-title":"Triple-negative breast cancer","volume":"363","author":"Foulkes","year":"2010","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.celrep.2025.116604_bib19","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1056\/NEJMoa2202809","article-title":"Pembrolizumab plus Chemotherapy in Advanced Triple-Negative Breast Cancer","volume":"387","author":"Cortes","year":"2022","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.celrep.2025.116604_bib20","doi-asserted-by":"crossref","first-page":"1738","DOI":"10.1200\/JCO.23.01409","article-title":"Final Results From the Randomized Phase III ASCENT Clinical Trial in Metastatic Triple-Negative Breast Cancer and Association of Outcomes by Human Epidermal Growth Factor Receptor 2 and Trophoblast Cell Surface Antigen 2 Expression","volume":"42","author":"Bardia","year":"2024","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.celrep.2025.116604_bib21","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1056\/NEJMoa2203690","article-title":"Trastuzumab Deruxtecan in Previously Treated HER2-Low Advanced Breast Cancer","volume":"387","author":"Modi","year":"2022","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.celrep.2025.116604_bib22","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1056\/NEJMoa0900212","article-title":"Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers","volume":"361","author":"Fong","year":"2009","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.celrep.2025.116604_bib23","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1038\/nm.3369","article-title":"Mechanisms of resistance to therapies targeting BRCA-mutant cancers","volume":"19","author":"Lord","year":"2013","journal-title":"Nat. Med."},{"key":"10.1016\/j.celrep.2025.116604_bib24","doi-asserted-by":"crossref","first-page":"5858","DOI":"10.1074\/jbc.273.10.5858","article-title":"DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139","volume":"273","author":"Rogakou","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.celrep.2025.116604_bib25","doi-asserted-by":"crossref","first-page":"6159","DOI":"10.1158\/1078-0432.CCR-10-1027","article-title":"A marker of homologous recombination predicts pathologic complete response to neoadjuvant chemotherapy in primary breast cancer","volume":"16","author":"Graeser","year":"2010","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.celrep.2025.116604_bib26","doi-asserted-by":"crossref","first-page":"1646","DOI":"10.1158\/0008-5472.CAN-21-2409","article-title":"Preclinical In Vivo Validation of the RAD51 Test for Identification of Homologous Recombination-Deficient Tumors and Patient Stratification","volume":"82","author":"Pellegrino","year":"2022","journal-title":"Cancer Res."},{"key":"10.1016\/j.celrep.2025.116604_bib27","doi-asserted-by":"crossref","first-page":"9390","DOI":"10.1074\/jbc.275.13.9390","article-title":"Initiation of DNA fragmentation during apoptosis induces phosphorylation of H2AX histone at serine 139","volume":"275","author":"Rogakou","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.celrep.2025.116604_bib28","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1038\/nrc2523","article-title":"GammaH2AX and cancer","volume":"8","author":"Bonner","year":"2008","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.celrep.2025.116604_bib29","first-page":"3507","article-title":"Omomyc, a potential Myc dominant negative, enhances Myc-induced apoptosis","volume":"62","author":"Soucek","year":"2002","journal-title":"Cancer Res."},{"key":"10.1016\/j.celrep.2025.116604_bib30","doi-asserted-by":"crossref","first-page":"1888","DOI":"10.1158\/0008-5472.CAN-24-2531","article-title":"Harnessing STING Signaling and Natural Killer Cells Overcomes PARP Inhibitor Resistance in Homologous Recombination-Deficient Breast Cancer","volume":"85","author":"Pedretti","year":"2025","journal-title":"Cancer Res."},{"key":"10.1016\/j.celrep.2025.116604_bib31","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1016\/j.bbagrm.2014.03.013","article-title":"Myc and cell cycle control","volume":"1849","author":"Bretones","year":"2015","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.celrep.2025.116604_bib32","doi-asserted-by":"crossref","first-page":"6584","DOI":"10.1073\/pnas.0802785105","article-title":"Activation of PI3K\/Akt and MAPK pathways regulates Myc-mediated transcription by phosphorylating and promoting the degradation of Mad1","volume":"105","author":"Zhu","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2025.116604_bib33","doi-asserted-by":"crossref","first-page":"2305","DOI":"10.1182\/blood-2007-09-111856","article-title":"Translational control of c-MYC by rapamycin promotes terminal myeloid differentiation","volume":"112","author":"Wall","year":"2008","journal-title":"Blood"},{"key":"10.1016\/j.celrep.2025.116604_bib34","doi-asserted-by":"crossref","first-page":"5326","DOI":"10.1021\/pr200584y","article-title":"Analysis of secretome changes uncovers an autocrine\/paracrine component in the modulation of cell proliferation and motility by c-Myc","volume":"10","author":"Pocsfalvi","year":"2011","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.celrep.2025.116604_bib35","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.molcel.2010.09.019","article-title":"The DNA damage response: making it safe to play with knives","volume":"40","author":"Ciccia","year":"2010","journal-title":"Mol. Cell"},{"key":"10.1016\/j.celrep.2025.116604_bib36","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1038\/nature08467","article-title":"The DNA-damage response in human biology and disease","volume":"461","author":"Jackson","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2025.116604_bib37","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1038\/nature10760","article-title":"The DNA damage response and cancer therapy","volume":"481","author":"Lord","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2025.116604_bib38","doi-asserted-by":"crossref","first-page":"2402","DOI":"10.1001\/jama.2017.7112","article-title":"Risks of Breast, Ovarian, and Contralateral Breast Cancer for BRCA1 and BRCA2 Mutation Carriers","volume":"317","author":"Kuchenbaecker","year":"2017","journal-title":"JAMA"},{"key":"10.1016\/j.celrep.2025.116604_bib39","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1002\/cncr.28914","article-title":"Subtyping of triple-negative breast cancer: implications for therapy","volume":"121","author":"Abramson","year":"2015","journal-title":"Cancer"},{"key":"10.1016\/j.celrep.2025.116604_bib40","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1016\/j.tcb.2019.07.008","article-title":"PARP Inhibitor Resistance: A Tug-of-War in BRCA-Mutated Cells","volume":"29","author":"Noordermeer","year":"2019","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.celrep.2025.116604_bib41","doi-asserted-by":"crossref","DOI":"10.1016\/j.tranon.2021.101012","article-title":"Clinical use and mechanisms of resistance for PARP inhibitors in homologous recombination-deficient cancers","volume":"14","author":"Janysek","year":"2021","journal-title":"Transl. Oncol."},{"key":"10.1016\/j.celrep.2025.116604_bib42","doi-asserted-by":"crossref","first-page":"10","DOI":"10.3389\/fcell.2017.00010","article-title":"Strategies to Inhibit Myc and Their Clinical Applicability","volume":"5","author":"Whitfield","year":"2017","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.celrep.2025.116604_bib43","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1038\/nature11412","article-title":"Comprehensive molecular portraits of human breast tumours","volume":"490","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2025.116604_bib44","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1038\/nrm3376","article-title":"New insights into the molecular and cellular functions of poly(ADP-ribose) and PARPs","volume":"13","author":"Gibson","year":"2012","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.celrep.2025.116604_bib45","doi-asserted-by":"crossref","first-page":"42729","DOI":"10.1074\/jbc.R300027200","article-title":"Rad51 recombinase and recombination mediators","volume":"278","author":"Sung","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.celrep.2025.116604_bib46","doi-asserted-by":"crossref","first-page":"400","DOI":"10.3390\/pathophysiology30030031","article-title":"Unraveling MYC's Role in Orchestrating Tumor Intrinsic and Tumor Microenvironment Interactions Driving Tumorigenesis and Drug Resistance","volume":"30","author":"Doha","year":"2023","journal-title":"Pathophysiology"},{"key":"10.1016\/j.celrep.2025.116604_bib47","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a014217","article-title":"MYC, metabolism, cell growth, and tumorigenesis","volume":"3","author":"Dang","year":"2013","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"10.1016\/j.celrep.2025.116604_bib48","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a014225","article-title":"MYC and mitochondrial biogenesis","volume":"4","author":"Morrish","year":"2014","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"10.1016\/j.celrep.2025.116604_bib49","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1158\/1541-7786.MCR-10-0510","article-title":"c-MYC oncoprotein dictates transcriptional profiles of ATP-binding cassette transporter genes in chronic myelogenous leukemia CD34+ hematopoietic progenitor cells","volume":"9","author":"Porro","year":"2011","journal-title":"Mol. Cancer Res."},{"key":"10.1016\/j.celrep.2025.116604_bib50","doi-asserted-by":"crossref","first-page":"17079","DOI":"10.1073\/pnas.0806092105","article-title":"High sensitivity of BRCA1-deficient mammary tumors to the PARP inhibitor AZD2281 alone and in combination with platinum drugs","volume":"105","author":"Rottenberg","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2025.116604_bib51","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1016\/j.ccell.2018.05.008","article-title":"Selective Loss of PARG Restores PARylation and Counteracts PARP Inhibitor-Mediated Synthetic Lethality","volume":"33","author":"Gogola","year":"2018","journal-title":"Cancer Cell"},{"key":"10.1016\/j.celrep.2025.116604_bib52","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1084\/jem.20121044","article-title":"Poly(ADP-ribose) polymerase 1 regulates nuclear reprogramming and promotes iPSC generation without c-Myc","volume":"210","author":"Chiou","year":"2013","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.celrep.2025.116604_bib53","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1093\/annonc\/mdy099","article-title":"RAD51 foci as a functional biomarker of homologous recombination repair and PARP inhibitor resistance in germline BRCA-mutated breast cancer","volume":"29","author":"Cruz","year":"2018","journal-title":"Ann. Oncol."},{"key":"10.1016\/j.celrep.2025.116604_bib54","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1158\/2159-8290.CD-17-0419","article-title":"Secondary Somatic Mutations Restoring RAD51C and RAD51D Associated with Acquired Resistance to the PARP Inhibitor Rucaparib in High-Grade Ovarian Carcinoma","volume":"7","author":"Kondrashova","year":"2017","journal-title":"Cancer Discov."},{"key":"10.1016\/j.celrep.2025.116604_bib55","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1200\/JCO.2016.71.3677","article-title":"Somatic BRCA1\/2 Recovery as a Resistance Mechanism After Exceptional Response to Poly (ADP-ribose) Polymerase Inhibition","volume":"35","author":"Lheureux","year":"2017","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.celrep.2025.116604_bib56","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.molcel.2021.11.016","article-title":"MYC assembles and stimulates topoisomerases 1 and 2 in a \u201ctopoisome\u201d","volume":"82","author":"Das","year":"2022","journal-title":"Mol. Cell"},{"key":"10.1016\/j.celrep.2025.116604_bib57","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1016\/j.csbj.2015.09.001","article-title":"Searching for Drug Synergy in Complex Dose-Response Landscapes Using an Interaction Potency Model","volume":"13","author":"Yadav","year":"2015","journal-title":"Comput. Struct. Biotechnol. J."}],"container-title":["Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124725013762?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124725013762?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T12:42:46Z","timestamp":1790599366000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211124725013762"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":57,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["S2211124725013762"],"URL":"https:\/\/doi.org\/10.1016\/j.celrep.2025.116604","relation":{},"ISSN":["2211-1247"],"issn-type":[{"value":"2211-1247","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"MYC inhibition by Omomyc causes DNA damage and overcomes PARPi resistance in breast cancer","name":"articletitle","label":"Article Title"},{"value":"Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.celrep.2025.116604","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"116604"}}