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Co-existence of substance P and calcitonin gene-related peptide-like immunoreactivities in sensory nerves in relation to cardiovascular and bronchoconstrictor effects of capsaicin. Eur. J. Pharmacol. 108, 315-319. https:\/\/doi.org\/10.1016\/0014-2999(85)90456-x.","DOI":"10.1016\/0014-2999(85)90456-X"},{"key":"10.1016\/j.celrep.2025.116613_bib86","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1007\/BF00218323","article-title":"Primary sensory neurons of the rat showing calcitonin gene-related peptide immunoreactivity and their relation to substance P-somatostatin-galanin-vasoactive intestinal polypeptide- and cholecystokinin-immunoreactive ganglion cells","volume":"247","author":"Ju","year":"1987","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.celrep.2025.116613_bib87","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/0196-9781(87)90117-3","article-title":"Calcitonin gene-related peptide (CGRP) in capsaicin-sensitive substance P-immunoreactive sensory neurons in animals and man: distribution and release by capsaicin","volume":"8","author":"Franco-Cereceda","year":"1987","journal-title":"Peptides"},{"key":"10.1016\/j.celrep.2025.116613_bib88","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1007\/BF01945354","article-title":"Coexistence of peptides with classical neurotransmitters","volume":"43","author":"H\u00f6kfelt","year":"1987","journal-title":"Experientia"},{"key":"10.1016\/j.celrep.2025.116613_bib89","doi-asserted-by":"crossref","first-page":"1737","DOI":"10.1053\/gast.2001.24848","article-title":"Role of peripheral N-methyl-D-aspartate (NMDA) receptors in visceral nociception in rats","volume":"120","author":"McRoberts","year":"2001","journal-title":"Gastroenterology"},{"key":"10.1016\/j.celrep.2025.116613_bib90","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1038\/386721a0","article-title":"NMDA-receptor regulation of substance P release from primary afferent nociceptors","volume":"386","author":"Liu","year":"1997","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2025.116613_bib91","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/0167-0115(89)90176-6","article-title":"Calcitonin gene-related peptide is metabolized by an endopeptidase hydrolyzing substance P","volume":"25","author":"Le Grev\u00e9s","year":"1989","journal-title":"Regul. 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