{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T13:01:23Z","timestamp":1790600483711,"version":"4.1.0"},"reference-count":84,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T00:00:00Z","timestamp":1762992000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100023741","name":"University of California-San Diego","doi-asserted-by":"publisher","award":["SCR_022039"],"award-info":[{"award-number":["SCR_022039"]}],"id":[{"id":"10.13039\/100023741","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AI054503"],"award-info":[{"award-number":["R01AI054503"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000009","name":"FNIH","doi-asserted-by":"publisher","award":["2021-A-17088"],"award-info":[{"award-number":["2021-A-17088"]}],"id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["F32 AI104240-02"],"award-info":[{"award-number":["F32 AI104240-02"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["223103\/Z\/21\/Z"],"award-info":[{"award-number":["223103\/Z\/21\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005595","name":"University of California","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005595","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018645","name":"Musculoskeletal Research Center, Washington University in St. Louis","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100018645","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["DGE-2038238"],"award-info":[{"award-number":["DGE-2038238"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Reports"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.celrep.2025.116661","type":"journal-article","created":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T03:46:40Z","timestamp":1765424800000},"page":"116661","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["Mycobacteria trehalose dimycolate interactions with host Mincle remodel blood-brain barrier junctions for brain invasion"],"prefix":"10.1016","volume":"44","author":[{"given":"Megan I.","family":"Hayes","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumedha","family":"Ravishankar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan K.","family":"Shanahan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam J.","family":"Fountain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0692-5533","authenticated-orcid":false,"given":"Lalita","family":"Ramakrishnan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cressida A.","family":"Madigan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.celrep.2025.116661_bib1","doi-asserted-by":"crossref","DOI":"10.1111\/cmi.13132","article-title":"Strategies used by bacterial pathogens to cross the blood-brain barrier","volume":"22","author":"Le Guennec","year":"2020","journal-title":"Cell. Microbiol."},{"key":"10.1016\/j.celrep.2025.116661_bib2","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1038\/nrmicro.2016.178","article-title":"A journey into the brain: insight into how bacterial pathogens cross blood-brain barriers","volume":"15","author":"Coureuil","year":"2017","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.celrep.2025.116661_bib3","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1016\/S1474-4422(13)70168-6","article-title":"Tuberculous meningitis: more questions, still too few answers","volume":"12","author":"Thwaites","year":"2013","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.celrep.2025.116661_bib4","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1038\/nrneurol.2017.120","article-title":"Tuberculous meningitis","volume":"13","author":"Wilkinson","year":"2017","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.celrep.2025.116661_bib5","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/S1474-4422(21)00435-X","article-title":"Tuberculous meningitis: progress and remaining questions","volume":"21","author":"Huynh","year":"2022","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.celrep.2025.116661_bib6","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.conb.2018.12.014","article-title":"Transcytosis at the blood-brain barrier","volume":"57","author":"Ayloo","year":"2019","journal-title":"Curr. Opin. Neurobiol."},{"key":"10.1016\/j.celrep.2025.116661_bib7","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a020412","article-title":"The blood-brain barrier","volume":"7","author":"Daneman","year":"2015","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.celrep.2025.116661_bib8","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1146\/annurev-cellbio-100617-062608","article-title":"Development and Cell Biology of the Blood-Brain Barrier","volume":"35","author":"Langen","year":"2019","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"10.1016\/j.celrep.2025.116661_bib9","doi-asserted-by":"crossref","first-page":"164","DOI":"10.4161\/viru.18639","article-title":"Mechanism of meningeal invasion by Neisseria meningitidis","volume":"3","author":"Coureuil","year":"2012","journal-title":"Virulence"},{"key":"10.1016\/j.celrep.2025.116661_bib10","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/j.molmed.2014.08.002","article-title":"Invasive meningococcal disease: a disease of the endothelial cells","volume":"20","author":"Coureuil","year":"2014","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.celrep.2025.116661_bib11","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.jinf.2004.02.010","article-title":"Tuberculous meningitis and miliary tuberculosis: the Rich focus revisited","volume":"50","author":"Donald","year":"2005","journal-title":"J. Infect."},{"key":"10.1016\/j.celrep.2025.116661_bib12","first-page":"5","article-title":"The Pathogenesis of Tuberculous Meningitis","volume":"52","author":"Rich","year":"1933","journal-title":"Bull. Johns Hopkins Hosp."},{"key":"10.1016\/j.celrep.2025.116661_bib13","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/S0022-3476(34)80049-2","article-title":"Some aspects of tuberculous meningitis and the possibility of its prevention","volume":"5","author":"Gothenburg","year":"1934","journal-title":"J. Pediatr."},{"key":"10.1016\/j.celrep.2025.116661_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.tube.2020.102016","article-title":"The immunological architecture of granulomatous inflammation in central nervous system tuberculosis","volume":"125","author":"Zaharie","year":"2020","journal-title":"Tuberculosis"},{"key":"10.1016\/j.celrep.2025.116661_bib15","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1002\/path.1700450312","article-title":"Tuberculosis of the central nervous system, with special reference to tuberculous meningitis","volume":"45","author":"Macgregor","year":"1937","journal-title":"J. Pathol. Bacteriol."},{"key":"10.1016\/j.celrep.2025.116661_bib16","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1038\/s41590-018-0119-x","article-title":"Tuberculous meningitis: a roadmap for advancing basic and translational research","volume":"19","author":"Jain","year":"2018","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.celrep.2025.116661_bib17","doi-asserted-by":"crossref","DOI":"10.1126\/science.abh2841","article-title":"Tumor necrosis factor induces pathogenic mitochondrial ROS in tuberculosis through reverse electron transport","volume":"376","author":"Roca","year":"2022","journal-title":"Science"},{"key":"10.1016\/j.celrep.2025.116661_bib18","doi-asserted-by":"crossref","first-page":"3720","DOI":"10.1016\/j.cell.2022.08.018","article-title":"mTOR-regulated mitochondrial metabolism limits mycobacterium-induced cytotoxicity","volume":"185","author":"Pag\u00e1n","year":"2022","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2025.116661_bib19","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/S1074-7613(02)00475-2","article-title":"Real-time visualization of mycobacterium-macrophage interactions leading to initiation of granuloma formation in zebrafish embryos","volume":"17","author":"Davis","year":"2002","journal-title":"Immunity"},{"key":"10.1016\/j.celrep.2025.116661_bib20","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.mib.2020.01.011","article-title":"Mycobacterium tuberculosis pathogenicity viewed through the lens of molecular Koch's postulates","volume":"54","author":"Ramakrishnan","year":"2020","journal-title":"Curr. Opin. Microbiol."},{"key":"10.1016\/j.celrep.2025.116661_bib21","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1016\/j.cell.2017.07.030","article-title":"A Macrophage Response to Mycobacterium leprae Phenolic Glycolipid Initiates Nerve Damage in Leprosy","volume":"170","author":"Madigan","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2025.116661_bib22","doi-asserted-by":"crossref","DOI":"10.1111\/cmi.12858","article-title":"Mycobacteria employ two different mechanisms to cross the blood-brain barrier","volume":"20","author":"van Leeuwen","year":"2018","journal-title":"Cell. Microbiol."},{"key":"10.1016\/j.celrep.2025.116661_bib23","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0194982","article-title":"A zebrafish model for ocular tuberculosis","volume":"13","author":"Takaki","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.celrep.2025.116661_bib24","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/978-1-0716-3199-7_4","article-title":"Zebrafish Larvae as an Experimental Model of Cryptococcal Meningitis","volume":"2667","author":"Chalakova","year":"2023","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.celrep.2025.116661_bib26","doi-asserted-by":"crossref","DOI":"10.1128\/spectrum.04315-22","article-title":"Roles for Microglia in Cryptococcal Brain Dissemination in the Zebrafish Larva","volume":"11","author":"Nielson","year":"2023","journal-title":"Microbiol. Spectr."},{"key":"10.1016\/j.celrep.2025.116661_bib27","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.3003236","article-title":"Group B Streptococci lyse endothelial cells to infect the brain in a zebrafish meningitis model","volume":"23","author":"Ravishankar","year":"2025","journal-title":"PLoS Biol."},{"key":"10.1016\/j.celrep.2025.116661_bib28","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/1471-2180-12-7","article-title":"Role of Mycobacterium tuberculosis pknD in the pathogenesis of central nervous system tuberculosis","volume":"12","author":"Be","year":"2012","journal-title":"BMC Microbiol."},{"key":"10.1016\/j.celrep.2025.116661_bib29","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1086\/502631","article-title":"Mycobacterium tuberculosis invasion and traversal across an in vitro human blood-brain barrier as a pathogenic mechanism for central nervous system tuberculosis","volume":"193","author":"Jain","year":"2006","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.celrep.2025.116661_bib30","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.47326","article-title":"Suppression of transcytosis regulates zebrafish blood-brain barrier function","volume":"8","author":"O'Brown","year":"2019","journal-title":"eLife"},{"key":"10.1016\/j.celrep.2025.116661_bib31","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1016\/j.ydbio.2007.01.023","article-title":"FoxH1 negatively modulates flk1 gene expression and vascular formation in zebrafish","volume":"304","author":"Choi","year":"2007","journal-title":"Dev. Biol."},{"key":"10.1016\/j.celrep.2025.116661_bib32","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms15764","article-title":"Strength of Neisseria meningitidis binding to endothelial cells requires highly-ordered CD147\/beta2-adrenoceptor clusters assembled by alpha-actinin-4","volume":"8","author":"Maissa","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2025.116661_bib33","doi-asserted-by":"crossref","first-page":"2979","DOI":"10.1128\/IAI.68.5.2979-2984.2000","article-title":"Invasion of the brain and chronic central nervous system infection after systemic Mycobacterium avium complex infection in mice","volume":"68","author":"Wu","year":"2000","journal-title":"Infect. Immun."},{"key":"10.1016\/j.celrep.2025.116661_bib25","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.cell.2008.11.014","article-title":"The role of the granuloma in expansion and dissemination of early tuberculous infection","volume":"136","author":"Davis","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2025.116661_bib34","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.chom.2007.06.004","article-title":"Dichotomous role of the macrophage in early Mycobacterium marinum infection of the zebrafish","volume":"2","author":"Clay","year":"2007","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.celrep.2025.116661_bib35","doi-asserted-by":"crossref","first-page":"e49","DOI":"10.1182\/blood-2010-10-314120","article-title":"mpeg1 promoter transgenes direct macrophage-lineage expression in zebrafish","volume":"117","author":"Ellett","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.celrep.2025.116661_bib36","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1038\/nn.4475","article-title":"The role of peripheral immune cells in the CNS in steady state and disease","volume":"20","author":"Prinz","year":"2017","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.celrep.2025.116661_bib37","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.1016\/j.cell.2014.11.024","article-title":"Host evasion and exploitation schemes of Mycobacterium tuberculosis","volume":"159","author":"Cambier","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2025.116661_bib38","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1038\/ni1091","article-title":"Superinfecting mycobacteria home to established tuberculous granulomas","volume":"5","author":"Cosma","year":"2004","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.celrep.2025.116661_bib39","doi-asserted-by":"crossref","first-page":"1598","DOI":"10.1128\/iai.63.4.1598-1602.1995","article-title":"CD14 receptor-mediated uptake of nonopsonized Mycobacterium tuberculosis by human microglia","volume":"63","author":"Peterson","year":"1995","journal-title":"Infect. Immun."},{"key":"10.1016\/j.celrep.2025.116661_bib40","doi-asserted-by":"crossref","DOI":"10.1128\/msphere.00504-23","article-title":"Survival in macrophages induces enhanced virulence in Cryptococcus","volume":"9","author":"Nielson","year":"2024","journal-title":"mSphere"},{"key":"10.1016\/j.celrep.2025.116661_bib41","doi-asserted-by":"crossref","first-page":"2776","DOI":"10.1242\/dev.091876","article-title":"The zebrafish common cardinal veins develop by a novel mechanism: lumen ensheathment","volume":"140","author":"Helker","year":"2013","journal-title":"Development"},{"key":"10.1016\/j.celrep.2025.116661_bib42","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.1016\/j.neuron.2022.02.017","article-title":"Pericyte-to-endothelial cell signaling via vitronectin-integrin regulates blood-CNS barrier","volume":"110","author":"Ayloo","year":"2022","journal-title":"Neuron"},{"key":"10.1016\/j.celrep.2025.116661_bib43","doi-asserted-by":"crossref","first-page":"5074","DOI":"10.1128\/iai.65.12.5074-5081.1997","article-title":"Invasion of brain microvascular endothelial cells by group B streptococci","volume":"65","author":"Nizet","year":"1997","journal-title":"Infect. Immun."},{"key":"10.1016\/j.celrep.2025.116661_bib44","article-title":"Group B streptococci lyse endothelial cells to infect the brain in a zebrafish meningitis model","author":"Ravishankar","year":"2024","journal-title":"bioRxiv"},{"key":"10.1016\/j.celrep.2025.116661_bib45","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2122161119","article-title":"The C terminus of the mycobacterium ESX-1 secretion system substrate ESAT-6 is required for phagosomal membrane damage and virulence","volume":"119","author":"Osman","year":"2022","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2025.116661_bib46","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1073\/pnas.1620133114","article-title":"Mycobacterial ESX-1 secretion system mediates host cell lysis through bacterium contact-dependent gross membrane disruptions","volume":"114","author":"Conrad","year":"2017","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2025.116661_bib47","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.yexcr.2017.03.061","article-title":"Interplay between tight junctions & adherens junctions","volume":"358","author":"Campbell","year":"2017","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.celrep.2025.116661_bib48","doi-asserted-by":"crossref","first-page":"2506","DOI":"10.3390\/ijms22052506","article-title":"Tight Junctions as a Key for Pathogens Invasion in Intestinal Epithelial Cells","volume":"22","author":"Paradis","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.celrep.2025.116661_bib49","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1038\/nrm1433","article-title":"Alpha-catenin: at the junction of intercellular adhesion and actin dynamics","volume":"5","author":"Kobielak","year":"2004","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.celrep.2025.116661_bib51","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1016\/j.devcel.2020.07.022","article-title":"A Weak Link with Actin Organizes Tight Junctions to Control Epithelial Permeability","volume":"54","author":"Belardi","year":"2020","journal-title":"Dev. Cell"},{"key":"10.1016\/j.celrep.2025.116661_bib52","doi-asserted-by":"crossref","first-page":"25649","DOI":"10.1073\/pnas.1910368116","article-title":"The conical shape of DIM lipids promotes Mycobacterium tuberculosis infection of macrophages","volume":"116","author":"Augenstreich","year":"2019","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2025.116661_bib53","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.60648","article-title":"Spreading of a mycobacterial cell-surface lipid into host epithelial membranes promotes infectivity","volume":"9","author":"Cambier","year":"2020","journal-title":"eLife"},{"key":"10.1016\/j.celrep.2025.116661_bib54","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1016\/S1097-2765(00)80250-6","article-title":"A novel mycolic acid cyclopropane synthetase is required for cording, persistence, and virulence of Mycobacterium tuberculosis","volume":"5","author":"Glickman","year":"2000","journal-title":"Mol. Cell"},{"key":"10.1016\/j.celrep.2025.116661_bib55","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1016\/j.chom.2018.09.004","article-title":"Cyclopropane Modification of Trehalose Dimycolate Drives Granuloma Angiogenesis and Mycobacterial Growth through Vegf Signaling","volume":"24","author":"Walton","year":"2018","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.celrep.2025.116661_bib56","doi-asserted-by":"crossref","first-page":"21698","DOI":"10.1074\/jbc.M110.125724","article-title":"Temperature-dependent regulation of mycolic acid cyclopropanation in saprophytic mycobacteria: role of the Mycobacterium smegmatis 1351 gene (MSMEG_1351) in CIS-cyclopropanation of alpha-mycolates","volume":"285","author":"Alibaud","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.celrep.2025.116661_bib57","doi-asserted-by":"crossref","first-page":"5135","DOI":"10.1016\/j.cell.2023.09.016","article-title":"Mechanopathology of biofilm-like Mycobacterium tuberculosis cords","volume":"186","author":"Mishra","year":"2023","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2025.116661_bib58","doi-asserted-by":"crossref","first-page":"2879","DOI":"10.1084\/jem.20091750","article-title":"Direct recognition of the mycobacterial glycolipid, trehalose dimycolate, by C-type lectin Mincle","volume":"206","author":"Ishikawa","year":"2009","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.celrep.2025.116661_bib59","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1084\/jem.20041668","article-title":"Mycobacterium tuberculosis controls host innate immune activation through cyclopropane modification of a glycolipid effector molecule","volume":"201","author":"Rao","year":"2005","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.celrep.2025.116661_bib60","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1000474","article-title":"MARCO, TLR2, and CD14 are required for macrophage cytokine responses to mycobacterial trehalose dimycolate and Mycobacterium tuberculosis","volume":"5","author":"Bowdish","year":"2009","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.celrep.2025.116661_bib61","doi-asserted-by":"crossref","first-page":"2315","DOI":"10.1099\/00221287-147-8-2315","article-title":"Erp, an extracellular protein family specific to mycobacteria","volume":"147","author":"de Mendon\u00e7a-Lima","year":"2001","journal-title":"Microbiology (Read.)"},{"key":"10.1016\/j.celrep.2025.116661_bib62","doi-asserted-by":"crossref","first-page":"5","DOI":"10.3389\/fimmu.2013.00005","article-title":"Recognition of the mycobacterial cord factor by Mincle: relevance for granuloma formation and resistance to tuberculosis","volume":"4","author":"Lang","year":"2013","journal-title":"Front. Immunol."},{"key":"10.1016\/j.celrep.2025.116661_bib63","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2120489119","article-title":"A mechanism of self-lipid endocytosis mediated by the receptor Mincle","volume":"119","author":"Kostarnoy","year":"2022","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2025.116661_bib64","doi-asserted-by":"crossref","first-page":"3177","DOI":"10.1038\/srep03177","article-title":"Involvement of Mincle and Syk in the changes to innate immunity after ischemic stroke","volume":"3","author":"Suzuki","year":"2013","journal-title":"Sci. Rep."},{"key":"10.1016\/j.celrep.2025.116661_bib65","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1128\/mBio.00938-18","article-title":"Rational Design of Biosafety Level 2-Approved, Multidrug-Resistant Strains of Mycobacterium tuberculosis through Nutrient Auxotrophy","volume":"9","author":"Vilcheze","year":"2018","journal-title":"mBio"},{"key":"10.1016\/j.celrep.2025.116661_bib66","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1016\/j.cell.2015.10.067","article-title":"Establishment and Dysfunction of the Blood-Brain Barrier","volume":"163","author":"Zhao","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2025.116661_bib67","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1038\/nature09513","article-title":"Pericytes are required for blood-brain barrier integrity during embryogenesis","volume":"468","author":"Daneman","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2025.116661_bib68","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1002\/jps.23022","article-title":"In vitro blood-brain barrier models: current and perspective technologies","volume":"101","author":"Naik","year":"2012","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.celrep.2025.116661_bib69","doi-asserted-by":"crossref","first-page":"E5069","DOI":"10.1073\/pnas.1321205110","article-title":"Osmosensory signaling in Mycobacterium tuberculosis mediated by a eukaryotic-like Ser\/Thr protein kinase","volume":"110","author":"Hatzios","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2025.116661_bib70","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1242\/jcs.115.6.1231","article-title":"Microvilli-like structures are associated with the internalization of virulent capsulated Neisseria meningitidis into vascular endothelial cells","volume":"115","author":"Eug\u00e8ne","year":"2002","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.celrep.2025.116661_bib71","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1126\/science.1173196","article-title":"Meningococcal type IV pili recruit the polarity complex to cross the brain endothelium","volume":"325","author":"Coureuil","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.celrep.2025.116661_bib72","doi-asserted-by":"crossref","first-page":"E943","DOI":"10.1073\/pnas.1321390111","article-title":"Mycobacterium abscessus cording prevents phagocytosis and promotes abscess formation","volume":"111","author":"Bernut","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2025.116661_bib81","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1038\/nprot.2013.068","article-title":"Evaluation of the pathogenesis and treatment of Mycobacterium marinum infection in zebrafish","volume":"8","author":"Takaki","year":"2013","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.celrep.2025.116661_bib86","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1016\/j.cell.2019.08.004","article-title":"TNF Induces Pathogenic Programmed Macrophage Necrosis in Tuberculosis through a Mitochondrial-Lysosomal-Endoplasmic Reticulum Circuit","volume":"178","author":"Roca","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2025.116661_bib76","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1002\/dvg.22955","article-title":"Zebrafish lines expressing UAS-driven red probes for monitoring cytoskeletal dynamics","volume":"54","author":"Mizoguchi","year":"2016","journal-title":"Genesis"},{"key":"10.1016\/j.celrep.2025.116661_bib78","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1038\/ng.321","article-title":"Ccbe1 is required for embryonic lymphangiogenesis and venous sprouting","volume":"41","author":"Hogan","year":"2009","journal-title":"Nat. Genet."},{"key":"10.1016\/j.celrep.2025.116661_bib77","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1006\/dbio.2002.0711","article-title":"In vivo imaging of embryonic vascular development using transgenic zebrafish","volume":"248","author":"Lawson","year":"2002","journal-title":"Dev. Biol."},{"key":"10.1016\/j.celrep.2025.116661_bib75","doi-asserted-by":"crossref","first-page":"13990","DOI":"10.1073\/pnas.0700825104","article-title":"A betaPix Pak2a signaling pathway regulates cerebral vascular stability in zebrafish","volume":"104","author":"Liu","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2025.116661_bib73","doi-asserted-by":"crossref","first-page":"3119","DOI":"10.1242\/dev.048785","article-title":"Moesin1 and Ve-cadherin are required in endothelial cells during in vivo tubulogenesis","volume":"137","author":"Wang","year":"2010","journal-title":"Development"},{"key":"10.1016\/j.celrep.2025.116661_bib80","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1007\/978-1-4939-2450-9_10","article-title":"Mycobacterial recombineering","volume":"1285","author":"Murphy","year":"2015","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.celrep.2025.116661_bib82","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.01467-18","article-title":"ORBIT: a New Paradigm for Genetic Engineering of Mycobacterial Chromosomes","volume":"9","author":"Murphy","year":"2018","journal-title":"mBio"},{"key":"10.1016\/j.celrep.2025.116661_bib79","article-title":"Zebrafish and frog models of Mycobacterium marinum infection","volume":"10","author":"Cosma","year":"2006","journal-title":"Curr Protoc Microbiol"},{"key":"10.1016\/j.celrep.2025.116661_bib83","doi-asserted-by":"crossref","DOI":"10.1038\/srep27459","article-title":"IVA cloning: A single-tube universal cloning system exploiting bacterial In Vivo Assembly","volume":"6","author":"Garcia-Nafria","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.celrep.2025.116661_bib84","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1016\/j.cell.2011.12.023","article-title":"Host genotype-specific therapies can optimize the inflammatory response to mycobacterial infections","volume":"148","author":"Tobin","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2025.116661_bib85","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/0022-1759(96)00056-7","article-title":"Apoptosis of macrophages induced by liposome-mediated intracellular delivery of clodronate and propamidine","volume":"193","author":"van Rooijen","year":"1996","journal-title":"J. Immunol. Methods"}],"container-title":["Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124725014330?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124725014330?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T12:43:56Z","timestamp":1790599436000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211124725014330"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":84,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["S2211124725014330"],"URL":"https:\/\/doi.org\/10.1016\/j.celrep.2025.116661","relation":{},"ISSN":["2211-1247"],"issn-type":[{"value":"2211-1247","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mycobacteria trehalose dimycolate interactions with host Mincle remodel blood-brain barrier junctions for brain invasion","name":"articletitle","label":"Article Title"},{"value":"Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.celrep.2025.116661","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"116661"}}