{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T20:44:55Z","timestamp":1791837895465,"version":"4.3.4"},"reference-count":62,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T00:00:00Z","timestamp":1763337600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003141","name":"Consejo Nacional de Humanidades Ciencias y Tecnolog\u00edas","doi-asserted-by":"publisher","award":["303067"],"award-info":[{"award-number":["303067"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003141","name":"Consejo Nacional de Humanidades Ciencias y Tecnolog\u00edas","doi-asserted-by":"publisher","award":["302962"],"award-info":[{"award-number":["302962"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003141","name":"Consejo Nacional de Humanidades Ciencias y Tecnolog\u00edas","doi-asserted-by":"publisher","award":["942680"],"award-info":[{"award-number":["942680"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003141","name":"Consejo Nacional de Humanidades Ciencias y Tecnolog\u00edas","doi-asserted-by":"publisher","award":["941356"],"award-info":[{"award-number":["941356"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008237","name":"Department of Surgery","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008237","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Reports"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.celrep.2025.116680","type":"journal-article","created":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T21:37:24Z","timestamp":1765489044000},"page":"116680","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["The transcription factor Helios restrains the anti-tumor capacity of CD8+ T cells"],"prefix":"10.1016","volume":"44","author":[{"given":"Rosa M.","family":"Rubio","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerardo","family":"Su\u00e1rez-Rojas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adri\u00e1n","family":"Albarr\u00e1n-God\u00ednez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara\u00ed G.","family":"De Le\u00f3n-Rodr\u00edguez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Aguilar-Flores","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Fonseca-Monta\u00f1o","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"T\u00e9llez-S\u00fctterlin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sofia V.","family":"de los Santos-Carmona","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karla","family":"Guzm\u00e1n-Barrenechea","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Candanedo-Gonz\u00e1lez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrique","family":"Soto-Perez-de-Celis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"G\u00f3mez-Romero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diego","family":"Cortez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marysol","family":"Gonz\u00e1lez-Ya\u00f1ez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura C.","family":"Bonifaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iris K.","family":"Madera-Salcedo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 C.","family":"Crisp\u00edn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7270-4515","authenticated-orcid":false,"given":"Florencia","family":"Rosetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.celrep.2025.116680_bib1","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1038\/s41577-020-0307-4","article-title":"Clonal expansion of innate and adaptive lymphocytes","volume":"20","author":"Adams","year":"2020","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.celrep.2025.116680_bib2","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/j.it.2024.04.012","article-title":"CD8 is down(regulated) for tolerance","volume":"45","author":"Rodr\u00edguez-Rodr\u00edguez","year":"2024","journal-title":"Trends Immunol."},{"key":"10.1016\/j.celrep.2025.116680_bib3","doi-asserted-by":"crossref","first-page":"4207","DOI":"10.4049\/jimmunol.1402775","article-title":"Programmed Cell Death 1 and Helios Distinguish TCR-\u03b1\u03b2+ Double-Negative (CD4\u2212CD8\u2212) T Cells That Derive from Self-Reactive CD8 T Cells","volume":"194","author":"Rodr\u00edguez-Rodr\u00edguez","year":"2015","journal-title":"J. Immunol."},{"key":"10.1016\/j.celrep.2025.116680_bib4","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1016\/j.immuni.2024.04.026","article-title":"The CD8+ T cell tolerance checkpoint triggers a distinct differentiation state defined by protein translation defects","volume":"57","author":"Van Der Byl","year":"2024","journal-title":"Immunity"},{"key":"10.1016\/j.celrep.2025.116680_bib5","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.coi.2017.11.005","article-title":"The Ikaros family in lymphocyte development","volume":"51","author":"Heizmann","year":"2018","journal-title":"Curr. Opin. Immunol."},{"key":"10.1016\/j.celrep.2025.116680_bib6","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.stem.2018.10.016","article-title":"IKZF2 Drives Leukemia Stem Cell Self-Renewal and Inhibits Myeloid Differentiation","volume":"24","author":"Park","year":"2019","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.celrep.2025.116680_bib7","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1111\/imm.13115","article-title":"Helios: still behind the clouds","volume":"158","author":"Thornton","year":"2019","journal-title":"Immunology"},{"key":"10.1016\/j.celrep.2025.116680_bib8","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1038\/s41586-019-1836-5","article-title":"An intra-tumoral niche maintains and differentiates stem-like CD8 T cells","volume":"576","author":"Jansen","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2025.116680_bib9","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.immuni.2022.12.008","article-title":"Microenvironment-driven metabolic adaptations guiding CD8+ T cell anti-tumor immunity","volume":"56","author":"Park","year":"2023","journal-title":"Immunity"},{"key":"10.1016\/j.celrep.2025.116680_bib10","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1038\/nri3862","article-title":"Molecular and cellular insights into T cell exhaustion","volume":"15","author":"Wherry","year":"2015","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.celrep.2025.116680_bib11","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1016\/j.immuni.2007.09.006","article-title":"Molecular Signature of CD8+ T Cell Exhaustion during Chronic Viral Infection","volume":"27","author":"Wherry","year":"2007","journal-title":"Immunity"},{"key":"10.1016\/j.celrep.2025.116680_bib12","doi-asserted-by":"crossref","first-page":"715234","DOI":"10.3389\/fimmu.2021.715234","article-title":"CD8+ T Cell Exhaustion in Cancer","volume":"12","author":"Dolina","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.celrep.2025.116680_bib13","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1016\/j.immuni.2019.09.013","article-title":"TCF-1-Centered Transcriptional Network Drives an Effector versus Exhausted CD8 T Cell-Fate Decision","volume":"51","author":"Chen","year":"2019","journal-title":"Immunity"},{"key":"10.1016\/j.celrep.2025.116680_bib14","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1038\/s41586-019-1324-y","article-title":"TOX is a critical regulator of tumour-specific T cell differentiation","volume":"571","author":"Scott","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2025.116680_bib15","doi-asserted-by":"crossref","first-page":"4355","DOI":"10.1016\/j.cell.2024.07.016","article-title":"LAG-3 and PD-1 synergize on CD8+ T cells to drive T cell exhaustion and hinder autocrine IFN-\u03b3-dependent anti-tumor immunity","volume":"187","author":"Andrews","year":"2024","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2025.116680_bib16","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1056\/NEJMoa1302369","article-title":"Nivolumab plus Ipilimumab in Advanced Melanoma","volume":"369","author":"Wolchok","year":"2013","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.celrep.2025.116680_bib17","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1038\/nature19330","article-title":"Defining CD8+ T cells that provide the proliferative burst after PD-1 therapy","volume":"537","author":"Im","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2025.116680_bib18","doi-asserted-by":"crossref","first-page":"3490","DOI":"10.3390\/cancers15133490","article-title":"The Effectiveness of Cancer Immune Checkpoint Inhibitor Retreatment and Rechallenge\u2014A Systematic Review","volume":"15","author":"Perdyan","year":"2023","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.celrep.2025.116680_bib19","doi-asserted-by":"crossref","first-page":"5117","DOI":"10.4049\/jimmunol.1501657","article-title":"Landscape of Tumor Antigens in T Cell Immunotherapy","volume":"195","author":"Ilyas","year":"2015","journal-title":"J. Immunol."},{"key":"10.1016\/j.celrep.2025.116680_bib20","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1038\/s41590-024-02044-z","article-title":"Low-avidity T cells drive endogenous tumor immunity in mice and humans","volume":"26","author":"Singhaviranon","year":"2025","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.celrep.2025.116680_bib21","doi-asserted-by":"crossref","first-page":"643","DOI":"10.4049\/jimmunol.160.2.643","article-title":"Activation of low avidity CTL specific for a self epitope results in tumor rejection but not autoimmunity","volume":"160","author":"Morgan","year":"1998","journal-title":"J. Immunol."},{"key":"10.1016\/j.celrep.2025.116680_bib22","doi-asserted-by":"crossref","first-page":"6697","DOI":"10.4049\/jimmunol.0800997","article-title":"Chronic Antigen Stimulation Alone Is Sufficient to Drive CD8+ T Cell Exhaustion","volume":"182","author":"Bucks","year":"2009","journal-title":"J. Immunol."},{"key":"10.1016\/j.celrep.2025.116680_bib23","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1038\/s41586-021-03752-4","article-title":"Transcriptional programs of neoantigen-specific TIL in anti-PD-1-treated lung cancers","volume":"596","author":"Caushi","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2025.116680_bib24","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.1182\/blood-2008-12-195792","article-title":"Tumor antigen-specific CD8 T cells infiltrating the tumor express high levels of PD-1 and are functionally impaired","volume":"114","author":"Ahmadzadeh","year":"2009","journal-title":"Blood"},{"key":"10.1016\/j.celrep.2025.116680_bib25","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1038\/s41590-019-0312-6","article-title":"Subsets of exhausted CD8+ T cells differentially mediate tumor control and respond to checkpoint blockade","volume":"20","author":"Miller","year":"2019","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.celrep.2025.116680_bib26","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1038\/s41568-019-0235-4","article-title":"CD8+ T cell states in human cancer: insights from single-cell analysis","volume":"20","author":"van der Leun","year":"2020","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.celrep.2025.116680_bib27","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1038\/s41590-020-00834-9","article-title":"Mitochondrial stress induced by continuous stimulation under hypoxia rapidly drives T cell exhaustion","volume":"22","author":"Scharping","year":"2021","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.celrep.2025.116680_bib28","doi-asserted-by":"crossref","first-page":"4461","DOI":"10.1038\/s41467-022-31250-2","article-title":"Breast cancer cell-derived extracellular vesicles promote CD8+ T cell exhaustion via TGF-\u03b2 type II receptor signaling","volume":"13","author":"Xie","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2025.116680_bib29","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1038\/s41568-023-00615-0","article-title":"Stem-like exhausted and memory CD8+ T cells in cancer","volume":"23","author":"Gebhardt","year":"2023","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.celrep.2025.116680_bib30","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1002\/JLB.5MR1120-778R","article-title":"TCF-1 maintains CD8+ T cell stemness in tumor microenvironment","volume":"110","author":"Wen","year":"2021","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.celrep.2025.116680_bib31","doi-asserted-by":"crossref","first-page":"2653","DOI":"10.1007\/s00432-021-03845-7","article-title":"TCF-1+ PD-1+ CD8+T cells are associated with the response to PD-1 blockade in non-small cell lung cancer patients","volume":"148","author":"Fang","year":"2022","journal-title":"J. Cancer Res. Clin. Oncol."},{"key":"10.1016\/j.celrep.2025.116680_bib32","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.immuni.2018.12.021","article-title":"Intratumoral Tcf1 + PD-1 + CD8 + T Cells with Stem-like Properties Promote Tumor Control in Response to Vaccination and Checkpoint Blockade Immunotherapy","volume":"50","author":"Siddiqui","year":"2019","journal-title":"Immunity"},{"key":"10.1016\/j.celrep.2025.116680_bib33","doi-asserted-by":"crossref","first-page":"10.34.1","DOI":"10.1002\/0471142735.im1034s105","article-title":"Immunologic applications of conditional gene modification technology in the mouse","volume":"105","author":"Sharma","year":"2014","journal-title":"Curr. Protoc. Immunol."},{"key":"10.1016\/j.celrep.2025.116680_bib34","doi-asserted-by":"crossref","first-page":"1762","DOI":"10.1183\/13993003.00176-2014","article-title":"Tumour islet Foxp3+ T-cell infiltration predicts poor outcome in nonsmall cell lung cancer","volume":"46","author":"O\u2019Callaghan","year":"2015","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.celrep.2025.116680_bib35","doi-asserted-by":"crossref","first-page":"6248","DOI":"10.1073\/pnas.1604765113","article-title":"Instability of Helios-deficient Tregs is associated with conversion to a T-effector phenotype and enhanced antitumor immunity","volume":"113","author":"Nakagawa","year":"2016","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2025.116680_bib36","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1038\/ni.1649","article-title":"Notch2 integrates signaling by the transcription factors RBP-J and CREB1 to promote T cell cytotoxicity","volume":"9","author":"Maekawa","year":"2008","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.celrep.2025.116680_bib37","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1016\/j.cell.2018.10.038","article-title":"Defining T Cell States Associated with Response to Checkpoint Immunotherapy in Melanoma","volume":"175","author":"Sade-Feldman","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2025.116680_bib38","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1016\/j.immuni.2020.04.014","article-title":"Developmental Relationships of Four Exhausted CD8+ T Cell Subsets Reveals Underlying Transcriptional and Epigenetic Landscape Control Mechanisms","volume":"52","author":"Beltra","year":"2020","journal-title":"Immunity"},{"key":"10.1016\/j.celrep.2025.116680_bib39","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.chembiol.2023.02.005","article-title":"Discovery and characterization of a selective IKZF2 glue degrader for cancer immunotherapy","volume":"30","author":"Bonazzi","year":"2023","journal-title":"Cell Chem. Biol."},{"key":"10.1016\/j.celrep.2025.116680_bib40","doi-asserted-by":"crossref","first-page":"61057","DOI":"10.18632\/oncotarget.17841","article-title":"Downregulation of X-linked inhibitor of apoptosis protein by \u201c7-Benzylidenenaltrexone maleate\u201d sensitizes pancreatic cancer cells to TRAIL-induced apoptosis","volume":"8","author":"Kim","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.celrep.2025.116680_bib41","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1007\/PL00000232","article-title":"Inhibition of P-selectin specific cell adhesion by a low molecular weight, non-carbohydrate compound, KF38789","volume":"50","author":"Ohta","year":"2001","journal-title":"Inflamm. Res."},{"key":"10.1016\/j.celrep.2025.116680_bib42","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1038\/s41584-021-00741-9","article-title":"Regulation of activated T cell survival in rheumatic autoimmune diseases","volume":"18","author":"Rosetti","year":"2022","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.celrep.2025.116680_bib43","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.immuni.2011.07.010","article-title":"CD8+ T Cells: Foot Soldiers of the Immune System","volume":"35","author":"Zhang","year":"2011","journal-title":"Immunity"},{"key":"10.1016\/j.celrep.2025.116680_bib44","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1146\/annurev-med-012017-043208","article-title":"CD8 T Cell Exhaustion in Chronic Infection and Cancer: Opportunities for Interventions","volume":"69","author":"Hashimoto","year":"2018","journal-title":"Annu. Rev. Med."},{"key":"10.1016\/j.celrep.2025.116680_bib45","doi-asserted-by":"crossref","first-page":"2782","DOI":"10.1038\/s41467-021-23044-9","article-title":"Antigen-driven EGR2 expression is required for exhausted CD8+ T cell stability and maintenance","volume":"12","author":"Wagle","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2025.116680_bib46","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1111\/imm.12074","article-title":"T-cell memory differentiation: insights from transcriptional signatures and epigenetics","volume":"139","author":"Youngblood","year":"2013","journal-title":"Immunology"},{"key":"10.1016\/j.celrep.2025.116680_bib47","doi-asserted-by":"crossref","first-page":"30227","DOI":"10.1074\/jbc.M702541200","article-title":"Predominant interaction of both Ikaros and Helios with the NuRD complex in immature thymocytes","volume":"282","author":"Sridharan","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.celrep.2025.116680_bib48","article-title":"Alternative splice variants modulates dominant-negative function of Helios in T-cell leukemia","volume":"11","author":"Zhao","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.celrep.2025.116680_bib49","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1038\/s41590-023-01685-w","article-title":"FOXP1 and KLF2 reciprocally regulate checkpoints of stem-like to effector transition in CAR T cells","volume":"25","author":"Zhu","year":"2024","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.celrep.2025.116680_bib50","doi-asserted-by":"crossref","first-page":"1652","DOI":"10.1016\/j.cell.2023.03.006","article-title":"Immune checkpoint therapy\u2014current perspectives and future directions","volume":"186","author":"Sharma","year":"2023","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2025.116680_bib51","doi-asserted-by":"crossref","first-page":"144","DOI":"10.4049\/jimmunol.1501704","article-title":"Helios Controls a Limited Subset of Regulatory T Cell Functions","volume":"196","author":"Sebastian","year":"2016","journal-title":"J. Immunol."},{"key":"10.1016\/j.celrep.2025.116680_bib52","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1126\/science.aad0616","article-title":"Stable inhibitory activity of regulatory T cells requires the transcription factor Helios","volume":"350","author":"Kim","year":"2015","journal-title":"Science"},{"key":"10.1016\/j.celrep.2025.116680_bib53","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1308539","article-title":"HELIOS-expressing human CD8 T cells exhibit limited effector functions","volume":"14","author":"Neyens","year":"2023","journal-title":"Front. Immunol."},{"key":"10.1016\/j.celrep.2025.116680_bib54","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1002\/art.39091","article-title":"Helios enhances treg cell function in cooperation with FoxP3","volume":"67","author":"Takatori","year":"2015","journal-title":"Arthritis Rheumatol."},{"key":"10.1016\/j.celrep.2025.116680_bib55","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0024226","article-title":"Helios expression is a marker of T cell activation and proliferation","volume":"6","author":"Akimova","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.celrep.2025.116680_bib56","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1038\/nmeth.3364","article-title":"MiXCR: software for comprehensive adaptive immunity profiling","volume":"12","author":"Bolotin","year":"2015","journal-title":"Nat. Methods"},{"key":"10.1016\/j.celrep.2025.116680_bib57","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1038\/nbt.3979","article-title":"Antigen receptor repertoire profiling from RNA-seq data","volume":"35","author":"Bolotin","year":"2017","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.celrep.2025.116680_bib58","doi-asserted-by":"crossref","first-page":"583382","DOI":"10.3389\/fimmu.2020.583382","article-title":"Induction of Progenitor Exhausted Tissue-Resident Memory CD8+ T Cells Upon Salmonella Typhi Porins Adjuvant Immunization Correlates With Melanoma Control and Anti-PD-1 Immunotherapy Cooperation","volume":"11","author":"Le\u00f3n-Letelier","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.celrep.2025.116680_bib59","doi-asserted-by":"crossref","first-page":"4786","DOI":"10.3390\/ijms24054786","article-title":"Acral Melanoma Is Infiltrated with cDC1s and Functional Exhausted CD8 T Cells Similar to the Cutaneous Melanoma of Sun-Exposed Skin","volume":"24","author":"De Leon-Rodr\u00edguez","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.celrep.2025.116680_bib60","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2022\/9775736","article-title":"A Machine Learning Workflow of Multiplexed Immunofluorescence Images to Interrogate Activator and Tolerogenic Profiles of Conventional Type 1 Dendritic Cells Infiltrating Melanomas of Disease-Free and Metastatic Patients","volume":"2022","author":"De Le\u00f3n Rodr\u00edguez","year":"2022","journal-title":"J. Oncol."},{"key":"10.1016\/j.celrep.2025.116680_bib61","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1038\/s41592-020-01018-x","article-title":"Cellpose: a generalist algorithm for cellular segmentation","volume":"18","author":"Stringer","year":"2021","journal-title":"Nat. Methods"},{"key":"10.1016\/j.celrep.2025.116680_bib62","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1038\/s41589-021-00802-w","article-title":"Acute pharmacological degradation of Helios destabilizes regulatory T cells","volume":"17","author":"Wang","year":"2021","journal-title":"Nat. Chem. Biol."}],"container-title":["Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124725014524?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124725014524?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T12:56:12Z","timestamp":1790600172000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211124725014524"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":62,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["S2211124725014524"],"URL":"https:\/\/doi.org\/10.1016\/j.celrep.2025.116680","relation":{},"ISSN":["2211-1247"],"issn-type":[{"value":"2211-1247","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The transcription factor Helios restrains the anti-tumor capacity of CD8+ T cells","name":"articletitle","label":"Article Title"},{"value":"Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.celrep.2025.116680","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"116680"}}