{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T18:59:03Z","timestamp":1791831543971,"version":"4.3.4"},"reference-count":70,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T00:00:00Z","timestamp":1763337600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005010","name":"Italian Association for Cancer Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005010","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Reports"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.celrep.2025.116681","type":"journal-article","created":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T00:55:29Z","timestamp":1765500929000},"page":"116681","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["An organotypic model of ductular reaction reveals a mevalonate-dependent vulnerability in reactive biliary cells"],"prefix":"10.1016","volume":"44","author":[{"given":"Beatrice","family":"Anfuso","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suresh","family":"Velnati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davide","family":"Selvestrel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clara","family":"Garlant","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Ferracci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriele","family":"Baj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pietro","family":"Parisse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diletta","family":"Overi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca","family":"Bertolio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta","family":"Bulla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aurelio","family":"Sonzogni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Bramuzzo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Loredana","family":"Casalis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas","family":"Cocomello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Baratta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Del Ben","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo","family":"Giraudi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio","family":"Tiribelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia","family":"Rosso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuela","family":"Mastronardi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Tarchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurizio","family":"Pinamonti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabrizio","family":"Zanconati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicol\u00f2","family":"de Manzini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugenio","family":"Gaudio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Palmisano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah","family":"Bonazza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giannino","family":"Del Sal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guido","family":"Carpino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fulvio","family":"Chiacchiera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8628-8778","authenticated-orcid":false,"given":"Giovanni","family":"Sorrentino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.celrep.2025.116681_bib1","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1038\/nature23015","article-title":"Cholangiocytes act as facultative liver stem cells during impaired hepatocyte regeneration","volume":"547","author":"Raven","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2025.116681_bib2","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1038\/s41419-025-07590-4","article-title":"Microenvironmental control of the ductular reaction: balancing repair and disease progression","volume":"16","author":"Sorrentino","year":"2025","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.celrep.2025.116681_bib3","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1053\/j.gastro.2024.07.044","article-title":"Portal Fibrosis and the Ductular Reaction: Pathophysiological Role in the Progression of Liver Disease and Translational Opportunities","volume":"168","author":"Gupta","year":"2025","journal-title":"Gastroenterology"},{"key":"10.1016\/j.celrep.2025.116681_bib4","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1038\/s41586-024-07465-2","article-title":"Acquisition of epithelial plasticity in human chronic liver disease","volume":"630","author":"Gribben","year":"2024","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2025.116681_bib5","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1002\/hep.30150","article-title":"Ductular Reaction in Liver Diseases: Pathological Mechanisms and Translational Significances","volume":"69","author":"Sato","year":"2019","journal-title":"Hepatology"},{"key":"10.1016\/j.celrep.2025.116681_bib6","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1192840","article-title":"Cholangiokines: undervalued modulators in the hepatic microenvironment","volume":"14","author":"Cai","year":"2023","journal-title":"Front. Immunol."},{"key":"10.1016\/j.celrep.2025.116681_bib7","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1002\/hep.31211","article-title":"Targeted Apoptosis of Ductular Reactive Cells Reduces Hepatic Fibrosis in a Mouse Model of Cholestasis","volume":"72","author":"Azad","year":"2020","journal-title":"Hepatology"},{"key":"10.1016\/j.celrep.2025.116681_bib8","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1016\/j.ajpath.2019.04.011","article-title":"Invasive Ductular Reaction Operates Hepatobiliary Junctions upon Hepatocellular Injury in Rodents and Humans","volume":"189","author":"Clerbaux","year":"2019","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.celrep.2025.116681_bib9","doi-asserted-by":"crossref","first-page":"2180","DOI":"10.1002\/hep.30472","article-title":"Ductular Reaction Cells Display an Inflammatory Profile and Recruit Neutrophils in Alcoholic Hepatitis","volume":"69","author":"Aguilar-Bravo","year":"2019","journal-title":"Hepatology"},{"key":"10.1016\/j.celrep.2025.116681_bib10","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1172\/JCI93562","article-title":"The balancing act of the liver: tissue regeneration versus fibrosis","volume":"128","author":"Cordero-Espinoza","year":"2018","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.celrep.2025.116681_bib11","doi-asserted-by":"crossref","first-page":"1907","DOI":"10.1016\/j.stem.2021.07.002","article-title":"Dynamic cell contacts between periportal mesenchyme and ductal epithelium act as a rheostat for liver cell proliferation","volume":"28","author":"Cordero-Espinoza","year":"2021","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.celrep.2025.116681_bib12","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1055\/s-0041-1739455","article-title":"The Neglected Role of Bile Duct Epithelial Cells in NASH","volume":"42","author":"Cadamuro","year":"2022","journal-title":"Semin. Liver Dis."},{"key":"10.1016\/j.celrep.2025.116681_bib13","doi-asserted-by":"crossref","first-page":"1931","DOI":"10.1002\/hep.25614","article-title":"Liver progenitor cell markers correlate with liver damage and predict short-term mortality in patients with alcoholic hepatitis","volume":"55","author":"Sancho-Bru","year":"2012","journal-title":"Hepatology"},{"key":"10.1016\/j.celrep.2025.116681_bib14","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.1016\/j.ajpath.2020.02.013","article-title":"Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand Receptor Deficiency Promotes the Ductular Reaction, Macrophage Accumulation, and Hepatic Fibrosis in the Abcb4(-\/-) Mouse","volume":"190","author":"Krishnan","year":"2020","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.celrep.2025.116681_bib15","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1097\/MOG.0b013e32834550b4","article-title":"Hedgehog signaling in cholangiocytes","volume":"27","author":"Omenetti","year":"2011","journal-title":"Curr. Opin. Gastroenterol."},{"key":"10.1016\/j.celrep.2025.116681_bib16","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1038\/s41556-019-0402-6","article-title":"Epigenetic remodelling licences adult cholangiocytes for organoid formation and liver regeneration","volume":"21","author":"Aloia","year":"2019","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.celrep.2025.116681_bib17","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.stem.2019.04.005","article-title":"YAP, but Not RSPO-LGR4\/5, Signaling in Biliary Epithelial Cells Promotes a Ductular Reaction in Response to Liver Injury","volume":"25","author":"Planas-Paz","year":"2019","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.celrep.2025.116681_bib18","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1136\/gut.2009.182345","article-title":"Characterisation of a stereotypical cellular and extracellular adult liver progenitor cell niche in rodents and diseased human liver","volume":"59","author":"Lorenzini","year":"2010","journal-title":"Gut"},{"key":"10.1016\/j.celrep.2025.116681_bib19","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1016\/j.jhep.2022.06.022","article-title":"2D and 3D liver models","volume":"78","author":"Saxton","year":"2023","journal-title":"J. Hepatol."},{"key":"10.1016\/j.celrep.2025.116681_bib20","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1016\/j.jhep.2013.01.009","article-title":"Precision-cut liver slices: a tool to model the liver ex vivo","volume":"58","author":"Olinga","year":"2013","journal-title":"J. Hepatol."},{"key":"10.1016\/j.celrep.2025.116681_bib21","doi-asserted-by":"crossref","first-page":"1540","DOI":"10.1038\/nprot.2010.111","article-title":"Preparation and incubation of precision-cut liver and intestinal slices for application in drug metabolism and toxicity studies","volume":"5","author":"de Graaf","year":"2010","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.celrep.2025.116681_bib22","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1038\/nature11826","article-title":"In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration","volume":"494","author":"Huch","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2025.116681_bib23","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1038\/s41591-021-01398-3","article-title":"An ex vivo tumor fragment platform to dissect response to PD-1 blockade in cancer","volume":"27","author":"Voabil","year":"2021","journal-title":"Nat. Med."},{"key":"10.1016\/j.celrep.2025.116681_bib24","doi-asserted-by":"crossref","first-page":"1805","DOI":"10.1136\/gutjnl-2013-306373","article-title":"Osteopontin induces ductular reaction contributing to liver fibrosis","volume":"63","author":"Wang","year":"2014","journal-title":"Gut"},{"key":"10.1016\/j.celrep.2025.116681_bib25","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1136\/gutjnl-2013-306484","article-title":"Osteopontin neutralisation abrogates the liver progenitor cell response and fibrogenesis in mice","volume":"64","author":"Coombes","year":"2015","journal-title":"Gut"},{"key":"10.1016\/j.celrep.2025.116681_bib26","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1016\/S0002-9440(10)63489-X","article-title":"Oxidative stress and oval cell accumulation in mice and humans with alcoholic and nonalcoholic fatty liver disease","volume":"163","author":"Roskams","year":"2003","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.celrep.2025.116681_bib27","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.81926","article-title":"Hepatic lipid overload triggers biliary epithelial cell activation via E2Fs","volume":"12","author":"Yildiz","year":"2023","journal-title":"eLife"},{"key":"10.1016\/j.celrep.2025.116681_bib28","doi-asserted-by":"crossref","DOI":"10.3389\/fmed.2022.862185","article-title":"Improved Precision-Cut Liver Slice Cultures for Testing Drug-Induced Liver Fibrosis","volume":"9","author":"Dewyse","year":"2022","journal-title":"Front. Med."},{"key":"10.1016\/j.celrep.2025.116681_bib29","first-page":"433","article-title":"Ductular hepatocytes","volume":"10","author":"Sirica","year":"1995","journal-title":"Histol. Histopathol."},{"key":"10.1016\/j.celrep.2025.116681_bib30","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1101\/gad.207803.112","article-title":"Robust cellular reprogramming occurs spontaneously during liver regeneration","volume":"27","author":"Yanger","year":"2013","journal-title":"Genes Dev."},{"key":"10.1016\/j.celrep.2025.116681_bib31","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1111\/j.1600-0676.1986.tb01067.x","article-title":"Immunohistochemical study on bile ductular proliferation in various hepatobiliary diseases","volume":"6","author":"Nakanuma","year":"1986","journal-title":"Liver"},{"key":"10.1016\/j.celrep.2025.116681_bib32","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1111\/j.1365-2559.1988.tb02092.x","article-title":"A cytokeratin immunohistochemical study of alcoholic liver disease: evidence that hepatocytes can express \u2018bile duct-type\u2019 cytokeratins","volume":"13","author":"Van Eyken","year":"1988","journal-title":"Histopathology"},{"key":"10.1016\/j.celrep.2025.116681_bib33","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/j.jhep.2015.04.011","article-title":"The Hippo pathway effector YAP controls mouse hepatic stellate cell activation","volume":"63","author":"Mannaerts","year":"2015","journal-title":"J. Hepatol."},{"key":"10.1016\/j.celrep.2025.116681_bib34","doi-asserted-by":"crossref","first-page":"1839","DOI":"10.1016\/j.ajpath.2011.06.042","article-title":"Kupffer cells influence parenchymal invasion and phenotypic orientation, but not the proliferation, of liver progenitor cells in a murine model of liver injury","volume":"179","author":"Van Hul","year":"2011","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.celrep.2025.116681_bib35","doi-asserted-by":"crossref","first-page":"6542","DOI":"10.1073\/pnas.1302168110","article-title":"Bone marrow injection stimulates hepatic ductular reactions in the absence of injury via macrophage-mediated TWEAK signaling","volume":"110","author":"Bird","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2025.116681_bib36","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1016\/j.tem.2021.06.002","article-title":"Metabolic hallmarks of liver regeneration","volume":"32","author":"Solhi","year":"2021","journal-title":"Trends Endocrinol. Metab."},{"key":"10.1016\/j.celrep.2025.116681_bib37","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1038\/nrc1751","article-title":"Statins and cancer prevention","volume":"5","author":"Demierre","year":"2005","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.celrep.2025.116681_bib38","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1038\/343425a0","article-title":"Regulation of the mevalonate pathway","volume":"343","author":"Goldstein","year":"1990","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2025.116681_bib39","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.stem.2017.12.017","article-title":"Phospholipid Remodeling and Cholesterol Availability Regulate Intestinal Stemness and Tumorigenesis","volume":"22","author":"Wang","year":"2018","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.celrep.2025.116681_bib40","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.1038\/s41467-019-09152-7","article-title":"Sterol regulatory element binding protein 1 couples mechanical cues and lipid metabolism","volume":"10","author":"Bertolio","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2025.116681_bib41","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1165\/rcmb.2019-0296OC","article-title":"Screening for YAP Inhibitors Identifies Statins as Modulators of Fibrosis","volume":"62","author":"Santos","year":"2020","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.celrep.2025.116681_bib42","doi-asserted-by":"crossref","first-page":"1724","DOI":"10.1038\/nprot.2016.097","article-title":"Culture and establishment of self-renewing human and mouse adult liver and pancreas 3D organoids and their genetic manipulation","volume":"11","author":"Broutier","year":"2016","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.celrep.2025.116681_bib43","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1038\/nrc.2016.76","article-title":"The interplay between cell signalling and the mevalonate pathway in cancer","volume":"16","author":"Mullen","year":"2016","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.celrep.2025.116681_bib44","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/ncb2936","article-title":"Metabolic control of YAP and TAZ by the mevalonate pathway","volume":"16","author":"Sorrentino","year":"2014","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.celrep.2025.116681_bib45","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1186\/1756-9966-30-74","article-title":"Statin-induced apoptosis via the suppression of ERK1\/2 and Akt activation by inhibition of the geranylgeranyl-pyrophosphate biosynthesis in glioblastoma","volume":"30","author":"Yanae","year":"2011","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"10.1016\/j.celrep.2025.116681_bib46","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.cell.2014.11.050","article-title":"Long-term culture of genome-stable bipotent stem cells from adult human liver","volume":"160","author":"Huch","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2025.116681_bib47","doi-asserted-by":"crossref","DOI":"10.3892\/mmr.2022.12855","article-title":"Comparison of single-nucleus and single-cell transcriptomes in hepatocellular carcinoma tissue","volume":"26","author":"Wen","year":"2022","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.celrep.2025.116681_bib48","doi-asserted-by":"crossref","first-page":"2330","DOI":"10.1172\/JCI23486","article-title":"TWEAK induces liver progenitor cell proliferation","volume":"115","author":"Jakubowski","year":"2005","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.celrep.2025.116681_bib49","doi-asserted-by":"crossref","DOI":"10.3390\/cells8101117","article-title":"Meta-Analysis of Human and Mouse Biliary Epithelial Cell Gene Profiles","volume":"8","author":"Verhulst","year":"2019","journal-title":"Cells"},{"key":"10.1016\/j.celrep.2025.116681_bib50","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1146\/annurev.pharmtox.45.120403.095748","article-title":"Pleiotropic effects of statins","volume":"45","author":"Liao","year":"2005","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1016\/j.celrep.2025.116681_bib51","doi-asserted-by":"crossref","first-page":"1860","DOI":"10.1016\/j.cgh.2018.11.002","article-title":"Statin Use Is Associated With Improved Outcomes of Patients With Primary Sclerosing Cholangitis","volume":"17","author":"Stokkeland","year":"2019","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"10.1016\/j.celrep.2025.116681_bib52","first-page":"235","article-title":"Long Term Effect of Simvastatin in Primary Sclerosing Cholangitits: A Placebo-Controlled, Double-Blind, Multicenter Phase III Study (Piscatin)","volume":"4","author":"Annika Bergquist","year":"2022","journal-title":"Br. J. Gastroenterol."},{"key":"10.1016\/j.celrep.2025.116681_bib53","doi-asserted-by":"crossref","first-page":"1883","DOI":"10.1136\/gutjnl-2024-333074","article-title":"Long-term liver-related outcomes and liver stiffness progression of statin usage in steatotic liver disease","volume":"73","author":"Zhou","year":"2024","journal-title":"Gut"},{"key":"10.1016\/j.celrep.2025.116681_bib54","article-title":"Statins in MASLD: Challenges and future directions","volume":"7","author":"Zhou","year":"2025","journal-title":"JHEP Rep."},{"key":"10.1016\/j.celrep.2025.116681_bib55","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/4186308","article-title":"The Emerging Role of Rab5 in Membrane Receptor Trafficking and Signaling Pathways","volume":"2020","author":"Yuan","year":"2020","journal-title":"Biochem. Res. Int."},{"key":"10.1016\/j.celrep.2025.116681_bib56","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1016\/j.tcb.2020.04.004","article-title":"Metabolic Regulation of Tissue Stem Cells","volume":"30","author":"Shapira","year":"2020","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.celrep.2025.116681_bib57","doi-asserted-by":"crossref","first-page":"12869","DOI":"10.18632\/oncotarget.7331","article-title":"SREBP-2 promotes stem cell-like properties and metastasis by transcriptional activation of c-Myc in prostate cancer","volume":"7","author":"Li","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.celrep.2025.116681_bib58","doi-asserted-by":"crossref","first-page":"2736","DOI":"10.1016\/j.molcel.2021.04.009","article-title":"The ZMYND8-regulated mevalonate pathway endows YAP-high intestinal cancer with metabolic vulnerability","volume":"81","author":"Pan","year":"2021","journal-title":"Mol. Cell"},{"key":"10.1016\/j.celrep.2025.116681_bib60","doi-asserted-by":"crossref","DOI":"10.1097\/HC9.0000000000000745","article-title":"Rbpj deletion in hepatic progenitor cells attenuates endothelial responses and fibrosis in DDC-fed mice","volume":"9","author":"Lee","year":"2025","journal-title":"Hepatol. Commun."},{"key":"10.1016\/j.celrep.2025.116681_bib61","article-title":"Single-nucleus RNA sequencing of pre-malignant liver reveals disease-associated hepatocyte state with HCC prognostic potential","volume":"3","author":"Carlessi","year":"2023","journal-title":"Cell Genom."},{"key":"10.1016\/j.celrep.2025.116681_bib62","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-17204-5","article-title":"QuPath: Open source software for digital pathology image analysis","volume":"7","author":"Bankhead","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.celrep.2025.116681_bib63","doi-asserted-by":"crossref","DOI":"10.1117\/1.JBO.19.1.016007","article-title":"Computational segmentation of collagen fibers from second-harmonic generation images of breast cancer","volume":"19","author":"Bredfeldt","year":"2014","journal-title":"J. Biomed. Opt."},{"key":"10.1016\/j.celrep.2025.116681_bib64","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1038\/s41587-023-01767-y","article-title":"Dictionary learning for integrative, multimodal and scalable single-cell analysis","volume":"42","author":"Hao","year":"2024","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.celrep.2025.116681_bib65","doi-asserted-by":"crossref","first-page":"1542","DOI":"10.1016\/j.jhep.2023.06.003","article-title":"A multisociety Delphi consensus statement on new fatty liver disease nomenclature","volume":"79","author":"Rinella","year":"2023","journal-title":"J. Hepatol."},{"key":"10.1016\/j.celrep.2025.116681_bib66","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1016\/j.jhep.2024.04.031","article-title":"EASL-EASD-EASO Clinical Practice Guidelines on the management of metabolic dysfunction-associated steatotic liver disease (MASLD)","volume":"81","year":"2024","journal-title":"J. Hepatol."},{"key":"10.1016\/j.celrep.2025.116681_bib67","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.1016\/j.jhep.2015.11.004","article-title":"EASL-EASD-EASO Clinical Practice Guidelines for the management of non-alcoholic fatty liver disease","volume":"64","year":"2016","journal-title":"J. Hepatol."},{"key":"10.1016\/j.celrep.2025.116681_bib68","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1002\/hep.27173","article-title":"Utility and appropriateness of the fatty liver inhibition of progression (FLIP) algorithm and steatosis, activity, and fibrosis (SAF) score in the evaluation of biopsies of nonalcoholic fatty liver disease","volume":"60","author":"Bedossa","year":"2014","journal-title":"Hepatology"},{"key":"10.1016\/j.celrep.2025.116681_bib69","article-title":"Role of ductular reaction and ductular-canalicular junctions in identifying severe primary biliary cholangitis","volume":"4","author":"Overi","year":"2022","journal-title":"JHEP Rep."},{"key":"10.1016\/j.celrep.2025.116681_bib70","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1002\/hep.31056","article-title":"Increased Liver Localization of Lipopolysaccharides in Human and Experimental NAFLD","volume":"72","author":"Carpino","year":"2020","journal-title":"Hepatology"},{"key":"10.1016\/j.celrep.2025.116681_bib71","series-title":"Cell Detection with Star-Convex Polygons","first-page":"265","author":"Uwe Schmidt","year":"2018"}],"container-title":["Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124725014536?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124725014536?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T12:53:27Z","timestamp":1790600007000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211124725014536"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":70,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["S2211124725014536"],"URL":"https:\/\/doi.org\/10.1016\/j.celrep.2025.116681","relation":{},"ISSN":["2211-1247"],"issn-type":[{"value":"2211-1247","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"An organotypic model of ductular reaction reveals a mevalonate-dependent vulnerability in reactive biliary cells","name":"articletitle","label":"Article Title"},{"value":"Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.celrep.2025.116681","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"116681"}}