{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T00:33:12Z","timestamp":1793579592768,"version":"4.5.0"},"reference-count":149,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T00:00:00Z","timestamp":1763337600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Institutes of Health National Cancer Institute","doi-asserted-by":"publisher","award":["P30CA006927"],"award-info":[{"award-number":["P30CA006927"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005189","name":"Leukemia and Lymphoma Society","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005189","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006492","name":"National Institute of Allergy and Infectious Diseases Division of Intramural Research","doi-asserted-by":"publisher","award":["R37AI110985"],"award-info":[{"award-number":["R37AI110985"]}],"id":[{"id":"10.13039\/100006492","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Reports"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.celrep.2025.116688","type":"journal-article","created":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T23:39:16Z","timestamp":1765582756000},"page":"116688","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["Ribosomal protein control of hematopoietic stem cell transformation through regulation of metabolism"],"prefix":"10.1016","volume":"44","author":[{"given":"Bryan","family":"Harris","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dinesh K.","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Billy","family":"Truong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Rhodes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachael","family":"Price","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Shinton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monika","family":"Verma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bridget","family":"Aylward","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shawn P.","family":"Fahl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanna R.","family":"Sprinkle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Aminov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minshi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaqueline","family":"Perrigoue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Kessel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suraj","family":"Peri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua","family":"West","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Orsi","family":"Giricz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacqueline","family":"Boultwood","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Pellagatti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.H.","family":"Ramesh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Montagna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kith","family":"Pradhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey W.","family":"Tyner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian K.","family":"Kennedy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Holinstat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrich","family":"Steidl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Sykes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amit","family":"Verma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0792-3188","authenticated-orcid":false,"given":"David L.","family":"Wiest","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.celrep.2025.116688_bib1","doi-asserted-by":"crossref","first-page":"3196","DOI":"10.1182\/blood-2009-10-178129","article-title":"Ribosomopathies: human disorders of ribosome dysfunction","volume":"115","author":"Narla","year":"2010","journal-title":"Blood"},{"key":"10.1016\/j.celrep.2025.116688_bib2","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1242\/dmm.020529","article-title":"Ribosomopathies: how a common root can cause a tree of pathologies","volume":"8","author":"Danilova","year":"2015","journal-title":"Dis. Model. Mech."},{"key":"10.1016\/j.celrep.2025.116688_bib3","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1093\/nar\/gkz637","article-title":"Hallmarks of ribosomopathies","volume":"48","author":"Kampen","year":"2020","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.celrep.2025.116688_bib4","first-page":"7","article-title":"Ribosomopathies: mechanisms of disease","volume":"7","author":"Nakhoul","year":"2014","journal-title":"Clin. Med. Insights Blood Disord."},{"key":"10.1016\/j.celrep.2025.116688_bib5","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1038\/nrc2047","article-title":"Myelodysplastic syndromes: the complexity of stem-cell diseases","volume":"7","author":"Corey","year":"2007","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.celrep.2025.116688_bib6","doi-asserted-by":"crossref","first-page":"229","DOI":"10.3390\/cells8030229","article-title":"Cancer Biogenesis in Ribosomopathies","volume":"8","author":"Sulima","year":"2019","journal-title":"Cells"},{"key":"10.1016\/j.celrep.2025.116688_bib7","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1182\/blood-2014-10-569616","article-title":"Ribosomopathies and the paradox of cellular hypo- to hyperproliferation","volume":"125","author":"De Keersmaecker","year":"2015","journal-title":"Blood"},{"key":"10.1016\/j.celrep.2025.116688_bib8","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.cell.2018.02.036","article-title":"Ribosome Levels Selectively Regulate Translation and Lineage Commitment in Human Hematopoiesis","volume":"173","author":"Khajuria","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2025.116688_bib9","doi-asserted-by":"crossref","DOI":"10.1002\/wrna.1644","article-title":"Ribosome heterogeneity and specialization in development","volume":"12","author":"Norris","year":"2021","journal-title":"Wiley Interdiscip. Rev. RNA"},{"key":"10.1016\/j.celrep.2025.116688_bib10","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.cell.2011.03.028","article-title":"Ribosome-mediated specificity in Hox mRNA translation and vertebrate tissue patterning","volume":"145","author":"Kondrashov","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2025.116688_bib11","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/j.molcel.2018.07.018","article-title":"The Discovery of Ribosome Heterogeneity and Its Implications for Gene Regulation and Organismal Life","volume":"71","author":"Genuth","year":"2018","journal-title":"Mol. Cell"},{"key":"10.1016\/j.celrep.2025.116688_bib12","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1038\/s41392-021-00728-8","article-title":"Ribosomal proteins and human diseases: molecular mechanisms and targeted therapy","volume":"6","author":"Kang","year":"2021","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.celrep.2025.116688_bib13","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1038\/nm.4047","article-title":"Rps14 haploinsufficiency causes a block in erythroid differentiation mediated by S100A8 and S100A9","volume":"22","author":"Schneider","year":"2016","journal-title":"Nat. Med."},{"key":"10.1016\/j.celrep.2025.116688_bib14","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1134\/S0026893306040091","article-title":"[Eukaryotic ribosomal proteins: interaction with their own pre-mRNAs and involvement in the splicing regulation]","volume":"40","author":"Ivanov","year":"2006","journal-title":"Mol. Biol."},{"key":"10.1016\/j.celrep.2025.116688_bib15","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1073\/pnas.0810205106","article-title":"Regulation of ribonuclease E activity by the L4 ribosomal protein of Escherichia coli","volume":"106","author":"Singh","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2025.116688_bib16","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/0005-2787(79)90012-1","article-title":"Kinetic studies on ribosomal proteins assembly in preribosomal particles and ribosomal subunits of mammalian cells","volume":"563","author":"Auger-Buendia","year":"1979","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.celrep.2025.116688_bib17","doi-asserted-by":"crossref","first-page":"13939","DOI":"10.1073\/pnas.0907143106","article-title":"Cell-type-specific isolation of ribosome-associated mRNA from complex tissues","volume":"106","author":"Sanz","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2025.116688_bib18","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1003708","article-title":"The ribosomal protein Rpl22 controls ribosome composition by directly repressing expression of its own paralog, Rpl22l1","volume":"9","author":"O'Leary","year":"2013","journal-title":"PLoS Genet."},{"key":"10.1016\/j.celrep.2025.116688_bib19","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/j.immuni.2007.04.012","article-title":"Ablation of ribosomal protein L22 selectively impairs alphabeta T cell development by activation of a p53-dependent checkpoint","volume":"26","author":"Anderson","year":"2007","journal-title":"Immunity"},{"key":"10.1016\/j.celrep.2025.116688_bib20","doi-asserted-by":"crossref","first-page":"200","DOI":"10.4049\/jimmunol.1402242","article-title":"Rpl22 Loss Impairs the Development of B Lymphocytes by Activating a p53-Dependent Checkpoint","volume":"194","author":"Fahl","year":"2015","journal-title":"J. Immunol."},{"key":"10.1016\/j.celrep.2025.116688_bib21","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/j.devcel.2013.01.018","article-title":"Control of hematopoietic stem cell emergence by antagonistic functions of ribosomal protein paralogs","volume":"24","author":"Zhang","year":"2013","journal-title":"Dev. Cell"},{"key":"10.1016\/j.celrep.2025.116688_bib22","doi-asserted-by":"crossref","first-page":"3764","DOI":"10.1182\/blood-2012-03-415349","article-title":"Inactivation of ribosomal protein L22 promotes transformation by induction of the stemness factor, Lin28B","volume":"120","author":"Rao","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.celrep.2025.116688_bib23","doi-asserted-by":"crossref","first-page":"5901","DOI":"10.1038\/ncomms6901","article-title":"Combining gene mutation with gene expression data improves outcome prediction in myelodysplastic syndromes","volume":"6","author":"Gerstung","year":"2015","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2025.116688_bib24","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1038\/s41586-018-0623-z","article-title":"Functional genomic landscape of acute myeloid leukaemia","volume":"562","author":"Tyner","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2025.116688_bib25","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1182\/blood-2012-01-404699","article-title":"Overexpression of IL-1 receptor accessory protein in stem and progenitor cells and outcome correlation in AML and MDS","volume":"120","author":"Barreyro","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.celrep.2025.116688_bib26","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1182\/asheducation-2009.1.385","article-title":"Independent prognostic factors for AML outcome","volume":"2009","author":"Grimwade","year":"2009","journal-title":"Hematology Am. Soc. Hematol. Educ. Program"},{"key":"10.1016\/j.celrep.2025.116688_bib27","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1038\/367645a0","article-title":"A cell initiating human acute myeloid leukaemia after transplantation into SCID mice","volume":"367","author":"Lapidot","year":"1994","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2025.116688_bib28","article-title":"Prognostication and risk stratification of patients with myelodysplastic syndromes","volume":"10","author":"DeZern","year":"2023","journal-title":"Blood"},{"key":"10.1016\/j.celrep.2025.116688_bib29","first-page":"11","article-title":"The preleukemic syndrome: clinical and laboratory features, natural course, and management","volume":"17","author":"Linman","year":"1976","journal-title":"Nouv. Rev. Fr. Hematol. Blood Cells"},{"key":"10.1016\/j.celrep.2025.116688_bib30","doi-asserted-by":"crossref","first-page":"2076","DOI":"10.1182\/blood-2011-12-399683","article-title":"Stem and progenitor cells in myelodysplastic syndromes show aberrant stage-specific expansion and harbor genetic and epigenetic alterations","volume":"120","author":"Will","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.celrep.2025.116688_bib31","doi-asserted-by":"crossref","first-page":"13576","DOI":"10.1073\/pnas.1301891110","article-title":"Acute myeloid leukemia does not deplete normal hematopoietic stem cells but induces cytopenias by impeding their differentiation","volume":"110","author":"Miraki-Moud","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2025.116688_bib32","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1016\/j.ccr.2014.03.036","article-title":"Myelodysplastic syndromes are propagated by rare and distinct human cancer stem cells in vivo","volume":"25","author":"Woll","year":"2014","journal-title":"Cancer Cell"},{"key":"10.1016\/j.celrep.2025.116688_bib33","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1016\/j.cell.2005.05.026","article-title":"SLAM family receptors distinguish hematopoietic stem and progenitor cells and reveal endothelial niches for stem cells","volume":"121","author":"Kiel","year":"2005","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2025.116688_bib34","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.stem.2013.05.014","article-title":"SLAM family markers resolve functionally distinct subpopulations of hematopoietic stem cells and multipotent progenitors","volume":"13","author":"Oguro","year":"2013","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.celrep.2025.116688_bib35","doi-asserted-by":"crossref","first-page":"4253","DOI":"10.1038\/onc.2010.189","article-title":"Ribosome biogenesis surveillance: probing the ribosomal protein-Mdm2-p53 pathway","volume":"29","author":"Deisenroth","year":"2010","journal-title":"Oncogene"},{"key":"10.1016\/j.celrep.2025.116688_bib36","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1126\/science.7660125","article-title":"Inducible gene targeting in mice","volume":"269","author":"Kuhn","year":"1995","journal-title":"Science"},{"key":"10.1016\/j.celrep.2025.116688_bib37","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/j.celrep.2016.12.034","article-title":"Ribosomal Proteins Rpl22 and Rpl22l1 Control Morphogenesis by Regulating Pre-mRNA Splicing","volume":"18","author":"Zhang","year":"2017","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2025.116688_bib38","doi-asserted-by":"crossref","first-page":"5139","DOI":"10.1038\/onc.2013.520","article-title":"Stem cell origin of myelodysplastic syndromes","volume":"33","author":"Elias","year":"2014","journal-title":"Oncogene"},{"key":"10.1016\/j.celrep.2025.116688_bib39","doi-asserted-by":"crossref","DOI":"10.3390\/jcm5030033","article-title":"Acute Myeloid Leukemia: A Concise Review","volume":"5","author":"Saultz","year":"2016","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.celrep.2025.116688_bib40","doi-asserted-by":"crossref","first-page":"7164","DOI":"10.1038\/sj.onc.1207933","article-title":"Concepts of human leukemic development","volume":"23","author":"Warner","year":"2004","journal-title":"Oncogene"},{"key":"10.1016\/j.celrep.2025.116688_bib41","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1038\/leu.2012.343","article-title":"MLL-AF9-mediated immortalization of human hematopoietic cells along different lineages changes during ontogeny","volume":"27","author":"Horton","year":"2013","journal-title":"Leukemia"},{"key":"10.1016\/j.celrep.2025.116688_bib42","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1016\/S0092-8674(00)81269-6","article-title":"An Mll-AF9 fusion gene made by homologous recombination causes acute leukemia in chimeric mice: a method to create fusion oncogenes","volume":"85","author":"Corral","year":"1996","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2025.116688_bib43","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1038\/nature13035","article-title":"Haematopoietic stem cells require a highly regulated protein synthesis rate","volume":"509","author":"Signer","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2025.116688_bib44","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1073\/pnas.1111561108","article-title":"Imaging protein synthesis in cells and tissues with an alkyne analog of puromycin","volume":"109","author":"Liu","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2025.116688_bib45","doi-asserted-by":"crossref","first-page":"4660","DOI":"10.1128\/MCB.01174-13","article-title":"Loss of tumor suppressor RPL5\/RPL11 does not induce cell cycle arrest but impedes proliferation due to reduced ribosome content and translation capacity","volume":"33","author":"Teng","year":"2013","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.celrep.2025.116688_bib46","doi-asserted-by":"crossref","first-page":"3430","DOI":"10.1093\/hmg\/ddq254","article-title":"Mitochondrial ATP synthase deficiency due to a mutation in the ATP5E gene for the F1 epsilon subunit","volume":"19","author":"Mayr","year":"2010","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.celrep.2025.116688_bib47","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1038\/nm.2882","article-title":"A PML-PPAR-delta pathway for fatty acid oxidation regulates hematopoietic stem cell maintenance","volume":"18","author":"Ito","year":"2012","journal-title":"Nat. Med."},{"key":"10.1016\/j.celrep.2025.116688_bib48","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.molcel.2014.09.024","article-title":"Regulation of substrate utilization by the mitochondrial pyruvate carrier","volume":"56","author":"Vacanti","year":"2014","journal-title":"Mol. Cell"},{"key":"10.1016\/j.celrep.2025.116688_bib49","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1038\/s43018-020-00126-z","article-title":"Fatty acid metabolism underlies venetoclax resistance in acute myeloid leukemia stem cells","volume":"1","author":"Stevens","year":"2020","journal-title":"Nat. Cancer"},{"key":"10.1016\/j.celrep.2025.116688_bib50","doi-asserted-by":"crossref","first-page":"16146","DOI":"10.1074\/jbc.273.26.16146","article-title":"Molecular or pharmacologic perturbation of the link between glucose and lipid metabolism is without effect on glucose-stimulated insulin secretion. A re-evaluation of the long-chain acyl-CoA hypothesis","volume":"273","author":"Antinozzi","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.celrep.2025.116688_bib51","doi-asserted-by":"crossref","first-page":"288","DOI":"10.3181\/00379727-178-42012","article-title":"Inhibition of mitochondrial carnitine palmitoyl transferase A in vivo with methyl 2-tetradecylglycidate (methyl palmoxirate) and its relationship to ketonemia and glycemia","volume":"178","author":"Tutwiler","year":"1985","journal-title":"Proc. Soc. Exp. Biol. Med."},{"key":"10.1016\/j.celrep.2025.116688_bib52","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/j.bbalip.2014.10.002","article-title":"Mammalian lipoxygenases and their biological relevance","volume":"1851","author":"Kuhn","year":"2015","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.celrep.2025.116688_bib53","doi-asserted-by":"crossref","first-page":"27438","DOI":"10.1074\/jbc.M109.023572","article-title":"Increased lipid oxidation causes oxidative stress, increased peroxisome proliferator-activated receptor-gamma expression, and diminished pro-osteogenic Wnt signaling in the skeleton","volume":"284","author":"Almeida","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.celrep.2025.116688_bib54","doi-asserted-by":"crossref","first-page":"8027","DOI":"10.1128\/jvi.69.12.8027-8034.1995","article-title":"In vitro selection of RNA ligands for the ribosomal L22 protein associated with Epstein-Barr virus-expressed RNA by using randomized and cDNA-derived RNA libraries","volume":"69","author":"Dobbelstein","year":"1995","journal-title":"J. Virol."},{"key":"10.1016\/j.celrep.2025.116688_bib55","doi-asserted-by":"crossref","first-page":"24055","DOI":"10.1074\/jbc.271.39.24055","article-title":"Disruption of 12\/15-lipoxygenase expression in peritoneal macrophages. Enhanced utilization of the 5-lipoxygenase pathway and diminished oxidation of low density lipoprotein","volume":"271","author":"Sun","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.celrep.2025.116688_bib56","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1038\/s41418-024-01288-4","article-title":"Proteinase 3 depletion attenuates leukemia by promoting myeloid differentiation","volume":"31","author":"Liu","year":"2024","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.celrep.2025.116688_bib57","doi-asserted-by":"crossref","DOI":"10.1016\/j.cellsig.2023.110623","article-title":"LAPTM4B promotes AML progression through regulating RPS9\/STAT3 axis","volume":"106","author":"Huang","year":"2023","journal-title":"Cell. Signal."},{"key":"10.1016\/j.celrep.2025.116688_bib58","doi-asserted-by":"crossref","first-page":"72250","DOI":"10.18632\/oncotarget.19706","article-title":"High expression of dedicator of cytokinesis 1 (DOCK1) confers poor prognosis in acute myeloid leukemia","volume":"8","author":"Lee","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.celrep.2025.116688_bib59","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1111\/bjh.20140","article-title":"Inhibition of DOCK1 suppresses Notch signalling pathway and impairs leukaemogenesis","volume":"207","author":"Lin","year":"2025","journal-title":"Br. J. Haematol."},{"key":"10.1016\/j.celrep.2025.116688_bib60","doi-asserted-by":"crossref","first-page":"2200","DOI":"10.1111\/cas.14033","article-title":"Six1 regulates leukemia stem cell maintenance in acute myeloid leukemia","volume":"110","author":"Chu","year":"2019","journal-title":"Cancer Sci."},{"key":"10.1016\/j.celrep.2025.116688_bib61","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.3324\/haematol.2018.211201","article-title":"Meningioma 1 is indispensable for mixed lineage leukemia-rearranged acute myeloid leukemia","volume":"105","author":"Sharma","year":"2020","journal-title":"Haematologica"},{"key":"10.1016\/j.celrep.2025.116688_bib62","doi-asserted-by":"crossref","first-page":"411","DOI":"10.3324\/haematol.2023.282837","article-title":"miR-30e-5p regulates leukemia stem cell self-renewal through the Cyb561\/ROS signaling pathway","volume":"109","author":"Ge","year":"2024","journal-title":"Haematologica"},{"key":"10.1016\/j.celrep.2025.116688_bib63","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/j.celrep.2019.03.080","article-title":"lncRNA Spehd Regulates Hematopoietic Stem and Progenitor Cells and Is Required for Multilineage Differentiation","volume":"27","author":"Del\u00e1s","year":"2019","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2025.116688_bib64","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.ccr.2012.06.032","article-title":"ASXL1 mutations promote myeloid transformation through loss of PRC2-mediated gene repression","volume":"22","author":"Abdel-Wahab","year":"2012","journal-title":"Cancer Cell"},{"key":"10.1016\/j.celrep.2025.116688_bib65","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1038\/sj.onc.1207074","article-title":"The differential impact of p16(INK4a) or p19(ARF) deficiency on cell growth and tumorigenesis","volume":"23","author":"Sharpless","year":"2004","journal-title":"Oncogene"},{"key":"10.1016\/j.celrep.2025.116688_bib66","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1101\/sqb.2005.70.004","article-title":"p53-Dependent and -independent functions of the Arf tumor suppressor","volume":"70","author":"Sherr","year":"2005","journal-title":"Cold Spring Harb. Symp. Quant. Biol."},{"key":"10.1016\/j.celrep.2025.116688_bib67","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1007\/978-3-030-34521-1_36","article-title":"The Good and Bad Sides of Heparanase-1 and Heparanase-2","volume":"1221","author":"Pinhal","year":"2020","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.celrep.2025.116688_bib68","doi-asserted-by":"crossref","first-page":"25208","DOI":"10.18632\/oncotarget.8199","article-title":"Differential regulation of the c-Myc\/Lin28 axis discriminates subclasses of rearranged MLL leukemia","volume":"7","author":"Chen","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.celrep.2025.116688_bib69","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2023.112099","article-title":"A fetal tumor suppressor axis abrogates MLL-fusion-driven acute myeloid leukemia","volume":"42","author":"Eldeeb","year":"2023","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2025.116688_bib70","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.stem.2013.03.005","article-title":"Lin28: primal regulator of growth and metabolism in stem cells","volume":"12","author":"Shyh-Chang","year":"2013","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.celrep.2025.116688_bib71","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1038\/ng.392","article-title":"Lin28 promotes transformation and is associated with advanced human malignancies","volume":"41","author":"Viswanathan","year":"2009","journal-title":"Nat. Genet."},{"key":"10.1016\/j.celrep.2025.116688_bib72","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.stem.2016.05.009","article-title":"LIN28 Regulates Stem Cell Metabolism and Conversion to Primed Pluripotency","volume":"19","author":"Zhang","year":"2016","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.celrep.2025.116688_bib73","doi-asserted-by":"crossref","DOI":"10.15252\/embr.201948115","article-title":"Lin28 enhances de novo fatty acid synthesis to promote cancer progression via SREBP-1","volume":"20","author":"Zhang","year":"2019","journal-title":"EMBO Rep."},{"key":"10.1016\/j.celrep.2025.116688_bib74","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1186\/s13045-017-0507-y","article-title":"Inhibition of LIN28B impairs leukemia cell growth and metabolism in acute myeloid leukemia","volume":"10","author":"Zhou","year":"2017","journal-title":"J. Hematol. Oncol."},{"key":"10.1016\/j.celrep.2025.116688_bib75","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.cell.2011.08.033","article-title":"The Lin28\/let-7 axis regulates glucose metabolism","volume":"147","author":"Zhu","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2025.116688_bib76","doi-asserted-by":"crossref","first-page":"2233","DOI":"10.1101\/gad.224659.113","article-title":"LIN28B promotes growth and tumorigenesis of the intestinal epithelium via Let-7","volume":"27","author":"Madison","year":"2013","journal-title":"Genes Dev."},{"key":"10.1016\/j.celrep.2025.116688_bib77","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.05005","article-title":"Predicting effective microRNA target sites in mammalian mRNAs","volume":"4","author":"Agarwal","year":"2015","journal-title":"eLife"},{"key":"10.1016\/j.celrep.2025.116688_bib78","doi-asserted-by":"crossref","first-page":"3100","DOI":"10.1038\/s41467-023-38934-3","article-title":"Mechanism of action for small-molecule inhibitors of triacylglycerol synthesis","volume":"14","author":"Sui","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2025.116688_bib79","doi-asserted-by":"crossref","first-page":"13018","DOI":"10.1073\/pnas.95.22.13018","article-title":"Identification of a gene encoding an acyl CoA:diacylglycerol acyltransferase, a key enzyme in triacylglycerol synthesis","volume":"95","author":"Cases","year":"1998","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2025.116688_bib80","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.molcel.2014.09.026","article-title":"A role for the mitochondrial pyruvate carrier as a repressor of the Warburg effect and colon cancer cell growth","volume":"56","author":"Schell","year":"2014","journal-title":"Mol. Cell"},{"key":"10.1016\/j.celrep.2025.116688_bib81","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2020.00155","article-title":"Fatty Acid Metabolism, Bone Marrow Adipocytes, and AML","volume":"10","author":"Tabe","year":"2020","journal-title":"Front. Oncol."},{"key":"10.1016\/j.celrep.2025.116688_bib82","doi-asserted-by":"crossref","first-page":"11570","DOI":"10.1074\/jbc.M311773200","article-title":"A novel pathway involving progesterone receptor, 12\/15-lipoxygenase-derived eicosanoids, and peroxisome proliferator-activated receptor gamma regulates implantation in mice","volume":"279","author":"Li","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.celrep.2025.116688_bib83","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1182\/asheducation-2011.1.487","article-title":"Diamond Blackfan anemia","volume":"2011","author":"Ball","year":"2011","journal-title":"Hematology. Am. Soc. Hematol. Educ. Program"},{"key":"10.1016\/j.celrep.2025.116688_bib84","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1016\/j.tplants.2009.06.009","article-title":"A role for the ribosome in development","volume":"14","author":"Byrne","year":"2009","journal-title":"Trends Plant Sci."},{"key":"10.1016\/j.celrep.2025.116688_bib85","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1002\/humu.20874","article-title":"Identification of mutations in the ribosomal protein L5 (RPL5) and ribosomal protein L11 (RPL11) genes in Czech patients with Diamond-Blackfan anemia","volume":"30","author":"Cmejla","year":"2009","journal-title":"Hum. Mutat."},{"key":"10.1016\/j.celrep.2025.116688_bib86","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1002\/humu.20608","article-title":"Ribosomal protein S17 gene (RPS17) is mutated in Diamond-Blackfan anemia","volume":"28","author":"Cmejla","year":"2007","journal-title":"Hum. Mutat."},{"key":"10.1016\/j.celrep.2025.116688_bib87","doi-asserted-by":"crossref","first-page":"5228","DOI":"10.1182\/blood-2008-01-132290","article-title":"Ribosomal protein S19 deficiency in zebrafish leads to developmental abnormalities and defective erythropoiesis through activation of p53 protein family","volume":"112","author":"Danilova","year":"2008","journal-title":"Blood"},{"key":"10.1016\/j.celrep.2025.116688_bib88","doi-asserted-by":"crossref","first-page":"6087","DOI":"10.1182\/blood-2011-08-371963","article-title":"Mice with ribosomal protein S19 deficiency develop bone marrow failure and symptoms like patients with Diamond-Blackfan anemia","volume":"118","author":"Jaako","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.celrep.2025.116688_bib89","doi-asserted-by":"crossref","first-page":"49","DOI":"10.5045\/br.2022.2022012","article-title":"Overview of inherited bone marrow failure syndromes","volume":"57","author":"Park","year":"2022","journal-title":"Blood Res."},{"key":"10.1016\/j.celrep.2025.116688_bib90","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1615\/CritRevImmunol.v35.i5.30","article-title":"Regulatory Roles of Rpl22 in Hematopoiesis: An Old Dog with New Tricks","volume":"35","author":"Fahl","year":"2015","journal-title":"Crit. Rev. Immunol."},{"key":"10.1016\/j.celrep.2025.116688_bib91","doi-asserted-by":"crossref","first-page":"3387","DOI":"10.1158\/0008-5472.CAN-15-2698","article-title":"Ribosomal Protein Rpl22 Controls the Dissemination of T-cell Lymphoma","volume":"76","author":"Rao","year":"2016","journal-title":"Cancer Res."},{"key":"10.1016\/j.celrep.2025.116688_bib92","doi-asserted-by":"crossref","first-page":"2280","DOI":"10.4049\/jimmunol.1600815","article-title":"Rpl22 Loss Selectively Impairs alphabeta T Cell Development by Dysregulating Endoplasmic Reticulum Stress Signaling","volume":"197","author":"Solanki","year":"2016","journal-title":"J. Immunol."},{"key":"10.1016\/j.celrep.2025.116688_bib93","doi-asserted-by":"crossref","first-page":"664","DOI":"10.4049\/jimmunol.1100029","article-title":"Developmental arrest of T cells in Rpl22-deficient mice is dependent upon multiple p53 effectors","volume":"187","author":"Stadanlick","year":"2011","journal-title":"J. Immunol."},{"key":"10.1016\/j.celrep.2025.116688_bib94","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.molcel.2017.05.021","article-title":"Heterogeneous Ribosomes Preferentially Translate Distinct Subpools of mRNAs Genome-wide","volume":"67","author":"Shi","year":"2017","journal-title":"Mol. Cell"},{"key":"10.1016\/j.celrep.2025.116688_bib95","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1093\/jmcb\/mjv014","article-title":"Ribosomal proteins: functions beyond the ribosome","volume":"7","author":"Zhou","year":"2015","journal-title":"J. Mol. Cell Biol."},{"key":"10.1016\/j.celrep.2025.116688_bib96","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.molcel.2009.03.006","article-title":"How common are extraribosomal functions of ribosomal proteins?","volume":"34","author":"Warner","year":"2009","journal-title":"Mol. Cell"},{"key":"10.1016\/j.celrep.2025.116688_bib97","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1182\/blood.2024024956","article-title":"Proteostasis disruption in inherited bone marrow failure syndromes","volume":"146","author":"Yu","year":"2025","journal-title":"Blood"},{"key":"10.1016\/j.celrep.2025.116688_bib98","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.stemcr.2020.11.017","article-title":"Developmental Stage-Specific Changes in Protein Synthesis Differentially Sensitize Hematopoietic Stem Cells and Erythroid Progenitors to Impaired Ribosome Biogenesis","volume":"16","author":"Magee","year":"2021","journal-title":"Stem Cell Rep."},{"key":"10.1016\/j.celrep.2025.116688_bib99","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1146\/annurev-cellbio-100814-125346","article-title":"Translating the genome in time and space: specialized ribosomes, RNA regulons, and RNA-binding proteins","volume":"31","author":"Shi","year":"2015","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"10.1016\/j.celrep.2025.116688_bib100","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1038\/s41576-018-0008-z","article-title":"Heterogeneity and specialized functions of translation machinery: from genes to organisms","volume":"19","author":"Genuth","year":"2018","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.celrep.2025.116688_bib101","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1016\/j.molcel.2012.06.006","article-title":"Protection of extraribosomal RPL13a by GAPDH and dysregulation by S-nitrosylation","volume":"47","author":"Jia","year":"2012","journal-title":"Mol. Cell"},{"key":"10.1016\/j.celrep.2025.116688_bib102","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0005306","article-title":"Clusters of basic amino acids contribute to RNA binding and nucleolar localization of ribosomal protein L22","volume":"4","author":"Houmani","year":"2009","journal-title":"PLoS One"},{"key":"10.1016\/j.celrep.2025.116688_bib103","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1126\/science.1211204","article-title":"Crystal structure of the eukaryotic 60S ribosomal subunit in complex with initiation factor 6","volume":"334","author":"Klinge","year":"2011","journal-title":"Science"},{"key":"10.1016\/j.celrep.2025.116688_bib104","doi-asserted-by":"crossref","first-page":"4689","DOI":"10.1182\/blood-2009-05-220988","article-title":"Canonical BMP signaling is dispensable for hematopoietic stem cell function in both adult and fetal liver hematopoiesis, but essential to preserve colon architecture","volume":"115","author":"Singbrant","year":"2010","journal-title":"Blood"},{"key":"10.1016\/j.celrep.2025.116688_bib105","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.immuni.2005.11.012","article-title":"Developmental and molecular characterization of emerging beta- and gammadelta-selected pre-T cells in the adult mouse thymus","volume":"24","author":"Taghon","year":"2006","journal-title":"Immunity"},{"key":"10.1016\/j.celrep.2025.116688_bib106","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1038\/s41375-022-01518-z","article-title":"Multi-omics reveals mitochondrial metabolism proteins susceptible for drug discovery in AML","volume":"36","author":"Caplan","year":"2022","journal-title":"Leukemia"},{"key":"10.1016\/j.celrep.2025.116688_bib107","doi-asserted-by":"crossref","DOI":"10.1016\/j.gene.2021.145407","article-title":"Electron transfer flavoprotein and its role in mitochondrial energy metabolism in health and disease","volume":"776","author":"Henriques","year":"2021","journal-title":"Gene"},{"key":"10.1016\/j.celrep.2025.116688_bib108","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1038\/nature21408","article-title":"LACTB is a tumour suppressor that modulates lipid metabolism and cell state","volume":"543","author":"Keckesova","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2025.116688_bib109","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1038\/nrc3483","article-title":"Cancer metabolism: fatty acid oxidation in the limelight","volume":"13","author":"Carracedo","year":"2013","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.celrep.2025.116688_bib110","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1172\/JCI38942","article-title":"Pharmacologic inhibition of fatty acid oxidation sensitizes human leukemia cells to apoptosis induction","volume":"120","author":"Samudio","year":"2010","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.celrep.2025.116688_bib111","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/j.cmet.2015.02.002","article-title":"Glycolysis-mediated changes in acetyl-CoA and histone acetylation control the early differentiation of embryonic stem cells","volume":"21","author":"Moussaieff","year":"2015","journal-title":"Cell Metab."},{"key":"10.1016\/j.celrep.2025.116688_bib112","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1016\/j.celrep.2016.10.012","article-title":"Lipids Reprogram Metabolism to Become a Major Carbon Source for Histone Acetylation","volume":"17","author":"McDonnell","year":"2016","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2025.116688_bib113","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1126\/science.1216557","article-title":"Lin28b reprograms adult bone marrow hematopoietic progenitors to mediate fetal-like lymphopoiesis","volume":"335","author":"Yuan","year":"2012","journal-title":"Science"},{"key":"10.1016\/j.celrep.2025.116688_bib114","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.canlet.2015.06.015","article-title":"MYCN-driven regulatory mechanisms controlling LIN28B in neuroblastoma","volume":"366","author":"Beckers","year":"2015","journal-title":"Cancer Lett."},{"key":"10.1016\/j.celrep.2025.116688_bib115","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0005799","article-title":"N-Myc regulates expression of pluripotency genes in neuroblastoma including lif, klf2, klf4, and lin28b","volume":"4","author":"Cotterman","year":"2009","journal-title":"PLoS One"},{"key":"10.1016\/j.celrep.2025.116688_bib116","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1038\/ng.2436","article-title":"LIN28B induces neuroblastoma and enhances MYCN levels via let-7 suppression","volume":"44","author":"Molenaar","year":"2012","journal-title":"Nat. Genet."},{"key":"10.1016\/j.celrep.2025.116688_bib117","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/j.immuni.2016.07.014","article-title":"Cellular Barcoding Links B-1a B Cell Potential to a Fetal Hematopoietic Stem Cell State at the Single-Cell Level","volume":"45","author":"Kristiansen","year":"2016","journal-title":"Immunity"},{"key":"10.1016\/j.celrep.2025.116688_bib118","doi-asserted-by":"crossref","first-page":"2963","DOI":"10.1002\/1873-3468.15004","article-title":"The role of Lin28A and Lin28B in cancer beyond Let-7","volume":"598","author":"Cotino-N\u00e1jera","year":"2024","journal-title":"FEBS Lett."},{"key":"10.1016\/j.celrep.2025.116688_bib119","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.molcel.2008.09.014","article-title":"Lin28 mediates the terminal uridylation of let-7 precursor MicroRNA","volume":"32","author":"Heo","year":"2008","journal-title":"Mol. Cell"},{"key":"10.1016\/j.celrep.2025.116688_bib120","doi-asserted-by":"crossref","first-page":"4185","DOI":"10.1038\/onc.2011.131","article-title":"LIN28B fosters colon cancer migration, invasion and transformation through let-7-dependent and -independent mechanisms","volume":"30","author":"King","year":"2011","journal-title":"Oncogene"},{"key":"10.1016\/j.celrep.2025.116688_bib121","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2025.1592193","article-title":"LIN28B promotes the progression of endometrial cancer through upregulating MYC and correlates with immune microenvironment","volume":"15","author":"Diao","year":"2025","journal-title":"Front. Oncol."},{"key":"10.1016\/j.celrep.2025.116688_bib122","doi-asserted-by":"crossref","first-page":"16516","DOI":"10.1073\/pnas.1922692117","article-title":"LIN28B regulates transcription and potentiates MYCN-induced neuroblastoma through binding to ZNF143 at target gene promotors","volume":"117","author":"Tao","year":"2020","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2025.116688_bib123","doi-asserted-by":"crossref","first-page":"12501","DOI":"10.1073\/pnas.0503132102","article-title":"Stearoyl-CoA desaturase-2 gene expression is required for lipid synthesis during early skin and liver development","volume":"102","author":"Miyazaki","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2025.116688_bib124","doi-asserted-by":"crossref","first-page":"35299","DOI":"10.1074\/jbc.273.52.35299","article-title":"Nuclear sterol regulatory element-binding proteins activate genes responsible for the entire program of unsaturated fatty acid biosynthesis in transgenic mouse liver","volume":"273","author":"Shimomura","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.celrep.2025.116688_bib125","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1016\/j.stem.2020.07.021","article-title":"Nicotinamide Metabolism Mediates Resistance to Venetoclax in Relapsed Acute Myeloid Leukemia Stem Cells","volume":"27","author":"Jones","year":"2020","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.celrep.2025.116688_bib126","article-title":"Simultaneous inhibition of Sirtuin 3 and cholesterol homeostasis targets acute myeloid leukemia stem cells by perturbing fatty acid \u03b2-oxidation and inducing lipotoxicity","volume":"6","author":"O'Brien","year":"2023","journal-title":"Haematologica"},{"key":"10.1016\/j.celrep.2025.116688_bib127","doi-asserted-by":"crossref","first-page":"133","DOI":"10.3233\/CBM-210043","article-title":"CPT1B, a metabolic molecule, is also an independent risk factor in CN-AML","volume":"37","author":"Ling","year":"2023","journal-title":"Cancer Biomark."},{"key":"10.1016\/j.celrep.2025.116688_bib128","doi-asserted-by":"crossref","first-page":"8282","DOI":"10.3390\/ijms23158282","article-title":"Dysregulation of SIRT3 SUMOylation Confers AML Chemoresistance via Controlling HES1-Dependent Fatty Acid Oxidation","volume":"23","author":"Zhang","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.celrep.2025.116688_bib129","doi-asserted-by":"crossref","first-page":"1446","DOI":"10.3390\/cancers14061446","article-title":"Synergy of Venetoclax and 8-Chloro-Adenosine in AML: The Interplay of rRNA Inhibition and Fatty Acid Metabolism","volume":"14","author":"Hoang","year":"2022","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.celrep.2025.116688_bib130","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1186\/s13045-021-01076-4","article-title":"Targeting the metabolic vulnerability of acute myeloid leukemia blasts with a combination of venetoclax and 8-chloro-adenosine","volume":"14","author":"Buettner","year":"2021","journal-title":"J. Hematol. Oncol."},{"key":"10.1016\/j.celrep.2025.116688_bib131","doi-asserted-by":"crossref","first-page":"2538","DOI":"10.1161\/STROKEAHA.108.514927","article-title":"Protecting against cerebrovascular injury: contributions of 12\/15-lipoxygenase to edema formation after transient focal ischemia","volume":"39","author":"Jin","year":"2008","journal-title":"Stroke"},{"key":"10.1016\/j.celrep.2025.116688_bib132","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1042\/CS20060307","article-title":"A double-blind randomized multicentre clinical trial to evaluate the efficacy and safety of two doses of etomoxir in comparison with placebo in patients with moderate congestive heart failure: the ERGO (etomoxir for the recovery of glucose oxidation) study","volume":"113","author":"Holubarsch","year":"2007","journal-title":"Clin. Sci."},{"key":"10.1016\/j.celrep.2025.116688_bib133","doi-asserted-by":"crossref","first-page":"1814","DOI":"10.1038\/s41375-025-02645-z","article-title":"Targeting lipid metabolism in acute myeloid leukemia: biological insights and therapeutic opportunities","volume":"39","author":"Dembitz","year":"2025","journal-title":"Leukemia"},{"key":"10.1016\/j.celrep.2025.116688_bib134","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2024.107214","article-title":"Disruption of polyunsaturated fatty acid biosynthesis drives STING-dependent acute myeloid leukemia cell maturation and death","volume":"300","author":"Kanefsky","year":"2024","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.celrep.2025.116688_bib135","doi-asserted-by":"crossref","DOI":"10.1002\/jcp.70000","article-title":"Reprogramming of Fatty Acid Metabolism in Acute Leukemia","volume":"240","author":"Sokei","year":"2025","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.celrep.2025.116688_bib146","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.78136","article-title":"Activation of targetable inflammatory immune signaling is seen in myelodysplastic syndromes with SF3B1 mutations","volume":"11","author":"Choudhary","year":"2022","journal-title":"Elife"},{"key":"10.1016\/j.celrep.2025.116688_bib147","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1016\/j.cell.2011.07.032","article-title":"AKT\/FOXO signaling enforces reversible differentiation blockade in myeloid leukemias","volume":"146","author":"Sykes","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2025.116688_bib148","article-title":"Epigenetic control of gene expression in leukemogenesis: Cooperation between wild type MLL and MLL fusion proteins","volume":"1","author":"Ballabio","year":"2014","journal-title":"Mol. Cell Oncol."},{"key":"10.1016\/j.celrep.2025.116688_bib149","doi-asserted-by":"crossref","first-page":"870","DOI":"10.4049\/jimmunol.2100668","article-title":"Loss of Ribosomal Protein Paralog Rpl22-like1 Blocks Lymphoid Development without Affecting Protein Synthesis","volume":"208","author":"Fahl","year":"2022","journal-title":"J Immunol."},{"key":"10.1016\/j.celrep.2025.116688_bib136","article-title":"Ribosomal protein control of hematopoietic stem cell transformation through direct, non-canonical regulation of metabolism","author":"Harris","year":"2023","journal-title":"bioRxiv"},{"key":"10.1016\/j.celrep.2025.116688_bib137","doi-asserted-by":"crossref","first-page":"R36","DOI":"10.1186\/gb-2013-14-4-r36","article-title":"TopHat2: accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusions","volume":"14","author":"Kim","year":"2013","journal-title":"Genome Biol."},{"key":"10.1016\/j.celrep.2025.116688_bib138","first-page":"166","article-title":"HTSeq--a Python framework to work with high-throughput sequencing data","volume":"31","author":"Anders","year":"2015","journal-title":"Bioinformatics (Oxford, England)"},{"key":"10.1016\/j.celrep.2025.116688_bib139","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol."},{"key":"10.1016\/j.celrep.2025.116688_bib140","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.ccell.2016.05.011","article-title":"MLL-AF9 Expression in Hematopoietic Stem Cells Drives a Highly Invasive AML Expressing EMT-Related Genes Linked to Poor Outcome","volume":"30","author":"Stavropoulou","year":"2016","journal-title":"Cancer Cell"},{"key":"10.1016\/j.celrep.2025.116688_bib141","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1093\/biostatistics\/4.2.249","article-title":"Exploration, normalization, and summaries of high density oligonucleotide array probe level data","volume":"4","author":"Irizarry","year":"2003","journal-title":"Biostatistics"},{"key":"10.1016\/j.celrep.2025.116688_bib142","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkv007","article-title":"limma powers differential expression analyses for RNA-sequencing and microarray studies","volume":"43","author":"Ritchie","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.celrep.2025.116688_bib143","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1038\/nmeth.3252","article-title":"Orchestrating high-throughput genomic analysis with Bioconductor","volume":"12","author":"Huber","year":"2015","journal-title":"Nat. Methods"},{"key":"10.1016\/j.celrep.2025.116688_bib144","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1038\/nmeth.4197","article-title":"Salmon provides fast and bias-aware quantification of transcript expression","volume":"14","author":"Patro","year":"2017","journal-title":"Nat. Methods"},{"key":"10.1016\/j.celrep.2025.116688_bib145","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1038\/s41568-024-00763-x","article-title":"The present and future of the Cancer Dependency Map","volume":"25","author":"Arafeh","year":"2025","journal-title":"Nat. Rev. Cancer"}],"container-title":["Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124725014603?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124725014603?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T12:44:44Z","timestamp":1790599484000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211124725014603"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":149,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["S2211124725014603"],"URL":"https:\/\/doi.org\/10.1016\/j.celrep.2025.116688","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2023.05.31.543132","asserted-by":"object"}]},"ISSN":["2211-1247"],"issn-type":[{"value":"2211-1247","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Ribosomal protein control of hematopoietic stem cell transformation through regulation of metabolism","name":"articletitle","label":"Article Title"},{"value":"Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.celrep.2025.116688","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"116688"}}