{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T04:52:57Z","timestamp":1791262377272,"version":"4.1.0"},"reference-count":73,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T00:00:00Z","timestamp":1764028800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009068","name":"University of Bern","doi-asserted-by":"publisher","award":["CLA-AA-H173"],"award-info":[{"award-number":["CLA-AA-H173"]}],"id":[{"id":"10.13039\/100009068","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009068","name":"University of Bern","doi-asserted-by":"publisher","award":["CLA-SR-H007"],"award-info":[{"award-number":["CLA-SR-H007"]}],"id":[{"id":"10.13039\/100009068","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014867","name":"Department for BioMedical Research, Universit\u00e4t Bern","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014867","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Swiss National Science Foundation","doi-asserted-by":"publisher","award":["320030-228020"],"award-info":[{"award-number":["320030-228020"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Swiss National Science Foundation","doi-asserted-by":"publisher","award":["310030_179394"],"award-info":[{"award-number":["310030_179394"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Reports"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.celrep.2025.116753","type":"journal-article","created":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T16:58:56Z","timestamp":1766509136000},"page":"116753","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["Intestinal low-abundant bacteria drive MyD88\/Trif-dependent CD8+ T cell exhaustion in chronic myeloid leukemia"],"prefix":"10.1016","volume":"45","author":[{"given":"Francesca","family":"Ronchi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magdalena","family":"Hinterbrandner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viviana","family":"Rubino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michaela","family":"R\u00f6mmele","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanja","family":"Chiorazzo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Mooser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie C.","family":"Ganal-Vonarburg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathy D.","family":"McCoy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravi","family":"Bhatia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew J.","family":"Macpherson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian F.","family":"Ochsenbein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7512-513X","authenticated-orcid":false,"given":"Carsten","family":"Riether","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.celrep.2025.116753_bib1","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.1182\/blood-2016-09-696013","article-title":"The chronic myeloid leukemia stem cell: stemming the tide of persistence","volume":"129","author":"Holyoake","year":"2017","journal-title":"Blood"},{"key":"10.1016\/j.celrep.2025.116753_bib2","doi-asserted-by":"crossref","first-page":"2738","DOI":"10.3324\/haematol.2019.242891","article-title":"Discontinuation of tyrosine kinase inhibitors in chronic myeloid leukemia: when and for whom?","volume":"105","author":"Atallah","year":"2020","journal-title":"haematol"},{"key":"10.1016\/j.celrep.2025.116753_bib3","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1056\/NEJMra020777","article-title":"Chronic Myeloid Leukemia \u2014 Advances in Biology and New Approaches to Treatment","volume":"349","author":"Goldman","year":"2003","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.celrep.2025.116753_bib4","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1126\/science.aaa4971","article-title":"Neoantigens in cancer immunotherapy","volume":"348","author":"Schumacher","year":"2015","journal-title":"Science"},{"key":"10.1016\/j.celrep.2025.116753_bib5","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.1049301","article-title":"Regulation of hematopoietic and leukemia stem cells by regulatory T cells","volume":"13","author":"Riether","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.celrep.2025.116753_bib6","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.151797","article-title":"Tnfrsf4-expressing regulatory T cells promote immune escape of chronic myeloid leukemia stem cells","volume":"6","author":"Hinterbrandner","year":"2021","journal-title":"JCI Insight"},{"key":"10.1016\/j.celrep.2025.116753_bib7","doi-asserted-by":"crossref","first-page":"2892","DOI":"10.1182\/blood-2003-01-0150","article-title":"Functional leukemia-associated antigen-specific memory CD8+ T cells exist in healthy individuals and in patients with chronic myelogenous leukemia before and after stem cell transplantation","volume":"102","author":"Rezvani","year":"2003","journal-title":"Blood"},{"key":"10.1016\/j.celrep.2025.116753_bib8","doi-asserted-by":"crossref","first-page":"1781","DOI":"10.1038\/leu.2015.26","article-title":"Blocking programmed cell death 1 in combination with adoptive cytotoxic T-cell transfer eradicates chronic myelogenous leukemia stem cells","volume":"29","author":"Riether","year":"2015","journal-title":"Leukemia"},{"key":"10.1016\/j.celrep.2025.116753_bib9","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1084\/jem.20121229","article-title":"Cytotoxic T cells induce proliferation of chronic myeloid leukemia stem cells by secreting interferon-\u03b3","volume":"210","author":"Sch\u00fcrch","year":"2013","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.celrep.2025.116753_bib10","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1172\/JCI45977","article-title":"CD27 signaling on chronic myelogenous leukemia stem cells activates Wnt target genes and promotes disease progression","volume":"122","author":"Sch\u00fcrch","year":"2012","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.celrep.2025.116753_bib11","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1038\/cdd.2014.89","article-title":"Regulation of hematopoietic and leukemic stem cells by the immune system","volume":"22","author":"Riether","year":"2015","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.celrep.2025.116753_bib12","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1038\/s41422-020-0332-7","article-title":"Interaction between microbiota and immunity in health and disease","volume":"30","author":"Zheng","year":"2020","journal-title":"Cell Res."},{"key":"10.1016\/j.celrep.2025.116753_bib13","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.cell.2014.03.011","article-title":"Role of the Microbiota in Immunity and Inflammation","volume":"157","author":"Belkaid","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2025.116753_bib14","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1038\/s41591-022-01779-2","article-title":"Targeting the gut and tumor microbiota in cancer","volume":"28","author":"Park","year":"2022","journal-title":"Nat. Med."},{"key":"10.1016\/j.celrep.2025.116753_bib15","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1126\/science.abc3421","article-title":"Microbiome-derived inosine modulates response to checkpoint inhibitor immunotherapy","volume":"369","author":"Mager","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.celrep.2025.116753_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2022.104163","article-title":"Gut microbiome in modulating immune checkpoint inhibitors","volume":"82","author":"Li","year":"2022","journal-title":"EBioMedicine"},{"key":"10.1016\/j.celrep.2025.116753_bib17","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1038\/s41586-023-05728-y","article-title":"Microbiota-derived 3-IAA influences chemotherapy efficacy in pancreatic cancer","volume":"615","author":"Tintelnot","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2025.116753_bib18","doi-asserted-by":"crossref","first-page":"5273","DOI":"10.4049\/jimmunol.1400762","article-title":"Microbiota-Derived Compounds Drive Steady-State Granulopoiesis via MyD88\/TICAM Signaling","volume":"193","author":"Balmer","year":"2014","journal-title":"J. Immunol."},{"key":"10.1016\/j.celrep.2025.116753_bib19","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1182\/blood-2016-06-723742","article-title":"Sensing of the microbiota by NOD1 in mesenchymal stromal cells regulates murine hematopoiesis","volume":"129","author":"Iwamura","year":"2017","journal-title":"Blood"},{"key":"10.1016\/j.celrep.2025.116753_bib20","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.chom.2014.02.006","article-title":"Gut Microbiota Promote Hematopoiesis to Control Bacterial Infection","volume":"15","author":"Khosravi","year":"2014","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.celrep.2025.116753_bib21","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1182\/blood-2016-03-708594","article-title":"Antibiotics impair murine hematopoiesis by depleting the intestinal microbiota","volume":"129","author":"Josefsdottir","year":"2017","journal-title":"Blood"},{"key":"10.1016\/j.celrep.2025.116753_bib22","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1002\/1097-0142(19861001)58:7<1569::AID-CNCR2820580731>3.0.CO;2-U","article-title":"Colorectal and extracolonic malignancy in ulcerative colitis","volume":"58","author":"Mir-Madjlessi","year":"1986","journal-title":"Cancer"},{"key":"10.1016\/j.celrep.2025.116753_bib23","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0017996","article-title":"Depletion of Murine Intestinal Microbiota: Effects on Gut Mucosa and Epithelial Gene Expression","volume":"6","author":"Reikvam","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.celrep.2025.116753_bib24","doi-asserted-by":"crossref","first-page":"e00951-16","DOI":"10.1128\/genomeA.00951-16","article-title":"Complete Genome Sequences of 12 Species of Stable Defined Moderately Diverse Mouse Microbiota 2","volume":"4","author":"Uchimura","year":"2016","journal-title":"Genome Announc."},{"key":"10.1016\/j.celrep.2025.116753_bib25","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1038\/s41590-023-01530-0","article-title":"Lactation-associated macrophages exist in murine mammary tissue and human milk","volume":"24","author":"Cansever","year":"2023","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.celrep.2025.116753_bib26","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1182\/blood.2022018196","article-title":"Metabolic adaptation to tyrosine kinase inhibition in leukemia stem cells","volume":"142","author":"Qiu","year":"2023","journal-title":"Blood"},{"key":"10.1016\/j.celrep.2025.116753_bib27","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1099\/00207713-46-1-252","article-title":"Sutterella wadsworthensis gen. nov., sp. nov., Bile-Resistant Microaerophilic Campylobacter gracilis-Like Clinical Isolates","volume":"46","author":"Wexler","year":"1996","journal-title":"Int. J. Syst. Bacteriol."},{"key":"10.1016\/j.celrep.2025.116753_bib28","doi-asserted-by":"crossref","first-page":"3405","DOI":"10.1099\/00221287-135-12-3405","article-title":"Bilophila wadsworthia, gen. nov. and sp. nov., a Unique Gram-negative Anaerobic Rod Recovered from Appendicitis Specimens and Human Faeces","volume":"135","author":"Baron","year":"1989","journal-title":"Microbiology"},{"key":"10.1016\/j.celrep.2025.116753_bib29","doi-asserted-by":"crossref","first-page":"6881","DOI":"10.1128\/JB.00619-08","article-title":"The Pangenome Structure of Escherichia coli : Comparative Genomic Analysis of E. coli Commensal and Pathogenic Isolates","volume":"190","author":"Rasko","year":"2008","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.celrep.2025.116753_bib30","doi-asserted-by":"crossref","unstructured":"Parker, C.T., Garrity, G.M., Parker, C.T., Osier, N.D., and Garrity, G.M. (2009). Nomenclature Abstract for Lactobacillus reuteri Kandler et al. 1982. (NamesforLife, LLC). https:\/\/doi.org\/10.1601\/nm.5423.","DOI":"10.1601\/nm.5423"},{"key":"10.1016\/j.celrep.2025.116753_bib31","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2016.00034","article-title":"Peracetic Acid Treatment Generates Potent Inactivated Oral Vaccines from a Broad Range of Culturable Bacterial Species","volume":"7","author":"Moor","year":"2016","journal-title":"Front. Immunol."},{"key":"10.1016\/j.celrep.2025.116753_bib38","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1126\/science.1172747","article-title":"Innate and adaptive immunity cooperate flexibly to maintain host-microbiota mutualism","volume":"325","author":"Slack","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.celrep.2025.116753_bib32","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2016.01706","article-title":"Mucosal Prevalence and Interactions with the Epithelium Indicate Commensalism of Sutterella spp","volume":"7","author":"Hiippala","year":"2016","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.celrep.2025.116753_bib33","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1038\/s41586-019-1325-x","article-title":"TOX transcriptionally and epigenetically programs CD8+ T cell exhaustion","volume":"571","author":"Khan","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2025.116753_bib34","doi-asserted-by":"crossref","first-page":"3335","DOI":"10.1182\/blood-2013-02-485607","article-title":"Autocrine TNF-\u03b1 production supports CML stem and progenitor cell survival and enhances their proliferation","volume":"122","author":"Gallipoli","year":"2013","journal-title":"Blood"},{"key":"10.1016\/j.celrep.2025.116753_bib35","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1172\/JCI68101","article-title":"Positive feedback between NF-\u03baB and TNF-\u03b1 promotes leukemia-initiating cell capacity","volume":"124","author":"Kagoya","year":"2014","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.celrep.2025.116753_bib36","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1101\/gad.284091.116","article-title":"Metabolites: messengers between the microbiota and the immune system","volume":"30","author":"Levy","year":"2016","journal-title":"Genes Dev."},{"key":"10.1016\/j.celrep.2025.116753_bib37","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1126\/science.1223490","article-title":"Interactions Between the Microbiota and the Immune System","volume":"336","author":"Hooper","year":"2012","journal-title":"Science"},{"key":"10.1016\/j.celrep.2025.116753_bib39","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1182\/blood.2024026310","article-title":"The evolution of treatment-free remission","volume":"145","author":"Hughes","year":"2025","journal-title":"Blood"},{"key":"10.1016\/j.celrep.2025.116753_bib40","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0058825","article-title":"The Microaerophilic Microbiota of De-Novo Paediatric Inflammatory Bowel Disease: The BISCUIT Study","volume":"8","author":"Hansen","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.celrep.2025.116753_bib41","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1038\/nrgastro.2012.14","article-title":"IBD\u2014what role do Proteobacteria play?","volume":"9","author":"Mukhopadhya","year":"2012","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.celrep.2025.116753_bib42","series-title":"Bilophila. In Lexikon der Infektionskrankheiten des Menschen","first-page":"72","author":"Geiss","year":"2009"},{"key":"10.1016\/j.celrep.2025.116753_bib43","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1016\/S0140-6736(17)30182-4","article-title":"Multidonor intensive faecal microbiota transplantation for active ulcerative colitis: a randomised placebo-controlled trial","volume":"389","author":"Paramsothy","year":"2017","journal-title":"Lancet"},{"key":"10.1016\/j.celrep.2025.116753_bib44","doi-asserted-by":"crossref","first-page":"2238","DOI":"10.3324\/haematol.2021.280455","article-title":"The gut microbiome in patients with chronic lymphocytic leukemia","volume":"107","author":"Faitov\u00e1","year":"2022","journal-title":"Haematologica"},{"key":"10.1016\/j.celrep.2025.116753_bib45","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1038\/nature14139","article-title":"Vertically transmitted faecal IgA levels determine extra-chromosomal phenotypic variation","volume":"521","author":"Moon","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2025.116753_bib46","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1126\/science.aac4255","article-title":"Commensal Bifidobacterium promotes antitumor immunity and facilitates anti\u2013PD-L1 efficacy","volume":"350","author":"Sivan","year":"2015","journal-title":"Science"},{"key":"10.1016\/j.celrep.2025.116753_bib47","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1126\/science.aad1329","article-title":"Anticancer immunotherapy by CTLA-4 blockade relies on the gut microbiota","volume":"350","author":"V\u00e9tizou","year":"2015","journal-title":"Science"},{"key":"10.1016\/j.celrep.2025.116753_bib48","doi-asserted-by":"crossref","DOI":"10.1002\/cam4.6799","article-title":"Gut microbiota, microbiota-derived metabolites, and graft-versus-host disease","volume":"13","author":"Yue","year":"2024","journal-title":"Cancer Med."},{"key":"10.1016\/j.celrep.2025.116753_bib49","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.immuni.2015.01.010","article-title":"Binding of the Fap2 Protein of Fusobacterium nucleatum to Human Inhibitory Receptor TIGIT Protects Tumors from Immune Cell Attack","volume":"42","author":"Gur","year":"2015","journal-title":"Immunity"},{"key":"10.1016\/j.celrep.2025.116753_bib50","doi-asserted-by":"crossref","first-page":"604","DOI":"10.3390\/ph17050604","article-title":"Influence of Gut Microbiota-Mediated Immune Regulation on Response to Chemotherapy","volume":"17","author":"Deng","year":"2024","journal-title":"Pharmaceuticals"},{"key":"10.1016\/j.celrep.2025.116753_bib51","article-title":"Relating Gut Microbiome and Its Modulating Factors to Immunotherapy in Solid Tumors: A Systematic Review","volume":"11","author":"Huang","year":"2021","journal-title":"Front. Oncol."},{"key":"10.1016\/j.celrep.2025.116753_bib52","doi-asserted-by":"crossref","first-page":"5317","DOI":"10.3390\/cancers14215317","article-title":"Gut Microbiota and Tumor Immune Escape: A New Perspective for Improving Tumor Immunotherapy","volume":"14","author":"He","year":"2022","journal-title":"Cancers"},{"key":"10.1016\/j.celrep.2025.116753_bib53","doi-asserted-by":"crossref","first-page":"847","DOI":"10.21037\/tlcr.2019.10.23","article-title":"The role of the gut microbiome on the efficacy of immune checkpoint inhibitors in Japanese responder patients with advanced non-small cell lung cancer","volume":"8","author":"Katayama","year":"2019","journal-title":"Transl. Lung Cancer Res."},{"key":"10.1016\/j.celrep.2025.116753_bib54","doi-asserted-by":"crossref","DOI":"10.1016\/j.neo.2023.100923","article-title":"Checkpoint inhibitor responses can be regulated by the gut microbiota \u2013 A systematic review","volume":"43","author":"Zeriouh","year":"2023","journal-title":"Neoplasia"},{"key":"10.1016\/j.celrep.2025.116753_bib55","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1038\/s41579-020-0433-9","article-title":"Gut microbiota in human metabolic health and disease","volume":"19","author":"Fan","year":"2021","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.celrep.2025.116753_bib56","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.eururo.2023.12.014","article-title":"Stool Microbiome Signature Associated with Response to Neoadjuvant Pembrolizumab in Patients with Muscle-invasive Bladder Cancer","volume":"85","author":"Pederzoli","year":"2024","journal-title":"Eur. Urol."},{"key":"10.1016\/j.celrep.2025.116753_bib57","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.stem.2021.12.009","article-title":"The microbiota regulates hematopoietic stem cell fate decisions by controlling iron availability in bone marrow","volume":"29","author":"Zhang","year":"2022","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.celrep.2025.116753_bib58","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1016\/j.ajpath.2024.02.012","article-title":"Deletion of MyD88 in T Cells Improves Antitumor Activity in Melanoma","volume":"194","author":"Bayer","year":"2024","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.celrep.2025.116753_bib67","doi-asserted-by":"crossref","first-page":"8292","DOI":"10.1038\/ncomms9292","article-title":"The outer mucus layer hosts a distinct intestinal microbial niche","volume":"6","author":"Li","year":"2015","journal-title":"Nat Commun"},{"key":"10.1016\/j.celrep.2025.116753_bib68","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1186\/1471-2180-7-108","article-title":"Bacterial flora-typing with targeted, chip-based Pyrosequencing","volume":"7","author":"Sundquist","year":"2007","journal-title":"BMC Microbiol"},{"issue":"1","key":"10.1016\/j.celrep.2025.116753_bib69","doi-asserted-by":"crossref","first-page":"7850","DOI":"10.1038\/s41467-024-52252-2","article-title":"TCF-1 and TOX regulate the memory formation of intestinal group 2 innate lymphoid cells in asthma","volume":"15","author":"Bao","year":"2024","journal-title":"Nat Commun"},{"issue":"11","key":"10.1016\/j.celrep.2025.116753_bib70","doi-asserted-by":"crossref","first-page":"101826","DOI":"10.1016\/j.xcrm.2024.101826","article-title":"IL-21\/IL-21R signaling renders acute myeloid leukemia stem cells more susceptible to cytarabine treatment and CAR T cell therapy","volume":"5","author":"Rubino","year":"2024","journal-title":"Cell Rep Med"},{"key":"10.1016\/j.celrep.2025.116753_bib60","doi-asserted-by":"crossref","first-page":"4203","DOI":"10.1038\/s41467-025-59229-9","article-title":"HiBC: a publicly available collection of bacterial strains isolated from the human gut","volume":"16","author":"Hitch","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2025.116753_bib61","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.smim.2006.10.002","article-title":"Use of axenic animals in studying the adaptation of mammals to their commensal intestinal microbiota","volume":"19","author":"Smith","year":"2007","journal-title":"Semin. Immunol."},{"key":"10.1016\/j.celrep.2025.116753_bib62","unstructured":"Kr\u00fcger, M. (2015). TrimGalore: a wrapper around Cutadapt and FastQC to consistently apply adapter and quality trimming to FastQ files, with extra functionality for RRBS data."},{"key":"10.1016\/j.celrep.2025.116753_bib63","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1038\/nature08821","article-title":"A human gut microbial gene catalogue established by metagenomic sequencing","volume":"464","author":"Qin","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2025.116753_bib64","doi-asserted-by":"crossref","first-page":"10","DOI":"10.14806\/ej.17.1.200","article-title":"Cutadapt removes adapter sequences from high-throughput sequencing reads","volume":"17","author":"Martin","year":"2011","journal-title":"EMBnet. j."},{"key":"10.1016\/j.celrep.2025.116753_bib71","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1038\/nmeth.f.303","article-title":"QIIME allows analysis of high-throughput community sequencing data","volume":"7","author":"Caporaso","year":"2010","journal-title":"Nat Methods"},{"key":"10.1016\/j.celrep.2025.116753_bib72","doi-asserted-by":"crossref","first-page":"2194","DOI":"10.1093\/bioinformatics\/btr381","article-title":"UCHIME improves sensitivity and speed of chimera detection","volume":"27","author":"Edgar","year":"2011","journal-title":"Bioinformatics"},{"key":"10.1016\/j.celrep.2025.116753_bib73","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1038\/nmeth.3869","article-title":"DADA2: High-resolution sample inference from Illumina amplicon data","volume":"13","author":"Callahan","year":"2016","journal-title":"Nat Methods"},{"key":"10.1016\/j.celrep.2025.116753_bib65","unstructured":"R Core Team (2022). A Language and Environment for Statistical Computing."},{"key":"10.1016\/j.celrep.2025.116753_bib66","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1038\/s41587-023-01688-w","article-title":"Extending and improving metagenomic taxonomic profiling with uncharacterized species using MetaPhlAn 4","volume":"41","author":"Blanco-M\u00edguez","year":"2023","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.celrep.2025.116753_bib59","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1002\/eji.201646297","article-title":"High-resolution microbiota flow cytometry reveals dynamic colitis-associated changes in fecal bacterial composition","volume":"46","author":"Zimmermann","year":"2016","journal-title":"Eur. J. Immunol."}],"container-title":["Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124725015256?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124725015256?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T04:23:59Z","timestamp":1791260639000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211124725015256"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":73,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["S2211124725015256"],"URL":"https:\/\/doi.org\/10.1016\/j.celrep.2025.116753","relation":{},"ISSN":["2211-1247"],"issn-type":[{"value":"2211-1247","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Intestinal low-abundant bacteria drive MyD88\/Trif-dependent CD8+ T cell exhaustion in chronic myeloid leukemia","name":"articletitle","label":"Article Title"},{"value":"Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.celrep.2025.116753","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"116753"}}