{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T04:55:07Z","timestamp":1791262507824,"version":"4.1.0"},"reference-count":97,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T00:00:00Z","timestamp":1764115200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006691","name":"Harvard Medical School","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008732","name":"Uehara Memorial Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008732","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP21H04791"],"award-info":[{"award-number":["JP21H04791"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP24K21281"],"award-info":[{"award-number":["JP24K21281"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP22ama121038"],"award-info":[{"award-number":["JP22ama121038"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002241","name":"Japan Science and Technology Agency","doi-asserted-by":"publisher","award":["JPMJMS2023"],"award-info":[{"award-number":["JPMJMS2023"]}],"id":[{"id":"10.13039\/501100002241","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002241","name":"Japan Science and Technology Agency","doi-asserted-by":"publisher","award":["JPMJFR215T"],"award-info":[{"award-number":["JPMJFR215T"]}],"id":[{"id":"10.13039\/501100002241","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100002590","name":"American Lung Association","doi-asserted-by":"publisher","award":["JP24K21281"],"award-info":[{"award-number":["JP24K21281"]}],"id":[{"id":"10.13039\/100002590","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100002590","name":"American Lung Association","doi-asserted-by":"publisher","award":["JP21H04791"],"award-info":[{"award-number":["JP21H04791"]}],"id":[{"id":"10.13039\/100002590","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R37AI052353"],"award-info":[{"award-number":["R37AI052353"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R01AI136041"],"award-info":[{"award-number":["R01AI136041"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["U19AI095219"],"award-info":[{"award-number":["U19AI095219"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R01AI175149"],"award-info":[{"award-number":["R01AI175149"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R01AI130109"],"award-info":[{"award-number":["R01AI130109"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R01AI078908"],"award-info":[{"award-number":["R01AI078908"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["T32AI007306"],"award-info":[{"award-number":["T32AI007306"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R21AI156068"],"award-info":[{"award-number":["R21AI156068"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart Lung and Blood Institute","doi-asserted-by":"publisher","award":["R01HL136209"],"award-info":[{"award-number":["R01HL136209"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart Lung and Blood Institute","doi-asserted-by":"publisher","award":["HL111113"],"award-info":[{"award-number":["HL111113"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart Lung and Blood Institute","doi-asserted-by":"publisher","award":["HL117945"],"award-info":[{"award-number":["HL117945"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Reports"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.celrep.2025.116758","type":"journal-article","created":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T22:28:52Z","timestamp":1766183332000},"page":"116758","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Mast cell-specific CysLT2 receptor signaling inhibits cysteinyl leukotriene-dependent mast cell activation and type 2 allergic lung inflammation"],"prefix":"10.1016","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4720-5065","authenticated-orcid":false,"given":"Jun","family":"Nagai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madeline M.","family":"Hastings","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Airi","family":"Nishida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sreyashi","family":"Majumdar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kendall","family":"Zaleski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sofia A.","family":"Marshall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junrui","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mira A.S.","family":"Saliman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yumi","family":"Tani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yamato","family":"Murakami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunli","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Perniss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caitlin","family":"Wong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lora G.","family":"Bankova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asuka","family":"Inoue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nora A.","family":"Barrett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2401-2351","authenticated-orcid":false,"given":"Joshua A.","family":"Boyce","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.celrep.2025.116758_bib1","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/j.jaci.2009.05.046","article-title":"The leukotriene E4 puzzle: finding the missing pieces and revealing the pathobiologic implications","volume":"124","author":"Austen","year":"2009","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.celrep.2025.116758_bib2","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1111\/j.1749-6632.1994.tb12038.x","article-title":"Leukotriene C4 formation by transcellular biosynthesis","volume":"714","author":"Maclouf","year":"1994","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.celrep.2025.116758_bib3","doi-asserted-by":"crossref","first-page":"3790","DOI":"10.1182\/blood-2011-10-384826","article-title":"Cysteinyl leukotriene overproduction in aspirin-exacerbated respiratory disease is driven by platelet-adherent leukocytes","volume":"119","author":"Laidlaw","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.celrep.2025.116758_bib4","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.aax7224","article-title":"Airway brush cells generate cysteinyl leukotrienes through the ATP sensor P2Y2","volume":"5","author":"Ualiyeva","year":"2020","journal-title":"Sci. Immunol."},{"key":"10.1016\/j.celrep.2025.116758_bib5","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/S0002-9440(10)64204-6","article-title":"Gamma-glutamyl leukotrienase, a novel endothelial membrane protein, is specifically responsible for leukotriene D(4) formation in vivo","volume":"161","author":"Han","year":"2002","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.celrep.2025.116758_bib6","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1056\/NEJM198302243080807","article-title":"Effects of leukotriene D on the airways in asthma","volume":"308","author":"Griffin","year":"1983","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.celrep.2025.116758_bib7","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/0014-2999(90)90288-H","article-title":"Evidence for two leukotriene receptor types in the guinea-pig isolated ileum","volume":"182","author":"Gardiner","year":"1990","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.celrep.2025.116758_bib8","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1111\/1523-1747.ep12531738","article-title":"Local effects of synthetic leukotrienes (LTC4, LTD4, LTE4, and LTB4) in human skin","volume":"80","author":"Soter","year":"1983","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.celrep.2025.116758_bib9","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1096\/fj.02-0899fje","article-title":"Identification of two additional members of the membrane-bound dipeptidase family","volume":"17","author":"Habib","year":"2003","journal-title":"FASEB J."},{"key":"10.1016\/j.celrep.2025.116758_bib10","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1038\/21658","article-title":"Characterization of the human cysteinyl leukotriene CysLT1 receptor","volume":"399","author":"Lynch","year":"1999","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2025.116758_bib11","doi-asserted-by":"crossref","first-page":"30531","DOI":"10.1074\/jbc.M003490200","article-title":"Characterization of the human cysteinyl leukotriene 2 receptor","volume":"275","author":"Heise","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.celrep.2025.116758_bib12","doi-asserted-by":"crossref","first-page":"10967","DOI":"10.1074\/jbc.C113.453704","article-title":"Identification of GPR99 protein as a potential third cysteinyl leukotriene receptor with a preference for leukotriene E4 ligand","volume":"288","author":"Kanaoka","year":"2013","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.celrep.2025.116758_bib13","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1164\/ajrccm\/146.1.104","article-title":"Recovery of leukotriene E4 from the urine of patients with airway obstruction","volume":"146","author":"Drazen","year":"1992","journal-title":"Am. Rev. Respir. Dis."},{"key":"10.1016\/j.celrep.2025.116758_bib14","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1164\/ajrccm\/143.5_Pt_1.1025","article-title":"Urinary leukotriene E4 concentrations increase after aspirin challenge in aspirin-sensitive asthmatic subjects","volume":"143","author":"Christie","year":"1991","journal-title":"Am. Rev. Respir. Dis."},{"key":"10.1016\/j.celrep.2025.116758_bib15","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1016\/j.jaci.2017.01.022","article-title":"Microparticles in nasal lavage fluids in chronic rhinosinusitis: Potential biomarkers for diagnosis of aspirin-exacerbated respiratory disease","volume":"140","author":"Takahashi","year":"2017","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.celrep.2025.116758_bib16","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1056\/NEJMcibr1514013","article-title":"Aspirin-Exacerbated Respiratory Disease - New Prime Suspects","volume":"374","author":"Laidlaw","year":"2016","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.celrep.2025.116758_bib17","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.7326\/0003-4819-119-11-199312010-00001","article-title":"The effect of inhibition of 5-lipoxygenase by zileuton in mild-to-moderate asthma","volume":"119","author":"Israel","year":"1993","journal-title":"Ann. Intern. Med."},{"key":"10.1016\/j.celrep.2025.116758_bib18","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1067\/mai.2002.129413","article-title":"Effects of montelukast and beclomethasone on airway function and asthma control","volume":"110","author":"Israel","year":"2002","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.celrep.2025.116758_bib19","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1046\/j.1365-2745.2002.01501.x","article-title":"The effect of leukotriene-modifier drugs on aspirin-induced asthma and rhinitis reactions","volume":"32","author":"Berges-Gimeno","year":"2002","journal-title":"Clin. Exp. Allergy"},{"key":"10.1016\/j.celrep.2025.116758_bib20","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1126\/science.7063880","article-title":"Bronchoconstrictor effects of leukotriene C in humans","volume":"216","author":"Weiss","year":"1982","journal-title":"Science"},{"key":"10.1016\/j.celrep.2025.116758_bib21","doi-asserted-by":"crossref","first-page":"4440","DOI":"10.4049\/jimmunol.176.7.4440","article-title":"Cysteinyl leukotrienes regulate Th2 cell-dependent pulmonary inflammation","volume":"176","author":"Kim","year":"2006","journal-title":"J. Immunol."},{"key":"10.1016\/j.celrep.2025.116758_bib22","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1084\/jem.20100793","article-title":"Dectin-2 mediates Th2 immunity through the generation of cysteinyl leukotrienes","volume":"208","author":"Barrett","year":"2011","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.celrep.2025.116758_bib23","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.jaci.2013.03.048","article-title":"Lung type 2 innate lymphoid cells express cysteinyl leukotriene receptor 1, which regulates TH2 cytokine production","volume":"132","author":"Doherty","year":"2013","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.celrep.2025.116758_bib24","doi-asserted-by":"crossref","first-page":"694","DOI":"10.4049\/jimmunol.1102474","article-title":"Leukotriene E4 activates human Th2 cells for exaggerated proinflammatory cytokine production in response to prostaglandin D2","volume":"188","author":"Xue","year":"2012","journal-title":"J. Immunol."},{"key":"10.1016\/j.celrep.2025.116758_bib25","doi-asserted-by":"crossref","first-page":"915","DOI":"10.4049\/jimmunol.1700603","article-title":"Type 2 Cysteinyl Leukotriene Receptors Drive IL-33-Dependent Type 2 Immunopathology and Aspirin Sensitivity","volume":"200","author":"Liu","year":"2018","journal-title":"J. Immunol."},{"key":"10.1016\/j.celrep.2025.116758_bib26","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.aat9453","article-title":"The cysteinyl leukotriene 3 receptor regulates expansion of IL-25-producing airway brush cells leading to type 2 inflammation","volume":"3","author":"Bankova","year":"2018","journal-title":"Sci. Immunol."},{"key":"10.1016\/j.celrep.2025.116758_bib27","doi-asserted-by":"crossref","first-page":"6242","DOI":"10.1073\/pnas.1605957113","article-title":"Leukotriene E4 elicits respiratory epithelial cell mucin release through the G-protein-coupled receptor, GPR99","volume":"113","author":"Bankova","year":"2016","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2025.116758_bib28","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1016\/S0091-6749(96)80002-9","article-title":"Acute and chronic effects of a 5-lipoxygenase inhibitor in asthma: a 6-month randomized multicenter trial","volume":"98","author":"Liu","year":"1996","journal-title":"Zileuton Study Group. J. Allergy Clin. Immunol"},{"key":"10.1016\/j.celrep.2025.116758_bib29","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1034\/j.1399-3003.1999.14a04.x","article-title":"Montelukast reduces airway eosinophilic inflammation in asthma: a randomized, controlled trial","volume":"14","author":"Pizzichini","year":"1999","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.celrep.2025.116758_bib30","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.3389\/fphar.2019.01094","article-title":"Montelukast Improves Symptoms and Lung Function in Asthmatic Women Compared With Men","volume":"10","author":"Esposito","year":"2019","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.celrep.2025.116758_bib31","doi-asserted-by":"crossref","first-page":"3167","DOI":"10.1172\/JCI92885","article-title":"Androgen-mediated sex bias impairs efficiency of leukotriene biosynthesis inhibitors in males","volume":"127","author":"Pace","year":"2017","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.celrep.2025.116758_bib32","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1097\/00008571-200310000-00008","article-title":"A cysteinyl leukotriene 2 receptor variant is associated with atopy in the population of Tristan da Cunha","volume":"13","author":"Thompson","year":"2003","journal-title":"Pharmacogenetics"},{"key":"10.1016\/j.celrep.2025.116758_bib33","doi-asserted-by":"crossref","first-page":"4556","DOI":"10.4049\/jimmunol.1201865","article-title":"Cysteinyl leukotriene 2 receptor on dendritic cells negatively regulates ligand-dependent allergic pulmonary inflammation","volume":"189","author":"Barrett","year":"2012","journal-title":"J. Immunol."},{"key":"10.1016\/j.celrep.2025.116758_bib34","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1038\/s41385-019-0134-8","article-title":"Cysteinyl leukotriene receptor 2 drives lung immunopathology through a platelet and high mobility box 1-dependent mechanism","volume":"12","author":"Liu","year":"2019","journal-title":"Mucosal Immunol."},{"key":"10.1016\/j.celrep.2025.116758_bib35","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1084\/jem.193.1.123","article-title":"T helper cell type 2 cytokines coordinately regulate immunoglobulin E-dependent cysteinyl leukotriene production by human cord blood-derived mast cells: profound induction of leukotriene C(4) synthase expression by interleukin 4","volume":"193","author":"Hsieh","year":"2001","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.celrep.2025.116758_bib36","doi-asserted-by":"crossref","first-page":"7964","DOI":"10.1073\/pnas.141221498","article-title":"Cysteinyl leukotriene receptor 1 is also a pyrimidinergic receptor and is expressed by human mast cells","volume":"98","author":"Mellor","year":"2001","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2025.116758_bib37","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1016\/j.jaci.2010.03.003","article-title":"Accumulation of intraepithelial mast cells with a unique protease phenotype in T(H)2-high asthma","volume":"125","author":"Dougherty","year":"2010","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.celrep.2025.116758_bib38","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.jaci.2008.05.020","article-title":"Airway hyperresponsiveness is dissociated from airway wall structural remodeling","volume":"122","author":"Siddiqui","year":"2008","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.celrep.2025.116758_bib39","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1038\/sj.bjp.0706664","article-title":"Prostaglandin E2 activates EP2 receptors to inhibit human lung mast cell degranulation","volume":"147","author":"Kay","year":"2006","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.celrep.2025.116758_bib40","doi-asserted-by":"crossref","first-page":"3537","DOI":"10.4049\/jimmunol.1500905","article-title":"Aspirin-Exacerbated Respiratory Disease Involves a Cysteinyl Leukotriene-Driven IL-33-Mediated Mast Cell Activation Pathway","volume":"195","author":"Liu","year":"2015","journal-title":"J. Immunol."},{"key":"10.1016\/j.celrep.2025.116758_bib41","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1016\/j.jaci.2018.02.024","article-title":"Leukotriene E4 induces airflow obstruction and mast cell activation through the cysteinyl leukotriene type 1 receptor","volume":"142","author":"Lazarinis","year":"2018","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.celrep.2025.116758_bib42","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1084\/jem.20020044","article-title":"Cysteinyl leukotrienes and uridine diphosphate induce cytokine generation by human mast cells through an interleukin 4-regulated pathway that is inhibited by leukotriene receptor antagonists","volume":"195","author":"Mellor","year":"2002","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.celrep.2025.116758_bib43","doi-asserted-by":"crossref","first-page":"3263","DOI":"10.1182\/blood-2007-07-100453","article-title":"CysLT2 receptors interact with CysLT1 receptors and down-modulate cysteinyl leukotriene dependent mitogenic responses of mast cells","volume":"110","author":"Jiang","year":"2007","journal-title":"Blood"},{"key":"10.1016\/j.celrep.2025.116758_bib44","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1124\/mol.105.020024","article-title":"Adenylyl cyclase superactivation induced by long-term treatment with opioid agonist is dependent on receptor localized within lipid rafts and is independent of receptor internalization","volume":"69","author":"Zhao","year":"2006","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.celrep.2025.116758_bib45","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1385\/JMN:27:2:195","article-title":"Inhibition and superactivation of the calcium-stimulated isoforms of adenylyl cyclase: role of Gbetagamma dimers","volume":"27","author":"Steiner","year":"2005","journal-title":"J. Mol. Neurosci."},{"key":"10.1016\/j.celrep.2025.116758_bib46","doi-asserted-by":"crossref","first-page":"11589","DOI":"10.1073\/pnas.2034927100","article-title":"Expression of the type 2 receptor for cysteinyl leukotrienes (CysLT2R) by human mast cells: Functional distinction from CysLT1R","volume":"100","author":"Mellor","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2025.116758_bib47","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1124\/mol.110.069054","article-title":"Differential signaling of cysteinyl leukotrienes and a novel cysteinyl leukotriene receptor 2 (CysLT(2)) agonist, N-methyl-leukotriene C(4), in calcium reporter and beta arrestin assays","volume":"79","author":"Yan","year":"2011","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.celrep.2025.116758_bib48","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1124\/jpet.113.203604","article-title":"HAMI 3379, a CysLT2 receptor antagonist, attenuates ischemia-like neuronal injury by inhibiting microglial activation","volume":"346","author":"Zhang","year":"2013","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.celrep.2025.116758_bib49","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1016\/S0306-3623(98)00080-9","article-title":"Regulation of human mast cell and basophil function by cAMP","volume":"31","author":"Weston","year":"1998","journal-title":"Gen. Pharmacol."},{"key":"10.1016\/j.celrep.2025.116758_bib50","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.1016\/j.jaci.2017.09.050","article-title":"Prostaglandin E2 suppresses human group 2 innate lymphoid cell function","volume":"141","author":"Maric","year":"2018","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.celrep.2025.116758_bib51","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1194\/jlr.M003236","article-title":"A role for inflammatory mediators in heterologous desensitization of CysLT1 receptor in human monocytes","volume":"51","author":"Capra","year":"2010","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.celrep.2025.116758_bib52","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1042\/BJ20041682","article-title":"Anti-inflammatory potential of CB1-mediated cAMP elevation in mast cells","volume":"388","author":"SMALL-HOWARD","year":"2005","journal-title":"Biochem. J."},{"key":"10.1016\/j.celrep.2025.116758_bib53","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1164\/rccm.201209-1739PP","article-title":"\u03b22-Agonist Therapy in Lung Disease","volume":"187","author":"Cazzola","year":"2013","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.celrep.2025.116758_bib54","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1165\/rcmb.2008-0080OC","article-title":"Prostaglandin E2 Inhibits Specific Lung Fibroblast Functions via Selective Actions of PKA and Epac-1","volume":"39","author":"Huang","year":"2008","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.celrep.2025.116758_bib55","doi-asserted-by":"crossref","first-page":"3243","DOI":"10.1182\/blood-2005-07-2772","article-title":"Human mast cells express multiple EP receptors for prostaglandin E2 that differentially modulate activation responses","volume":"107","author":"Feng","year":"2006","journal-title":"Blood"},{"key":"10.1016\/j.celrep.2025.116758_bib56","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1189\/jlb.0212109","article-title":"E-prostanoid 2 receptors dampen mast cell degranulation via cAMP\/PKA-mediated suppression of IgE-dependent signaling","volume":"92","author":"Serra-Pages","year":"2012","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.celrep.2025.116758_bib57","doi-asserted-by":"crossref","first-page":"23065","DOI":"10.1074\/jbc.M114.557652","article-title":"beta-Agonist-mediated relaxation of airway smooth muscle is protein kinase A-dependent","volume":"289","author":"Morgan","year":"2014","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.celrep.2025.116758_bib58","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1097\/00008571-200409000-00007","article-title":"A coding polymorphism in the CYSLT2 receptor with reduced affinity to LTD4 is associated with asthma","volume":"14","author":"Pillai","year":"2004","journal-title":"Pharmacogenetics"},{"key":"10.1016\/j.celrep.2025.116758_bib59","doi-asserted-by":"crossref","DOI":"10.1074\/jbc.RA120.015352","article-title":"Direct evidence that the GPCR CysLTR2 mutant causative of uveal melanoma is constitutively active with highly biased signaling","volume":"296","author":"Ceraudo","year":"2021","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.celrep.2025.116758_bib60","doi-asserted-by":"crossref","first-page":"2180","DOI":"10.1073\/pnas.94.6.2180","article-title":"Receptor and G betagamma isoform-specific interactions with G protein-coupled receptor kinases","volume":"94","author":"Daaka","year":"1997","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2025.116758_bib61","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1038\/ncb3307","article-title":"\u03b2-Arrestin drives MAP kinase signalling from clathrin-coated structures after GPCR dissociation","volume":"18","author":"Eichel","year":"2016","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.celrep.2025.116758_bib62","doi-asserted-by":"crossref","first-page":"21309","DOI":"10.1074\/jbc.271.35.21309","article-title":"Chronic opioid treatment induces adenylyl cyclase V superactivation. Involvement of Gbetagamma","volume":"271","author":"Avidor-Reiss","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.celrep.2025.116758_bib63","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2023.102924","article-title":"Multiple potassium channel tetramerization domain (KCTD) family members interact with Gbetagamma, with effects on cAMP signaling","volume":"299","author":"Sloan","year":"2023","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.celrep.2025.116758_bib64","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2024.116160","article-title":"Biochemical pharmacology of adenylyl cyclases in cancer","volume":"228","author":"Chandra Jena","year":"2024","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.celrep.2025.116758_bib65","doi-asserted-by":"crossref","first-page":"16987","DOI":"10.1073\/pnas.1313185110","article-title":"Prostaglandin E2 deficiency causes a phenotype of aspirin sensitivity that depends on platelets and cysteinyl leukotrienes","volume":"110","author":"Liu","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2025.116758_bib66","doi-asserted-by":"crossref","first-page":"6930","DOI":"10.1182\/blood-2011-03-343962","article-title":"Reduced mast cell and basophil numbers and function in Cpa3-Cre; Mcl-1fl\/fl mice","volume":"118","author":"Lilla","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.celrep.2025.116758_bib67","doi-asserted-by":"crossref","first-page":"2487","DOI":"10.1016\/j.celrep.2017.10.110","article-title":"Testosterone Attenuates Group 2 Innate Lymphoid Cell-Mediated Airway Inflammation","volume":"21","author":"Cephus","year":"2017","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2025.116758_bib68","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20200321","article-title":"Lineage-specific regulation of inducible and constitutive mast cells in allergic airway inflammation","volume":"218","author":"Derakhshan","year":"2021","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.celrep.2025.116758_bib69","doi-asserted-by":"crossref","first-page":"3710","DOI":"10.1073\/pnas.77.6.3710","article-title":"Slow reacting substances of anaphylaxis: identification of leukotrienes C-1 and D from human and rat sources","volume":"77","author":"Lewis","year":"1980","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2025.116758_bib70","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1038\/nature10731","article-title":"Cysteinyl leukotriene type I receptor desensitization sustains Ca2+-dependent gene expression","volume":"482","author":"Ng","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2025.116758_bib71","doi-asserted-by":"crossref","first-page":"5807","DOI":"10.4049\/jimmunol.1302187","article-title":"Cutting edge: Leukotriene C4 activates mouse platelets in plasma exclusively through the type 2 cysteinyl leukotriene receptor","volume":"191","author":"Cummings","year":"2013","journal-title":"J. Immunol."},{"key":"10.1016\/j.celrep.2025.116758_bib72","doi-asserted-by":"crossref","first-page":"6326","DOI":"10.1073\/pnas.0601223103","article-title":"Cysteinyl leukotriene 2 receptor and protease-activated receptor 1 activate strongly correlated early genes in human endothelial cells","volume":"103","author":"Uzonyi","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2025.116758_bib73","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1007\/5584_2016_123","article-title":"Role of P2Y(12) Receptor in Thrombosis","volume":"906","author":"Zhang","year":"2017","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.celrep.2025.116758_bib74","doi-asserted-by":"crossref","first-page":"2074","DOI":"10.4049\/jimmunol.167.4.2074","article-title":"Adenosine 3',5'-cyclic monophosphate (cAMP)-dependent inhibition of IL-5 from human T lymphocytes is not mediated by the cAMP-dependent protein kinase A","volume":"167","author":"Staples","year":"2001","journal-title":"J. Immunol."},{"key":"10.1016\/j.celrep.2025.116758_bib75","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1164\/rccm.201410-1793OC","article-title":"Prostaglandin I2 Signaling and Inhibition of Group 2 Innate Lymphoid Cell Responses","volume":"193","author":"Zhou","year":"2016","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.celrep.2025.116758_bib76","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1016\/j.jaci.2015.04.002","article-title":"Prostaglandin E2 inhibits mast cell-dependent bronchoconstriction in human small airways through the E prostanoid subtype 2 receptor","volume":"136","author":"Safholm","year":"2015","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.celrep.2025.116758_bib77","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/210324","article-title":"Dopamine D(2) Receptor-Mediated Heterologous Sensitization of AC5 Requires Signalosome Assembly","volume":"2012","author":"Ejendal","year":"2012","journal-title":"J. Signal Transduct."},{"key":"10.1016\/j.celrep.2025.116758_bib78","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1159\/000166277","article-title":"Physiological roles for G protein-regulated adenylyl cyclase isoforms: insights from knockout and overexpression studies","volume":"17","author":"Sadana","year":"2009","journal-title":"Neurosignals"},{"key":"10.1016\/j.celrep.2025.116758_bib79","doi-asserted-by":"crossref","first-page":"2755","DOI":"10.4049\/jimmunol.177.5.2755","article-title":"Cutting edge: Interleukin 4-dependent mast cell proliferation requires autocrine\/intracrine cysteinyl leukotriene-induced signaling","volume":"177","author":"Jiang","year":"2006","journal-title":"J. Immunol."},{"key":"10.1016\/j.celrep.2025.116758_bib80","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.4049\/jimmunol.1900745","article-title":"The Prostaglandin D(2) Receptor CRTH2 Promotes IL-33-Induced ILC2 Accumulation in the Lung","volume":"204","author":"Oyesola","year":"2020","journal-title":"J. Immunol."},{"key":"10.1016\/j.celrep.2025.116758_bib81","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1016\/j.immuni.2024.05.003","article-title":"Mast cells control lung type 2 inflammation via prostaglandin E(2)-driven soluble ST2","volume":"57","author":"Alhallak","year":"2024","journal-title":"Immunity"},{"key":"10.1016\/j.celrep.2025.116758_bib82","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.jaci.2020.10.041","article-title":"Leukotriene D4 Paradoxically Limits LTC4 Driven Platelet Activation and Lung Immunopathology","volume":"148","author":"Liu","year":"2021","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.celrep.2025.116758_bib83","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.jaci.2004.11.014","article-title":"Characterization of within-subject responses to fluticasone and montelukast in childhood asthma","volume":"115","author":"Szefler","year":"2005","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.celrep.2025.116758_bib84","doi-asserted-by":"crossref","first-page":"389","DOI":"10.2332\/allergolint.08-OA-0068","article-title":"Effect of suplatast tosilate on antileukotriene non-responders with mild-to-moderate persistent asthma","volume":"58","author":"Wada","year":"2009","journal-title":"Allergol. Int."},{"key":"10.1016\/j.celrep.2025.116758_bib85","doi-asserted-by":"crossref","first-page":"5169","DOI":"10.1172\/JCI129761","article-title":"P2Y6 signaling in alveolar macrophages prevents leukotriene-dependent type 2 allergic lung inflammation","volume":"129","author":"Nagai","year":"2019","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.celrep.2025.116758_bib86","doi-asserted-by":"crossref","first-page":"41512","DOI":"10.1074\/jbc.M312568200","article-title":"Protein kinase A inhibits leukotriene synthesis by phosphorylation of 5-lipoxygenase on serine 523","volume":"279","author":"Luo","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.celrep.2025.116758_bib87","doi-asserted-by":"crossref","first-page":"5811","DOI":"10.4049\/jimmunol.168.11.5811","article-title":"Lipopolysaccharide-dependent prostaglandin E(2) production is regulated by the glutathione-dependent prostaglandin E(2) synthase gene induced by the Toll-like receptor 4\/MyD88\/NF-IL6 pathway","volume":"168","author":"Uematsu","year":"2002","journal-title":"J. Immunol."},{"key":"10.1016\/j.celrep.2025.116758_bib88","doi-asserted-by":"crossref","first-page":"1508","DOI":"10.1016\/j.cell.2024.02.006","article-title":"A mouse DRG genetic toolkit reveals morphological and physiological diversity of somatosensory neuron subtypes","volume":"187","author":"Qi","year":"2024","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2025.116758_bib89","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1016\/j.immuni.2011.09.015","article-title":"Cre-mediated cell ablation contests mast cell contribution in models of antibody- and T cell-mediated autoimmunity","volume":"35","author":"Feyerabend","year":"2011","journal-title":"Immunity"},{"key":"10.1016\/j.celrep.2025.116758_bib90","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1084\/jem.190.2.267","article-title":"T helper cell type 2 cytokine-mediated comitogenic responses and CCR3 expression during differentiation of human mast cells in vitro","volume":"190","author":"Ochi","year":"1999","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.celrep.2025.116758_bib91","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms10156","article-title":"The experimental power of FR900359 to study Gq-regulated biological processes","volume":"6","author":"Schrage","year":"2015","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2025.116758_bib92","article-title":"Genetic evidence that beta-arrestins are dispensable for the initiation of beta(2)-adrenergic receptor signaling to ERK","volume":"10","author":"O'Hayre","year":"2017","journal-title":"Sci. Signal."},{"key":"10.1016\/j.celrep.2025.116758_bib93","doi-asserted-by":"crossref","first-page":"5443","DOI":"10.1074\/jbc.M116.763854","article-title":"Conformational Profiling of the AT1 Angiotensin II Receptor Reflects Biased Agonism, G Protein Coupling, and Cellular Context","volume":"292","author":"Devost","year":"2017","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.celrep.2025.116758_bib94","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1124\/mol.116.106419","article-title":"Purinergic Receptor Transactivation by the beta(2)-Adrenergic Receptor Increases Intracellular Ca(2+) in Nonexcitable Cells","volume":"91","author":"Stallaert","year":"2017","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.celrep.2025.116758_bib95","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1038\/s42003-023-04465-2","article-title":"Generation of Galphai knock-out HEK293 cells illuminates Galphai-coupling diversity of GPCRs","volume":"6","author":"Ono","year":"2023","journal-title":"Commun. Biol."},{"key":"10.1016\/j.celrep.2025.116758_bib96","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1038\/s41467-022-28056-7","article-title":"Heterotrimeric Gq proteins act as a switch for GRK5\/6 selectivity underlying beta-arrestin transducer bias","volume":"13","author":"Kawakami","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2025.116758_bib97","doi-asserted-by":"crossref","first-page":"1933","DOI":"10.1016\/j.cell.2019.04.044","article-title":"Illuminating G-Protein-Coupling Selectivity of GPCRs","volume":"177","author":"Inoue","year":"2019","journal-title":"Cell"}],"container-title":["Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S221112472501530X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S221112472501530X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T04:33:55Z","timestamp":1791261235000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S221112472501530X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":97,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["S221112472501530X"],"URL":"https:\/\/doi.org\/10.1016\/j.celrep.2025.116758","relation":{},"ISSN":["2211-1247"],"issn-type":[{"value":"2211-1247","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mast cell-specific CysLT2 receptor signaling inhibits cysteinyl leukotriene-dependent mast cell activation and type 2 allergic lung inflammation","name":"articletitle","label":"Article Title"},{"value":"Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.celrep.2025.116758","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"116758"}}