{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T04:36:33Z","timestamp":1793248593935,"version":"4.5.0"},"reference-count":82,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T00:00:00Z","timestamp":1764633600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004731","name":"Zhejiang Province Natural Science Foundation","doi-asserted-by":"publisher","award":["LR22H060001"],"award-info":[{"award-number":["LR22H060001"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020763","name":"National Key Project for Research on Transgenic Biology","doi-asserted-by":"publisher","award":["2023YFA0915000"],"award-info":[{"award-number":["2023YFA0915000"]}],"id":[{"id":"10.13039\/501100020763","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017529","name":"Major Scientific and Technological Project of Zhejiang Province","doi-asserted-by":"publisher","award":["2022PY071"],"award-info":[{"award-number":["2022PY071"]}],"id":[{"id":"10.13039\/501100017529","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018553","name":"Science and Technology Plan Project of Wenzhou Municipality","doi-asserted-by":"publisher","award":["ZY2022010"],"award-info":[{"award-number":["ZY2022010"]}],"id":[{"id":"10.13039\/501100018553","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82472488"],"award-info":[{"award-number":["82472488"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82470005"],"award-info":[{"award-number":["82470005"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82272522"],"award-info":[{"award-number":["82272522"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82272555"],"award-info":[{"award-number":["82272555"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82422044"],"award-info":[{"award-number":["82422044"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Reports"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.celrep.2025.116793","type":"journal-article","created":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T07:40:13Z","timestamp":1767598813000},"page":"116793","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"title":["METTL3 regulates \u03b1-KG-dependent mitophagy and apoptosis in nucleus pulposus cells through the MALAT1\/miR-23c\/IDH1 axis"],"prefix":"10.1016","volume":"45","author":[{"given":"Ouqiang","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxin","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shoutao","family":"Weng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiguang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keyu","family":"Tu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linjie","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qizhu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhihua","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morgan","family":"Jones","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinzhou","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenyu","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan Michael","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yangli","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuying","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aimin","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.celrep.2025.116793_bib1","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1016\/S0140-6736(20)30925-9","article-title":"Global burden of 369 diseases and injuries in 204 countries and territories, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019","volume":"396","year":"2020","journal-title":"Lancet"},{"key":"10.1016\/j.celrep.2025.116793_bib2","doi-asserted-by":"crossref","first-page":"e316","DOI":"10.1016\/S2665-9913(23)00098-X","article-title":"Global, regional, and national burden of low back pain, 1990-2020, its attributable risk factors, and projections to 2050: a systematic analysis of the Global Burden of Disease Study 2021","volume":"5","year":"2023","journal-title":"Lancet Rheumatol."},{"key":"10.1016\/j.celrep.2025.116793_bib3","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202102530","article-title":"Intervertebral Disc Degeneration: Biomaterials and Tissue Engineering Strategies toward Precision Medicine","volume":"11","author":"Mohd Isa","year":"2022","journal-title":"Adv. Healthc. Mater."},{"key":"10.1016\/j.celrep.2025.116793_bib4","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1111\/j.1469-7580.2012.01521.x","article-title":"Diversity of intervertebral disc cells: phenotype and function","volume":"221","author":"Pattappa","year":"2012","journal-title":"J. Anat."},{"key":"10.1016\/j.celrep.2025.116793_bib5","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/j.matbio.2018.02.025","article-title":"Glycosaminoglycan synthesis in the nucleus pulposus: Dysregulation and the pathogenesis of disc degeneration. Matrix biology","volume":"71\u201372","author":"Silagi","year":"2018","journal-title":"Matrix Biol."},{"key":"10.1016\/j.celrep.2025.116793_bib6","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1038\/s41413-020-00125-x","article-title":"Painful intervertebral disc degeneration and inflammation: from laboratory evidence to clinical interventions","volume":"9","author":"Lyu","year":"2021","journal-title":"Bone Res."},{"key":"10.1016\/j.celrep.2025.116793_bib7","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.jot.2023.10.004","article-title":"Exosomes from umbilical cord mesenchymal stem cells ameliorate intervertebral disc degeneration via repairing mitochondrial dysfunction","volume":"46","author":"Jia","year":"2024","journal-title":"J. Orthop. Translat."},{"key":"10.1016\/j.celrep.2025.116793_bib8","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202404275","article-title":"Hypoxia-Preconditioned BMSC-Derived Exosomes Induce Mitophagy via the BNIP3-ANAX2 Axis to Alleviate Intervertebral Disc Degeneration","volume":"11","author":"Jin","year":"2024","journal-title":"Adv. Sci."},{"key":"10.1016\/j.celrep.2025.116793_bib9","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1038\/s41467-022-28990-6","article-title":"WTAP-mediated m(6)A modification of lncRNA NORAD promotes intervertebral disc degeneration","volume":"13","author":"Li","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2025.116793_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2024.102323","article-title":"The role of oxidative stress in intervertebral disc degeneration: Mechanisms and therapeutic implications","volume":"98","author":"Chen","year":"2024","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.celrep.2025.116793_bib11","doi-asserted-by":"crossref","DOI":"10.1111\/cpr.13448","article-title":"Oxidative stress in intervertebral disc degeneration: Molecular mechanisms, pathogenesis and treatment","volume":"56","author":"Wang","year":"2023","journal-title":"Cell Prolif."},{"key":"10.1016\/j.celrep.2025.116793_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2020.101237","article-title":"Pleiotropic effects of alpha-ketoglutarate as a potential anti-ageing agent","volume":"66","author":"Bayliak","year":"2021","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.celrep.2025.116793_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.154075","article-title":"Osmundacetone modulates mitochondrial metabolism in non-small cell lung cancer cells by hijacking the glutamine\/glutamate\/\u03b1-KG metabolic axis","volume":"100","author":"Yang","year":"2022","journal-title":"Phytomedicine"},{"key":"10.1016\/j.celrep.2025.116793_bib14","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/S0945-053X(03)00006-4","article-title":"Prolyl 4-hydroxylases, the key enzymes of collagen biosynthesis. Matrix biology","volume":"22","author":"Myllyharju","year":"2003","journal-title":"Matrix Biol."},{"key":"10.1016\/j.celrep.2025.116793_bib15","doi-asserted-by":"crossref","first-page":"11273","DOI":"10.1021\/acs.jafc.8b04470","article-title":"Prevention of Oxidative Stress by \u03b1-Ketoglutarate via Activation of CAR Signaling and Modulation of the Expression of Key Antioxidant-Associated Targets in Vivo and in Vitro","volume":"66","author":"He","year":"2018","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.celrep.2025.116793_bib16","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.cmet.2020.08.004","article-title":"Alpha-Ketoglutarate, an Endogenous Metabolite, Extends Lifespan and Compresses Morbidity in Aging Mice","volume":"32","author":"Asadi Shahmirzadi","year":"2020","journal-title":"Cell Metab."},{"key":"10.1016\/j.celrep.2025.116793_bib17","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/j.cmet.2016.07.002","article-title":"\u03b1-Ketoglutarate Accelerates the Initial Differentiation of Primed Human Pluripotent Stem Cells","volume":"24","author":"TeSlaa","year":"2016","journal-title":"Cell Metab."},{"key":"10.1016\/j.celrep.2025.116793_bib18","doi-asserted-by":"crossref","DOI":"10.1111\/acel.13059","article-title":"Dietary alpha-ketoglutarate promotes beige adipogenesis and prevents obesity in middle-aged mice","volume":"19","author":"Tian","year":"2020","journal-title":"Aging Cell"},{"key":"10.1016\/j.celrep.2025.116793_bib19","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1038\/s41593-018-0332-9","article-title":"Mitophagy inhibits amyloid-\u03b2 and tau pathology and reverses cognitive deficits in models of Alzheimer's disease","volume":"22","author":"Fang","year":"2019","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.celrep.2025.116793_bib20","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1038\/s43587-021-00098-4","article-title":"Autophagy in healthy aging and disease","volume":"1","author":"Aman","year":"2021","journal-title":"Nat. Aging"},{"key":"10.1016\/j.celrep.2025.116793_bib21","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1038\/s12276-021-00650-7","article-title":"Mitochondrial quality control in intervertebral disc degeneration","volume":"53","author":"Song","year":"2021","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.celrep.2025.116793_bib22","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1016\/j.neuron.2022.01.017","article-title":"The different autophagy degradation pathways and neurodegeneration","volume":"110","author":"Fleming","year":"2022","journal-title":"Neuron"},{"key":"10.1016\/j.celrep.2025.116793_bib23","doi-asserted-by":"crossref","first-page":"367","DOI":"10.14348\/molcells.2016.0039","article-title":"Incredible RNA: Dual Functions of Coding and Noncoding","volume":"39","author":"Nam","year":"2016","journal-title":"Mol. Cells"},{"key":"10.1016\/j.celrep.2025.116793_bib24","doi-asserted-by":"crossref","first-page":"2652","DOI":"10.1016\/j.jmb.2016.02.019","article-title":"Noncoding RNAs: Regulators of the Mammalian Transcription Machinery","volume":"428","author":"Eidem","year":"2016","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.celrep.2025.116793_bib25","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S0092-8674(04)00045-5","article-title":"MicroRNAs: genomics, biogenesis, mechanism, and function","volume":"116","author":"Bartel","year":"2004","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2025.116793_bib26","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202304722","article-title":"Hypoxic Preconditional Engineering Small Extracellular Vesicles Promoted Intervertebral Disc Regeneration by Activating Mir-7-5p\/NF-\u039ab\/Cxcl2 Axis","volume":"10","author":"Hu","year":"2023","journal-title":"Adv. Sci."},{"key":"10.1016\/j.celrep.2025.116793_bib27","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1186\/s13287-019-1458-8","article-title":"lncRNAs: function and mechanism in cartilage development, degeneration, and regeneration","volume":"10","author":"Zhu","year":"2019","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.celrep.2025.116793_bib28","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1016\/j.cell.2018.06.046","article-title":"SnapShot: Messenger RNA Modifications","volume":"174","author":"Davalos","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2025.116793_bib29","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/nrm.2016.132","article-title":"Post-transcriptional gene regulation by mRNA modifications","volume":"18","author":"Zhao","year":"2017","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.celrep.2025.116793_bib30","doi-asserted-by":"crossref","first-page":"11356","DOI":"10.1093\/nar\/gkx778","article-title":"N6-methyladenosine demethylase FTO targets pre-mRNAs and regulates alternative splicing and 3'-end processing","volume":"45","author":"Bartosovic","year":"2017","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.celrep.2025.116793_bib31","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1038\/s41580-019-0168-5","article-title":"Reading, writing and erasing mRNA methylation","volume":"20","author":"Zaccara","year":"2019","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.celrep.2025.116793_bib32","doi-asserted-by":"crossref","DOI":"10.1111\/cpr.13294","article-title":"Novel insights into the interaction between N6-methyladenosine methylation and noncoding RNAs in musculoskeletal disorders","volume":"55","author":"Han","year":"2022","journal-title":"Cell Prolif."},{"key":"10.1016\/j.celrep.2025.116793_bib33","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1038\/s41413-021-00183-9","article-title":"I\u03baB-\u03b6 signaling promotes chondrocyte inflammatory phenotype, senescence, and erosive joint pathology","volume":"10","author":"Arra","year":"2022","journal-title":"Bone Res."},{"key":"10.1016\/j.celrep.2025.116793_bib34","doi-asserted-by":"crossref","DOI":"10.1083\/jcb.202201159","article-title":"Paradoxical roles of caspase-3 in regulating cell survival, proliferation, and tumorigenesis","volume":"221","author":"Eskandari","year":"2022","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.celrep.2025.116793_bib35","doi-asserted-by":"crossref","first-page":"8885","DOI":"10.1021\/acsnano.3c12163","article-title":"Mitochondrial-Targeted Metal-Phenolic Nanoparticles to Attenuate Intervertebral Disc Degeneration: Alleviating Oxidative Stress and Mitochondrial Dysfunction","volume":"12","author":"Chen","year":"2024","journal-title":"ACS Nano"},{"key":"10.1016\/j.celrep.2025.116793_bib36","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1080\/15548627.2019.1656957","article-title":"USP33 deubiquitinates PRKN\/parkin and antagonizes its role in mitophagy","volume":"16","author":"Niu","year":"2020","journal-title":"Autophagy"},{"key":"10.1016\/j.celrep.2025.116793_bib37","doi-asserted-by":"crossref","first-page":"3987","DOI":"10.1172\/JCI74985","article-title":"Mitophagy-dependent necroptosis contributes to the pathogenesis of COPD","volume":"124","author":"Mizumura","year":"2014","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.celrep.2025.116793_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2023.102663","article-title":"The physiological metabolite \u03b1-ketoglutarate ameliorates osteoarthritis by regulating mitophagy and oxidative stress","volume":"62","author":"Liu","year":"2023","journal-title":"Redox Biol."},{"key":"10.1016\/j.celrep.2025.116793_bib39","doi-asserted-by":"crossref","first-page":"1438","DOI":"10.1016\/j.apsb.2022.12.019","article-title":"The regulatory mechanisms and inhibitors of isocitrate dehydrogenase 1 in cancer","volume":"13","author":"Liu","year":"2023","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.celrep.2025.116793_bib40","doi-asserted-by":"crossref","first-page":"7533","DOI":"10.1093\/nar\/gkp812","article-title":"Expanded RNA-binding activities of mammalian Argonaute 2","volume":"37","author":"Tan","year":"2009","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.celrep.2025.116793_bib41","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1016\/j.cell.2017.05.045","article-title":"Dynamic RNA Modifications in Gene Expression Regulation","volume":"169","author":"Roundtree","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2025.116793_bib42","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkw104","article-title":"SRAMP: prediction of mammalian N6-methyladenosine (m6A) sites based on sequence-derived features","volume":"44","author":"Zhou","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.celrep.2025.116793_bib43","doi-asserted-by":"crossref","first-page":"1346","DOI":"10.1126\/science.aau1646","article-title":"RNA modifications modulate gene expression during development","volume":"361","author":"Frye","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.celrep.2025.116793_bib44","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1038\/s41413-024-00373-1","article-title":"KMT2A regulates the autophagy-GATA4 axis through METTL3-mediated m(6)A modification of ATG4a to promote NPCs senescence and IVDD progression","volume":"12","author":"Wu","year":"2024","journal-title":"Bone Res."},{"key":"10.1016\/j.celrep.2025.116793_bib45","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abq0117","article-title":"Mitochondrial pyruvate supports lymphoma proliferation by fueling a glutamate pyruvate transaminase 2-dependent glutaminolysis pathway","volume":"8","author":"Wei","year":"2022","journal-title":"Sci. Adv."},{"key":"10.1016\/j.celrep.2025.116793_bib46","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.biochi.2022.09.009","article-title":"Mitochondrial peptide Mtln contributes to oxidative metabolism in mice","volume":"204","author":"Averina","year":"2023","journal-title":"Biochimie"},{"key":"10.1016\/j.celrep.2025.116793_bib47","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1186\/s10020-024-00887-8","article-title":"Dysregulated lipid metabolism and intervertebral disc degeneration: the important role of ox-LDL\/LOX-1 in endplate chondrocyte senescence and calcification","volume":"30","author":"Bing","year":"2024","journal-title":"Mol. Med."},{"key":"10.1016\/j.celrep.2025.116793_bib48","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1186\/s12951-024-02683-2","article-title":"Rescue of nucleus pulposus cells from an oxidative stress microenvironment via glutathione-derived carbon dots to alleviate intervertebral disc degeneration","volume":"22","author":"Bu","year":"2024","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.celrep.2025.116793_bib49","first-page":"28","article-title":"D-mannose alleviates intervertebral disc degeneration through glutamine metabolism","volume":"11","author":"Dong","year":"2024","journal-title":"Mil. Med. Res."},{"key":"10.1016\/j.celrep.2025.116793_bib50","article-title":"Aging, cell senescence, the pathogenesis and targeted therapies of intervertebral disc degeneration","volume":"14","author":"Xu","year":"2023","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.celrep.2025.116793_bib51","doi-asserted-by":"crossref","first-page":"6877","DOI":"10.1074\/jbc.M113.512269","article-title":"Modulation of ten-eleven translocation 1 (TET1), Isocitrate Dehydrogenase (IDH) expression, \u03b1-Ketoglutarate (\u03b1-KG), and DNA hydroxymethylation levels by interleukin-1\u03b2 in primary human chondrocytes","volume":"289","author":"Haseeb","year":"2014","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.celrep.2025.116793_bib52","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1007\/BF00231871","article-title":"Effect of high pH on the plasma membrane potential and conductance in Elodea densa","volume":"128","author":"Miedema","year":"1992","journal-title":"J. Membr. Biol."},{"key":"10.1016\/j.celrep.2025.116793_bib53","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1111\/j.1439-0396.2007.00725.x","article-title":"The absorption, tissue distribution and excretion of enteraly administered alpha-ketoglutarate in rats","volume":"92","author":"Filip","year":"2008","journal-title":"J. Anim. Physiol. Anim. Nutr."},{"key":"10.1016\/j.celrep.2025.116793_bib54","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.tem.2021.11.003","article-title":"Alpha-Ketoglutarate dietary supplementation to improve health in humans","volume":"33","author":"Gyanwali","year":"2022","journal-title":"Trends Endocrinol. Metab."},{"key":"10.1016\/j.celrep.2025.116793_bib55","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1038\/ni.3796","article-title":"\u03b1-ketoglutarate orchestrates macrophage activation through metabolic and epigenetic reprogramming","volume":"18","author":"Liu","year":"2017","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.celrep.2025.116793_bib56","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1038\/s41584-021-00713-z","article-title":"A new immunometabolic perspective of intervertebral disc degeneration","volume":"18","author":"Francisco","year":"2022","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.celrep.2025.116793_bib57","doi-asserted-by":"crossref","first-page":"3955","DOI":"10.1016\/j.ymthe.2024.09.022","article-title":"Therapeutic CRISPR epigenome editing of inflammatory receptors in the intervertebral disc","volume":"32","author":"Stover","year":"2024","journal-title":"Mol. Ther."},{"key":"10.1016\/j.celrep.2025.116793_bib58","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2023.101902","article-title":"Epigenetic modifications of inflammation in intervertebral disc degeneration","volume":"87","author":"Kang","year":"2023","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.celrep.2025.116793_bib59","article-title":"Enhanced Mitochondrial Targeting and Inhibition of Pyroptosis with Multifunctional Metallopolyphenol Nanoparticles in Intervertebral Disc Degeneration","volume":"20","author":"Zhou","year":"2024","journal-title":"Small"},{"key":"10.1016\/j.celrep.2025.116793_bib60","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2021.102088","article-title":"Alpha-ketoglutarate ameliorates pressure overload-induced chronic cardiac dysfunction in mice","volume":"46","author":"An","year":"2021","journal-title":"Redox Biol."},{"key":"10.1016\/j.celrep.2025.116793_bib61","doi-asserted-by":"crossref","DOI":"10.1111\/acel.14294","article-title":"\u03b2-Hydroxybutyrate enhances chondrocyte mitophagy and reduces cartilage degeneration in osteoarthritis via the HCAR2\/AMPK\/PINK1\/Parkin pathway","volume":"23","author":"Zhuang","year":"2024","journal-title":"Aging Cell"},{"key":"10.1016\/j.celrep.2025.116793_bib62","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1080\/15548627.2024.2395799","article-title":"Mir221- and Mir222-enriched adsc-exosomes mitigate PM exposure-exacerbated cardiac ischemia-reperfusion injury through the modulation of the BNIP3-MAP1LC3B-BBC3\/PUMA pathway","volume":"21","author":"Lee","year":"2024","journal-title":"Autophagy"},{"key":"10.1016\/j.celrep.2025.116793_bib63","doi-asserted-by":"crossref","first-page":"2164","DOI":"10.1080\/15548627.2024.2358736","article-title":"Poly-GP accumulation due to C9orf72 loss of function induces motor neuron apoptosis through autophagy and mitophagy defects","volume":"20","author":"de Calbiac","year":"2024","journal-title":"Autophagy"},{"key":"10.1016\/j.celrep.2025.116793_bib64","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.1000298","article-title":"PINK1 is selectively stabilized on impaired mitochondria to activate Parkin","volume":"8","author":"Narendra","year":"2010","journal-title":"PLoS Biol."},{"key":"10.1016\/j.celrep.2025.116793_bib65","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202300880","article-title":"Selenium Nanodots (SENDs) as Antioxidants and Antioxidant-Prodrugs to Rescue Islet \u03b2 Cells in Type 2 Diabetes Mellitus by Restoring Mitophagy and Alleviating Endoplasmic Reticulum Stress","volume":"10","author":"Huang","year":"2023","journal-title":"Adv. Sci."},{"key":"10.1016\/j.celrep.2025.116793_bib66","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1038\/nrd.2016.246","article-title":"MicroRNA therapeutics: towards a new era for the management of cancer and other diseases","volume":"16","author":"Rupaimoole","year":"2017","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.celrep.2025.116793_bib67","first-page":"107","article-title":"Engineered high-strength biohydrogel as a multifunctional platform to deliver nucleic acid for ameliorating intervertebral disc degeneration","volume":"25","author":"Chen","year":"2023","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.celrep.2025.116793_bib68","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1186\/s12951-024-02561-x","article-title":"Effective delivery of miR-150-5p with nucleus pulposus cell-specific nanoparticles attenuates intervertebral disc degeneration","volume":"22","author":"Jiang","year":"2024","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.celrep.2025.116793_bib69","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1038\/s42003-024-06055-2","article-title":"CircEYA3 aggravates intervertebral disc degeneration through the miR-196a-5p\/EBF1 axis and NF-\u03baB signaling","volume":"7","author":"Wang","year":"2024","journal-title":"Commun. Biol."},{"key":"10.1016\/j.celrep.2025.116793_bib70","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1038\/nature12986","article-title":"The multilayered complexity of ceRNA crosstalk and competition","volume":"505","author":"Tay","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2025.116793_bib71","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1016\/j.cell.2013.02.012","article-title":"Long noncoding RNAs: cellular address codes in development and disease","volume":"152","author":"Batista","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2025.116793_bib72","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1016\/j.omtn.2019.11.021","article-title":"lncRNA UCA1 Functions as a ceRNA to Promote Prostate Cancer Progression via Sponging miR143","volume":"19","author":"Yu","year":"2020","journal-title":"Mol. Ther. Nucleic Acids"},{"key":"10.1016\/j.celrep.2025.116793_bib73","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1038\/nature12730","article-title":"N6-methyladenosine-dependent regulation of messenger RNA stability","volume":"505","author":"Wang","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2025.116793_bib74","doi-asserted-by":"crossref","DOI":"10.1002\/ctm2.70039","article-title":"N(6)-methyladenosine-mediated upregulation of LNCAROD confers radioresistance in esophageal squamous cell carcinoma through stabilizing PARP1","volume":"14","author":"Shi","year":"2024","journal-title":"Clin. Transl. Med."},{"key":"10.1016\/j.celrep.2025.116793_bib75","doi-asserted-by":"crossref","DOI":"10.1002\/ctm2.1801","article-title":"A novel peptide encoded by circ-SLC9A6 promotes lipid dyshomeostasis through the regulation of H4K16ac-mediated CD36 transcription in NAFLD","volume":"14","author":"Wang","year":"2024","journal-title":"Clin. Transl. Med."},{"key":"10.1016\/j.celrep.2025.116793_bib76","doi-asserted-by":"crossref","first-page":"1957","DOI":"10.1038\/s41418-023-01190-5","article-title":"N6-methyladenosine hypomethylation of circGPATCH2L regulates DNA damage and apoptosis through TRIM28 in intervertebral disc degeneration","volume":"30","author":"Chen","year":"2023","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.celrep.2025.116793_bib77","first-page":"10611","article-title":"The role of lncRNA MALAT1 in intervertebral degenerative disc disease","volume":"10","author":"Zhang","year":"2017","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"10.1016\/j.celrep.2025.116793_bib78","doi-asserted-by":"crossref","first-page":"4839","DOI":"10.1021\/acsbiomaterials.3c01944","article-title":"Unveiling the Therapeutic Potential of hUCMSC-Derived EVs in Intervertebral Disc Degeneration through MALAT1\/miR-138-5p\/SLC7A11 Coexpression Regulation","volume":"10","author":"Yu","year":"2024","journal-title":"ACS Biomater. Sci. Eng."},{"key":"10.1016\/j.celrep.2025.116793_bib79","doi-asserted-by":"crossref","first-page":"1821","DOI":"10.1080\/15548627.2022.2162245","article-title":"The mitophagy receptor BNIP3 is critical for the regulation of metabolic homeostasis and mitochondrial function in the nucleus pulposus cells of the intervertebral disc","volume":"19","author":"Madhu","year":"2023","journal-title":"Autophagy"},{"key":"10.1016\/j.celrep.2025.116793_bib80","doi-asserted-by":"crossref","DOI":"10.1002\/jsp2.70089","article-title":"Mechanistic Interactions Driving Nucleus Pulposus Cell Senescence in Intervertebral Disc Degeneration: A Multi-Axial Perspective of Mechanical, Immune, and Metabolic Pathways","volume":"8","author":"Yang","year":"2025","journal-title":"JOR Spine"},{"key":"10.1016\/j.celrep.2025.116793_bib82","doi-asserted-by":"crossref","first-page":"5051","DOI":"10.1038\/s41467-018-07360-1","article-title":"Preclinical development of a microRNA-based therapy for intervertebral disc degeneration.","volume":"9","author":"Ji","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2025.116793_bib81","doi-asserted-by":"crossref","first-page":"1925","DOI":"10.1097\/BRS.0b013e31817c64a9","article-title":"A simple disc degeneration model induced by percutaneous needle puncture in the rat tail","volume":"33","author":"Han","year":"2008","journal-title":"Spine"}],"container-title":["Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124725015657?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124725015657?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T04:26:09Z","timestamp":1791260769000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211124725015657"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":82,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["S2211124725015657"],"URL":"https:\/\/doi.org\/10.1016\/j.celrep.2025.116793","relation":{},"ISSN":["2211-1247"],"issn-type":[{"value":"2211-1247","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"METTL3 regulates \u03b1-KG-dependent mitophagy and apoptosis in nucleus pulposus cells through the MALAT1\/miR-23c\/IDH1 axis","name":"articletitle","label":"Article Title"},{"value":"Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.celrep.2025.116793","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"116793"}}