{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T17:43:57Z","timestamp":1792172637893,"version":"4.4.0"},"reference-count":71,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T00:00:00Z","timestamp":1764806400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["R01 DK124897"],"award-info":[{"award-number":["R01 DK124897"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Reports"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.celrep.2025.116811","type":"journal-article","created":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T10:24:12Z","timestamp":1768213452000},"page":"116811","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":79,"title":["PDX1 phosphorylation at S61 by mTORC1 links nutrient signaling to \u03b2 cell function and metabolic disease"],"prefix":"10.1016","volume":"45","author":[{"given":"Jialin","family":"Fan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinling","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tinghan","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen K.","family":"Burley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X.F. Steven","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.celrep.2025.116811_bib1","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1038\/s41574-020-0355-7","article-title":"Pancreatic \u03b2-cells in type 1 and type 2 diabetes mellitus: different pathways to failure","volume":"16","author":"Eizirik","year":"2020","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.celrep.2025.116811_bib2","doi-asserted-by":"crossref","first-page":"2133","DOI":"10.1152\/physrev.00063.2017","article-title":"Mechanisms of Insulin Action and Insulin Resistance","volume":"98","author":"Petersen","year":"2018","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.celrep.2025.116811_bib3","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1002\/dmrr.2322","article-title":"Basal state hyperinsulinemia in healthy normoglycemic adults heralds dysglycemia after more than two decades of follow up","volume":"28","author":"Dankner","year":"2012","journal-title":"Diabetes. Metab. Res. Rev."},{"key":"10.1016\/j.celrep.2025.116811_bib4","doi-asserted-by":"crossref","first-page":"R173","DOI":"10.1530\/JOE-16-0449","article-title":"A causal role for hyperinsulinemia in obesity","volume":"232","author":"Templeman","year":"2017","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.celrep.2025.116811_bib5","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1038\/nm.4350","article-title":"Insulin action and resistance in obesity and type 2 diabetes","volume":"23","author":"Czech","year":"2017","journal-title":"Nat. Med."},{"key":"10.1016\/j.celrep.2025.116811_bib6","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22157797","article-title":"Hyperinsulinemia and Its Pivotal Role in Aging, Obesity, Type 2 Diabetes, Cardiovascular Disease and Cancer","volume":"22","author":"Janssen","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.celrep.2025.116811_bib7","doi-asserted-by":"crossref","first-page":"285","DOI":"10.4093\/dmj.2020.0250","article-title":"Hyperinsulinemia in Obesity, Inflammation, and Cancer","volume":"45","author":"Zhang","year":"2021","journal-title":"Diabetes Metab. J."},{"key":"10.1016\/j.celrep.2025.116811_bib8","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/S0002-9343(99)00271-5","article-title":"Association of nonalcoholic fatty liver disease with insulin resistance","volume":"107","author":"Marchesini","year":"1999","journal-title":"Am. J. Med."},{"key":"10.1016\/j.celrep.2025.116811_bib9","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.amjmed.2010.08.012","article-title":"Hyperinsulinemia and the Development of Nonalcoholic Fatty Liver Disease in Nondiabetic Adults","volume":"124","author":"Rhee","year":"2011","journal-title":"Am. J. Med."},{"key":"10.1016\/j.celrep.2025.116811_bib10","doi-asserted-by":"crossref","first-page":"1727","DOI":"10.1210\/js.2019-00065","article-title":"Hyperinsulinemia: An Early Indicator of Metabolic Dysfunction","volume":"3","author":"Thomas","year":"2019","journal-title":"J. Endocr. Soc."},{"key":"10.1016\/j.celrep.2025.116811_bib11","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1016\/j.cmet.2018.04.010","article-title":"Early Time-Restricted Feeding Improves Insulin Sensitivity, Blood Pressure, and Oxidative Stress Even without Weight Loss in Men with Prediabetes","volume":"27","author":"Sutton","year":"2018","journal-title":"Cell Metab."},{"key":"10.1016\/j.celrep.2025.116811_bib12","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/j.cmet.2018.07.003","article-title":"Remission of Human Type 2 Diabetes Requires Decrease in Liver and Pancreas Fat Content but Is Dependent upon Capacity for beta Cell Recovery","volume":"28","author":"Taylor","year":"2018","journal-title":"Cell Metab."},{"key":"10.1016\/j.celrep.2025.116811_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2022.102623","article-title":"Biophysical insights into glucose-dependent transcriptional regulation by PDX1","volume":"298","author":"Usher","year":"2022","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.celrep.2025.116811_bib14","doi-asserted-by":"crossref","DOI":"10.3389\/fmolb.2022.1091757","article-title":"PDX1 is the cornerstone of pancreatic \u03b2-cell functions and identity","volume":"9","author":"Ebrahim","year":"2022","journal-title":"Front. Mol. Biosci."},{"key":"10.1016\/j.celrep.2025.116811_bib15","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.molmet.2019.03.006","article-title":"Point mutations in the PDX1 transactivation domain impair human beta-cell development and function","volume":"24","author":"Wang","year":"2019","journal-title":"Mol. Metab."},{"key":"10.1016\/j.celrep.2025.116811_bib16","doi-asserted-by":"crossref","first-page":"R41","DOI":"10.1172\/JCI7469","article-title":"Defective mutations in the insulin promoter factor-1 (IPF-1) gene in late-onset type 2 diabetes mellitus","volume":"104","author":"Hani","year":"1999","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.celrep.2025.116811_bib17","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1016\/S0006-291X(02)00747-7","article-title":"Functional expression and analysis of the pancreatic transcription factor PDX-1 in yeast","volume":"295","author":"Ozcan","year":"2002","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.celrep.2025.116811_bib18","doi-asserted-by":"crossref","first-page":"214","DOI":"10.21037\/atm.2016.03.51","article-title":"PDX1 associated therapy in translational medicine","volume":"4","author":"Yu","year":"2016","journal-title":"Ann. Transl. Med."},{"key":"10.1016\/j.celrep.2025.116811_bib19","doi-asserted-by":"crossref","first-page":"1935","DOI":"10.1042\/BCJ20160822","article-title":"Amino acid homeostasis and signalling in mammalian cells and organisms","volume":"474","author":"Broer","year":"2017","journal-title":"Biochem. J."},{"key":"10.1016\/j.celrep.2025.116811_bib20","doi-asserted-by":"crossref","first-page":"2491","DOI":"10.1101\/gad.1228804","article-title":"A dynamic transcriptional network communicates growth potential to ribosome synthesis and critical cell size","volume":"18","author":"Jorgensen","year":"2004","journal-title":"Genes Dev."},{"key":"10.1016\/j.celrep.2025.116811_bib21","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1016\/j.ceb.2008.09.009","article-title":"Nutrient signals driving cell growth","volume":"20","author":"Dechant","year":"2008","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.celrep.2025.116811_bib22","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1146\/annurev.genet.41.110306.130206","article-title":"How Saccharomyces responds to nutrients","volume":"42","author":"Zaman","year":"2008","journal-title":"Annu. Rev. Genet."},{"key":"10.1016\/j.celrep.2025.116811_bib23","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1038\/s41556-018-0205-1","article-title":"mTOR as a central hub of nutrient signalling and cell growth","volume":"21","author":"Kim","year":"2019","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.celrep.2025.116811_bib24","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1038\/s41580-019-0199-y","article-title":"mTOR at the nexus of nutrition, growth, ageing and disease","volume":"21","author":"Liu","year":"2020","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.celrep.2025.116811_bib25","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.drudis.2006.12.008","article-title":"Targeting mammalian target of rapamycin (mTOR) for health and diseases","volume":"12","author":"Tsang","year":"2007","journal-title":"Drug Discov. Today"},{"key":"10.1016\/j.celrep.2025.116811_bib26","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/S1097-2765(02)00636-6","article-title":"Two TOR Complexes, Only One of which Is Rapamycin Sensitive, Have Distinct Roles in Cell Growth Control","volume":"10","author":"Loewith","year":"2002","journal-title":"Mol. Cell"},{"key":"10.1016\/j.celrep.2025.116811_bib27","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1016\/j.ceb.2005.09.009","article-title":"Growing roles for the mTOR pathway","volume":"17","author":"Sarbassov","year":"2005","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.celrep.2025.116811_bib28","doi-asserted-by":"crossref","first-page":"14484","DOI":"10.1074\/jbc.273.23.14484","article-title":"Amino Acid Sufficiency and mTOR Regulate p70 S6 Kinase and eIF-4E BP1 through a Common Effector Mechanism","volume":"273","author":"Hara","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.celrep.2025.116811_bib29","doi-asserted-by":"crossref","first-page":"2538","DOI":"10.1038\/s41467-020-15935-0","article-title":"Raptor determines beta-cell identity and plasticity independent of hyperglycemia in mice","volume":"11","author":"Yin","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2025.116811_bib30","doi-asserted-by":"crossref","first-page":"2091","DOI":"10.1083\/jcb.201701085","article-title":"mTOR controls ChREBP transcriptional activity and pancreatic beta cell survival under diabetic stress","volume":"216","author":"Chau","year":"2017","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.celrep.2025.116811_bib31","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms15755","article-title":"Raptor regulates functional maturation of murine beta cells","volume":"8","author":"Ni","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2025.116811_bib32","doi-asserted-by":"crossref","first-page":"1950","DOI":"10.2337\/db19-0166","article-title":"Dual Effect of Raptor on Neonatal beta-Cell Proliferation and Identity Maintenance","volume":"68","author":"Wang","year":"2019","journal-title":"Diabetes"},{"key":"10.1016\/j.celrep.2025.116811_bib33","doi-asserted-by":"crossref","first-page":"2996","DOI":"10.2337\/db13-0970","article-title":"Pancreatic beta-cell failure mediated by mTORC1 hyperactivity and autophagic impairment","volume":"63","author":"Bartolome","year":"2014","journal-title":"Diabetes"},{"key":"10.1016\/j.celrep.2025.116811_bib34","doi-asserted-by":"crossref","first-page":"601","DOI":"10.5483\/BMBRep.2017.50.12.206","article-title":"Upstream signalling of mTORC1 and its hyperactivation in type 2 diabetes (T2D)","volume":"50","author":"Ali","year":"2017","journal-title":"BMB Rep."},{"key":"10.1016\/j.celrep.2025.116811_bib35","doi-asserted-by":"crossref","first-page":"2971","DOI":"10.1128\/MCB.01695-07","article-title":"Biphasic response of pancreatic beta-cell mass to ablation of tuberous sclerosis complex 2 in mice","volume":"28","author":"Shigeyama","year":"2008","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.celrep.2025.116811_bib36","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1007\/s00125-016-4188-9","article-title":"Reciprocal regulation of mTOR complexes in pancreatic islets from humans with type 2 diabetes","volume":"60","author":"Yuan","year":"2017","journal-title":"Diabetologia"},{"key":"10.1016\/j.celrep.2025.116811_bib37","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.cmet.2017.11.004","article-title":"mTORC1 Signaling: A Double-Edged Sword in Diabetic beta Cells","volume":"27","author":"Ardestani","year":"2018","journal-title":"Cell Metab."},{"key":"10.1016\/j.celrep.2025.116811_bib38","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1126\/science.aaa4570","article-title":"Making sense of amino acid sensing","volume":"347","author":"Abraham","year":"2015","journal-title":"Science"},{"key":"10.1016\/j.celrep.2025.116811_bib39","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/j.ccell.2014.10.011","article-title":"mTORC1 gRABs the Golgi","volume":"26","author":"Sanchez-Gurmaches","year":"2014","journal-title":"Cancer Cell"},{"key":"10.1016\/j.celrep.2025.116811_bib40","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1016\/j.ccell.2014.09.008","article-title":"Rab1A Is an mTORC1 Activator and a Colorectal Oncogene","volume":"26","author":"Thomas","year":"2014","journal-title":"Cancer Cell"},{"key":"10.1016\/j.celrep.2025.116811_bib41","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2021.108830","article-title":"Amino acids-Rab1A-mTORC1 signaling controls whole-body glucose homeostasis","volume":"34","author":"Zhang","year":"2021","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2025.116811_bib42","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejcb.2022.151240","article-title":"Amino acids control blood glucose levels through mTOR signaling","volume":"101","author":"Fan","year":"2022","journal-title":"Eur. J. Cell Biol."},{"key":"10.1016\/j.celrep.2025.116811_bib43","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1093\/nar\/gkh156","article-title":"Role of intrinsic DNA binding specificity in defining target genes of the mammalian transcription factor PDX1","volume":"32","author":"Liberzon","year":"2004","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.celrep.2025.116811_bib44","doi-asserted-by":"crossref","first-page":"1814","DOI":"10.1016\/j.cell.2022.04.013","article-title":"mTOR substrate phosphorylation in growth control","volume":"185","author":"Battaglioni","year":"2022","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2025.116811_bib45","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1126\/science.1199498","article-title":"The mTOR-regulated phosphoproteome reveals a mechanism of mTORC1-mediated inhibition of growth factor signaling","volume":"332","author":"Hsu","year":"2011","journal-title":"Science"},{"key":"10.1016\/j.celrep.2025.116811_bib46","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0035233","article-title":"Pdx1 is post-translationally modified in vivo and serine 61 is the principal site of phosphorylation","volume":"7","author":"Frogne","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.celrep.2025.116811_bib47","doi-asserted-by":"crossref","DOI":"10.1172\/JCI142244","article-title":"Monogenic diabetes: a gateway to precision medicine in diabetes","volume":"131","author":"Zhang","year":"2021","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.celrep.2025.116811_bib48","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.mce.2012.07.003","article-title":"Human Kr\u00fcppel-like factor 11 differentially regulates human insulin promoter activity in \u03b2-cells and non-\u03b2-cells via p300 and PDX1 through the regulatory sites A3 and CACCC box","volume":"363","author":"Perakakis","year":"2012","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.celrep.2025.116811_bib49","doi-asserted-by":"crossref","DOI":"10.3390\/nu15122749","article-title":"Global Impacts of Western Diet and Its Effects on Metabolism and Health: A Narrative Review","volume":"15","author":"Clemente-Su\u00e1rez","year":"2023","journal-title":"Nutrients"},{"key":"10.1016\/j.celrep.2025.116811_bib50","doi-asserted-by":"crossref","first-page":"3406","DOI":"10.1074\/jbc.M109.006734","article-title":"Glucose Regulates Steady-state Levels of PDX1 via the Reciprocal Actions of GSK3 and AKT Kinases","volume":"285","author":"Humphrey","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.celrep.2025.116811_bib51","doi-asserted-by":"crossref","first-page":"1422","DOI":"10.1016\/j.cmet.2019.02.012","article-title":"Phosphoproteomics Reveals the GSK3-PDX1 Axis as a Key Pathogenic Signaling Node in Diabetic Islets","volume":"29","author":"Sacco","year":"2019","journal-title":"Cell Metab."},{"key":"10.1016\/j.celrep.2025.116811_bib52","doi-asserted-by":"crossref","first-page":"32969","DOI":"10.1074\/jbc.M301198200","article-title":"Regulation of Insulin Gene Transcription by ERK1 and ERK2 in Pancreatic \u03b2 Cells","volume":"278","author":"Khoo","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.celrep.2025.116811_bib53","doi-asserted-by":"crossref","first-page":"3987","DOI":"10.1128\/MCB.17.7.3987","article-title":"Functional characterization of the transactivation properties of the PDX-1 homeodomain protein","volume":"17","author":"Peshavaria","year":"1997","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.celrep.2025.116811_bib54","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.cmet.2009.02.002","article-title":"A branched-chain amino acid-related metabolic signature that differentiates obese and lean humans and contributes to insulin resistance","volume":"9","author":"Newgard","year":"2009","journal-title":"Cell Metab."},{"key":"10.1016\/j.celrep.2025.116811_bib55","doi-asserted-by":"crossref","first-page":"2399","DOI":"10.1210\/jc.2003-030087","article-title":"Insulin resistance\/compensatory hyperinsulinemia, essential hypertension, and cardiovascular disease","volume":"88","author":"Reaven","year":"2003","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.celrep.2025.116811_bib56","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1038\/nrendo.2017.80","article-title":"Regulation of hepatic glucose metabolism in health and disease","volume":"13","author":"Petersen","year":"2017","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.celrep.2025.116811_bib57","doi-asserted-by":"crossref","first-page":"8164","DOI":"10.1074\/jbc.M800336200","article-title":"Pdx1 and BETA2\/NeuroD1 participate in a transcriptional complex that mediates short-range DNA looping at the insulin gene","volume":"283","author":"Babu","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.celrep.2025.116811_bib58","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1038\/nbt.1754","article-title":"Integrative genomics viewer","volume":"29","author":"Robinson","year":"2011","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.celrep.2025.116811_bib59","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1016\/j.ccell.2014.09.008","article-title":"Rab1A is an mTORC1 activator and a colorectal oncogene","volume":"26","author":"Thomas","year":"2014","journal-title":"Cancer Cell"},{"key":"10.1016\/j.celrep.2025.116811_bib60","article-title":"Hematoxylin and eosin staining of tissue and cell sections","volume":"2008","author":"Fischer","year":"2008","journal-title":"CSH Protoc"},{"key":"10.1016\/j.celrep.2025.116811_bib61","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.cmet.2009.08.008","article-title":"Loss of Lkb1 in adult beta cells increases beta cell mass and enhances glucose tolerance in mice","volume":"10","author":"Fu","year":"2009","journal-title":"Cell Metab."},{"key":"10.1016\/j.celrep.2025.116811_bib62","doi-asserted-by":"crossref","DOI":"10.3791\/57048","article-title":"A Simple High Efficiency Protocol for Pancreatic Islet Isolation from Mice","author":"Villarreal","year":"2019","journal-title":"J. Vis. Exp."},{"key":"10.1016\/j.celrep.2025.116811_bib63","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1038\/nprot.2009.150","article-title":"A protocol for islet isolation from mouse pancreas","volume":"4","author":"Li","year":"2009","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.celrep.2025.116811_bib64","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1242\/dmm.006239","article-title":"Standard operating procedures for describing and performing metabolic tests of glucose homeostasis in mice","volume":"3","author":"Ayala","year":"2010","journal-title":"Dis. Model. Mech."},{"key":"10.1016\/j.celrep.2025.116811_bib65","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1007\/978-1-61779-430-8_27","article-title":"A mouse model of diet-induced obesity and insulin resistance","volume":"821","author":"Wang","year":"2012","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.celrep.2025.116811_bib66","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0294236","article-title":"SRplot: A free online platform for data visualization and graphing","volume":"18","author":"Tang","year":"2023","journal-title":"PLoS One"},{"key":"10.1016\/j.celrep.2025.116811_bib67","doi-asserted-by":"crossref","first-page":"1754","DOI":"10.1093\/bioinformatics\/btp324","article-title":"Fast and accurate short read alignment with Burrows-Wheeler transform","volume":"25","author":"Li","year":"2009","journal-title":"Bioinformatics"},{"key":"10.1016\/j.celrep.2025.116811_bib68","doi-asserted-by":"crossref","first-page":"2503","DOI":"10.1093\/bioinformatics\/btu314","article-title":"SAMBLASTER: fast duplicate marking and structural variant read extraction","volume":"30","author":"Faust","year":"2014","journal-title":"Bioinformatics"},{"key":"10.1016\/j.celrep.2025.116811_bib69","doi-asserted-by":"crossref","DOI":"10.1186\/gb-2008-9-9-r137","article-title":"Model-based analysis of ChIP-Seq (MACS)","volume":"9","author":"Zhang","year":"2008","journal-title":"Genome Biol."},{"key":"10.1016\/j.celrep.2025.116811_bib70","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1093\/bib\/bbs017","article-title":"Integrative Genomics Viewer (IGV): high-performance genomics data visualization and exploration","volume":"14","author":"Thorvaldsdottir","year":"2013","journal-title":"Brief Bioinform"},{"key":"10.1016\/j.celrep.2025.116811_bib71","first-page":"28","article-title":"Fitting a mixture model by expectation maximization to discover motifs in biopolymers","volume":"2","author":"Bailey","year":"1994","journal-title":"Proc. Int. Conf. Intell. Syst. Mol. Biol."}],"container-title":["Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124725015839?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124725015839?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T04:34:38Z","timestamp":1791261278000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211124725015839"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":71,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["S2211124725015839"],"URL":"https:\/\/doi.org\/10.1016\/j.celrep.2025.116811","relation":{},"ISSN":["2211-1247"],"issn-type":[{"value":"2211-1247","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"PDX1 phosphorylation at S61 by mTORC1 links nutrient signaling to \u03b2 cell function and metabolic disease","name":"articletitle","label":"Article Title"},{"value":"Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.celrep.2025.116811","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"116811"}}