{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T05:50:50Z","timestamp":1791265850902,"version":"4.1.0"},"reference-count":49,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T00:00:00Z","timestamp":1765497600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100006691","name":"Harvard Medical School","doi-asserted-by":"publisher","award":["SC173"],"award-info":[{"award-number":["SC173"]}],"id":[{"id":"10.13039\/100006691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006691","name":"Harvard Medical School","doi-asserted-by":"publisher","award":["SC128"],"award-info":[{"award-number":["SC128"]}],"id":[{"id":"10.13039\/100006691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000297","name":"FRAXA Research Foundation","doi-asserted-by":"publisher","award":["MH094681"],"award-info":[{"award-number":["MH094681"]}],"id":[{"id":"10.13039\/100000297","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["R35GM149216"],"award-info":[{"award-number":["R35GM149216"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R01NS132935"],"award-info":[{"award-number":["R01NS132935"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011353","name":"Center for Clinical and Translational Science, University of Massachusetts","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011353","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007920","name":"University of Massachusetts Medical School","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007920","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007270","name":"University of Michigan","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007270","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["MH094681"],"award-info":[{"award-number":["MH094681"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["R21MH134127"],"award-info":[{"award-number":["R21MH134127"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008005","name":"Yonsei University College of Medicine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008005","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005294","name":"Massachusetts General Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005294","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Reports"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.celrep.2025.116857","type":"journal-article","created":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T20:17:42Z","timestamp":1768853862000},"page":"116857","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Metabolic reprogramming during human neuron differentiation indicates glutaminase as a key determinant in Fragile X syndrome"],"prefix":"10.1016","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0691-9566","authenticated-orcid":false,"given":"Sneha","family":"Shah","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Barnes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Botao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tenzin","family":"Tseyang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thang","family":"Do","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jodi L.","family":"Bubenik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suna","family":"Jung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mina N.","family":"Anadolu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria P.","family":"Ivshina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ver\u00f3nica","family":"Mart\u00ednez-Cerde\u00f1o","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Berry-Kravis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurice S.","family":"Swanson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica B.","family":"Spinelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel D.","family":"Richter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.celrep.2025.116857_bib1","doi-asserted-by":"crossref","first-page":"1474","DOI":"10.15252\/embj.201695810","article-title":"Brain metabolism in health, aging, and neurodegeneration","volume":"36","author":"Camandola","year":"2017","journal-title":"EMBO J."},{"key":"10.1016\/j.celrep.2025.116857_bib2","doi-asserted-by":"crossref","first-page":"213","DOI":"10.3389\/fnins.2020.00213","article-title":"Neurodegenerative Diseases \u2013 Is Metabolic Deficiency the Root Cause?","volume":"14","author":"Muddapu","year":"2020","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.celrep.2025.116857_bib3","doi-asserted-by":"crossref","first-page":"3988","DOI":"10.1016\/j.neuron.2023.09.014","article-title":"Species-specific FMRP regulation of RACK1 is critical for prenatal cortical development","volume":"111","author":"Shen","year":"2023","journal-title":"Neuron"},{"key":"10.1016\/j.celrep.2025.116857_bib4","doi-asserted-by":"crossref","first-page":"3988","DOI":"10.1016\/j.neuron.2023.09.014","article-title":"Species-specific FMRP Regulation of RACK1 Is Critical for Prenatal Cortical Development","volume":"111","author":"Shen","year":"2024","journal-title":"Neuron"},{"key":"10.1016\/j.celrep.2025.116857_bib5","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/j.devcel.2023.03.002","article-title":"Deregulation of ER-mitochondria contact formation and mitochondrial calcium homeostasis mediated by VDAC in fragile X syndrome","volume":"58","author":"Geng","year":"2023","journal-title":"Dev. Cell"},{"key":"10.1016\/j.celrep.2025.116857_bib6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fcell.2021.702020","article-title":"Mitochondrial Structure and Polarity in Dendrites and the Axon Initial Segment Are Regulated by Homeostatic Plasticity and Dysregulated in Fragile X Syndrome","volume":"9","author":"B\u00fclow","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.celrep.2025.116857_bib7","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1038\/s41593-019-0338-y","article-title":"Reduced mitochondrial fusion and Huntingtin levels contribute to impaired dendritic maturation and behavioral deficits in Fmr1 mutant mice","volume":"22","author":"Shen","year":"2019","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.celrep.2025.116857_bib8","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1016\/j.cell.2020.07.008","article-title":"ATP Synthase c-Subunit Leak Causes Aberrant Cellular Metabolism in Fragile X Syndrome","volume":"182","author":"Licznerski","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2025.116857_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuint.2021.105036","article-title":"Astrocyte-mediated disruption of ROS homeostasis in Fragile X mouse model","volume":"146","author":"Vandenberg","year":"2021","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.celrep.2025.116857_bib10","doi-asserted-by":"crossref","first-page":"17065","DOI":"10.1038\/nrdp.2017.65","article-title":"Fragile X syndrome","volume":"3","author":"Hagerman","year":"2017","journal-title":"Nat. Rev. Dis. Primers"},{"key":"10.1016\/j.celrep.2025.116857_bib11","doi-asserted-by":"crossref","first-page":"6344","DOI":"10.1093\/nar\/gky267","article-title":"HITS-CLIP in various brain areas reveals new targets and new modalities of RNA binding by fragile X mental retardation protein","volume":"46","author":"Maurin","year":"2018","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.celrep.2025.116857_bib12","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.cell.2011.06.013","article-title":"FMRP stalls ribosomal translocation on mRNAs linked to synaptic function and autism","volume":"146","author":"Darnell","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2025.116857_bib13","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1016\/j.neuron.2007.12.001","article-title":"Correction of Fragile X Syndrome in Mice","volume":"56","author":"D\u00f6len","year":"2007","journal-title":"Neuron"},{"key":"10.1016\/j.celrep.2025.116857_bib14","doi-asserted-by":"crossref","first-page":"e25","DOI":"10.1093\/nar\/gky1292","article-title":"Optimization of ribosome profiling using low-input brain tissue from fragile X syndrome model mice","volume":"47","author":"Liu","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.celrep.2025.116857_bib15","doi-asserted-by":"crossref","first-page":"4459","DOI":"10.1016\/j.celrep.2020.02.076","article-title":"FMRP Control of Ribosome Translocation Promotes Chromatin Modifications and Alternative Splicing of Neuronal Genes Linked to Autism","volume":"30","author":"Shah","year":"2020","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2025.116857_bib16","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1126\/science.aas9963","article-title":"Fragile X mental retardation 1 gene enhances the translation of large autism-related proteins","volume":"361","author":"Greenblatt","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.celrep.2025.116857_bib17","doi-asserted-by":"crossref","first-page":"e3002417","DOI":"10.1371\/journal.pbio.3002417","article-title":"FMRP deficiency leads to multifactorial dysregulation of splicing and mislocalization of MBNL1 to the cytoplasm","volume":"21","author":"Jung","year":"2023","journal-title":"PLoS Biol."},{"key":"10.1016\/j.celrep.2025.116857_bib18","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1016\/j.cell.2017.07.033","article-title":"Excess Translation of Epigenetic Regulators Contributes to Fragile X Syndrome and Is Alleviated by Brd4 Inhibition","volume":"170","author":"Korb","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2025.116857_bib19","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/j.tins.2004.04.009","article-title":"The mGluR theory of fragile X mental retardation","volume":"27","author":"Bear","year":"2004","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.celrep.2025.116857_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2023.112901","article-title":"Cell-type-specific disruption of cortico-striatal circuitry drives repetitive patterns of behavior in fragile X syndrome model mice","volume":"42","author":"Longo","year":"2023","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2025.116857_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2020.104978","article-title":"Regional rates of brain protein synthesis are unaltered in dexmedetomidine sedated young men with fragile X syndrome: A L-[1-11C]leucine PET study","volume":"143","author":"Schmidt","year":"2020","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.celrep.2025.116857_bib22","doi-asserted-by":"crossref","first-page":"1666","DOI":"10.1177\/0271678X221090997","article-title":"Decreased rates of cerebral protein synthesis in conscious young adults with fragile X syndrome demonstrated by L-[1-11C]leucine PET","volume":"42","author":"Schmidt","year":"2022","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.celrep.2025.116857_bib23","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1038\/s41583-021-00432-0","article-title":"The molecular biology of FMRP: new insights into fragile X syndrome","volume":"22","author":"Richter","year":"2021","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.celrep.2025.116857_bib24","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1038\/nrd.2017.221","article-title":"Drug development for neurodevelopmental disorders: Lessons learned from fragile X syndrome","volume":"17","author":"Berry-Kravis","year":"2018","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.celrep.2025.116857_bib25","doi-asserted-by":"crossref","first-page":"2061","DOI":"10.1038\/s41556-024-01544-2","article-title":"FMRP regulates MFF translation to locally direct mitochondrial fission in neurons","volume":"26","author":"Fenton","year":"2024","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.celrep.2025.116857_bib26","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2302534120","article-title":"Antisense oligonucleotide rescue of CGG expansion\u2013dependent FMR1 mis-splicing in fragile X syndrome restores FMRP","volume":"120","author":"Shah","year":"2023","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2025.116857_bib27","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2300052120","article-title":"Glial dysregulation in the human brain in fragile X-associated tremor\/ataxia syndrome","volume":"120","author":"Dias","year":"2023","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2025.116857_bib28","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.celrep.2015.08.084","article-title":"Reversion of FMR1 Methylation and Silencing by Editing the Triplet Repeats in Fragile X iPSC-Derived Neurons","volume":"13","author":"Park","year":"2015","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2025.116857_bib29","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0026203","article-title":"Epigenetic characterization of the FMR1 gene and aberrant neurodevelopment in human induced pluripotent stem cell models of fragile X syndrome","volume":"6","author":"Sheridan","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.celrep.2025.116857_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2021.108991","article-title":"Cell-type-specific profiling of human cellular models of fragile X syndrome reveal PI3K-dependent defects in translation and neurogenesis","volume":"35","author":"Raj","year":"2021","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2025.116857_bib31","doi-asserted-by":"crossref","first-page":"e0165499","DOI":"10.1371\/journal.pone.0165499","article-title":"Reactivation of FMR1 by CRISPR\/Cas9-mediated deletion of the expanded CGG-repeat of the fragile X chromosome","volume":"11","author":"Xie","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.celrep.2025.116857_bib32","article-title":"Elevated levels of FMRP-target MAP1B impair human and mouse neuronal development and mouse social behaviors via autophagy pathway","volume":"14","author":"Guo","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2025.116857_bib33","doi-asserted-by":"crossref","first-page":"E9707","DOI":"10.1073\/pnas.1808247115","article-title":"Activation of autophagy rescues synaptic and cognitive deficits in fragile X mice","volume":"115","author":"Yan","year":"2018","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2025.116857_bib34","doi-asserted-by":"crossref","first-page":"1502","DOI":"10.1038\/cdd.2016.36","article-title":"Metabolic reprogramming during neuronal differentiation","volume":"23","author":"Agostini","year":"2016","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.celrep.2025.116857_bib35","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1016\/j.neuron.2011.02.002","article-title":"Interplay between VGLUT isoforms and endophilin A1 regulates neurotransmitter release and short-term plasticity","volume":"69","author":"Weston","year":"2011","journal-title":"Neuron"},{"key":"10.1016\/j.celrep.2025.116857_bib36","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1007\/s00439-019-02104-7","article-title":"Altered mitochondrial function in cells carrying a premutation or unmethylated full mutation of the FMR1 gene","volume":"139","author":"Nobile","year":"2020","journal-title":"Hum. Genet."},{"key":"10.1016\/j.celrep.2025.116857_bib37","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1002\/ajmg.a.36207","article-title":"Neurochemical evaluation of brain function with 1H magnetic resonance spectroscopy in patients with fragile X syndrome","volume":"164","author":"Utine","year":"2014","journal-title":"Am. J. Med. Genet."},{"key":"10.1016\/j.celrep.2025.116857_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2022.105881","article-title":"Multimodal assessment of the GABA system in patients with fragile-X syndrome and neurofibromatosis of type 1","volume":"174","author":"Lacroix","year":"2022","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.celrep.2025.116857_bib39","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/1866-1955-5-20","article-title":"Aberrant basal ganglia metabolism in fragile X syndrome: a magnetic resonance spectroscopy study","volume":"5","author":"Bruno","year":"2013","journal-title":"J. Neurodev. Disord."},{"key":"10.1016\/j.celrep.2025.116857_bib40","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1002\/ajmg.a.32697","article-title":"Cholinergic Dysfunction in Fragile X Syndrome and Potential Intervention","volume":"149A","author":"Kesler","year":"2009","journal-title":"Am. J. Med. Genet."},{"key":"10.1016\/j.celrep.2025.116857_bib41","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1016\/j.cell.2016.11.013","article-title":"Impaired Amino Acid Transport at the Blood Brain Barrier Is a Cause of Autism Spectrum Disorder","volume":"167","author":"T\u0103rlungeanu","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2025.116857_bib42","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/braincomms\/fcaa170","article-title":"Current knowledge of SLC6A1-related neurodevelopmental disorders","volume":"2","author":"Goodspeed","year":"2020","journal-title":"Brain Commun"},{"key":"10.1016\/j.celrep.2025.116857_bib43","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1038\/s41593-019-0338-y","article-title":"Reduced mitochondrial fusion and Huntingtin levels contribute to impaired dendritic maturation and behavioral deficits in Fmr1-mutant mice","volume":"22","author":"Shen","year":"2019","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.celrep.2025.116857_bib44","first-page":"1871","article-title":"Vesicular Glutamate Transporters 1 and 2 Target to Functionally Distinct Synaptic Release Sites","volume":"124","author":"Fremeau","year":"2012","journal-title":"Science"},{"key":"10.1016\/j.celrep.2025.116857_bib45","article-title":"Alone and Together: Current Approaches to Targeting Glutaminase Enzymes As Part of Anti-Cancer Therapies","volume":"4","author":"Nguyen","year":"2023","journal-title":"Future Drug Discov."},{"key":"10.1016\/j.celrep.2025.116857_bib46","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2023.112712","article-title":"Glutaminase 1 deficiency confined in forebrain neurons causes autism spectrum disorder-like behaviors","volume":"42","author":"Ji","year":"2023","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2025.116857_bib47","article-title":"DolphinNext: A distributed data processing platform for high throughput genomics","author":"Yukselen","year":"2019","journal-title":"bioRxiv"},{"key":"10.1016\/j.celrep.2025.116857_bib48","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/nmeth.2019","article-title":"Fiji: An open-source platform for biological-image analysis","volume":"9","author":"Schindelin","year":"2012","journal-title":"Nat. Methods"},{"key":"10.1016\/j.celrep.2025.116857_bib49","doi-asserted-by":"crossref","first-page":"E87","DOI":"10.1152\/ajpendo.00457.2019","article-title":"A pipeline for multidimensional confocal analysis of mitochondrial morphology, function, and dynamics in pancreatic \u03b2-cells","volume":"318","author":"Chaudhry","year":"2020","journal-title":"Am. J. Physiol. Endocrinol. Metab."}],"container-title":["Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124725016298?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124725016298?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T04:54:08Z","timestamp":1791262448000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211124725016298"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":49,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["S2211124725016298"],"URL":"https:\/\/doi.org\/10.1016\/j.celrep.2025.116857","relation":{},"ISSN":["2211-1247"],"issn-type":[{"value":"2211-1247","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Metabolic reprogramming during human neuron differentiation indicates glutaminase as a key determinant in Fragile X syndrome","name":"articletitle","label":"Article Title"},{"value":"Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.celrep.2025.116857","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"116857"}}