{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T02:01:56Z","timestamp":1789783316176,"version":"4.0.1"},"reference-count":124,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,12,24]],"date-time":"2025-12-24T00:00:00Z","timestamp":1766534400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["AHA 935362"],"award-info":[{"award-number":["AHA 935362"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["25PRE1372983"],"award-info":[{"award-number":["25PRE1372983"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["T32GM144636"],"award-info":[{"award-number":["T32GM144636"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["R01DK096010"],"award-info":[{"award-number":["R01DK096010"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["R01DK128406"],"award-info":[{"award-number":["R01DK128406"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["R01DK134427"],"award-info":[{"award-number":["R01DK134427"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["R01DK075632"],"award-info":[{"award-number":["R01DK075632"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007229","name":"Harvard University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007229","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100015515","name":"Roy J. and Lucille A. Carver College of Medicine, University of Iowa","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100015515","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008601","name":"Charles A. King Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008601","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R01NS141072"],"award-info":[{"award-number":["R01NS141072"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart Lung and Blood Institute","doi-asserted-by":"publisher","award":["R00HL144923"],"award-info":[{"award-number":["R00HL144923"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart Lung and Blood Institute","doi-asserted-by":"publisher","award":["F31HL170784"],"award-info":[{"award-number":["F31HL170784"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008893","name":"University of Iowa","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008893","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001024","name":"Roy J. Carver Charitable Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Reports"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.celrep.2025.116904","type":"journal-article","created":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T20:01:01Z","timestamp":1769198461000},"page":"116904","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["A spatial and projection-based transcriptomic atlas of paraventricular hypothalamic cell types"],"prefix":"10.1016","volume":"45","author":[{"given":"Yuxi","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trevor C.","family":"Butler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Nardone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher L.","family":"Jacobs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amelia M.","family":"Douglass","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph C.","family":"Madara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miriam C.","family":"McDonough","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenkang","family":"Tao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elijah D.","family":"Lowenstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luhong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepti","family":"Pant","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel J.","family":"Walker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annette","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harini","family":"Srinivasan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zongfang","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John N.","family":"Campbell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linus T.","family":"Tsai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bradford B.","family":"Lowell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5409-7771","authenticated-orcid":false,"given":"Jon M.","family":"Resch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.celrep.2025.116904_bib1","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1002\/cne.22698","article-title":"Cyto- and chemoarchitecture of the hypothalamic paraventricular nucleus in the C57BL\/6J male mouse: a study of immunostaining and multiple fluorescent tract tracing","volume":"520","author":"Biag","year":"2012","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.celrep.2025.116904_bib2","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1002\/cne.901940306","article-title":"The paraventricular nucleus of the hypothalamus: cytoarchitectonic subdivisions and organization of projections to the pituitary, dorsal vagal complex, and spinal cord as demonstrated by retrograde fluorescence double-labeling methods","volume":"194","author":"Swanson","year":"1980","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.celrep.2025.116904_bib3","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1002\/cne.22126","article-title":"Comparison of the spatial distribution of seven types of neuroendocrine neurons in the rat paraventricular nucleus: toward a global 3D model","volume":"516","author":"Simmons","year":"2009","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.celrep.2025.116904_bib4","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1002\/cne.902050306","article-title":"Immunohistochemical identification of neurons in the paraventricular nucleus of the hypothalamus that project to the medulla or to the spinal cord in the rat","volume":"205","author":"Sawchenko","year":"1982","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.celrep.2025.116904_bib5","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/0006-8993(80)90354-6","article-title":"Separate neurons in the paraventricular nucleus project to the median eminence and to the medulla or spinal cord","volume":"198","author":"Swanson","year":"1980","journal-title":"Brain Res."},{"key":"10.1016\/j.celrep.2025.116904_bib6","first-page":"410","article-title":"Paraventricular nucleus: a site for the integration of neuroendocrine and autonomic mechanisms","volume":"31","author":"Swanson","year":"1980","journal-title":"Neuroendocrinology"},{"key":"10.1016\/j.celrep.2025.116904_bib7","doi-asserted-by":"crossref","first-page":"1931","DOI":"10.1016\/0306-4522(80)90040-8","article-title":"Subnuclei in the rat hypothalamic paraventricular nucleus: a cytoarchitectural, horseradish peroxidase and immunocytochemical analysis","volume":"5","author":"Armstrong","year":"1980","journal-title":"Neuroscience"},{"key":"10.1016\/j.celrep.2025.116904_bib8","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/0006-8993(77)91000-9","article-title":"Immunohistochemical evidence for a neurophysin-containing autonomic pathway arising in the paraventricular nucleus of the hypothalamus","volume":"128","author":"Swanson","year":"1977","journal-title":"Brain Res."},{"key":"10.1016\/j.celrep.2025.116904_bib9","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/0006-8993(76)90738-1","article-title":"Direct hypothalamo-autonomic connections","volume":"117","author":"Saper","year":"1976","journal-title":"Brain Res."},{"key":"10.1016\/j.celrep.2025.116904_bib10","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.1002\/cne.22283","article-title":"Paraventricular hypothalamic nucleus: axonal projections to the brainstem","volume":"518","author":"Geerling","year":"2010","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.celrep.2025.116904_bib11","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1038\/nn.4202","article-title":"Melanocortin-4 receptor\u2013regulated energy homeostasis","volume":"19","author":"Krashes","year":"2016","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.celrep.2025.116904_bib12","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1038\/nn.4011","article-title":"A neural basis for melanocortin-4 receptor-regulated appetite","volume":"18","author":"Garfield","year":"2015","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.celrep.2025.116904_bib13","doi-asserted-by":"crossref","first-page":"13193","DOI":"10.1073\/pnas.1407843111","article-title":"MC4R-expressing glutamatergic neurons in the paraventricular hypothalamus regulate feeding and are synaptically connected to the parabrachial nucleus","volume":"111","author":"Shah","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2025.116904_bib14","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/j.cell.2005.08.035","article-title":"Divergence of melanocortin pathways in the control of food intake and energy expenditure","volume":"123","author":"Balthasar","year":"2005","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2025.116904_bib15","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/j.cmet.2018.10.016","article-title":"Defined Paraventricular Hypothalamic Populations Exhibit Differential Responses to Food Contingent on Caloric State","volume":"29","author":"Li","year":"2019","journal-title":"Cell Metab."},{"key":"10.1016\/j.celrep.2025.116904_bib16","doi-asserted-by":"crossref","DOI":"10.1210\/endocr\/bqab072","article-title":"Paraventricular Calcitonin Receptor-Expressing Neurons Modulate Energy Homeostasis in Male Mice","volume":"162","author":"Gonzalez","year":"2021","journal-title":"Endocrinology"},{"key":"10.1016\/j.celrep.2025.116904_bib17","doi-asserted-by":"crossref","first-page":"5546","DOI":"10.1038\/s41598-020-62468-z","article-title":"Paraventricular, subparaventricular and periventricular hypothalamic IRS4-expressing neurons are required for normal energy balance","volume":"10","author":"Sutton Hickey","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.celrep.2025.116904_bib18","doi-asserted-by":"crossref","first-page":"1729","DOI":"10.1038\/s41467-020-15537-w","article-title":"TrkB-expressing paraventricular hypothalamic neurons suppress appetite through multiple neurocircuits","volume":"11","author":"An","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2025.116904_bib19","doi-asserted-by":"crossref","first-page":"15306","DOI":"10.1523\/JNEUROSCI.0226-14.2014","article-title":"Control of food intake and energy expenditure by Nos1 neurons of the paraventricular hypothalamus","volume":"34","author":"Sutton","year":"2014","journal-title":"J. Neurosci."},{"key":"10.1016\/j.celrep.2025.116904_bib20","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.molmet.2013.12.006","article-title":"AVP neurons in the paraventricular nucleus of the hypothalamus regulate feeding","volume":"3","author":"Pei","year":"2014","journal-title":"Mol. Metab."},{"key":"10.1016\/j.celrep.2025.116904_bib21","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1016\/j.neuron.2019.02.028","article-title":"The Paraventricular Hypothalamus Regulates Satiety and Prevents Obesity via Two Genetically Distinct Circuits","volume":"102","author":"Li","year":"2019","journal-title":"Neuron"},{"key":"10.1016\/j.celrep.2025.116904_bib22","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1038\/nature12956","article-title":"An excitatory paraventricular nucleus to AgRP neuron circuit that drives hunger","volume":"507","author":"Krashes","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2025.116904_bib23","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.cmet.2015.05.008","article-title":"Discrete BDNF Neurons in the Paraventricular Hypothalamus Control Feeding and Energy Expenditure","volume":"22","author":"An","year":"2015","journal-title":"Cell Metab."},{"key":"10.1016\/j.celrep.2025.116904_bib24","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1038\/s41586-020-2527-y","article-title":"A leptin\u2013BDNF pathway regulating sympathetic innervation of adipose tissue","volume":"583","author":"Wang","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2025.116904_bib25","doi-asserted-by":"crossref","DOI":"10.1111\/jne.13367","article-title":"An integrated single-cell RNA-seq atlas of the mouse hypothalamic paraventricular nucleus links transcriptomic and functional types","volume":"36","author":"Berkhout","year":"2024","journal-title":"J. Neuroendocrinol."},{"key":"10.1016\/j.celrep.2025.116904_bib26","doi-asserted-by":"crossref","DOI":"10.1126\/science.abb2494","article-title":"Behavioral state coding by molecularly defined paraventricular hypothalamic cell type ensembles","volume":"370","author":"Xu","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.celrep.2025.116904_bib27","doi-asserted-by":"crossref","first-page":"36","DOI":"10.15252\/embj.201488977","article-title":"A secretagogin locus of the mammalian hypothalamus controls stress hormone release","volume":"34","author":"Romanov","year":"2015","journal-title":"EMBO J."},{"key":"10.1016\/j.celrep.2025.116904_bib28","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1038\/s41586-023-06808-9","article-title":"Molecularly defined and spatially resolved cell atlas of the whole mouse brain","volume":"624","author":"Zhang","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2025.116904_bib29","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1038\/s41586-023-06812-z","article-title":"A high-resolution transcriptomic and spatial atlas of cell types in the whole mouse brain","volume":"624","author":"Yao","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2025.116904_bib30","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1038\/s41586-023-06569-5","article-title":"Spatial atlas of the mouse central nervous system at molecular resolution","volume":"622","author":"Shi","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2025.116904_bib31","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1038\/s41586-023-06818-7","article-title":"The molecular cytoarchitecture of the adult mouse brain","volume":"624","author":"Langlieb","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2025.116904_bib32","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1038\/s42255-022-00657-y","article-title":"HypoMap\u2014a unified single-cell gene expression atlas of the murine hypothalamus","volume":"4","author":"Steuernagel","year":"2022","journal-title":"Nat. Metab."},{"key":"10.1016\/j.celrep.2025.116904_bib33","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1016\/j.cell.2015.05.002","article-title":"Highly Parallel Genome-wide Expression Profiling of Individual Cells Using Nanoliter Droplets","volume":"161","author":"Macosko","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2025.116904_bib34","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1038\/nmeth.4407","article-title":"Massively parallel single-nucleus RNA-seq with DroNc-seq","volume":"14","author":"Habib","year":"2017","journal-title":"Nat. Methods"},{"key":"10.1016\/j.celrep.2025.116904_bib35","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1038\/s41587-023-01767-y","article-title":"Dictionary learning for integrative, multimodal and scalable single-cell analysis","volume":"42","author":"Hao","year":"2024","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.celrep.2025.116904_bib36","doi-asserted-by":"crossref","first-page":"1888","DOI":"10.1016\/j.cell.2019.05.031","article-title":"Comprehensive Integration of Single-Cell Data","volume":"177","author":"Stuart","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2025.116904_bib37","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1007\/s00429-008-0192-2","article-title":"Functional role of local GABAergic influences on the HPA axis","volume":"213","author":"Cullinan","year":"2008","journal-title":"Brain Struct. Funct."},{"key":"10.1016\/j.celrep.2025.116904_bib38","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1002\/cne.903320109","article-title":"Local origins of some GABAergic projections to the paraventricular and supraoptic nuclei of the hypothalamus in the rat","volume":"332","author":"Roland","year":"1993","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.celrep.2025.116904_bib39","doi-asserted-by":"crossref","first-page":"3264","DOI":"10.1101\/gad.12.20.3264","article-title":"Development of neuroendocrine lineages requires the bHLH-PAS transcription factor SIM1","volume":"12","author":"Michaud","year":"1998","journal-title":"Genes Dev."},{"key":"10.1016\/j.celrep.2025.116904_bib40","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1038\/nature05453","article-title":"Genome-wide atlas of gene expression in the adult mouse brain","volume":"445","author":"Lein","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2025.116904_bib41","doi-asserted-by":"crossref","DOI":"10.1111\/apha.13973","article-title":"Brain-wide mapping of efferent projections of glutamatergic (Onecut3(+) ) neurons in the lateral mouse hypothalamus","volume":"238","author":"Zupancic","year":"2023","journal-title":"Acta Physiol."},{"key":"10.1016\/j.celrep.2025.116904_bib42","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1016\/S0306-4522(02)00325-1","article-title":"Survey for paired-like homeodomain gene expression in the hypothalamus: restricted expression patterns of Rx, Alx4 and goosecoid","volume":"114","author":"Asbreuk","year":"2002","journal-title":"Neuroscience"},{"key":"10.1016\/j.celrep.2025.116904_bib43","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/0306-4522(91)90085-3","article-title":"Neurons with access to the general circulation in the central nervous system of the rat: a retrograde tracing study with fluoro-gold","volume":"44","author":"Merchenthaler","year":"1991","journal-title":"Neuroscience"},{"key":"10.1016\/j.celrep.2025.116904_bib44","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/0006-8993(89)90133-9","article-title":"Fluoro-Gold injected either subcutaneously or intravascularly results in extensive retrograde labelling of CNS neurones having axons terminating outside the blood-brain barrier","volume":"505","author":"Ambalavanar","year":"1989","journal-title":"Brain Res."},{"key":"10.1016\/j.celrep.2025.116904_bib45","doi-asserted-by":"crossref","first-page":"S19","DOI":"10.1507\/endocrj.45.Suppl_S19","article-title":"Growth hormone inhibits its own secretion by acting on the hypothalamus through its receptors on neuropeptide Y neurons in the arcuate nucleus and somatostatin neurons in the periventricular nucleus","volume":"45","author":"Minami","year":"1998","journal-title":"Endocr. J."},{"key":"10.1016\/j.celrep.2025.116904_bib46","doi-asserted-by":"crossref","first-page":"1966","DOI":"10.1038\/s41467-024-45907-7","article-title":"A spatially-resolved transcriptional atlas of the murine dorsal pons at single-cell resolution","volume":"15","author":"Nardone","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2025.116904_bib47","doi-asserted-by":"crossref","DOI":"10.1126\/science.aaa6090","article-title":"RNA imaging. Spatially resolved, highly multiplexed RNA profiling in single cells","volume":"348","author":"Chen","year":"2015","journal-title":"Science"},{"key":"10.1016\/j.celrep.2025.116904_bib48","article-title":"Comparative analysis of multiplexed in situ gene expression profiling technologies","volume":"13","author":"Hartman","year":"2024","journal-title":"eLife"},{"key":"10.1016\/j.celrep.2025.116904_bib49","series-title":"Paxinos and Franklin's the Mouse Brain in Stereotaxic Coordinates","author":"Paxinos","year":"2019"},{"key":"10.1016\/j.celrep.2025.116904_bib50","doi-asserted-by":"crossref","first-page":"1634","DOI":"10.1038\/s41592-022-01663-4","article-title":"Cellpose 2.0: how to train your own model","volume":"19","author":"Pachitariu","year":"2022","journal-title":"Nat. Methods"},{"key":"10.1016\/j.celrep.2025.116904_bib51","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1186\/s13059-024-03213-x","article-title":"Multi-slice spatial transcriptome domain analysis with SpaDo","volume":"25","author":"Duan","year":"2024","journal-title":"Genome Biol."},{"key":"10.1016\/j.celrep.2025.116904_bib52","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1016\/j.cmet.2023.03.002","article-title":"A synaptic amplifier of hunger for regaining body weight in the hypothalamus","volume":"35","author":"Grzelka","year":"2023","journal-title":"Cell Metab."},{"key":"10.1016\/j.celrep.2025.116904_bib53","article-title":"A hypothalamic circuit for anticipating future changes in energy balance","author":"Walker","year":"2025","journal-title":"bioRxiv"},{"key":"10.1016\/j.celrep.2025.116904_bib54","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1056\/NEJMra1812053","article-title":"New Neuroscience of Homeostasis and Drives for Food, Water, and Salt","volume":"380","author":"Lowell","year":"2019","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.celrep.2025.116904_bib55","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0040191","article-title":"Y1 and Y5 receptors are both required for the regulation of food intake and energy homeostasis in mice","volume":"7","author":"Nguyen","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.celrep.2025.116904_bib56","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1016\/S0306-4522(03)00561-X","article-title":"Estrogen receptor beta in the paraventricular nucleus of hypothalamus regulates the neuroendocrine response to stress and is regulated by corticosterone","volume":"121","author":"Isgor","year":"2003","journal-title":"Neuroscience"},{"key":"10.1016\/j.celrep.2025.116904_bib57","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1161\/01.HYP.0000248754.67128.ff","article-title":"Estrogen in the paraventricular nucleus attenuates L-glutamate-induced increases in mean arterial pressure through estrogen receptor beta and NO","volume":"48","author":"Gingerich","year":"2006","journal-title":"Hypertension"},{"key":"10.1016\/j.celrep.2025.116904_bib58","doi-asserted-by":"crossref","first-page":"5190","DOI":"10.1523\/JNEUROSCI.0164-21.2021","article-title":"Estrogen Receptor beta Contributes to Both Hypertension and Hypothalamic Plasticity in a Mouse Model of Peri-Menopause","volume":"41","author":"Milner","year":"2021","journal-title":"J. Neurosci."},{"key":"10.1016\/j.celrep.2025.116904_bib59","doi-asserted-by":"crossref","DOI":"10.3390\/biology13100819","article-title":"Estrogen Receptor Beta Agonist Influences Presynaptic NMDA Receptor Distribution in the Paraventricular Hypothalamic Nucleus Following Hypertension in a Mouse Model of Perimenopause","volume":"13","author":"Sommer","year":"2024","journal-title":"Biology"},{"key":"10.1016\/j.celrep.2025.116904_bib60","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2023.1162699","article-title":"C-type natriuretic peptide (CNP) in the paraventricular nucleus-mediated renal sympatho-inhibition","volume":"14","author":"Zheng","year":"2023","journal-title":"Front. Physiol."},{"key":"10.1016\/j.celrep.2025.116904_bib61","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/j.tem.2016.03.003","article-title":"Bombesin-Like Receptor 3: Physiology of a Functional Orphan","volume":"27","author":"Xiao","year":"2016","journal-title":"Trends Endocrinol. Metab."},{"key":"10.1016\/j.celrep.2025.116904_bib62","doi-asserted-by":"crossref","first-page":"1530","DOI":"10.1038\/s41593-018-0249-3","article-title":"Brs3 neurons in the mouse dorsomedial hypothalamus regulate body temperature, energy expenditure, and heart rate, but not food intake","volume":"21","author":"Pinol","year":"2018","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.celrep.2025.116904_bib63","doi-asserted-by":"crossref","DOI":"10.1002\/brb3.881","article-title":"Bombesin receptor subtype-3-expressing neurons regulate energy homeostasis through a novel neuronal pathway in the hypothalamus","volume":"8","author":"Maruyama","year":"2018","journal-title":"Brain Behav."},{"key":"10.1016\/j.celrep.2025.116904_bib64","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1210\/en.2008-0559","article-title":"Gastrin-releasing peptide messenger ribonucleic acid expression in the hypothalamic paraventricular nucleus is altered by melanocortin receptor stimulation and food deprivation","volume":"150","author":"Ladenheim","year":"2009","journal-title":"Endocrinology"},{"key":"10.1016\/j.celrep.2025.116904_bib65","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.64680","article-title":"Urocortin-3 neurons in the mouse perifornical area promote infant-directed neglect and aggression","volume":"10","author":"Autry","year":"2021","journal-title":"eLife"},{"key":"10.1016\/j.celrep.2025.116904_bib66","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.brainres.2015.03.009","article-title":"Stress-activated afferent inputs into the anterior parvicellular part of the paraventricular nucleus of the hypothalamus: Insights into urocortin 3 neuron activation","volume":"1611","author":"van-Hover","year":"2015","journal-title":"Brain Res."},{"key":"10.1016\/j.celrep.2025.116904_bib67","first-page":"2596","article-title":"Hypophysiotropic thyrotropin-releasing hormone-synthesizing neurons in the human hypothalamus are innervated by neuropeptide Y, agouti-related protein, and alpha-melanocyte-stimulating hormone","volume":"85","author":"Mihaly","year":"2000","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.celrep.2025.116904_bib68","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1002\/cne.902980302","article-title":"Galanin immunoreactive neurons in the human hypothalamus: colocalization with vasopressin-containing neurons","volume":"298","author":"Gai","year":"1990","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.celrep.2025.116904_bib69","doi-asserted-by":"crossref","first-page":"4591","DOI":"10.1002\/cne.22480","article-title":"Expression patterns of corticotropin-releasing factor, arginine vasopressin, histidine decarboxylase, melanin-concentrating hormone, and orexin genes in the human hypothalamus","volume":"518","author":"Krolewski","year":"2010","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.celrep.2025.116904_bib70","doi-asserted-by":"crossref","DOI":"10.1126\/science.add7046","article-title":"Transcriptomic diversity of cell types across the adult human brain","volume":"382","author":"Siletti","year":"2023","journal-title":"Science"},{"key":"10.1016\/j.celrep.2025.116904_bib71","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1038\/s41586-024-08504-8","article-title":"A comprehensive spatio-cellular map of the human hypothalamus","volume":"639","author":"Tadross","year":"2025","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2025.116904_bib72","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/S0091-3057(01)00681-5","article-title":"Local circuit regulation of paraventricular nucleus stress integration: glutamate-GABA connections","volume":"71","author":"Herman","year":"2002","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.celrep.2025.116904_bib73","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1002\/cne.902580205","article-title":"Efferent projections of the suprachiasmatic nucleus: II. Studies using retrograde transport of fluorescent dyes and simultaneous peptide immunohistochemistry in the rat","volume":"258","author":"Watts","year":"1987","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.celrep.2025.116904_bib74","doi-asserted-by":"crossref","first-page":"R1172","DOI":"10.1152\/ajpregu.00394.2004","article-title":"Water deprivation increases Fos immunoreactivity in PVN autonomic neurons with projections to the spinal cord and rostral ventrolateral medulla","volume":"287","author":"Stocker","year":"2004","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.celrep.2025.116904_bib75","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/S0306-4522(00)00283-9","article-title":"Identification of branching paraventricular neurons of the hypothalamus that project to the rostroventrolateral medulla and spinal cord","volume":"100","author":"Pyner","year":"2000","journal-title":"Neuroscience"},{"key":"10.1016\/j.celrep.2025.116904_bib76","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1002\/(SICI)1096-9861(19991115)414:2<255::AID-CNE8>3.0.CO;2-E","article-title":"Decussations of the descending paraventricular pathways to the brainstem and spinal cord autonomic centers","volume":"414","author":"Toth","year":"1999","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.celrep.2025.116904_bib77","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/S0006-8993(98)00587-3","article-title":"Neurons in the hypothalamic paraventricular nucleus send collaterals to the spinal cord and to the rostral ventrolateral medulla in the rat","volume":"801","author":"Shafton","year":"1998","journal-title":"Brain Res."},{"key":"10.1016\/j.celrep.2025.116904_bib78","doi-asserted-by":"crossref","first-page":"119","DOI":"10.2535\/ofaj1936.72.2-3_119","article-title":"Descending projections from the paraventricular hypothalamic nucleus to the spinal cord: anterograde tracing study in the rat","volume":"72","author":"Zheng","year":"1995","journal-title":"Okajimas Folia Anat. Jpn."},{"key":"10.1016\/j.celrep.2025.116904_bib79","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/0006-8993(85)90554-2","article-title":"The course of paraventricular hypothalamic efferents to autonomic structures in medulla and spinal cord","volume":"329","author":"Luiten","year":"1985","journal-title":"Brain Res."},{"key":"10.1016\/j.celrep.2025.116904_bib80","doi-asserted-by":"crossref","first-page":"3427","DOI":"10.1016\/j.cell.2024.04.022","article-title":"Spinal projecting neurons in rostral ventromedial medulla co-regulate motor and sympathetic tone","volume":"187","author":"Zhang","year":"2024","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2025.116904_bib81","doi-asserted-by":"crossref","first-page":"262","DOI":"10.2174\/157015911795596531","article-title":"Function and pharmacology of spinally-projecting sympathetic pre-autonomic neurones in the paraventricular nucleus of the hypothalamus","volume":"9","author":"Nunn","year":"2011","journal-title":"Curr. Neuropharmacol."},{"key":"10.1016\/j.celrep.2025.116904_bib82","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1046\/j.1365-2826.2001.00631.x","article-title":"Insulin and glucose administration stimulates Fos expression in neurones of the paraventricular nucleus that project to autonomic preganglionic structures","volume":"13","author":"Carrasco","year":"2001","journal-title":"J. Neuroendocrinol."},{"key":"10.1016\/j.celrep.2025.116904_bib83","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/0006-8993(93)91403-F","article-title":"A comparison of hypotensive and non-hypotensive hemorrhage on Fos expression in spinally projecting neurons of the paraventricular nucleus and rostral ventrolateral medulla","volume":"610","author":"Badoer","year":"1993","journal-title":"Brain Res."},{"key":"10.1016\/j.celrep.2025.116904_bib84","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1038\/s41586-023-06817-8","article-title":"A transcriptomic taxonomy of mouse brain-wide spinal projecting neurons","volume":"624","author":"Winter","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2025.116904_bib85","doi-asserted-by":"crossref","first-page":"8780","DOI":"10.1523\/JNEUROSCI.1197-22.2022","article-title":"Single nuclei analyses reveal transcriptional profiles and marker genes for diverse supraspinal populations","volume":"42","author":"Beine","year":"2022","journal-title":"J. Neurosci."},{"key":"10.1016\/j.celrep.2025.116904_bib86","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1016\/j.celrep.2016.12.087","article-title":"Simultaneous Transcriptional and Epigenomic Profiling from Specific Cell Types within Heterogeneous Tissues In Vivo","volume":"18","author":"Roh","year":"2017","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2025.116904_bib87","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1002\/cne.20432","article-title":"Neuropeptide Y Y1 receptor mRNA in rodent brain: distribution and colocalization with melanocortin-4 receptor","volume":"482","author":"Kishi","year":"2005","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.celrep.2025.116904_bib88","doi-asserted-by":"crossref","DOI":"10.1016\/j.molmet.2022.101455","article-title":"NPY derived from AGRP neurons controls feeding via Y1 and energy expenditure and food foraging behaviour via Y2 signalling","volume":"59","author":"Qi","year":"2022","journal-title":"Mol. Metab."},{"key":"10.1016\/j.celrep.2025.116904_bib89","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1038\/nature11270","article-title":"Deconstruction of a neural circuit for hunger","volume":"488","author":"Atasoy","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2025.116904_bib90","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1016\/j.cmet.2011.10.009","article-title":"NPY and MC4R signaling regulate thyroid hormone levels during fasting through both central and peripheral pathways","volume":"14","author":"Vella","year":"2011","journal-title":"Cell Metab."},{"key":"10.1016\/j.celrep.2025.116904_bib91","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1172\/JCI10741","article-title":"Transcriptional regulation of the thyrotropin-releasing hormone gene by leptin and melanocortin signaling","volume":"107","author":"Harris","year":"2001","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.celrep.2025.116904_bib92","doi-asserted-by":"crossref","DOI":"10.1016\/j.molmet.2020.02.012","article-title":"BRS3 in both MC4R- and SIM1-expressing neurons regulates energy homeostasis in mice","volume":"36","author":"Xiao","year":"2020","journal-title":"Mol. Metab."},{"key":"10.1016\/j.celrep.2025.116904_bib93","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1016\/j.neuron.2017.09.042","article-title":"Enhanced AMPA Receptor Trafficking Mediates the Anorexigenic Effect of Endogenous Glucagon-like Peptide-1 in the Paraventricular Hypothalamus","volume":"96","author":"Liu","year":"2017","journal-title":"Neuron"},{"key":"10.1016\/j.celrep.2025.116904_bib94","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1002\/cne.20993","article-title":"Aldosterone-sensitive neurons in the nucleus of the solitary tract: efferent projections","volume":"497","author":"Geerling","year":"2006","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.celrep.2025.116904_bib95","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/j.celrep.2017.03.048","article-title":"Rapid Molecular Profiling of Defined Cell Types Using Viral TRAP","volume":"19","author":"Nectow","year":"2017","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2025.116904_bib96","doi-asserted-by":"crossref","DOI":"10.1523\/ENEURO.0252-21.2021","article-title":"Cre Recombinase Driver Mice Reveal Lineage-Dependent and -Independent Expression of Brs3 in the Mouse Brain","volume":"8","author":"Mogul","year":"2021","journal-title":"eNeuro"},{"key":"10.1016\/j.celrep.2025.116904_bib97","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/j.cell.2018.06.035","article-title":"A Suite of Transgenic Driver and Reporter Mouse Lines with Enhanced Brain-Cell-Type Targeting and Functionality","volume":"174","author":"Daigle","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2025.116904_bib98","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1038\/1082","article-title":"Coexpression of Agrp and NPY in fasting-activated hypothalamic neurons","volume":"1","author":"Hahn","year":"1998","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.celrep.2025.116904_bib99","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S1569-9048(02)00131-3","article-title":"Paraventricular vasopressin-containing neurons project to brain stem and spinal cord respiratory-related sites","volume":"133","author":"Kc","year":"2002","journal-title":"Respir. Physiol. Neurobiol."},{"key":"10.1016\/j.celrep.2025.116904_bib100","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.cub.2020.09.089","article-title":"Oxytocin Influences Male Sexual Activity via Non-synaptic Axonal Release in the Spinal Cord","volume":"31","author":"Oti","year":"2021","journal-title":"Curr. Biol."},{"key":"10.1016\/j.celrep.2025.116904_bib101","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.cmet.2021.12.020","article-title":"A distinct hypothalamus-to-beta cell circuit modulates insulin secretion","volume":"34","author":"Papazoglou","year":"2022","journal-title":"Cell Metab."},{"key":"10.1016\/j.celrep.2025.116904_bib102","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/0006-8993(95)00020-Q","article-title":"Evidence that cholera toxin B subunit (CTb) can be avidly taken up and transported by fibers of passage","volume":"674","author":"Chen","year":"1995","journal-title":"Brain Res."},{"key":"10.1016\/j.celrep.2025.116904_bib103","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1016\/j.neuron.2023.12.022","article-title":"Single-neuron projectomes of mouse paraventricular hypothalamic nucleus oxytocin neurons reveal mutually exclusive projection patterns","volume":"112","author":"Li","year":"2024","journal-title":"Neuron"},{"key":"10.1016\/j.celrep.2025.116904_bib104","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.neuron.2020.10.032","article-title":"Reconstruction of the Hypothalamo-Neurohypophysial System and Functional Dissection of Magnocellular Oxytocin Neurons in the Brain","volume":"109","author":"Zhang","year":"2021","journal-title":"Neuron"},{"key":"10.1016\/j.celrep.2025.116904_bib105","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/0006-8993(87)91566-6","article-title":"Neuroendocrine CRF motoneurons: intrahypothalamic axon terminals shown with a new retrograde-Lucifer-immuno method","volume":"436","author":"Rho","year":"1987","journal-title":"Brain Res."},{"key":"10.1016\/j.celrep.2025.116904_bib106","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms11937","article-title":"Hypothalamic CRH neurons orchestrate complex behaviours after stress","volume":"7","author":"Fuzesi","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2025.116904_bib117","doi-asserted-by":"crossref","first-page":"2106","DOI":"10.1016\/j.neuron.2021.05.004","article-title":"Highly selective brain-to-gut communication via genetically defined vagus neurons","volume":"109","author":"Tao","year":"2021","journal-title":"Neuron"},{"key":"10.1016\/j.celrep.2025.116904_bib113","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.neuron.2011.05.028","article-title":"Leptin action on GABAergic neurons prevents obesity and reduces inhibitory tone to POMC neurons","volume":"71","author":"Vong","year":"2011","journal-title":"Neuron"},{"key":"10.1016\/j.celrep.2025.116904_bib109","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-17204-5","article-title":"QuPath: Open source software for digital pathology image analysis","volume":"7","author":"Bankhead","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.celrep.2025.116904_bib110","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/nmeth.2019","article-title":"Fiji: an open-source platform for biological-image analysis","volume":"9","author":"Schindelin","year":"2012","journal-title":"Nat. Methods"},{"key":"10.1016\/j.celrep.2025.116904_bib118","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1093\/bioinformatics\/bts635","article-title":"STAR: ultrafast universal RNA-seq aligner","volume":"29","author":"Dobin","year":"2013","journal-title":"Bioinformatics"},{"key":"10.1016\/j.celrep.2025.116904_bib119","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1038\/s41592-023-01943-7","article-title":"Unsupervised removal of systematic background noise from droplet-based single-cell experiments using CellBender","volume":"20","author":"Fleming","year":"2023","journal-title":"Nat. Methods"},{"key":"10.1016\/j.celrep.2025.116904_bib121","doi-asserted-by":"crossref","first-page":"3292","DOI":"10.1038\/s41596-024-01020-z","article-title":"Using clusterProfiler to characterize multiomics data","volume":"19","author":"Xu","year":"2024","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.celrep.2025.116904_bib114","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1038\/nn.4495","article-title":"A molecular census of arcuate hypothalamus and median eminence cell types","volume":"20","author":"Campbell","year":"2017","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.celrep.2025.116904_bib115","doi-asserted-by":"crossref","DOI":"10.1523\/JNEUROSCI.2211-23.2024","article-title":"Molecular organization of autonomic, respiratory, and spinally-projecting neurons in the mouse ventrolateral medulla","volume":"44","author":"Schwalbe","year":"2024","journal-title":"J. Neurosci."},{"key":"10.1016\/j.celrep.2025.116904_bib116","doi-asserted-by":"crossref","DOI":"10.1016\/j.xpro.2024.102893","article-title":"Protocol for flow cytometry-assisted single-nucleus RNA sequencing of human and mouse adipose tissue with sample multiplexing","volume":"5","author":"Gulko","year":"2024","journal-title":"STAR Protoc."},{"key":"10.1016\/j.celrep.2025.116904_bib120","doi-asserted-by":"crossref","first-page":"1860","DOI":"10.1101\/gr.192237.115","article-title":"Single-cell RNA-seq reveals changes in cell cycle and differentiation programs upon aging of hematopoietic stem cells","volume":"25","author":"Kowalczyk","year":"2015","journal-title":"Genome Res."},{"key":"10.1016\/j.celrep.2025.116904_bib108","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1016\/j.neuron.2018.04.001","article-title":"Different Neuronal Activity Patterns Induce Different Gene Expression Programs","volume":"98","author":"Tyssowski","year":"2018","journal-title":"Neuron"},{"key":"10.1016\/j.celrep.2025.116904_bib122","doi-asserted-by":"crossref","first-page":"3710","DOI":"10.1093\/bioinformatics\/bth456","article-title":"GO::TermFinder--open source software for accessing Gene Ontology information and finding significantly enriched Gene Ontology terms associated with a list of genes","volume":"20","author":"Boyle","year":"2004","journal-title":"Bioinformatics"},{"key":"10.1016\/j.celrep.2025.116904_bib107","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1126\/science.aad7038","article-title":"Div-Seq: Single-nucleus RNA-Seq reveals dynamics of rare adult newborn neurons","volume":"353","author":"Habib","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.celrep.2025.116904_bib123","doi-asserted-by":"crossref","first-page":"4410","DOI":"10.1038\/s41467-020-17197-2","article-title":"Suprachiasmatic VIP neurons are required for normal circadian rhythmicity and comprised of molecularly distinct subpopulations","volume":"11","author":"Todd","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2025.116904_bib111","doi-asserted-by":"crossref","DOI":"10.1126\/science.aau5324","article-title":"Molecular, spatial, and functional single-cell profiling of the hypothalamic preoptic region","volume":"362","author":"Moffitt","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.celrep.2025.116904_bib112","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.neuron.2017.09.014","article-title":"Aldosterone-Sensing Neurons in the NTS Exhibit State-Dependent Pacemaker Activity and Drive Sodium Appetite via Synergy with Angiotensin II Signaling","volume":"96","author":"Resch","year":"2017","journal-title":"Neuron"},{"key":"10.1016\/j.celrep.2025.116904_bib124","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1038\/s41586-023-06358-0","article-title":"Neural basis for fasting activation of the hypothalamic-pituitary-adrenal axis","volume":"620","author":"Douglass","year":"2023","journal-title":"Nature"}],"container-title":["Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124725016766?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124725016766?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T11:15:27Z","timestamp":1778843727000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211124725016766"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":124,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["S2211124725016766"],"URL":"https:\/\/doi.org\/10.1016\/j.celrep.2025.116904","relation":{},"ISSN":["2211-1247"],"issn-type":[{"value":"2211-1247","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A spatial and projection-based transcriptomic atlas of paraventricular hypothalamic cell types","name":"articletitle","label":"Article Title"},{"value":"Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.celrep.2025.116904","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"116904"}}