{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T14:29:31Z","timestamp":1792506571235,"version":"4.5.0"},"reference-count":50,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T00:00:00Z","timestamp":1767916800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["CA265768"],"award-info":[{"award-number":["CA265768"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["CA193837"],"award-info":[{"award-number":["CA193837"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["CA008748"],"award-info":[{"award-number":["CA008748"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["CA092629"],"award-info":[{"award-number":["CA092629"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100032631","name":"Calico Life Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100032631","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000011","name":"Howard Hughes Medical Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000011","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007316","name":"National Cancer Institute Division of Cancer Prevention","doi-asserted-by":"publisher","award":["CA274492"],"award-info":[{"award-number":["CA274492"]}],"id":[{"id":"10.13039\/100007316","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Reports"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.celrep.2026.116950","type":"journal-article","created":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T18:56:15Z","timestamp":1769885775000},"page":"116950","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["FOXA1 mutations co-opt nascent transcription factor networks in partnership with androgen receptor to enhance prostate tumorigenicity"],"prefix":"10.1016","volume":"45","author":[{"given":"Erik M.","family":"Ladewig","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abbas","family":"Nazir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tyler","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinson B.","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhendong","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob","family":"Hawk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren","family":"Kelly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Tjian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina S.","family":"Leslie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles L.","family":"Sawyers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.celrep.2026.116950_bib1","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1038\/s41586-019-1318-9","article-title":"FOXA1 mutations alter pioneering activity, differentiation and prostate cancer phenotypes","volume":"571","author":"Adams","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2026.116950_bib2","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1038\/s41586-019-1347-4","article-title":"Distinct structural classes of activating FOXA1 alterations in advanced prostate cancer","volume":"571","author":"Parolia","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2026.116950_bib3","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1016\/j.ccell.2020.08.003","article-title":"FOXA1 mutations reveal distinct chromatin profiles and influence therapeutic response in breast cancer","volume":"38","author":"Arruabarrena-Aristorena","year":"2020","journal-title":"Cancer Cell"},{"key":"10.1016\/j.celrep.2026.116950_bib4","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1038\/s41586-020-2135-x","article-title":"A genomic and epigenomic atlas of prostate cancer in Asian populations","volume":"580","author":"Li","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2026.116950_bib5","doi-asserted-by":"crossref","DOI":"10.1126\/science.adv2367","article-title":"Divergent FOXA1 mutations drive prostate tumorigenesis and therapy-resistant cellular plasticity","volume":"389","author":"Eyunni","year":"2025","journal-title":"Science"},{"key":"10.1016\/j.celrep.2026.116950_bib6","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1038\/s44319-024-00335-y","article-title":"Rar\u03b3-Foxa1 signaling promotes luminal identity in prostate progenitors and is disrupted in prostate cancer","volume":"26","author":"De Felice","year":"2024","journal-title":"EMBO Rep."},{"key":"10.1016\/j.celrep.2026.116950_bib7","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.jmoldx.2014.12.006","article-title":"Memorial Sloan Kettering-Integrated Mutation Profiling of Actionable Cancer Targets (MSK-IMPACT): A hybridization capture-based next-generation sequencing clinical assay for solid tumor molecular oncology","volume":"17","author":"Cheng","year":"2015","journal-title":"J. Mol. Diagn."},{"key":"10.1016\/j.celrep.2026.116950_bib8","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1038\/s41587-021-01033-z","article-title":"Differential abundance testing on single-cell data using k-nearest neighbor graphs","volume":"40","author":"Dann","year":"2022","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.celrep.2026.116950_bib9","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2110344118","article-title":"Rapid interrogation of cancer cell of origin through CRISPR editing","volume":"118","author":"Feng","year":"2021","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2026.116950_bib10","article-title":"ERG activates a stem-like proliferation-differentiation program in prostate epithelial cells with mixed basal-luminal identity","author":"Feng","year":"2024","journal-title":"bioRxiv"},{"key":"10.1016\/j.celrep.2026.116950_bib11","article-title":"The neuroendocrine transition in prostate cancer is dynamic and dependent on ASCL1","author":"Romero","year":"2024","journal-title":"bioRxiv"},{"key":"10.1016\/j.celrep.2026.116950_bib12","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1126\/science.aay0267","article-title":"Regenerative potential of prostate luminal cells revealed by single-cell analysis","volume":"368","author":"Karthaus","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.celrep.2026.116950_bib13","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.59465","article-title":"A single-cell atlas of the mouse and human prostate reveals heterogeneity and conservation of epithelial progenitors","volume":"9","author":"Crowley","year":"2020","journal-title":"eLife"},{"key":"10.1016\/j.celrep.2026.116950_bib14","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1126\/science.abn0478","article-title":"Lineage plasticity in prostate cancer depends on JAK\/STAT inflammatory signaling","volume":"377","author":"Chan","year":"2022","journal-title":"Science"},{"key":"10.1016\/j.celrep.2026.116950_bib15","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1016\/j.cels.2021.04.005","article-title":"Hotspot identifies informative gene modules across modalities of single-cell genomics","volume":"12","author":"DeTomaso","year":"2021","journal-title":"Cell Syst."},{"key":"10.1016\/j.celrep.2026.116950_bib16","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1038\/s41592-024-02274-x","article-title":"Scalable and unbiased sequence-informed embedding of single-cell ATAC-seq data with CellSpace","volume":"21","author":"Tayyebi","year":"2024","journal-title":"Nat. Methods"},{"key":"10.1016\/j.celrep.2026.116950_bib17","doi-asserted-by":"crossref","first-page":"2930","DOI":"10.1158\/2159-8290.CD-21-0865","article-title":"Loss of epigenetic regulation disrupts lineage integrity, induces aberrant alveogenesis, and promotes breast cancer","volume":"12","author":"Langille","year":"2022","journal-title":"Cancer Discov."},{"key":"10.1016\/j.celrep.2026.116950_bib18","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/j.molcel.2009.10.020","article-title":"The homeodomain protein HOXB13 regulates the cellular response to androgens","volume":"36","author":"Norris","year":"2009","journal-title":"Mol. Cell"},{"key":"10.1016\/j.celrep.2026.116950_bib19","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1038\/s41588-022-01045-8","article-title":"HOXB13 suppresses de novo lipogenesis through HDAC3-mediated epigenetic reprogramming in prostate cancer","volume":"54","author":"Lu","year":"2022","journal-title":"Nat. Genet."},{"key":"10.1016\/j.celrep.2026.116950_bib20","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-021-98323-y","article-title":"Primate-specific stress-induced transcription factor POU2F1Z protects human neuronal cells from stress","volume":"11","author":"Stepchenko","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.celrep.2026.116950_bib21","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/j.molcel.2007.05.041","article-title":"A hierarchical network of transcription factors governs androgen receptor-dependent prostate cancer growth","volume":"27","author":"Wang","year":"2007","journal-title":"Mol. Cell"},{"key":"10.1016\/j.celrep.2026.116950_bib22","doi-asserted-by":"crossref","first-page":"18261","DOI":"10.1073\/pnas.1421415111","article-title":"GATA2 facilitates steroid receptor coactivator recruitment to the androgen receptor complex","volume":"111","author":"He","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2026.116950_bib23","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1038\/s41588-024-01689-8","article-title":"Single-cell multi-ome regression models identify functional and disease-associated enhancers and enable chromatin potential analysis","volume":"56","author":"Mitra","year":"2024","journal-title":"Nat. Genet."},{"key":"10.1016\/j.celrep.2026.116950_bib24","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1016\/j.cell.2006.09.048","article-title":"GATA-3 maintains the differentiation of the luminal cell fate in the mammary gland","volume":"127","author":"Kouros-Mehr","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2026.116950_bib25","doi-asserted-by":"crossref","DOI":"10.1126\/science.aav1898","article-title":"The chromatin accessibility landscape of primary human cancers","volume":"362","author":"Corces","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.celrep.2026.116950_bib26","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.70169","article-title":"Recovering mixtures of fast-diffusing states from short single-particle trajectories","volume":"11","author":"Heckert","year":"2022","journal-title":"eLife"},{"key":"10.1016\/j.celrep.2026.116950_bib27","doi-asserted-by":"crossref","first-page":"6605","DOI":"10.1093\/nar\/gkab072","article-title":"Power-law behavior of transcription factor dynamics at the single-molecule level implies a continuum affinity model","volume":"49","author":"Garcia","year":"2021","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.celrep.2026.116950_bib28","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1016\/j.molcel.2019.06.042","article-title":"Transcriptional bursting and co-bursting regulation by steroid hormone release pattern and transcription factor mobility","volume":"75","author":"Stavreva","year":"2019","journal-title":"Mol. Cell"},{"key":"10.1016\/j.celrep.2026.116950_bib29","doi-asserted-by":"crossref","first-page":"5666","DOI":"10.1038\/onc.2013.508","article-title":"Elevated levels of FOXA1 facilitate androgen receptor chromatin binding resulting in a CRPC-like phenotype","volume":"33","author":"Robinson","year":"2014","journal-title":"Oncogene"},{"key":"10.1016\/j.celrep.2026.116950_bib30","doi-asserted-by":"crossref","first-page":"3962","DOI":"10.1038\/emboj.2011.328","article-title":"Dual role of FoxA1 in androgen receptor binding to chromatin, androgen signalling and prostate cancer","volume":"30","author":"Sahu","year":"2011","journal-title":"EMBO J."},{"key":"10.1016\/j.celrep.2026.116950_bib31","doi-asserted-by":"crossref","first-page":"3972","DOI":"10.1038\/ncomms4972","article-title":"Cooperativity and equilibrium with FOXA1 define the androgen receptor transcriptional program","volume":"5","author":"Jin","year":"2014","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2026.116950_bib32","doi-asserted-by":"crossref","first-page":"2132","DOI":"10.1038\/s41588-024-01893-6","article-title":"NSD2 is a requisite subunit of the AR\/FOXA1 neo-enhanceosome in promoting prostate tumorigenesis","volume":"56","author":"Parolia","year":"2024","journal-title":"Nat. Genet."},{"key":"10.1016\/j.celrep.2026.116950_bib33","doi-asserted-by":"crossref","first-page":"5924","DOI":"10.1172\/JCI137967","article-title":"ERG orchestrates chromatin interactions to drive prostate cell fate reprogramming","volume":"130","author":"Li","year":"2020","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.celrep.2026.116950_bib34","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1200\/PO.18.00036","article-title":"Impact of the SPOP mutant subtype on the interpretation of clinical parameters in prostate cancer","volume":"2018","author":"Liu","year":"2018","journal-title":"JCO Precis. Oncol."},{"key":"10.1016\/j.celrep.2026.116950_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2021.109625","article-title":"Reshaping of the androgen-driven chromatin landscape in normal prostate cells by early cancer drivers and effect on therapeutic sensitivity","volume":"36","author":"Grbesa","year":"2021","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2026.116950_bib36","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1038\/nm972","article-title":"Molecular determinants of resistance to antiandrogen therapy","volume":"10","author":"Chen","year":"2004","journal-title":"Nat. Med."},{"key":"10.1016\/j.celrep.2026.116950_bib37","first-page":"1809","article-title":"LNCaP model of human prostatic carcinoma","volume":"43","author":"Horoszewicz","year":"1983","journal-title":"Cancer Res."},{"key":"10.1016\/j.celrep.2026.116950_bib38","author":"Danner"},{"key":"10.1016\/j.celrep.2026.116950_bib39","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1038\/nmeth1171","article-title":"Highly inclined thin illumination enables clear single-molecule imaging in cells","volume":"5","author":"Tokunaga","year":"2008","journal-title":"Nat. Methods"},{"key":"10.1016\/j.celrep.2026.116950_bib40","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1021\/jacsau.1c00006","article-title":"A general method to improve fluorophores using deuterated auxochromes","volume":"1","author":"Grimm","year":"2021","journal-title":"JACS Au"},{"key":"10.1016\/j.celrep.2026.116950_bib41","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1038\/s41587-023-01767-y","article-title":"Dictionary learning for integrative, multimodal and scalable single-cell analysis","volume":"42","author":"Hao","year":"2024","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.celrep.2026.116950_bib42","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1186\/s13059-019-1874-1","article-title":"Normalization and variance stabilization of single-cell RNA-seq data using regularized negative binomial regression","volume":"20","author":"Hafemeister","year":"2019","journal-title":"Genome Biol."},{"key":"10.1016\/j.celrep.2026.116950_bib43","doi-asserted-by":"crossref","first-page":"3573","DOI":"10.1016\/j.cell.2021.04.048","article-title":"Integrated analysis of multimodal single-cell data","volume":"184","author":"Hao","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2026.116950_bib44","article-title":"Fast gene set enrichment analysis","author":"Korotkevich","year":"2016","journal-title":"bioRxiv"},{"key":"10.1016\/j.celrep.2026.116950_bib45","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1038\/s41588-021-00790-6","article-title":"ArchR is a scalable software package for integrative single-cell chromatin accessibility analysis","volume":"53","author":"Granja","year":"2021","journal-title":"Nat. Genet."},{"key":"10.1016\/j.celrep.2026.116950_bib46","doi-asserted-by":"crossref","DOI":"10.1186\/gb-2008-9-9-r137","article-title":"Model-based analysis of ChIP-Seq (MACS)","volume":"9","author":"Zhang","year":"2008","journal-title":"Genome Biol."},{"key":"10.1016\/j.celrep.2026.116950_bib47","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1038\/nmeth.4401","article-title":"chromVAR: inferring transcription-factor-associated accessibility from single-cell epigenomic data","volume":"14","author":"Schep","year":"2017","journal-title":"Nat. Methods"},{"key":"10.1016\/j.celrep.2026.116950_bib48","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol."},{"key":"10.1016\/j.celrep.2026.116950_bib49","doi-asserted-by":"crossref","DOI":"10.1002\/cpz1.585","article-title":"Exploring epigenomic datasets by ChIPseeker","volume":"2","author":"Wang","year":"2022","journal-title":"Curr. Protoc."},{"key":"10.1016\/j.celrep.2026.116950_bib50","doi-asserted-by":"crossref","first-page":"289","DOI":"10.32614\/RJ-2016-021","article-title":"mclust5: Clustering, Classification and Density Estimation Using Gaussian Finite Mixture Models","volume":"8","author":"Scrucca","year":"2016","journal-title":"R J."}],"container-title":["Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124726000288?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124726000288?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T04:48:04Z","timestamp":1777092484000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211124726000288"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":50,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["S2211124726000288"],"URL":"https:\/\/doi.org\/10.1016\/j.celrep.2026.116950","relation":{},"ISSN":["2211-1247"],"issn-type":[{"value":"2211-1247","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"FOXA1 mutations co-opt nascent transcription factor networks in partnership with androgen receptor to enhance prostate tumorigenicity","name":"articletitle","label":"Article Title"},{"value":"Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.celrep.2026.116950","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"116950"}}