{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T13:35:42Z","timestamp":1792503342219,"version":"4.5.0"},"reference-count":76,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T00:00:00Z","timestamp":1770163200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003824","name":"Hunan University","doi-asserted-by":"publisher","award":["531119200159"],"award-info":[{"award-number":["531119200159"]}],"id":[{"id":"10.13039\/501100003824","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFA0914200"],"award-info":[{"award-number":["2023YFA0914200"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82570152"],"award-info":[{"award-number":["82570152"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32000604"],"award-info":[{"award-number":["32000604"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82170160"],"award-info":[{"award-number":["82170160"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82173688"],"award-info":[{"award-number":["82173688"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82074508"],"award-info":[{"award-number":["82074508"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82204462"],"award-info":[{"award-number":["82204462"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001422","name":"American Society of Hematology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001422","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004735","name":"Hunan Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["2023JJ40200"],"award-info":[{"award-number":["2023JJ40200"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004735","name":"Hunan Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["2022JJ20021"],"award-info":[{"award-number":["2022JJ20021"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Reports"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1016\/j.celrep.2026.117042","type":"journal-article","created":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T19:28:13Z","timestamp":1772566093000},"page":"117042","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["FASN inactivation-induced progranulin (GRN) expression promotes lysosome-dependent cell death to suppress leukemogenesis"],"prefix":"10.1016","volume":"45","author":[{"given":"Meng","family":"Su","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinglin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyi","family":"Lv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinshu","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yating","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaohui","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanqi","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Ouyang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuezhen","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yexin","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ailing","family":"Zou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuqian","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lili","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caiming","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Sheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3163-1716","authenticated-orcid":false,"given":"Yong","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0432-2897","authenticated-orcid":false,"given":"Yang","family":"Mei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.celrep.2026.117042_bib1","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1038\/s41574-022-00773-5","article-title":"Metabolic determinants of tumour initiation","volume":"19","author":"Brunner","year":"2023","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.celrep.2026.117042_bib2","doi-asserted-by":"crossref","first-page":"1851","DOI":"10.1016\/j.stem.2021.06.004","article-title":"Nicotinamide phosphoribosyltransferase inhibitors selectively induce apoptosis of AML stem cells by disrupting lipid homeostasis","volume":"28","author":"Subedi","year":"2021","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.celrep.2026.117042_bib3","doi-asserted-by":"crossref","first-page":"1720","DOI":"10.1158\/2159-8290.CD-22-0411","article-title":"C\/EBPalpha Confers Dependence to Fatty Acid Anabolic Pathways and Vulnerability to Lipid Oxidative Stress-Induced Ferroptosis in FLT3-Mutant Leukemia","volume":"13","author":"Sabatier","year":"2023","journal-title":"Cancer Discov."},{"key":"10.1016\/j.celrep.2026.117042_bib4","doi-asserted-by":"crossref","first-page":"4056","DOI":"10.1038\/s41467-020-17882-2","article-title":"Autophagy regulates fatty acid availability for oxidative phosphorylation through mitochondria-endoplasmic reticulum contact sites","volume":"11","author":"Bosc","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2026.117042_bib5","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1038\/s41573-021-00367-2","article-title":"Lipogenesis inhibitors: therapeutic opportunities and challenges","volume":"21","author":"Batchuluun","year":"2022","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.celrep.2026.117042_bib6","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1038\/s41392-022-01099-4","article-title":"Discovery of a mammalian FASN inhibitor against xenografts of non-small cell lung cancer and melanoma","volume":"7","author":"Cao","year":"2022","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.celrep.2026.117042_bib7","doi-asserted-by":"crossref","first-page":"4327","DOI":"10.1038\/s41467-022-31963-4","article-title":"Targeting de novo lipogenesis and the Lands cycle induces ferroptosis in KRAS-mutant lung cancer","volume":"13","author":"Bartolacci","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2026.117042_bib8","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1002\/path.5587","article-title":"Genetic ablation of FASN attenuates the invasive potential of prostate cancer driven by Pten loss","volume":"253","author":"Bastos","year":"2021","journal-title":"J. Pathol."},{"key":"10.1016\/j.celrep.2026.117042_bib9","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1038\/s41392-023-01405-8","article-title":"FBXW7beta loss-of-function enhances FASN-mediated lipogenesis and promotes colorectal cancer growth","volume":"8","author":"Wei","year":"2023","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.celrep.2026.117042_bib10","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1038\/s43018-021-00183-y","article-title":"Fatty Acid Synthesis Is Required for Breast Cancer Brain Metastasis","volume":"2","author":"Ferraro","year":"2021","journal-title":"Nat. Cancer"},{"key":"10.1016\/j.celrep.2026.117042_bib11","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1002\/hep.32359","article-title":"Therapeutic efficacy of FASN inhibition in preclinical models of HCC","volume":"76","author":"Wang","year":"2022","journal-title":"Hepatology"},{"key":"10.1016\/j.celrep.2026.117042_bib12","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1038\/s41588-022-01045-8","article-title":"HOXB13 suppresses de novo lipogenesis through HDAC3-mediated epigenetic reprogramming in prostate cancer","volume":"54","author":"Lu","year":"2022","journal-title":"Nat. Genet."},{"key":"10.1016\/j.celrep.2026.117042_bib13","first-page":"532","article-title":"Breast cancer: FASN inhibitor increases survival","volume":"15","author":"Crunkhorn","year":"2016","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.celrep.2026.117042_bib14","article-title":"Fatty acid synthase, a novel poor prognostic factor for acute lymphoblastic leukemia which can be targeted by ginger extract","volume":"10","author":"Ghaeidamini Harouni","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.celrep.2026.117042_bib15","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2022.1018154","article-title":"Fatty acid metabolism predicts prognosis and NK cell immunosurveillance of acute myeloid leukemia patients","volume":"12","author":"Ye","year":"2022","journal-title":"Front. Oncol."},{"key":"10.1016\/j.celrep.2026.117042_bib16","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1186\/s12944-022-01687-x","article-title":"A novel fatty acid metabolism-related signature identifies features of the tumor microenvironment and predicts clinical outcome in acute myeloid leukemia","volume":"21","author":"Zhang","year":"2022","journal-title":"Lipids Health Dis."},{"key":"10.1016\/j.celrep.2026.117042_bib17","doi-asserted-by":"crossref","first-page":"2465","DOI":"10.1038\/s41418-021-00768-1","article-title":"Reducing FASN expression sensitizes acute myeloid leukemia cells to differentiation therapy","volume":"28","author":"Humbert","year":"2021","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.celrep.2026.117042_bib18","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1038\/s41375-023-01842-y","article-title":"The fatty acid elongase Elovl6 is crucial for hematopoietic stem cell engraftment and leukemia propagation","volume":"37","author":"Kiyoki","year":"2023","journal-title":"Leukemia"},{"key":"10.1016\/j.celrep.2026.117042_bib19","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202304895","article-title":"m6A-Modified circTET2 Interacting with HNRNPC Regulates Fatty Acid Oxidation to Promote the Proliferation of Chronic Lymphocytic Leukemia","volume":"10","author":"Wu","year":"2023","journal-title":"Adv. Sci."},{"key":"10.1016\/j.celrep.2026.117042_bib20","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1038\/s43018-020-00126-z","article-title":"Fatty acid metabolism underlies venetoclax resistance in acute myeloid leukemia stem cells","volume":"1","author":"Stevens","year":"2020","journal-title":"Nat. Cancer"},{"key":"10.1016\/j.celrep.2026.117042_bib21","doi-asserted-by":"crossref","DOI":"10.1172\/JCI141529","article-title":"Stabilization of fatty acid synthesis enzyme acetyl-CoA carboxylase 1 suppresses acute myeloid leukemia development","volume":"131","author":"Ito","year":"2021","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.celrep.2026.117042_bib22","doi-asserted-by":"crossref","first-page":"2070","DOI":"10.1158\/0008-5472.CAN-03-3645","article-title":"Orlistat is a novel inhibitor of fatty acid synthase with antitumor activity","volume":"64","author":"Kridel","year":"2004","journal-title":"Cancer Res."},{"key":"10.1016\/j.celrep.2026.117042_bib23","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1016\/j.ebiom.2015.06.020","article-title":"Inhibition of de novo Palmitate Synthesis by Fatty Acid Synthase Induces Apoptosis in Tumor Cells by Remodeling Cell Membranes, Inhibiting Signaling Pathways, and Reprogramming Gene Expression","volume":"2","author":"Ventura","year":"2015","journal-title":"EBioMedicine"},{"key":"10.1016\/j.celrep.2026.117042_bib24","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1592\/phco.20.4.270.34882","article-title":"Orlistat, a new lipase inhibitor for the management of obesity","volume":"20","author":"Heck","year":"2000","journal-title":"Pharmacotherapy"},{"key":"10.1016\/j.celrep.2026.117042_bib25","doi-asserted-by":"crossref","first-page":"5378","DOI":"10.1073\/pnas.1002588108","article-title":"Antidiabetic and antisteatotic effects of the selective fatty acid synthase (FAS) inhibitor platensimycin in mouse models of diabetes","volume":"108","author":"Wu","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2026.117042_bib26","doi-asserted-by":"crossref","first-page":"D917","DOI":"10.1093\/nar\/gkv1101","article-title":"BloodSpot: a database of gene expression profiles and transcriptional programs for healthy and malignant haematopoiesis","volume":"44","author":"Bagger","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.celrep.2026.117042_bib27","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1038\/nature04784","article-title":"Platensimycin is a selective FabF inhibitor with potent antibiotic properties","volume":"441","author":"Wang","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2026.117042_bib28","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1016\/j.jmb.2010.01.066","article-title":"Structure of the Human Fatty Acid Synthase KS\u2013MAT Didomain as a Framework for Inhibitor Design","volume":"397","author":"Pappenberger","year":"2010","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.celrep.2026.117042_bib29","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1126\/science.1174447","article-title":"A gene network regulating lysosomal biogenesis and function","volume":"325","author":"Sardiello","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.celrep.2026.117042_bib30","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.1038\/s41467-023-37016-8","article-title":"De novo lipogenesis fuels adipocyte autophagosome and lysosome membrane dynamics","volume":"14","author":"Rowland","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2026.117042_bib31","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1111\/tra.12613","article-title":"Lysosomal membrane permeabilization and cell death","volume":"19","author":"Wang","year":"2018","journal-title":"Traffic"},{"key":"10.1016\/j.celrep.2026.117042_bib32","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1080\/15548627.2015.1063871","article-title":"Sensitive detection of lysosomal membrane permeabilization by lysosomal galectin puncta assay","volume":"11","author":"Aits","year":"2015","journal-title":"Autophagy"},{"key":"10.1016\/j.celrep.2026.117042_bib33","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1038\/s41556-021-00644-7","article-title":"Lysosomal retargeting of Myoferlin mitigates membrane stress to enable pancreatic cancer growth","volume":"23","author":"Gupta","year":"2021","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.celrep.2026.117042_bib34","doi-asserted-by":"crossref","DOI":"10.1126\/science.aar5078","article-title":"Triggered recruitment of ESCRT machinery promotes endolysosomal repair","volume":"360","author":"Skowyra","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.celrep.2026.117042_bib35","doi-asserted-by":"crossref","first-page":"2233","DOI":"10.1016\/j.cub.2016.06.046","article-title":"Endolysosomes Are the Principal Intracellular Sites of Acid Hydrolase Activity","volume":"26","author":"Bright","year":"2016","journal-title":"Curr. Biol."},{"key":"10.1016\/j.celrep.2026.117042_bib36","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abb0205","article-title":"GADD34 is a modulator of autophagy during starvation","volume":"6","author":"Gambardella","year":"2020","journal-title":"Sci. Adv."},{"key":"10.1016\/j.celrep.2026.117042_bib37","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00401-018-1861-8","article-title":"The lysosomal function of progranulin, a guardian against neurodegeneration","volume":"136","author":"Paushter","year":"2018","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.celrep.2026.117042_bib38","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1084\/jem.20091568","article-title":"Exaggerated inflammation, impaired host defense, and neuropathology in progranulin-deficient mice","volume":"207","author":"Yin","year":"2010","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.celrep.2026.117042_bib39","doi-asserted-by":"crossref","first-page":"3955","DOI":"10.1172\/JCI63113","article-title":"Progranulin deficiency promotes neuroinflammation and neuron loss following toxin-induced injury","volume":"122","author":"Martens","year":"2012","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.celrep.2026.117042_bib40","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1186\/s13024-016-0114-3","article-title":"Trehalose upregulates progranulin expression in human and mouse models of GRN haploinsufficiency: a novel therapeutic lead to treat frontotemporal dementia","volume":"11","author":"Holler","year":"2016","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.celrep.2026.117042_bib41","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1016\/j.chembiol.2017.06.010","article-title":"Selectivity and Kinetic Requirements of HDAC Inhibitors as Progranulin Enhancers for Treating Frontotemporal Dementia","volume":"24","author":"She","year":"2017","journal-title":"Cell Chem. Biol."},{"key":"10.1016\/j.celrep.2026.117042_bib42","doi-asserted-by":"crossref","first-page":"5011","DOI":"10.1038\/s41467-019-13028-1","article-title":"Essentiality of fatty acid synthase in the 2D to anchorage-independent growth transition in transforming cells","volume":"10","author":"Bueno","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2026.117042_bib43","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.jhep.2015.10.004","article-title":"Inactivation of fatty acid synthase impairs hepatocarcinogenesis driven by AKT in mice and humans","volume":"64","author":"Li","year":"2016","journal-title":"J. Hepatol."},{"key":"10.1016\/j.celrep.2026.117042_bib44","doi-asserted-by":"crossref","first-page":"6358","DOI":"10.1073\/pnas.0931394100","article-title":"Fatty acid synthesis is essential in embryonic development: fatty acid synthase null mutants and most of the heterozygotes die in utero","volume":"100","author":"Chirala","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2026.117042_bib45","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1038\/nature11689","article-title":"Metabolic control of adult neural stem cell activity by Fasn-dependent lipogenesis","volume":"493","author":"Knobloch","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2026.117042_bib46","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.stem.2020.04.002","article-title":"FASN-Dependent Lipid Metabolism Links Neurogenic Stem\/Progenitor Cell Activity to Learning and Memory Deficits","volume":"27","author":"Bowers","year":"2020","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.celrep.2026.117042_bib47","doi-asserted-by":"crossref","first-page":"5509","DOI":"10.1074\/jbc.RA118.001921","article-title":"An unexpected link between fatty acid synthase and cholesterol synthesis in proinflammatory macrophage activation","volume":"293","author":"Carroll","year":"2018","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.celrep.2026.117042_bib48","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1038\/s41589-019-0344-0","article-title":"Toll-like receptor mediated inflammation requires FASN-dependent MYD88 palmitoylation","volume":"15","author":"Kim","year":"2019","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.celrep.2026.117042_bib49","doi-asserted-by":"crossref","first-page":"2539","DOI":"10.1172\/JCI31183","article-title":"Brain fatty acid synthase activates PPARalpha to maintain energy homeostasis","volume":"117","author":"Chakravarthy","year":"2007","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.celrep.2026.117042_bib50","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.cmet.2014.12.002","article-title":"Peroxisomal lipid synthesis regulates inflammation by sustaining neutrophil membrane phospholipid composition and viability","volume":"21","author":"Lodhi","year":"2015","journal-title":"Cell Metab."},{"key":"10.1016\/j.celrep.2026.117042_bib51","doi-asserted-by":"crossref","first-page":"3460","DOI":"10.1038\/s41467-023-39266-y","article-title":"Atomic model for core modifying region of human fatty acid synthase in complex with Denifanstat","volume":"14","author":"Hasan","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2026.117042_bib52","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.1038\/s42255-021-00479-4","article-title":"Pharmacological inhibition of fatty acid synthesis blocks SARS-CoV-2 replication","volume":"3","author":"Chu","year":"2021","journal-title":"Nat. Metab."},{"key":"10.1016\/j.celrep.2026.117042_bib53","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1016\/j.chembiol.2013.03.014","article-title":"Modulation of fatty acid synthase enzyme activity and expression during hepatitis C virus replication","volume":"20","author":"Nasheri","year":"2013","journal-title":"Chem. Biol."},{"key":"10.1016\/j.celrep.2026.117042_bib54","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0164133","article-title":"The Fatty Acid Synthase Inhibitor Platensimycin Improves Insulin Resistance without Inducing Liver Steatosis in Mice and Monkeys","volume":"11","author":"Singh","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.celrep.2026.117042_bib55","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1038\/s41375-023-02130-5","article-title":"Targeting ZDHHC21\/FASN axis for the treatment of diffuse large B-cell lymphoma","volume":"38","author":"Liu","year":"2024","journal-title":"Leukemia"},{"key":"10.1016\/j.celrep.2026.117042_bib56","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1016\/j.bbamcr.2008.09.008","article-title":"Lysosomal involvement in cell death and cancer","volume":"1793","author":"Kirkegaard","year":"2009","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.celrep.2026.117042_bib57","doi-asserted-by":"crossref","first-page":"1648","DOI":"10.1038\/s42255-021-00489-2","article-title":"Peroxisomal beta-oxidation acts as a sensor for intracellular fatty acids and regulates lipolysis","volume":"3","author":"Ding","year":"2021","journal-title":"Nat. Metab."},{"key":"10.1016\/j.celrep.2026.117042_bib58","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1016\/j.tcb.2017.07.006","article-title":"Emerging Roles for the Lysosome in Lipid Metabolism","volume":"27","author":"Thelen","year":"2017","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.celrep.2026.117042_bib59","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1038\/s41586-022-05164-4","article-title":"A phosphoinositide signalling pathway mediates rapid lysosomal repair","volume":"609","author":"Tan","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2026.117042_bib60","doi-asserted-by":"crossref","DOI":"10.15252\/embj.2022112677","article-title":"Cholesterol transfer via endoplasmic reticulum contacts mediates lysosome damage repair","volume":"41","author":"Radulovic","year":"2022","journal-title":"EMBO J."},{"key":"10.1016\/j.celrep.2026.117042_bib61","doi-asserted-by":"crossref","first-page":"1875","DOI":"10.1038\/s41467-022-29481-4","article-title":"Ca(2+)-activated sphingomyelin scrambling and turnover mediate ESCRT-independent lysosomal repair","volume":"13","author":"Niekamp","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2026.117042_bib62","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1038\/nature05016","article-title":"Mutations in progranulin cause tau-negative frontotemporal dementia linked to chromosome 17","volume":"442","author":"Baker","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2026.117042_bib63","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1038\/nature05017","article-title":"Null mutations in progranulin cause ubiquitin-positive frontotemporal dementia linked to chromosome 17q21","volume":"442","author":"Cruts","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2026.117042_bib64","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1093\/brain\/awn012","article-title":"Phenotype variability in progranulin mutation carriers: a clinical, neuropsychological, imaging and genetic study","volume":"131","author":"Le Ber","year":"2008","journal-title":"Brain"},{"key":"10.1016\/j.celrep.2026.117042_bib65","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1016\/j.tips.2021.11.015","article-title":"Progranulin as a therapeutic target in neurodegenerative diseases","volume":"43","author":"Rhinn","year":"2022","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.celrep.2026.117042_bib66","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1186\/s12974-023-02965-w","article-title":"Progranulin and GPNMB: interactions in endo-lysosome function and inflammation in neurodegenerative disease","volume":"20","author":"Gillett","year":"2023","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.celrep.2026.117042_bib67","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.stem.2020.04.009","article-title":"RNA Demethylase ALKBH5 Selectively Promotes Tumorigenesis and Cancer Stem Cell Self-Renewal in Acute Myeloid Leukemia","volume":"27","author":"Shen","year":"2020","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.celrep.2026.117042_bib68","doi-asserted-by":"crossref","first-page":"2838","DOI":"10.1182\/blood.2021011707","article-title":"A critical role of nuclear m6A reader YTHDC1 in leukemogenesis by regulating MCM complex-mediated DNA replication","volume":"138","author":"Sheng","year":"2021","journal-title":"Blood"},{"key":"10.1016\/j.celrep.2026.117042_bib69","doi-asserted-by":"crossref","first-page":"4898","DOI":"10.1073\/pnas.1119535109","article-title":"Regulation of neuroblastoma differentiation by forkhead transcription factors FOXO1\/3\/4 through the receptor tyrosine kinase PDGFRA","volume":"109","author":"Mei","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2026.117042_bib70","doi-asserted-by":"crossref","first-page":"3172","DOI":"10.1038\/s41467-020-16911-4","article-title":"Diaphanous-related formin mDia2 regulates beta2 integrins to control hematopoietic stem and progenitor cell engraftment","volume":"11","author":"Mei","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2026.117042_bib71","first-page":"700","article-title":"Granulocytic differentiation of human NB4 promyelocytic leukemia cells induced by all-trans retinoic acid metabolites","volume":"61","author":"Idres","year":"2001","journal-title":"Cancer Res."},{"key":"10.1016\/j.celrep.2026.117042_bib72","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1038\/leu.2017.326","article-title":"Age-related inflammatory bone marrow microenvironment induces ineffective erythropoiesis mimicking del(5q) MDS","volume":"32","author":"Mei","year":"2018","journal-title":"Leukemia"},{"key":"10.1016\/j.celrep.2026.117042_bib73","doi-asserted-by":"crossref","DOI":"10.1172\/JCI152673","article-title":"Bone marrow-confined IL-6 signaling mediates the progression of myelodysplastic syndromes to acute myeloid leukemia","volume":"132","author":"Mei","year":"2022","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.celrep.2026.117042_bib74","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1011084","article-title":"mDia formins form hetero-oligomers and cooperatively maintain murine hematopoiesis","volume":"19","author":"Li","year":"2023","journal-title":"PLoS Genet."},{"key":"10.1016\/j.celrep.2026.117042_bib75","doi-asserted-by":"crossref","first-page":"2100","DOI":"10.1038\/nprot.2014.138","article-title":"The cellular thermal shift assay for evaluating drug target interactions in cells","volume":"9","author":"Jafari","year":"2014","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.celrep.2026.117042_bib76","doi-asserted-by":"crossref","first-page":"3891","DOI":"10.1021\/acs.jcim.1c00203","article-title":"AutoDock Vina 1.2.0: New Docking Methods, Expanded Force Field, and Python Bindings","volume":"61","author":"Eberhardt","year":"2021","journal-title":"J. Chem. Inf. Model."}],"container-title":["Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124726001208?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124726001208?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T20:41:46Z","timestamp":1791405706000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211124726001208"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":76,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["S2211124726001208"],"URL":"https:\/\/doi.org\/10.1016\/j.celrep.2026.117042","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2025.05.06.652401","asserted-by":"object"}]},"ISSN":["2211-1247"],"issn-type":[{"value":"2211-1247","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"FASN inactivation-induced progranulin (GRN) expression promotes lysosome-dependent cell death to suppress leukemogenesis","name":"articletitle","label":"Article Title"},{"value":"Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.celrep.2026.117042","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"117042"}}