{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T20:56:32Z","timestamp":1791406592977,"version":"4.3.3"},"reference-count":39,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T00:00:00Z","timestamp":1770595200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100001607","name":"The Eye &amp; Ear Foundation of Pittsburgh","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001607","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001818","name":"Research to Prevent Blindness","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001818","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000053","name":"National Eye Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Reports"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1016\/j.celrep.2026.117064","type":"journal-article","created":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T15:54:37Z","timestamp":1772726077000},"page":"117064","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Genetically engineered eye-colonizing microbes that deliver the anti-inflammatory cytokine interleukin-10 enhance corneal tissue repair"],"prefix":"10.1016","volume":"45","author":[{"given":"Jackie","family":"Shane","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Evans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yannis","family":"Rigas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert M.Q.","family":"Shanks","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony J.","family":"St. Leger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.celrep.2026.117064_bib1","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1001\/archopht.123.5.662","article-title":"Incidence of Emergency Department\u2013Treated Eye Injury in the United States","volume":"123","author":"McGwin","year":"2005","journal-title":"Arch. Ophthalmol."},{"key":"10.1016\/j.celrep.2026.117064_bib2","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1016\/j.immuni.2020.10.013","article-title":"Production of the Cytokine VEGF-A by CD4(+) T and Myeloid Cells Disrupts the Corneal Nerve Landscape and Promotes Herpes Stromal Keratitis","volume":"53","author":"Yun","year":"2020","journal-title":"Immunity"},{"key":"10.1016\/j.celrep.2026.117064_bib3","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.51497","article-title":"Looking into nerve damage in the cornea","volume":"8","author":"GADJEVA","year":"2019","journal-title":"eLife"},{"key":"10.1016\/j.celrep.2026.117064_bib4","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.sjopt.2014.06.011","article-title":"Management strategies for persistent epithelial defects of the cornea","volume":"28","author":"Katzman","year":"2014","journal-title":"Saudi J. Ophthalmol."},{"key":"10.1016\/j.celrep.2026.117064_bib5","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/bs.pmbts.2015.05.002","article-title":"Corneal Epithelial Wound Healing","volume":"134","author":"Liu","year":"2015","journal-title":"Prog. Mol. Biol. Transl. Sci."},{"key":"10.1016\/j.celrep.2026.117064_bib6","doi-asserted-by":"crossref","first-page":"10081","DOI":"10.1002\/jcp.29823","article-title":"The proinflammatory cytokines IL-1beta and TNF-alpha modulate corneal epithelial wound healing through p16(Ink4a) suppressing STAT3 activity","volume":"235","author":"Wang","year":"2020","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.celrep.2026.117064_bib7","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.exer.2014.06.012","article-title":"IL-6 as a corneal wound healing mediator in an in vitro scratch assay","volume":"125","author":"Arranz-Valsero","year":"2014","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.celrep.2026.117064_bib8","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1016\/j.ajpath.2010.12.001","article-title":"IL-17 and VEGF are necessary for efficient corneal nerve regeneration","volume":"178","author":"Li","year":"2011","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.celrep.2026.117064_bib9","doi-asserted-by":"crossref","first-page":"2659","DOI":"10.1096\/fj.11-184804","article-title":"CCL20, \u03b3\u03b4 T cells, and IL-22 in corneal epithelial healing","volume":"25","author":"Li","year":"2011","journal-title":"FASEB J."},{"key":"10.1016\/j.celrep.2026.117064_bib10","doi-asserted-by":"crossref","first-page":"8446","DOI":"10.7150\/thno.31711","article-title":"Lentivirus-mediated IL-10-expressing Bone Marrow Mesenchymal Stem Cells promote corneal allograft survival via upregulating lncRNA 003946 in a rat model of corneal allograft rejection","volume":"10","author":"Lu","year":"2020","journal-title":"Theranostics"},{"key":"10.1016\/j.celrep.2026.117064_bib11","doi-asserted-by":"crossref","first-page":"636","DOI":"10.3389\/fcell.2020.00636","article-title":"The Role of an IL-10\/Hyaluronan Axis in Dermal Wound Healing","volume":"8","author":"Singampalli","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.celrep.2026.117064_bib12","doi-asserted-by":"crossref","first-page":"129","DOI":"10.3389\/fimmu.2013.00129","article-title":"Regulation of adaptive immunity; the role of interleukin-10","volume":"4","author":"Ng","year":"2013","journal-title":"Front. Immunol."},{"key":"10.1016\/j.celrep.2026.117064_bib13","doi-asserted-by":"crossref","first-page":"3018","DOI":"10.1073\/pnas.0914500107","article-title":"IL-10 directly suppresses CD4 but not CD8 T cell effector and memory responses following acute viral infection","volume":"107","author":"Brooks","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2026.117064_bib14","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.immuni.2018.01.006","article-title":"Interleukin-10 Directly Inhibits CD8(+) T Cell Function by Enhancing N-Glycan Branching to Decrease Antigen Sensitivity","volume":"48","author":"Smith","year":"2018","journal-title":"Immunity"},{"key":"10.1016\/j.celrep.2026.117064_bib15","doi-asserted-by":"crossref","first-page":"512","DOI":"10.3389\/fimmu.2019.00512","article-title":"The Role of T Cells in Herpes Stromal Keratitis","volume":"10","author":"Rajasagi","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.celrep.2026.117064_bib16","doi-asserted-by":"crossref","first-page":"S4","DOI":"10.1016\/j.ophtha.2017.07.010","article-title":"The Pathophysiology of Dry Eye Disease: What We Know and Future Directions for Research","volume":"124","author":"Pflugfelder","year":"2017","journal-title":"Ophthalmology"},{"key":"10.1016\/j.celrep.2026.117064_bib17","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1016\/j.cell.2012.01.035","article-title":"The impact of the gut microbiota on human health: an integrative view","volume":"148","author":"Clemente","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2026.117064_bib18","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1038\/nbt.4222","article-title":"Development of a synthetic live bacterial therapeutic for the human metabolic disease phenylketonuria","volume":"36","author":"Isabella","year":"2018","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.celrep.2026.117064_bib19","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/s12934-015-0198-4","article-title":"Serine protease inhibitors protect better than IL-10 and TGF-beta anti-inflammatory cytokines against mouse colitis when delivered by recombinant lactococci","volume":"14","author":"Bermudez-Humaran","year":"2015","journal-title":"Microb. Cell Fact."},{"key":"10.1016\/j.celrep.2026.117064_bib20","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1053\/j.gastro.2013.09.060","article-title":"Oral delivery of IL-27 recombinant bacteria attenuates immune colitis in mice","volume":"146","author":"Hanson","year":"2014","journal-title":"Gastroenterology"},{"key":"10.1016\/j.celrep.2026.117064_bib21","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1126\/science.289.5483.1352","article-title":"Treatment of Murine Colitis by Lactococcus lactis Secreting Interleukin-10","volume":"289","author":"Steidler","year":"2000","journal-title":"Science"},{"key":"10.1016\/j.celrep.2026.117064_bib22","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1016\/j.cgh.2006.03.028","article-title":"A phase I trial with transgenic bacteria expressing interleukin-10 in Crohn's disease","volume":"4","author":"Braat","year":"2006","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"10.1016\/j.celrep.2026.117064_bib23","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/j.jtos.2017.05.006","article-title":"TFOS DEWS II Management and Therapy Report","volume":"15","author":"Jones","year":"2017","journal-title":"Ocul. Surf."},{"key":"10.1016\/j.celrep.2026.117064_bib24","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1097\/IJG.0b013e3181f7b10e","article-title":"Prevalence and correlates of self-reported nonadherence with eye drop treatment: the Belgian Compliance Study in Ophthalmology (BCSO)","volume":"20","author":"Vandenbroeck","year":"2011","journal-title":"J. Glaucoma"},{"key":"10.1016\/j.celrep.2026.117064_bib25","doi-asserted-by":"crossref","DOI":"10.3390\/jcm11020367","article-title":"Adherence to Eye Drops Usage in Dry Eye Patients and Reasons for Non-Compliance: A Web-Based Survey","volume":"11","author":"Uchino","year":"2022","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.celrep.2026.117064_bib26","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.immuni.2017.06.014","article-title":"An Ocular Commensal Protects against Corneal Infection by Driving an Interleukin-17 Response from Mucosal gammadelta T Cells","volume":"47","author":"St Leger","year":"2017","journal-title":"Immunity"},{"key":"10.1016\/j.celrep.2026.117064_bib27","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1167\/iovs.64.2.19","article-title":"Genetic Manipulation of Corynebacterium mastitidis to Better Understand the Ocular Microbiome","volume":"64","author":"Rigas","year":"2023","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.celrep.2026.117064_bib28","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1098\/rstb.2011.0210","article-title":"Protein secretion and surface display in Gram-positive bacteria","volume":"367","author":"Schneewind","year":"2012","journal-title":"Philos. Trans. R. Soc. Lond. B Biol. Sci."},{"key":"10.1016\/j.celrep.2026.117064_bib29","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1038\/s41587-019-0036-z","article-title":"SignalP 5.0 improves signal peptide predictions using deep neural networks","volume":"37","author":"Almagro Armenteros","year":"2019","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.celrep.2026.117064_bib30","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1615\/CritRevImmunol.2016017480","article-title":"IL10, A Tale of an Evolutionarily Conserved Cytokine across Vertebrates","volume":"36","author":"Piazzon","year":"2016","journal-title":"Crit. Rev. Immunol."},{"key":"10.1016\/j.celrep.2026.117064_bib31","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1084\/jem.20170369","article-title":"STAT-3-independent production of IL-17 by mouse innate-like alphabeta T cells controls ocular infection","volume":"215","author":"St Leger","year":"2018","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.celrep.2026.117064_bib32","doi-asserted-by":"crossref","first-page":"2496","DOI":"10.1167\/iovs.02-0851","article-title":"Mucin gene expression in immortalized human corneal-limbal and conjunctival epithelial cell lines","volume":"44","author":"Gipson","year":"2003","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.celrep.2026.117064_bib33","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1128\/JB.01130-10","article-title":"Control of heme homeostasis in Corynebacterium glutamicum by the two-component system HrrSA","volume":"193","author":"Frunzke","year":"2011","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.celrep.2026.117064_bib34","doi-asserted-by":"crossref","DOI":"10.15252\/msb.202211037","article-title":"Bacterial expression of a designed single-chain IL-10 prevents severe lung inflammation","volume":"19","author":"Montero-Blay","year":"2023","journal-title":"Mol. Syst. Biol."},{"key":"10.1016\/j.celrep.2026.117064_bib35","doi-asserted-by":"crossref","first-page":"3263","DOI":"10.1016\/j.cell.2022.06.050","article-title":"Intestinal transgene delivery with native E. coli chassis allows persistent physiological changes","volume":"185","author":"Russell","year":"2022","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2026.117064_bib36","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1165\/rcmb.2021-0508OC","article-title":"Microbial-induced Redox Imbalance in the Neonatal Lung Is Ameliorated by Live Biotherapeutics","volume":"68","author":"Freeman","year":"2023","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.celrep.2026.117064_bib37","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/nmeth.2019","article-title":"Fiji: an open-source platform for biological-image analysis","volume":"9","author":"Schindelin","year":"2012","journal-title":"Nat. Methods"},{"key":"10.1016\/j.celrep.2026.117064_bib38","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0184355","article-title":"Improving heterologous membrane protein production in Escherichia coli by combining transcriptional tuning and codon usage algorithms","volume":"12","author":"Claassens","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.celrep.2026.117064_bib39","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1167\/iovs.63.2.4","article-title":"Sensory Nerve Retraction and Sympathetic Nerve Innervation Contribute to Immunopathology of Murine Recurrent Herpes Stromal Keratitis","volume":"63","author":"Yun","year":"2022","journal-title":"Investig. Ophthalmol. Vis. Sci."}],"container-title":["Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124726001427?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124726001427?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T20:37:19Z","timestamp":1791405439000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211124726001427"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":39,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["S2211124726001427"],"URL":"https:\/\/doi.org\/10.1016\/j.celrep.2026.117064","relation":{},"ISSN":["2211-1247"],"issn-type":[{"value":"2211-1247","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Genetically engineered eye-colonizing microbes that deliver the anti-inflammatory cytokine interleukin-10 enhance corneal tissue repair","name":"articletitle","label":"Article Title"},{"value":"Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.celrep.2026.117064","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"117064"}}