{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T05:06:53Z","timestamp":1793423213209,"version":"4.5.0"},"reference-count":80,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T00:00:00Z","timestamp":1771372800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Reports"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1016\/j.celrep.2026.117110","type":"journal-article","created":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T01:21:22Z","timestamp":1773451282000},"page":"117110","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"title":["Single-nucleus multiome analysis in the human prefrontal cortex identifies gene expression and cis-regulatory elements associated with aging"],"prefix":"10.1016","volume":"45","author":[{"given":"Adam","family":"Catching","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cory A.","family":"Weller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangle","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Bromberek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shahroze","family":"Abbas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kensuke","family":"Daida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laksh","family":"Malik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Breeana","family":"Baker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pavan K.","family":"Auluck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurel A.","family":"Screven","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kate M.","family":"Andersh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimberley J.","family":"Billingsley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Marenco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark R.","family":"Cookson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kendall","family":"Van Keuren-Jensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mike A.","family":"Nalls","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew B.","family":"Singleton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cornelis","family":"Blauwendraat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7563-9365","authenticated-orcid":false,"given":"Xylena","family":"Reed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.celrep.2026.117110_bib1","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1038\/nmeth.1315","article-title":"mRNA-Seq whole-transcriptome analysis of a single cell","volume":"6","author":"Tang","year":"2009","journal-title":"Nat. Methods"},{"key":"10.1016\/j.celrep.2026.117110_bib2","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1038\/s41586-019-1506-7","article-title":"Conserved cell types with divergent features in human versus mouse cortex","volume":"573","author":"Hodge","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2026.117110_bib3","doi-asserted-by":"crossref","first-page":"4422","DOI":"10.1016\/j.cell.2023.08.040","article-title":"Epigenomic dissection of Alzheimer\u2019s disease pinpoints causal variants and reveals epigenome erosion","volume":"186","author":"Xiong","year":"2023","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2026.117110_bib4","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1038\/s41586-019-1195-2","article-title":"Single-cell transcriptomic analysis of Alzheimer\u2019s disease","volume":"570","author":"Mathys","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2026.117110_bib5","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/s40478-020-0880-6","article-title":"Single-nucleus RNA-seq identifies Huntington disease astrocyte states","volume":"8","author":"Al-Dalahmah","year":"2020","journal-title":"Acta Neuropathol. Commun."},{"key":"10.1016\/j.celrep.2026.117110_bib6","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1038\/s41586-024-07871-6","article-title":"Cellular communities reveal trajectories of brain ageing and Alzheimer\u2019s disease","volume":"633","author":"Green","year":"2024","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2026.117110_bib7","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1038\/s41586-024-07606-7","article-title":"Single-cell multiregion dissection of Alzheimer\u2019s disease","volume":"632","author":"Mathys","year":"2024","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2026.117110_bib8","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1093\/brain\/awab446","article-title":"Single-cell sequencing of human midbrain reveals glial activation and a Parkinson-specific neuronal state","volume":"145","author":"Smaji\u0107","year":"2022","journal-title":"Brain"},{"key":"10.1016\/j.celrep.2026.117110_bib9","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/s13024-023-00699-0","article-title":"Unravelling cell type-specific responses to Parkinson\u2019s Disease at single cell resolution","volume":"19","author":"Martirosyan","year":"2024","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.celrep.2026.117110_bib10","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1038\/s41597-025-04687-5","article-title":"Population-scale cross-disorder atlas of the human prefrontal cortex at single-cell resolution","volume":"12","author":"Fullard","year":"2025","journal-title":"Sci. Data"},{"key":"10.1016\/j.celrep.2026.117110_bib11","doi-asserted-by":"crossref","first-page":"4428","DOI":"10.1016\/j.cell.2022.09.039","article-title":"Human prefrontal cortex gene regulatory dynamics from gestation to adulthood at single-cell resolution","volume":"185","author":"Herring","year":"2022","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2026.117110_bib12","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1038\/s41467-024-44742-0","article-title":"Leveraging single-cell ATAC-seq and RNA-seq to identify disease-critical fetal and adult brain cell types","volume":"15","author":"Kim","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2026.117110_bib13","doi-asserted-by":"crossref","first-page":"5053","DOI":"10.1016\/j.cell.2021.07.039","article-title":"Chromatin and gene-regulatory dynamics of the developing human cerebral cortex at single-cell resolution","volume":"184","author":"Trevino","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2026.117110_bib14","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/j.devcel.2024.10.005","article-title":"Comparative single-cell multiome identifies evolutionary changes in neural progenitor cells during primate brain development","volume":"60","author":"Liu","year":"2025","journal-title":"Dev. Cell"},{"key":"10.1016\/j.celrep.2026.117110_bib15","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/s13064-024-00189-z","article-title":"scMultiome analysis identifies a single caudal hindbrain compartment in the developing zebrafish nervous system","volume":"19","author":"Warns","year":"2024","journal-title":"Neural Dev."},{"key":"10.1016\/j.celrep.2026.117110_bib16","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1038\/nmeth.2688","article-title":"Transposition of native chromatin for fast and sensitive epigenomic profiling of open chromatin, DNA-binding proteins and nucleosome position","volume":"10","author":"Buenrostro","year":"2013","journal-title":"Nat. Methods"},{"key":"10.1016\/j.celrep.2026.117110_bib17","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-024-54448-y","article-title":"A multi-regional human brain atlas of chromatin accessibility and gene expression facilitates promoter-isoform resolution genetic fine-mapping","volume":"15","author":"Dong","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2026.117110_bib18","doi-asserted-by":"crossref","DOI":"10.1126\/science.adf7044","article-title":"A comparative atlas of single-cell chromatin accessibility in the human brain","volume":"382","author":"Li","year":"2023","journal-title":"Science"},{"key":"10.1016\/j.celrep.2026.117110_bib19","doi-asserted-by":"crossref","first-page":"2679","DOI":"10.1038\/s41591-024-03150-z","article-title":"A brain cell atlas integrating single-cell transcriptomes across human brain regions","volume":"30","author":"Chen","year":"2024","journal-title":"Nat. Med."},{"key":"10.1016\/j.celrep.2026.117110_bib20","doi-asserted-by":"crossref","DOI":"10.1126\/science.add7046","article-title":"Transcriptomic diversity of cell types across the adult human brain","volume":"382","author":"Siletti","year":"2023","journal-title":"Science"},{"key":"10.1016\/j.celrep.2026.117110_bib21","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a008524","article-title":"Genetic variation and adaptation in Africa: implications for human evolution and disease","volume":"6","author":"Gomez","year":"2014","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.celrep.2026.117110_bib22","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1016\/j.neurobiolaging.2012.10.021","article-title":"Age-associated changes in gene expression in human brain and isolated neurons","volume":"34","author":"Kumar","year":"2013","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.celrep.2026.117110_bib23","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-17322-0","article-title":"Transcriptomic profiling of the human brain reveals that altered synaptic gene expression is associated with chronological aging","volume":"7","author":"Dillman","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.celrep.2026.117110_bib24","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-023-37105-0","article-title":"Author Correction: Temporal changes in the gene expression heterogeneity during brain development and aging","volume":"13","author":"I\u015f\u0131ldak","year":"2023","journal-title":"Sci. Rep."},{"key":"10.1016\/j.celrep.2026.117110_bib25","article-title":"A single-cell transcriptomic atlas of the prefrontal cortex across the human lifespan","author":"Yang","year":"2025","journal-title":"medRxiv"},{"key":"10.1016\/j.celrep.2026.117110_bib26","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1038\/s41586-024-07109-5","article-title":"A concerted neuron-astrocyte program declines in ageing and schizophrenia","volume":"627","author":"Ling","year":"2024","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2026.117110_bib27","doi-asserted-by":"crossref","DOI":"10.1126\/science.adf0834","article-title":"Single-cell analysis of prenatal and postnatal human cortical development","volume":"382","author":"Velmeshev","year":"2023","journal-title":"Science"},{"key":"10.1016\/j.celrep.2026.117110_bib28","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1038\/s41586-024-08351-7","article-title":"Molecular and cellular dynamics of the developing human neocortex","volume":"647","author":"Wang","year":"2025","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2026.117110_bib29","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1038\/s43588-023-00476-5","article-title":"Mapping disease regulatory circuits at cell-type resolution from single-cell multiomics data","volume":"3","author":"Chen","year":"2023","journal-title":"Nat. Comput. Sci."},{"key":"10.1016\/j.celrep.2026.117110_bib30","doi-asserted-by":"crossref","DOI":"10.1126\/science.adi5199","article-title":"Single-cell genomics and regulatory networks for 388 human brains","volume":"384","author":"Emani","year":"2024","journal-title":"Science"},{"key":"10.1016\/j.celrep.2026.117110_bib31","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.adg3754","article-title":"Multi-omic profiling of the developing human cerebral cortex at the single-cell level","volume":"9","author":"Zhu","year":"2023","journal-title":"Sci. Adv."},{"key":"10.1016\/j.celrep.2026.117110_bib32","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.adq2290","article-title":"Contrasting genetic predisposition and diagnosis in psychiatric disorders: A multi-omic single-nucleus analysis of the human OFC","volume":"11","author":"Gerstner","year":"2025","journal-title":"Sci. Adv."},{"key":"10.1016\/j.celrep.2026.117110_bib33","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1000952","article-title":"Abundant quantitative trait loci exist for DNA methylation and gene expression in human brain","volume":"6","author":"Gibbs","year":"2010","journal-title":"PLoS Genet."},{"key":"10.1016\/j.celrep.2026.117110_bib34","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1038\/s41592-023-01993-x","article-title":"Scalable Nanopore sequencing of human genomes provides a comprehensive view of haplotype-resolved variation and methylation","volume":"20","author":"Kolmogorov","year":"2023","journal-title":"Nat. Methods"},{"key":"10.1016\/j.celrep.2026.117110_bib35","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1007\/s00401-023-02599-5","article-title":"Cryptic exon detection and transcriptomic changes revealed in single-nuclei RNA sequencing of C9ORF72 patients spanning the ALS-FTD spectrum","volume":"146","author":"Gittings","year":"2023","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.celrep.2026.117110_bib36","doi-asserted-by":"crossref","DOI":"10.4161\/cib.26839","article-title":"Dock protein family in brain development and neurological disease","volume":"6","author":"Shi","year":"2013","journal-title":"Commun. Integr. Biol."},{"key":"10.1016\/j.celrep.2026.117110_bib37","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0020988","article-title":"Copy number variation in familial Parkinson disease","volume":"6","author":"Pankratz","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.celrep.2026.117110_bib38","doi-asserted-by":"crossref","first-page":"11370","DOI":"10.1073\/pnas.1816847116","article-title":"Epigenetic upregulation of FKBP5 by aging and stress contributes to NF-\u03baB-driven inflammation and cardiovascular risk","volume":"116","author":"Zannas","year":"2019","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2026.117110_bib39","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1523\/JNEUROSCI.04-02-00585.1984","article-title":"Fibrous and protoplasmic astrocytes are biochemically and developmentally distinct","volume":"4","author":"Miller","year":"1984","journal-title":"J. Neurosci."},{"key":"10.1016\/j.celrep.2026.117110_bib40","doi-asserted-by":"crossref","DOI":"10.3390\/cells13020129","article-title":"The Matrix Receptor CD44 Is Present in Astrocytes throughout the Human Central Nervous System and Accumulates in Hypoxia and Seizures","volume":"13","author":"Al-Dalahmah","year":"2024","journal-title":"Cells"},{"key":"10.1016\/j.celrep.2026.117110_bib41","doi-asserted-by":"crossref","first-page":"114","DOI":"10.3389\/fnins.2015.00114","article-title":"Diverse subtypes of astrocytes and their development during corticogenesis","volume":"9","author":"Tabata","year":"2015","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.celrep.2026.117110_bib42","doi-asserted-by":"crossref","DOI":"10.1016\/j.brainres.2022.147814","article-title":"LINC00943 acts as miR-338-3p sponge to promote MPP+-induced SK-N-SH cell injury by directly targeting SP1 in Parkinson\u2019s disease","volume":"1782","author":"Sun","year":"2022","journal-title":"Brain Res."},{"key":"10.1016\/j.celrep.2026.117110_bib43","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1007\/s11357-021-00456-5","article-title":"DNA damage-induced degradation of Sp1 promotes cellular senescence","volume":"44","author":"Swift","year":"2022","journal-title":"GeroScience"},{"key":"10.1016\/j.celrep.2026.117110_bib44","doi-asserted-by":"crossref","first-page":"B66","DOI":"10.1093\/gerona\/51A.1.B66","article-title":"YY1 and Sp1 transcription factors bind the human transferrin gene in an age-related manner","volume":"51","author":"Adrian","year":"1996","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"key":"10.1016\/j.celrep.2026.117110_bib45","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.aaz2978","article-title":"Single-cell transcriptome analysis reveals cell lineage specification in temporal-spatial patterns in human cortical development","volume":"6","author":"Fan","year":"2020","journal-title":"Sci. Adv."},{"key":"10.1016\/j.celrep.2026.117110_bib46","doi-asserted-by":"crossref","first-page":"D638","DOI":"10.1093\/nar\/gkac1000","article-title":"The STRING database in 2023: protein-protein association networks and functional enrichment analyses for any sequenced genome of interest","volume":"51","author":"Szklarczyk","year":"2023","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.celrep.2026.117110_bib47","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1007\/BF01170826","article-title":"VIP neurons as prime synaptic targets for serotonin afferents in rat suprachiasmatic nucleus: a combined radioautographic and immunocytochemical study","volume":"14","author":"Bosler","year":"1985","journal-title":"J. Neurocytol."},{"key":"10.1016\/j.celrep.2026.117110_bib48","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1002\/cne.903290408","article-title":"Differential regulation of substance P and somatostatin in Martinotti cells of the developing cat visual cortex","volume":"329","author":"Wahle","year":"1993","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.celrep.2026.117110_bib49","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/0006-8993(94)91060-X","article-title":"Three distinct subpopulations of GABAergic neurons in rat frontal agranular cortex","volume":"649","author":"Kubota","year":"1994","journal-title":"Brain Res."},{"key":"10.1016\/j.celrep.2026.117110_bib58","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0157052","article-title":"LAMP5 Fine-Tunes GABAergic Synaptic Transmission in Defined Circuits of the Mouse Brain","volume":"11","author":"Tiveron","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.celrep.2026.117110_bib50","doi-asserted-by":"crossref","DOI":"10.1172\/JCI141566","article-title":"RUNX2 regulates leukemic cell metabolism and chemotaxis in high-risk T cell acute lymphoblastic leukemia","volume":"131","author":"Matthijssens","year":"2021","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.celrep.2026.117110_bib51","article-title":"14-3-3\u03b6 Mediates Tau Aggregation in Human Neuroblastoma M17 Cells","volume":"11","author":"Li","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.celrep.2026.117110_bib52","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1038\/2673","article-title":"Calsenilin: a calcium-binding protein that interacts with the presenilins and regulates the levels of a presenilin fragment","volume":"4","author":"Buxbaum","year":"1998","journal-title":"Nat. Med."},{"key":"10.1016\/j.celrep.2026.117110_bib53","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/S0165-5728(01)00240-5","article-title":"CD81 and microglial activation in vitro: proliferation, phagocytosis and nitric oxide production","volume":"114","author":"Dijkstra","year":"2001","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.celrep.2026.117110_bib54","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1073\/pnas.1513853113","article-title":"TLR4-activated microglia require IFN-\u03b3 to induce severe neuronal dysfunction and death in situ","volume":"113","author":"Papageorgiou","year":"2016","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2026.117110_bib55","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1038\/s41392-023-01588-0","article-title":"Microglia in neurodegenerative diseases: mechanism and potential therapeutic targets","volume":"8","author":"Gao","year":"2023","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.celrep.2026.117110_bib56","doi-asserted-by":"crossref","first-page":"2759","DOI":"10.1038\/s41598-018-21256-6","article-title":"Guanosine monophosphate reductase 1 is a potential therapeutic target for Alzheimer\u2019s disease","volume":"8","author":"Liu","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.celrep.2026.117110_bib59","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1002\/ana.26676","article-title":"Associations of VGF with Neuropathologies and Cognitive Health in Older Adults","volume":"94","author":"Yu","year":"2023","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.celrep.2026.117110_bib60","doi-asserted-by":"crossref","first-page":"D316","DOI":"10.1093\/nar\/gkab996","article-title":"ReMap 2022: a database of Human, Mouse, Drosophila and Arabidopsis regulatory regions from an integrative analysis of DNA-binding sequencing experiments","volume":"50","author":"Hammal","year":"2022","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.celrep.2026.117110_bib61","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1038\/s41592-023-01943-7","article-title":"Unsupervised removal of systematic background noise from droplet-based single-cell experiments using CellBender","volume":"20","author":"Fleming","year":"2023","journal-title":"Nat. Methods"},{"key":"10.1016\/j.celrep.2026.117110_bib62","doi-asserted-by":"crossref","first-page":"1888","DOI":"10.1016\/j.cell.2019.05.031","article-title":"Comprehensive Integration of Single-Cell Data","volume":"177","author":"Stuart","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2026.117110_bib63","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/s13059-017-1382-0","article-title":"SCANPY: large-scale single-cell gene expression data analysis","volume":"19","author":"Wolf","year":"2018","journal-title":"Genome Biol."},{"key":"10.1016\/j.celrep.2026.117110_bib64","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.cels.2018.11.005","article-title":"Scrublet: Computational Identification of Cell Doublets in Single-Cell Transcriptomic Data","volume":"8","author":"Wolock","year":"2019","journal-title":"Cell Syst."},{"key":"10.1016\/j.celrep.2026.117110_bib65","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1038\/s41592-018-0229-2","article-title":"Deep generative modeling for single-cell transcriptomics","volume":"15","author":"Lopez","year":"2018","journal-title":"Nat. Methods"},{"key":"10.1016\/j.celrep.2026.117110_bib66","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1038\/s41592-023-02112-6","article-title":"Modeling fragment counts improves single-cell ATAC-seq analysis","volume":"21","author":"Martens","year":"2024","journal-title":"Nat. Methods"},{"key":"10.1016\/j.celrep.2026.117110_bib67","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/s13059-021-02577-8","article-title":"MUON: multimodal omics analysis framework","volume":"23","author":"Bredikhin","year":"2022","journal-title":"Genome Biol."},{"key":"10.1016\/j.celrep.2026.117110_bib68","series-title":"Proceedings of the 9th Python in Science Conference Proceedings of the python in Science Conference","doi-asserted-by":"crossref","first-page":"92","DOI":"10.25080\/Majora-92bf1922-011","article-title":"Statsmodels: Econometric and Statistical Modeling with Python","author":"Seabold","year":"2010"},{"key":"10.1016\/j.celrep.2026.117110_bib69","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.1101\/gr.1239303","article-title":"Cytoscape: a software environment for integrated models of biomolecular interaction networks","volume":"13","author":"Shannon","year":"2003","journal-title":"Genome Res."},{"key":"10.1016\/j.celrep.2026.117110_bib70","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1016\/j.molcel.2018.06.044","article-title":"Cicero Predicts cis-Regulatory DNA Interactions from Single-Cell Chromatin Accessibility Data","volume":"71","author":"Pliner","year":"2018","journal-title":"Mol. Cell"},{"key":"10.1016\/j.celrep.2026.117110_bib71","doi-asserted-by":"crossref","first-page":"33","DOI":"10.12688\/f1000research.29032.2","article-title":"Sustainable data analysis with Snakemake","volume":"10","author":"M\u00f6lder","year":"2021","journal-title":"F1000Res."},{"key":"10.1016\/j.celrep.2026.117110_bib72","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0177459","article-title":"Singularity: Scientific containers for mobility of compute","volume":"12","author":"Kurtzer","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.celrep.2026.117110_bib73","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1038\/s41592-023-02139-9","article-title":"A fast, scalable and versatile tool for analysis of single-cell omics data","volume":"21","author":"Zhang","year":"2024","journal-title":"Nat. Methods"},{"key":"10.1016\/j.celrep.2026.117110_bib74","doi-asserted-by":"crossref","DOI":"10.1186\/gb-2008-9-9-r137","article-title":"Model-based analysis of ChIP-Seq (MACS)","volume":"9","author":"Zhang","year":"2008","journal-title":"Genome Biol."},{"key":"10.1016\/j.celrep.2026.117110_bib75","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1038\/s41592-019-0367-1","article-title":"cisTopic: cis-regulatory topic modeling on single-cell ATAC-seq data","volume":"16","author":"Bravo Gonz\u00e1lez-Blas","year":"2019","journal-title":"Nat. Methods"},{"key":"10.1016\/j.celrep.2026.117110_bib76","doi-asserted-by":"crossref","first-page":"W415","DOI":"10.1093\/nar\/gkae456","article-title":"WebGestalt 2024: faster gene set analysis and new support for metabolomics and multi-omics","volume":"52","author":"Elizarraras","year":"2024","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.celrep.2026.117110_bib57","doi-asserted-by":"crossref","first-page":"2899","DOI":"10.1093\/hmg\/ddaa182","article-title":"Integrative genomics approach identifies conserved transcriptomic networks in Alzheimer\u2019s disease","volume":"29","author":"Morabito","year":"2020","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.celrep.2026.117110_bib77","doi-asserted-by":"crossref","DOI":"10.1016\/j.xpro.2022.101491","article-title":"Protocol for single-nucleus ATAC sequencing and bioinformatic analysis in frozen human brain tissue","volume":"3","author":"Shi","year":"2022","journal-title":"STAR Protoc."},{"key":"10.1016\/j.celrep.2026.117110_bib78","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1038\/s41588-021-00894-z","article-title":"Single-nucleus chromatin accessibility and transcriptomic characterization of Alzheimer\u2019s disease","volume":"53","author":"Morabito","year":"2021","journal-title":"Nat. Genet."},{"key":"10.1016\/j.celrep.2026.117110_bib79","doi-asserted-by":"crossref","DOI":"10.1093\/bioadv\/vbac016","article-title":"decoupleR: ensemble of computational methods to infer biological activities from omics data","volume":"2","author":"Badia-I-Mompel","year":"2022","journal-title":"Bioinform. Adv."},{"key":"10.1016\/j.celrep.2026.117110_bib80","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1038\/s41592-019-0686-2","article-title":"SciPy 1.0: fundamental algorithms for scientific computing in Python","volume":"17","author":"Virtanen","year":"2020","journal-title":"Nat. Methods"}],"container-title":["Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124726001889?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124726001889?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T20:31:30Z","timestamp":1791405090000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211124726001889"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":80,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["S2211124726001889"],"URL":"https:\/\/doi.org\/10.1016\/j.celrep.2026.117110","relation":{},"ISSN":["2211-1247"],"issn-type":[{"value":"2211-1247","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Single-nucleus multiome analysis in the human prefrontal cortex identifies gene expression and cis-regulatory elements associated with aging","name":"articletitle","label":"Article Title"},{"value":"Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.celrep.2026.117110","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"117110"}}