{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T05:01:31Z","timestamp":1785474091370,"version":"3.56.0"},"reference-count":50,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T00:00:00Z","timestamp":1772755200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001677","name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001677","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Reports"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1016\/j.celrep.2026.117185","type":"journal-article","created":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T16:18:05Z","timestamp":1774714685000},"page":"117185","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["Targeting systemic and tumor metabolic balances with ketogenic diets enhance efficacy of therapy in FLT3-ITD acute myeloid leukemia"],"prefix":"10.1016","volume":"45","author":[{"given":"L\u00e9a","family":"Goupille","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre","family":"Boudet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Lauture","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ambrine","family":"Sahal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillaume","family":"Gautier-Renard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emeline","family":"Chu-Van","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anvi Laetitia","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9line","family":"Chollet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Coralie","family":"Alcazar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Bernard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Vergez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V\u00e9ronique","family":"de Mas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"R\u00e9cher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tony","family":"Kaoma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Gallipoli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vilma","family":"Dembitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Basili","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flavia","family":"Bernardi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Ayrault","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carine","family":"Joffre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florence","family":"Castelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benoit","family":"Colsch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Bourg\u00e8s-Abella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fanny","family":"Granat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Emmanuel","family":"Sarry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.celrep.2026.117185_bib1","doi-asserted-by":"crossref","first-page":"1752","DOI":"10.1182\/blood.V98.6.1752","volume":"98","author":"Kottaridis","year":"2001","journal-title":"Blood"},{"key":"10.1016\/j.celrep.2026.117185_bib2","doi-asserted-by":"crossref","first-page":"2209","DOI":"10.1056\/NEJMoa1516192","article-title":"Genomic Classification and Prognosis in Acute Myeloid Leukemia","volume":"374","author":"Papaemmanuil","year":"2016","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.celrep.2026.117185_bib3","doi-asserted-by":"crossref","first-page":"4326","DOI":"10.1182\/blood.V99.12.4326","volume":"99","author":"Thiede","year":"2002","journal-title":"Blood"},{"key":"10.1016\/j.celrep.2026.117185_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.blre.2021.100905","article-title":"A review of FLT3 inhibitors in acute myeloid leukemia","volume":"52","author":"Zhao","year":"2022","journal-title":"Blood Rev."},{"key":"10.1016\/j.celrep.2026.117185_bib5","doi-asserted-by":"crossref","first-page":"2143","DOI":"10.1038\/leu.2017.45","article-title":"ITD mutation in FLT3 tyrosine kinase promotes Warburg effect and renders therapeutic sensitivity to glycolytic inhibition","volume":"31","author":"Ju","year":"2017","journal-title":"Leukemia"},{"key":"10.1016\/j.celrep.2026.117185_bib6","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.1182\/blood-2017-12-820035","article-title":"Glutaminolysis is a metabolic dependency in FLT3ITD acute myeloid leukemia unmasked by FLT3 tyrosine kinase inhibition","volume":"131","author":"Gallipoli","year":"2018","journal-title":"Blood"},{"key":"10.1016\/j.celrep.2026.117185_bib7","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.1158\/2159-8290.CD-20-0738","article-title":"Serine Biosynthesis Is a Metabolic Vulnerability in FLT3-ITD\u2013Driven Acute Myeloid Leukemia","volume":"11","author":"Bjelosevic","year":"2021","journal-title":"Cancer Discov."},{"key":"10.1016\/j.celrep.2026.117185_bib8","doi-asserted-by":"crossref","first-page":"1720","DOI":"10.1158\/2159-8290.CD-22-0411","article-title":"C\/EBP\u03b1 Confers Dependence to Fatty Acid Anabolic Pathways and Vulnerability to Lipid Oxidative Stress\u2013Induced Ferroptosis in FLT3-Mutant Leukemia","volume":"13","author":"Sabatier","year":"2023","journal-title":"Cancer Discov."},{"key":"10.1016\/j.celrep.2026.117185_bib9","unstructured":"Joshi, S.K. The AML microenvironment catalyzes a stepwise evolution to gilteritinib resistance. OPEN ACCESS."},{"key":"10.1016\/j.celrep.2026.117185_bib10","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.molmet.2019.06.026","article-title":"Ketogenic diet in the treatment of cancer \u2013 Where do we stand?","volume":"33","author":"Weber","year":"2020","journal-title":"Mol. Metab."},{"key":"10.1016\/j.celrep.2026.117185_bib11","doi-asserted-by":"crossref","first-page":"4932","DOI":"10.3390\/nu14224932","article-title":"Molecular Mechanisms for Ketone Body Metabolism, Signaling Functions, and Therapeutic Potential in Cancer","volume":"14","author":"Hwang","year":"2022","journal-title":"Nutrients"},{"key":"10.1016\/j.celrep.2026.117185_bib12","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.cmet.2016.12.022","article-title":"Multi-dimensional Roles of Ketone Bodies in Fuel Metabolism, Signaling, and Therapeutics","volume":"25","author":"Puchalska","year":"2017","journal-title":"Cell Metab."},{"key":"10.1016\/j.celrep.2026.117185_bib13","first-page":"606","article-title":"A ketogenic diet attenuates proliferation and stemness of glioma stem-like cells by altering metabolism resulting in increased ROS production","volume":"56","author":"Ji","year":"2020","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.celrep.2026.117185_bib14","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2024.1344891","article-title":"Ketogenic diet enhances the anti-cancer effects of PD-L1 blockade in renal cell carcinoma","volume":"15","author":"Richard","year":"2024","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.celrep.2026.117185_bib15","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1038\/s41586-018-0343-4","article-title":"Suppression of insulin feedback enhances the efficacy of PI3K inhibitors","volume":"560","author":"Hopkins","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2026.117185_bib16","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1038\/s41586-021-04049-2","article-title":"Low glycemic diets alter lipid metabolism to influence tumor growth","volume":"599","author":"Lien","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2026.117185_bib17","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.adm9481","article-title":"An unexpected role for the ketogenic diet in triggering tumor metastasis by modulating BACH1-mediated transcription","volume":"10","author":"Su","year":"2024","journal-title":"Sci. Adv."},{"key":"10.1016\/j.celrep.2026.117185_bib18","doi-asserted-by":"crossref","DOI":"10.15252\/embj.2021110466","article-title":"Ketogenic HMG-CoA lyase and its product \u03b2-hydroxybutyrate promote pancreatic cancer progression","volume":"41","author":"Gouirand","year":"2022","journal-title":"EMBO J."},{"key":"10.1016\/j.celrep.2026.117185_bib19","doi-asserted-by":"crossref","DOI":"10.1111\/obr.13053","article-title":"Scientific evidence underlying contraindications to the ketogenic diet: An update","volume":"21","author":"Watanabe","year":"2020","journal-title":"Obes. Rev."},{"key":"10.1016\/j.celrep.2026.117185_bib20","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-73020-4","article-title":"High-fat diet intensifies MLL-AF9-induced acute myeloid leukemia through activation of the FLT3 signaling in mouse primitive hematopoietic cells","volume":"10","author":"Hermetet","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.celrep.2026.117185_bib21","doi-asserted-by":"crossref","DOI":"10.1002\/cam4.6949","article-title":"Feasible diet and circadian interventions reduce in vivo progression of FLT3-ITD-positive acute myeloid leukemia","volume":"13","author":"Rodriguez","year":"2024","journal-title":"Cancer Med."},{"key":"10.1016\/j.celrep.2026.117185_bib22","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.molcel.2016.03.036","article-title":"Metabolic Regulation of Gene Expression by Histone Lysine \u03b2-Hydroxybutyrylation","volume":"62","author":"Xie","year":"2016","journal-title":"Mol. Cell"},{"key":"10.1016\/j.celrep.2026.117185_bib23","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1007\/s13238-021-00846-7","article-title":"Metabolic reprogramming and epigenetic modifications on the path to cancer","volume":"13","author":"Sun","year":"2022","journal-title":"Protein Cell"},{"key":"10.1016\/j.celrep.2026.117185_bib24","doi-asserted-by":"crossref","first-page":"788","DOI":"10.3390\/nu12030788","article-title":"Modulation of Cellular Biochemistry, Epigenetics and Metabolomics by Ketone Bodies. Implications of the Ketogenic Diet in the Physiology of the Organism and Pathological States","volume":"12","author":"D\u0105bek","year":"2020","journal-title":"Nutrients"},{"key":"10.1016\/j.celrep.2026.117185_bib25","article-title":"Anti-Tumor Effects of BDH1 in Acute Myeloid Leukemia","volume":"11","author":"Han","year":"2021","journal-title":"Front. Oncol."},{"key":"10.1016\/j.celrep.2026.117185_bib26","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1038\/s41586-024-08258-3","article-title":"Dietary fructose enhances tumour growth indirectly via interorgan lipid transfer","volume":"636","author":"Fowle-Grider","year":"2024","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2026.117185_bib27","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/4592170","article-title":"Quantitative Proteomics Analysis Expands the Roles of Lysine \u03b2-Hydroxybutyrylation Pathway in Response to Environmental \u03b2-Hydroxybutyrate","volume":"2022","author":"Hou","year":"2022","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.celrep.2026.117185_bib28","doi-asserted-by":"crossref","DOI":"10.1038\/s41419-024-07268-3","article-title":"\u03b2-Hydroxybutyrate suppresses M1 macrophage polarization through \u03b2-hydroxybutyrylation of the STAT1 protein","volume":"15","author":"Bai","year":"2024","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.celrep.2026.117185_bib29","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1007\/s00412-023-00799-2","article-title":"The regulation of Tfh cell differentiation by \u03b2-hydroxybutyrylation modification of transcription factor Bcl6","volume":"132","author":"Guo","year":"2023","journal-title":"Chromosoma"},{"key":"10.1016\/j.celrep.2026.117185_bib30","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1182\/bloodadvances.2018029496","article-title":"Gilteritinib induces differentiation in relapsed and refractory FLT3-mutated acute myeloid leukemia","volume":"3","author":"McMahon","year":"2019","journal-title":"Blood Adv."},{"key":"10.1016\/j.celrep.2026.117185_bib31","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1038\/s41589-020-0501-5","article-title":"Selective covalent targeting of GPX4 using masked nitrile-oxide electrophiles","volume":"16","author":"Eaton","year":"2020","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.celrep.2026.117185_bib32","doi-asserted-by":"crossref","first-page":"3083","DOI":"10.1038\/s41467-020-16138-3","article-title":"Fasting mimicking diet as an adjunct to neoadjuvant chemotherapy for breast cancer in the multicentre randomized phase 2 DIRECT trial","volume":"11","author":"de Groot","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2026.117185_bib33","doi-asserted-by":"crossref","first-page":"2056","DOI":"10.1016\/j.bbadis.2015.07.009","article-title":"Adaptive changes in amino acid metabolism permit normal longevity in mice consuming a low-carbohydrate ketogenic diet","volume":"1852","author":"Douris","year":"2015","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.celrep.2026.117185_bib34","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1038\/s41591-023-02761-2","article-title":"Differential peripheral immune signatures elicited by vegan versus ketogenic diets in humans","volume":"30","author":"Link","year":"2024","journal-title":"Nat. Med."},{"key":"10.1016\/j.celrep.2026.117185_bib35","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1111\/j.1365-277X.2011.01172.x","article-title":"The effect of the classical and medium chain triglyceride ketogenic diet on vitamin and mineral levels","volume":"25","author":"Christodoulides","year":"2012","journal-title":"J. Hum. Nutr. Diet."},{"key":"10.1016\/j.celrep.2026.117185_bib36","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.3390\/metabo12121288","article-title":"Ketogenic Diet and Vitamin D Metabolism: A Review of Evidence","volume":"12","author":"Detopoulou","year":"2022","journal-title":"Metabolites"},{"key":"10.1016\/j.celrep.2026.117185_bib37","doi-asserted-by":"crossref","first-page":"874","DOI":"10.3390\/nu16060874","article-title":"Higher-Level Steatosis Is Associated with a Greater Decrease in Metabolic Dysfunction-Associated Steatoic Liver Disease after Eight Weeks of a Very Low-Calorie Ketogenic Diet (VLCKD) in Subjects Affected by Overweight and Obesity","volume":"16","author":"Sila","year":"2024","journal-title":"Nutrients"},{"key":"10.1016\/j.celrep.2026.117185_bib38","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1186\/s13023-022-02581-6","article-title":"Ketogenic diet as a glycine lowering therapy in nonketotic hyperglycinemia and impact on brain glycine levels","volume":"17","author":"Shelkowitz","year":"2022","journal-title":"Orphanet J. Rare Dis."},{"key":"10.1016\/j.celrep.2026.117185_bib39","doi-asserted-by":"crossref","first-page":"64728","DOI":"10.18632\/oncotarget.20041","article-title":"A ketogenic diet supplemented with medium-chain triglycerides enhances the anti-tumor and anti-angiogenic efficacy of chemotherapy on neuroblastoma xenografts in a CD1-nu mouse model","volume":"8","author":"Aminzadeh-Gohari","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.celrep.2026.117185_bib40","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1038\/s41391-022-00525-6","article-title":"Serum metabolomic analysis of men on a low-carbohydrate diet for biochemically recurrent prostate cancer reveals the potential role of ketogenesis to slow tumor growth: a secondary analysis of the CAPS2 diet trial","volume":"25","author":"Chi","year":"2022","journal-title":"Prostate Cancer Prostatic Dis."},{"key":"10.1016\/j.celrep.2026.117185_bib41","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1139\/y59-099","article-title":"A rapid method of total lipid extraction and purification","volume":"37","author":"Bligh","year":"1959","journal-title":"Can. J. Biochem. Physiol."},{"key":"10.1016\/j.celrep.2026.117185_bib42","doi-asserted-by":"crossref","first-page":"2534","DOI":"10.1093\/bioinformatics\/btn323","article-title":"ProteoWizard: open source software for rapid proteomics tools development","volume":"24","author":"Kessner","year":"2008","journal-title":"Bioinformatics"},{"key":"10.1016\/j.celrep.2026.117185_bib43","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1093\/bioinformatics\/btu813","article-title":"Workflow4Metabolomics: a collaborative research infrastructure for computational metabolomics","volume":"31","author":"Giacomoni","year":"2015","journal-title":"Bioinformatics"},{"key":"10.1016\/j.celrep.2026.117185_bib44","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1038\/nmeth.3393","article-title":"MS-DIAL: data-independent MS\/MS deconvolution for comprehensive metabolome analysis","volume":"12","author":"Tsugawa","year":"2015","journal-title":"Nat. Methods"},{"key":"10.1016\/j.celrep.2026.117185_bib45","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1007\/s11306-016-1023-8","article-title":"Annotation of the human cerebrospinal fluid lipidome using high resolution mass spectrometry and a dedicated data processing workflow","volume":"12","author":"Seyer","year":"2016","journal-title":"Metabolomics"},{"key":"10.1016\/j.celrep.2026.117185_bib46","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.jchromb.2014.04.025","article-title":"Annotation of the human serum metabolome by coupling three liquid chromatography methods to high-resolution mass spectrometry","volume":"966","author":"Boudah","year":"2014","journal-title":"J. Chromatogr. B Analyt. Technol. Biomed. Life Sci."},{"key":"10.1016\/j.celrep.2026.117185_bib47","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1007\/s11306-007-0082-2","article-title":"Proposed minimum reporting standards for chemical analysis Chemical Analysis Working Group (CAWG) Metabolomics Standards Initiative (MSI)","volume":"3","author":"Sumner","year":"2007","journal-title":"Metabolomics"},{"key":"10.1016\/j.celrep.2026.117185_bib48","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1093\/nar\/28.1.27","article-title":"KEGG: kyoto encyclopedia of genes and genomes","volume":"28","author":"Kanehisa","year":"2000","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.celrep.2026.117185_bib49","doi-asserted-by":"crossref","first-page":"D521","DOI":"10.1093\/nar\/gkl923","article-title":"HMDB: the Human Metabolome Database","volume":"35","author":"Wishart","year":"2007","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.celrep.2026.117185_bib50","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1097\/01.ftd.0000179845.53213.39","article-title":"METLIN: a metabolite mass spectral database","volume":"27","author":"Smith","year":"2005","journal-title":"Ther. Drug Monit."}],"container-title":["Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124726002639?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124726002639?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T04:56:37Z","timestamp":1785473797000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211124726002639"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":50,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["S2211124726002639"],"URL":"https:\/\/doi.org\/10.1016\/j.celrep.2026.117185","relation":{},"ISSN":["2211-1247"],"issn-type":[{"value":"2211-1247","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Targeting systemic and tumor metabolic balances with ketogenic diets enhance efficacy of therapy in FLT3-ITD acute myeloid leukemia","name":"articletitle","label":"Article Title"},{"value":"Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.celrep.2026.117185","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"117185"}}