{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T05:01:29Z","timestamp":1785474089547,"version":"3.56.0"},"reference-count":63,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T00:00:00Z","timestamp":1773964800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["21H04976"],"award-info":[{"award-number":["21H04976"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003769","name":"Eisai","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003769","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003382","name":"Core Research for Evolutional Science and Technology","doi-asserted-by":"publisher","award":["JP20gm1110002"],"award-info":[{"award-number":["JP20gm1110002"]}],"id":[{"id":"10.13039\/501100003382","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Reports"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1016\/j.celrep.2026.117250","type":"journal-article","created":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T01:12:10Z","timestamp":1775783530000},"page":"117250","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Activation of neurogenesis improves amyloid-\u03b2 pathology and cognitive function through AMP kinase signaling in Alzheimer\u2019s disease model mice"],"prefix":"10.1016","volume":"45","author":[{"given":"Masahiro","family":"Fukui","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Kaise","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taimu","family":"Masaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tyler","family":"Sakamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5985-1120","authenticated-orcid":false,"given":"Ryoichiro","family":"Kageyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.celrep.2026.117250_bib1","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1016\/j.cell.2016.10.021","article-title":"Adult neurogenesis in the hippocampus: from stem cells to behavior","volume":"167","author":"Gon\u00e7alves","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2026.117250_bib2","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1038\/s41591-019-0375-9","article-title":"Adult hippocampal neurogenesis is abundant in neurologically healthy subjects and drops sharply in patients with Alzheimer\u2019s disease","volume":"25","author":"Moreno-Jim\u00e9nez","year":"2019","journal-title":"Nat. Med."},{"key":"10.1016\/j.celrep.2026.117250_bib3","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1016\/j.stem.2019.05.003","article-title":"Human hippocampal neurogenesis persists in aged adults and Alzheimer\u2019s disease patients","volume":"24","author":"Tobin","year":"2019","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.celrep.2026.117250_bib4","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1038\/s41586-022-04912-w","article-title":"Molecular landscapes of human hippocampal immature neurons across lifespan","volume":"607","author":"Zhou","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2026.117250_bib5","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1038\/nn.2185","article-title":"Roles of continuous neurogenesis in the structural and functional integrity of the adult forebrain","volume":"11","author":"Imayoshi","year":"2008","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.celrep.2026.117250_bib6","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/j.stem.2010.03.017","article-title":"Quiescent and active hippocampal neural stem cells with distinct morphologies respond selectively to physiological and pathological stimuli and aging","volume":"6","author":"Lugert","year":"2010","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.celrep.2026.117250_bib7","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1016\/j.stem.2011.03.010","article-title":"Division-coupled astrocytic differentiation and age-related depletion of neural stem cells in the adult hippocampus","volume":"8","author":"Encinas","year":"2011","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.celrep.2026.117250_bib8","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1016\/j.stem.2013.04.014","article-title":"Mobilization of endogenous progenitor cells regenerates functionally-integrated medium spiny striopallidal projection neurons and delays disease progression in a transgenic model of Huntington\u2019s disease","volume":"12","author":"Benraiss","year":"2013","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.celrep.2026.117250_bib9","doi-asserted-by":"crossref","DOI":"10.1126\/science.aan8821","article-title":"Combined adult neurogenesis and BDNF mimic exercise effects on cognition in an Alzheimer\u2019s mouse model","volume":"361","author":"Choi","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.celrep.2026.117250_bib10","doi-asserted-by":"crossref","first-page":"11625","DOI":"10.1073\/pnas.1813205115","article-title":"Noggin rescues age-related stem cell loss in the brain of senescent mice with neurodegenerative pathology","volume":"115","author":"D\u00edaz-Moreno","year":"2018","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2026.117250_bib11","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1101\/gad.323196.118","article-title":"High Hes1 expression and resultant Ascl1 suppression regulate quiescent vs. active neural stem cells in the adult mouse brain","volume":"33","author":"Sueda","year":"2019","journal-title":"Genes Dev."},{"key":"10.1016\/j.celrep.2026.117250_bib12","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1016\/j.celrep.2019.07.014","article-title":"Id4 downstream of Notch2 maintains neural stem cell quiescence in the adult hippocampus","volume":"28","author":"Zhang","year":"2019","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2026.117250_bib13","doi-asserted-by":"crossref","first-page":"10129","DOI":"10.1523\/JNEUROSCI.1202-06.2006","article-title":"Intraneuronal beta-amyloid aggregates, neurodegeneration, and neuron loss in transgenic mice with five familial Alzheimer's disease mutations: potential factors in amyloid plaque formation","volume":"26","author":"Oakley","year":"2006","journal-title":"J. Neurosci."},{"key":"10.1016\/j.celrep.2026.117250_bib14","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.stem.2023.02.006","article-title":"Activation of hypothalamic-enhanced adult-born neurons restores cognitive and affective function in Alzheimer\u2019s disease","volume":"30","author":"Li","year":"2023","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.celrep.2026.117250_bib15","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.stem.2023.01.002","article-title":"Adult hippocampal neurogenesis in Alzheimer\u2019s disease: a road map to clinical relevance","volume":"30","author":"Salta","year":"2023","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.celrep.2026.117250_bib16","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1101\/gad.349000.121","article-title":"Functional rejuvenation of aged neural stem cells by Plagl2 and anti-Dyrk1a activity","volume":"36","author":"Kaise","year":"2022","journal-title":"Genes Dev."},{"key":"10.1016\/j.celrep.2026.117250_bib17","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1038\/4151030a","article-title":"Functional neurogenesis in the adult hippocampus","volume":"415","author":"van Praag","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2026.117250_bib18","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1038\/s41590-021-00913-5","article-title":"Microglia use TAM receptors to detect and engulf amyloid \u03b2 plaques","volume":"22","author":"Huang","year":"2021","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.celrep.2026.117250_bib19","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1038\/s43587-023-00491-1","article-title":"The VCAM1-ApoE pathway directs microglial chemotaxis and alleviates Alzheimer\u2019s disease pathology","volume":"3","author":"Lau","year":"2023","journal-title":"Nat. Aging"},{"key":"10.1016\/j.celrep.2026.117250_bib20","doi-asserted-by":"crossref","first-page":"1604","DOI":"10.1038\/s41591-025-03574-1","article-title":"Microglial mechanisms drive amyloid-\u03b2 clearance in immunized patients with Alzheimer\u2019s disease","volume":"31","author":"van Olst","year":"2025","journal-title":"Nat. Med."},{"key":"10.1016\/j.celrep.2026.117250_bib21","doi-asserted-by":"crossref","first-page":"R15","DOI":"10.1172\/JCI6179","article-title":"Expression of human apolipoprotein E reduces amyloid-\u03b2 deposition in a mouse model of Alzheimer\u2019s disease","volume":"103","author":"Holtzman","year":"1999","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.celrep.2026.117250_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2020.107530","article-title":"IL-33-PU.1 transcriptome reprogramming drives functional state transition and clearance activity of microglia in Alzheimer\u2019s disease","volume":"31","author":"Lau","year":"2020","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2026.117250_bib23","doi-asserted-by":"crossref","first-page":"1704","DOI":"10.1016\/j.celrep.2013.11.020","article-title":"An optimized microRNA backbone for effective single-copy RNAi","volume":"5","author":"Fellmann","year":"2013","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2026.117250_bib24","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1038\/s41593-020-0624-8","article-title":"Disease-associated astrocytes in Alzheimer\u2019s disease and aging","volume":"23","author":"Habib","year":"2020","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.celrep.2026.117250_bib25","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.cell.2014.12.019","article-title":"Glial lipid droplets and ROS induced by mitochondrial defects promote neurodegeneration","volume":"160","author":"Liu","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2026.117250_bib26","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1016\/j.cmet.2024.03.014","article-title":"Microglial lipid droplet accumulation in tauopathy brain is regulated by neuronal AMPK","volume":"36","author":"Li","year":"2024","journal-title":"Cell Metab."},{"key":"10.1016\/j.celrep.2026.117250_bib27","doi-asserted-by":"crossref","first-page":"1536","DOI":"10.1016\/j.immuni.2025.04.029","article-title":"Amyloid-\u03b2 induces lipid droplet-mediated microglial dysfunction via the enzyme DGAT2 in Alzheimer's disease","volume":"58","author":"Prakash","year":"2025","journal-title":"Immunity"},{"key":"10.1016\/j.celrep.2026.117250_bib28","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.bbi.2017.12.009","article-title":"Metformin treatment prevents amyloid plaque deposition and memory impairment in APP\/PS1 mice","volume":"69","author":"Ou","year":"2018","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.celrep.2026.117250_bib29","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1038\/ncb2329","article-title":"The AMPK signalling pathway coordinates cell growth, autophagy and metabolism","volume":"13","author":"Mihaylova","year":"2011","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.celrep.2026.117250_bib30","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1038\/nrm.2017.95","article-title":"AMPK: guardian of metabolism and mitochondrial homeostasis","volume":"19","author":"Herzig","year":"2018","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.celrep.2026.117250_bib31","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1038\/s41380-022-01631-6","article-title":"Mitophagy in Alzheimer\u2019s disease: molecular defects and therapeutic approaches","volume":"28","author":"Mary","year":"2023","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.celrep.2026.117250_bib32","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1038\/nm1058","article-title":"Apolipoprotein E promotes astrocyte colocalization and degradation of deposited amyloid-b peptides","volume":"10","author":"Koistinaho","year":"2004","journal-title":"Nat. Med."},{"key":"10.1016\/j.celrep.2026.117250_bib33","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/j.neuron.2008.04.010","article-title":"ApoE promotes the proteolytic degradation of A\u03b2","volume":"58","author":"Jiang","year":"2008","journal-title":"Neuron"},{"key":"10.1016\/j.celrep.2026.117250_bib34","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/j.stem.2010.08.014","article-title":"Microglia shape adult hippocampal neurogenesis through apoptosis-coupled phagocytosis","volume":"7","author":"Sierra","year":"2010","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.celrep.2026.117250_bib35","doi-asserted-by":"crossref","first-page":"6333","DOI":"10.1523\/JNEUROSCI.0829-08.2008","article-title":"Complement C3 deficiency leads to accelerated A\u03b2 plaque deposition and neurodegeneration and modulation of the microglia\/macrophage phenotype in amyloid precursor protein transgenic mice","volume":"28","author":"Maier","year":"2008","journal-title":"J. Neurosci."},{"key":"10.1016\/j.celrep.2026.117250_bib36","article-title":"Reducing microglial lipid load enhances \u03b2 amyloid phagocytosis in an Alzheimer\u2019s disease mouse model","volume":"11","author":"Wu","year":"2025","journal-title":"Sci. Adv."},{"key":"10.1016\/j.celrep.2026.117250_bib37","doi-asserted-by":"crossref","first-page":"441","DOI":"10.3233\/JAD-190948","article-title":"PRKAG2 gene expression is elevated and its protein levels are associated with increased Amyloid-\u03b2 accumulation in the Alzheimer\u2019s disease brain","volume":"74","author":"Bharadwaj","year":"2020","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.celrep.2026.117250_bib38","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1042\/bj3460659","article-title":"Characterization of AMP-activated protein kinase \u03b3-subunit isoforms and their role in AMP binding","volume":"346","author":"Cheung","year":"2000","journal-title":"Biochem. J."},{"key":"10.1016\/j.celrep.2026.117250_bib39","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-67030-5","article-title":"The importance of the AMPK gamma 1 subunit in metformin suppression of liver glucose production","volume":"10","author":"An","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.celrep.2026.117250_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.114473","article-title":"Magnolol improves Alzheimer\u2019s disease-like pathologies and cognitive decline by promoting autophagy through activation of the AMPK\/mTOR\/ULK1 pathway","volume":"161","author":"Wang","year":"2023","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.celrep.2026.117250_bib41","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.stem.2012.03.016","article-title":"Metformin activates an atypical PKC-CBP pathway to promote neurogenesis and enhance spatial memory formation","volume":"11","author":"Wang","year":"2012","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.celrep.2026.117250_bib42","doi-asserted-by":"crossref","DOI":"10.1186\/s12967-024-05436-9","article-title":"Metformin enhances endogenous neural stem cells proliferation, neuronal differentiation, and inhibits ferroptosis through activating AMPK pathway after spinal cord injury","volume":"22","author":"Xing","year":"2024","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.celrep.2026.117250_bib43","doi-asserted-by":"crossref","first-page":"485","DOI":"10.3233\/JAD-2011-101524","article-title":"Incidence of dementia is increased in type 2 diabetes and reduced by the use of sulfonylureas and metformin","volume":"24","author":"Hsu","year":"2011","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.celrep.2026.117250_bib44","doi-asserted-by":"crossref","DOI":"10.1038\/s41398-024-02755-9","article-title":"Reconsidering repurposing: long-term metformin treatment impairs cognition in Alzheimer\u2019s model mice","volume":"14","author":"Cho","year":"2024","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.celrep.2026.117250_bib45","doi-asserted-by":"crossref","first-page":"3511","DOI":"10.1172\/JCI133982","article-title":"Brain-specific repression of AMPA \u03b11 alleviates pathophysiology in Alzheimer\u2019s model mice","volume":"130","author":"Zimmermann","year":"2020","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.celrep.2026.117250_bib46","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1093\/hmg\/ddv513","article-title":"AMPK activation protects from neuronal dysfunction and vulnerability across nematode, cellular and mouse models of Huntington's disease","volume":"25","author":"V\u00e1zquez-Manrique","year":"2016","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.celrep.2026.117250_bib47","doi-asserted-by":"crossref","first-page":"161","DOI":"10.3233\/JPD-171296","article-title":"Targeting AMPK signaling as a neuroprotective strategy in Parkinson\u2019s disease","volume":"8","author":"Curry","year":"2018","journal-title":"J. Parkinsons Dis."},{"key":"10.1016\/j.celrep.2026.117250_bib48","doi-asserted-by":"crossref","first-page":"1544","DOI":"10.1038\/s43587-023-00521-y","article-title":"Refeeding-associated AMPK\u03b31 complex activity is a hallmark of health and longevity","volume":"3","author":"Ripa","year":"2023","journal-title":"Nat. Aging"},{"key":"10.1016\/j.celrep.2026.117250_bib49","doi-asserted-by":"crossref","DOI":"10.1038\/s41597-021-01090-8","article-title":"Insights into the changes in the proteome of Alzheimer disease elucidated by a meta-analysis","volume":"8","author":"Haytural","year":"2021","journal-title":"Sci. Data"},{"key":"10.1016\/j.celrep.2026.117250_bib50","doi-asserted-by":"crossref","first-page":"13127","DOI":"10.1523\/JNEUROSCI.2582-13.2014","article-title":"Deficiency of GDNF receptor GFR\u03b11 in Alzheimer\u2019s neurons results in neuronal death","volume":"34","author":"Konishi","year":"2014","journal-title":"J. Neurosci."},{"key":"10.1016\/j.celrep.2026.117250_bib51","doi-asserted-by":"crossref","first-page":"331","DOI":"10.3233\/JAD-2009-1146","article-title":"Glial cell-line derived neurotrophic factor (GDNF) concentrations in cerebrospinal fluid and serum of patients with early Alzheimer\u2019s disease and normal controls","volume":"18","author":"Straten","year":"2009","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.celrep.2026.117250_bib52","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1111\/j.1460-9568.2004.03475.x","article-title":"Impaired behavioural flexibility and memory in mice lacking GDNF family receptor \u03b12","volume":"20","author":"V\u00f5ikar","year":"2004","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.celrep.2026.117250_bib53","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1111\/bpa.12335","article-title":"Altered machinery of protein synthesis in Alzheimer\u2019s: from the nucleolus to the ribosome","volume":"26","author":"Hern\u00e1ndez-Ortega","year":"2015","journal-title":"Brain Pathol."},{"key":"10.1016\/j.celrep.2026.117250_bib54","doi-asserted-by":"crossref","first-page":"50612","DOI":"10.1074\/jbc.M209529200","article-title":"Identification of new human mastermind proteins defines a family that consists of positive regulators for notch signaling","volume":"277","author":"Lin","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.celrep.2026.117250_bib55","doi-asserted-by":"crossref","first-page":"7688","DOI":"10.1128\/MCB.22.21.7688-7700.2002","article-title":"Identification of a family of mastermind-like transcriptional coactivators for mammalian notch receptors","volume":"22","author":"Wu","year":"2002","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.celrep.2026.117250_bib56","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1101\/gad.1383706","article-title":"The Notch coactivator, MAML1, functions as a novel coactivator for MEF2C-mediated transcription and is required for normal myogenesis","volume":"20","author":"Shen","year":"2006","journal-title":"Genes Dev."},{"key":"10.1016\/j.celrep.2026.117250_bib57","doi-asserted-by":"crossref","first-page":"4422","DOI":"10.1016\/j.cell.2023.08.040","article-title":"Epigenomic dissection of Alzheimer\u2019s disease pinpoints causal variants and reveals epigenome erosion","volume":"186","author":"Xiong","year":"2023","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2026.117250_bib58","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1038\/s41418-019-0409-3","article-title":"Impaired adult neurogenesis is an early event in Alzheimer\u2019s disease neurodegeneration, mediated by intracellular A\u03b2 oligomers","volume":"27","author":"Scopa","year":"2020","journal-title":"Cell Death Diff"},{"key":"10.1016\/j.celrep.2026.117250_bib59","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.cell.2012.01.046","article-title":"Young dentate granule cells mediate pattern separation, whereas old granule cells facilitate pattern completion","volume":"149","author":"Nakashiba","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2026.117250_bib60","doi-asserted-by":"crossref","first-page":"1805","DOI":"10.1016\/j.stem.2021.05.001","article-title":"Restoring miR-132 expression rescues adult hippocampal neurogenesis and memory deficits in Alzheimer\u2019s disease","volume":"28","author":"Walgrave","year":"2021","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.celrep.2026.117250_bib61","doi-asserted-by":"crossref","first-page":"D1541","DOI":"10.1093\/nar\/gkaa1011","article-title":"MitoCarta3.0: an updated mitochondrial proteome now with sub-organelle localization and pathway annotations","volume":"49","author":"Rath","year":"2021","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.celrep.2026.117250_bib62","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-025-57047-7","article-title":"Unveiling the cell-type-specific landscape of cellular senescence through single-cell transcriptomics using SenePy","volume":"16","author":"Sanborn","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2026.117250_bib63","doi-asserted-by":"crossref","first-page":"3573","DOI":"10.1016\/j.cell.2021.04.048","article-title":"Integrated analysis of multimodal single-cell data","volume":"184","author":"Hao","year":"2021","journal-title":"Cell"}],"container-title":["Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124726003281?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124726003281?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T04:56:18Z","timestamp":1785473778000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211124726003281"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":63,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["S2211124726003281"],"URL":"https:\/\/doi.org\/10.1016\/j.celrep.2026.117250","relation":{"has-preprint":[{"id-type":"doi","id":"10.64898\/2025.12.24.696442","asserted-by":"object"}]},"ISSN":["2211-1247"],"issn-type":[{"value":"2211-1247","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Activation of neurogenesis improves amyloid-\u03b2 pathology and cognitive function through AMP kinase signaling in Alzheimer\u2019s disease model mice","name":"articletitle","label":"Article Title"},{"value":"Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.celrep.2026.117250","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"117250"}}