{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T19:14:11Z","timestamp":1790709251689,"version":"4.1.0"},"reference-count":82,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T00:00:00Z","timestamp":1775779200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100008091","name":"University of Rochester","doi-asserted-by":"publisher","award":["P30CA272302"],"award-info":[{"award-number":["P30CA272302"]}],"id":[{"id":"10.13039\/100008091","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["AI181865"],"award-info":[{"award-number":["AI181865"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["AI150698"],"award-info":[{"award-number":["AI150698"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["AI184380"],"award-info":[{"award-number":["AI184380"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009750","name":"University of Rochester Medical Center","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009750","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U2C-DK119886"],"award-info":[{"award-number":["U2C-DK119886"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["OT2-OD030544"],"award-info":[{"award-number":["OT2-OD030544"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["GM068411"],"award-info":[{"award-number":["GM068411"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AI118689"],"award-info":[{"award-number":["AI118689"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AI049815"],"award-info":[{"award-number":["AI049815"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Reports"],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1016\/j.celrep.2026.117329","type":"journal-article","created":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:24:58Z","timestamp":1777595098000},"page":"117329","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["HCMV infection depends on EGLN1-mediated mitochondrial activation to increase dNTP pools for viral DNA replication"],"prefix":"10.1016","volume":"45","author":[{"given":"Lucas A.","family":"Simpson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana M.","family":"Dunn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wyatt","family":"Fales","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zachary J.","family":"Moore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica H.","family":"Ciesla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole C.","family":"Waild","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew H.","family":"Raymonda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isaac S.","family":"Harris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5379-9440","authenticated-orcid":false,"given":"Joshua","family":"Munger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.celrep.2026.117329_bib1","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1038\/s41579-021-00582-z","article-title":"Pathogenesis of human cytomegalovirus in the immunocompromised host","volume":"19","author":"Griffiths","year":"2021","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.celrep.2026.117329_bib2","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1002\/rmv.535","article-title":"Review and meta-analysis of the epidemiology of congenital cytomegalovirus (CMV) infection","volume":"17","author":"Kenneson","year":"2007","journal-title":"Rev. Med. Virol."},{"key":"10.1016\/j.celrep.2026.117329_bib3","doi-asserted-by":"crossref","first-page":"S178","DOI":"10.1093\/cid\/cit629","article-title":"Congenital cytomegalovirus infection: clinical outcome","volume":"57","author":"Boppana","year":"2013","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.celrep.2026.117329_bib4","doi-asserted-by":"crossref","first-page":"85","DOI":"10.15171\/jrip.2016.18","article-title":"The effect of cytomegalovirus infection on acute rejection in kidney transplanted patients","volume":"5","author":"Hasanzamani","year":"2016","journal-title":"J. Ren. Inj. Prev."},{"key":"10.1016\/j.celrep.2026.117329_bib5","doi-asserted-by":"crossref","DOI":"10.3390\/v15061358","article-title":"An Update on Current Antiviral Strategies to Combat Human Cytomegalovirus Infection","volume":"15","author":"Panda","year":"2023","journal-title":"Viruses"},{"key":"10.1016\/j.celrep.2026.117329_bib6","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.antiviral.2013.10.011","article-title":"Resistance of human cytomegalovirus to ganciclovir\/valganciclovir: a comprehensive review of putative resistance pathways","volume":"101","author":"Komatsu","year":"2014","journal-title":"Antiviral Res."},{"key":"10.1016\/j.celrep.2026.117329_bib7","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1128\/JVI.01557-10","article-title":"Inhibition of calmodulin-dependent kinase kinase blocks human cytomegalovirus-induced glycolytic activation and severely attenuates production of viral progeny","volume":"85","author":"McArdle","year":"2011","journal-title":"J. Virol."},{"key":"10.1016\/j.celrep.2026.117329_bib8","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.0020132","article-title":"Dynamics of the Cellular Metabolome during Human Cytomegalovirus Infection","volume":"2","author":"Munger","year":"2006","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.celrep.2026.117329_bib9","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1038\/nbt.1500","article-title":"Systems-level metabolic flux profiling identifies fatty acid synthesis as a target for antiviral therapy","volume":"26","author":"Munger","year":"2008","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.celrep.2026.117329_bib10","doi-asserted-by":"crossref","first-page":"5814","DOI":"10.1128\/JVI.02630-10","article-title":"Human cytomegalovirus induces the activity and expression of acetyl-coenzyme a carboxylase, a Fatty Acid biosynthetic enzyme whose inhibition attenuates viral replication","volume":"85","author":"Spencer","year":"2011","journal-title":"J. Virol."},{"key":"10.1016\/j.celrep.2026.117329_bib11","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1016\/j.celrep.2015.02.003","article-title":"Fatty Acid elongase 7 catalyzes lipidome remodeling essential for human cytomegalovirus replication","volume":"10","author":"Purdy","year":"2015","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2026.117329_bib12","doi-asserted-by":"crossref","DOI":"10.1128\/mbio.03031-23","article-title":"Cytomegalovirus-induced inactivation of TSC2 disrupts the coupling of fatty acid biosynthesis to glucose availability resulting in a vulnerability to glucose starvation","volume":"15","author":"Raymonda","year":"2024","journal-title":"mBio"},{"key":"10.1016\/j.celrep.2026.117329_bib13","doi-asserted-by":"crossref","DOI":"10.1128\/jvi.00302-25","article-title":"dNTP depletion and beyond: the multifaceted nature of SAMHD1-mediated viral restriction","volume":"99","author":"Cheung","year":"2025","journal-title":"J. Virol."},{"key":"10.1016\/j.celrep.2026.117329_bib14","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1038\/nature10117","article-title":"SAMHD1 is the dendritic- and myeloid-cell-specific HIV-1 restriction factor counteracted by Vpx","volume":"474","author":"Laguette","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2026.117329_bib15","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1038\/ni.2236","article-title":"SAMHD1 restricts the replication of human immunodeficiency virus type 1 by depleting the intracellular pool of deoxynucleoside triphosphates","volume":"13","author":"Lahouassa","year":"2012","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.celrep.2026.117329_bib16","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.antiviral.2006.05.020","article-title":"Perspectives on the development of acyclic nucleotide analogs as antiviral drugs","volume":"71","author":"Lee","year":"2006","journal-title":"Antiviral Res."},{"key":"10.1016\/j.celrep.2026.117329_bib17","doi-asserted-by":"crossref","first-page":"S17","DOI":"10.2146\/ajhp060379","article-title":"Antiviral dosing and efficacy for prophylaxis of cytomegalovirus disease in solid organ transplant recipients","volume":"63","author":"Cochrane","year":"2006","journal-title":"Am. J. Health Syst. Pharm."},{"key":"10.1016\/j.celrep.2026.117329_bib18","first-page":"132","article-title":"Novel inhibitors of human CMV","volume":"9","author":"Andrei","year":"2008","journal-title":"Curr. Opin. Investig. Drugs"},{"key":"10.1016\/j.celrep.2026.117329_bib19","doi-asserted-by":"crossref","first-page":"173","DOI":"10.7326\/0003-4819-118-3-199302010-00003","article-title":"Ganciclovir prophylaxis to prevent cytomegalovirus disease after allogeneic marrow transplant","volume":"118","author":"Goodrich","year":"1993","journal-title":"Ann. Intern. Med."},{"key":"10.1016\/j.celrep.2026.117329_bib20","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1016\/j.cmet.2019.01.020","article-title":"Deubiquitinases Maintain Protein Homeostasis and Survival of Cancer Cells upon Glutathione Depletion","volume":"29","author":"Harris","year":"2019","journal-title":"Cell Metab."},{"key":"10.1016\/j.celrep.2026.117329_bib21","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.virol.2021.11.008","article-title":"Pharmacologic profiling reveals lapatinib as a novel antiviral against SARS-CoV-2 in vitro","volume":"566","author":"Raymonda","year":"2022","journal-title":"Virology"},{"key":"10.1016\/j.celrep.2026.117329_bib72","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1177\/108705719900400206","article-title":"A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays","volume":"4","author":"Zhang","year":"1999","journal-title":"J. Biomol. Screen"},{"key":"10.1016\/j.celrep.2026.117329_bib22","doi-asserted-by":"crossref","first-page":"18019","DOI":"10.1073\/pnas.1415864111","article-title":"Cytomegalovirus-mediated activation of pyrimidine biosynthesis drives UDP-sugar synthesis to support viral protein glycosylation","volume":"111","author":"DeVito","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2026.117329_bib23","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1126\/science.1142984","article-title":"Complex I binding by a virally encoded RNA regulates mitochondria-induced cell death","volume":"316","author":"Reeves","year":"2007","journal-title":"Science"},{"key":"10.1016\/j.celrep.2026.117329_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.antiviral.2021.105159","article-title":"Inhibiting cytomegalovirus replication through targeting the host electron transport chain","volume":"194","author":"Combs","year":"2021","journal-title":"Antiviral Res."},{"key":"10.1016\/j.celrep.2026.117329_bib25","doi-asserted-by":"crossref","DOI":"10.3390\/antiox11020220","article-title":"Structure-Activity Relationships and Transcriptomic Analysis of Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitors","volume":"11","author":"Poloznikov","year":"2022","journal-title":"Antioxidants"},{"key":"10.1016\/j.celrep.2026.117329_bib26","doi-asserted-by":"crossref","first-page":"45","DOI":"10.2174\/1872312813666181129100950","article-title":"\"Branched Tail\" Oxyquinoline Inhibitors of HIF Prolyl Hydroxylase: Early Evaluation of Toxicity and Metabolism Using Liver-on-a-chip","volume":"13","author":"Poloznikov","year":"2019","journal-title":"Drug Metab. Lett."},{"key":"10.1016\/j.celrep.2026.117329_bib27","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/S0092-8674(01)00507-4","article-title":"C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation","volume":"107","author":"Epstein","year":"2001","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2026.117329_bib28","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1042\/BJ20041736","article-title":"Regulation of the prolyl hydroxylase domain protein 2 (phd2\/egln-1) gene: identification of a functional hypoxia-responsive element","volume":"387","author":"Metzen","year":"2005","journal-title":"Biochem. J."},{"key":"10.1016\/j.celrep.2026.117329_bib29","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1126\/science.1066373","article-title":"A Conserved Family of Prolyl-4-Hydroxylases That Modify HIF","volume":"294","author":"Bruick","year":"2001","journal-title":"Science"},{"key":"10.1016\/j.celrep.2026.117329_bib30","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1010722","article-title":"TNFalpha-induced metabolic reprogramming drives an intrinsic anti-viral state","volume":"18","author":"Ciesla","year":"2022","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.celrep.2026.117329_bib31","doi-asserted-by":"crossref","first-page":"110","DOI":"10.3390\/v12010110","article-title":"Bright and Early: Inhibiting Human Cytomegalovirus by Targeting Major Immediate-Early Gene Expression or Protein Function","volume":"12","author":"Adamson","year":"2020","journal-title":"Viruses"},{"key":"10.1016\/j.celrep.2026.117329_bib32","doi-asserted-by":"crossref","first-page":"14223","DOI":"10.1073\/pnas.2334032100","article-title":"Functional profiling of a human cytomegalovirus genome","volume":"100","author":"Dunn","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2026.117329_bib33","doi-asserted-by":"crossref","first-page":"12396","DOI":"10.1073\/pnas.1635160100","article-title":"Functional map of human cytomegalovirus AD169 defined by global mutational analysis","volume":"100","author":"Yu","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2026.117329_bib34","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1161\/ATVBAHA.109.192542","article-title":"Interferon-gamma induces prolyl hydroxylase (PHD)3 through a STAT1-dependent mechanism in human endothelial cells","volume":"29","author":"Gerber","year":"2009","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.celrep.2026.117329_bib35","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.cyto.2008.01.016","article-title":"IL-4-induced Stat6 activities affect apoptosis and gene expression in breast cancer cells","volume":"42","author":"Zhang","year":"2008","journal-title":"Cytokine"},{"key":"10.1016\/j.celrep.2026.117329_bib36","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.virol.2005.09.065","article-title":"Prolonged activation of NF-kappaB by human cytomegalovirus promotes efficient viral replication and late gene expression","volume":"346","author":"DeMeritt","year":"2006","journal-title":"Virology"},{"key":"10.1016\/j.celrep.2026.117329_bib37","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1002\/jcb.20067","article-title":"Regulation of HIF prolyl hydroxylases by hypoxia-inducible factors","volume":"92","author":"Aprelikova","year":"2004","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.celrep.2026.117329_bib38","doi-asserted-by":"crossref","DOI":"10.15252\/embj.2023113743","article-title":"A mitochondrial EglN1-AMPK\u03b1 axis drives breast cancer progression by enhancing metabolic adaptation to hypoxic stress","volume":"42","author":"Jiang","year":"2023","journal-title":"Embo j"},{"key":"10.1016\/j.celrep.2026.117329_bib39","doi-asserted-by":"crossref","first-page":"2953","DOI":"10.15252\/embj.201591437","article-title":"EglN2 associates with the NRF1-PGC1\u03b1 complex and controls mitochondrial function in breast cancer","volume":"34","author":"Zhang","year":"2015","journal-title":"Embo j"},{"key":"10.1016\/j.celrep.2026.117329_bib40","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1016\/j.mito.2011.08.008","article-title":"Human cytomegalovirus infection increases mitochondrial biogenesis","volume":"11","author":"Kaarb\u00f8","year":"2011","journal-title":"Mitochondrion"},{"key":"10.1016\/j.celrep.2026.117329_bib41","doi-asserted-by":"crossref","first-page":"e01183-19","DOI":"10.1128\/JVI.01183-19","article-title":"Human Cytomegalovirus Alters Host Cell Mitochondrial Function during Acute Infection","volume":"94","author":"Combs","year":"2020","journal-title":"J. Virol."},{"key":"10.1016\/j.celrep.2026.117329_bib42","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1038\/262414a0","article-title":"Human cytomegalovirus infection of WI-38 cells stimulates mitochondrial DNA synthesis","volume":"262","author":"Furukawa","year":"1976","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2026.117329_bib43","doi-asserted-by":"crossref","first-page":"2466","DOI":"10.1093\/nar\/gkv047","article-title":"Regulation of mammalian nucleotide metabolism and biosynthesis","volume":"43","author":"Lane","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.celrep.2026.117329_bib44","doi-asserted-by":"crossref","first-page":"4322","DOI":"10.1016\/S0021-9258(19)41421-X","article-title":"Superoxide production and electron transport in mitochondrial oxidation of dihydroorotic acid","volume":"250","author":"Forman","year":"1975","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.celrep.2026.117329_bib45","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1111\/j.1432-1033.1984.tb08249.x","article-title":"On auxotrophy for pyrimidines of respiration-deficient chick embryo cells","volume":"142","author":"Gr\u00e9goire","year":"1984","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.celrep.2026.117329_bib46","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2022.102447","article-title":"The coupling of mitoproteolysis and oxidative phosphorylation enables tracking of an active mitochondrial state through MitoTimer fluorescence","volume":"56","author":"Xie","year":"2022","journal-title":"Redox Biol."},{"key":"10.1016\/j.celrep.2026.117329_bib47","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1007\/s13238-020-00768-w","article-title":"Novel and potent inhibitors targeting DHODH are broad-spectrum antivirals against RNA viruses including newly-emerged coronavirus SARS-CoV-2","volume":"11","author":"Xiong","year":"2020","journal-title":"Protein Cell"},{"key":"10.1016\/j.celrep.2026.117329_bib48","doi-asserted-by":"crossref","first-page":"4064","DOI":"10.1016\/j.vaccine.2017.06.003","article-title":"The complexity and cost of vaccine manufacturing - An overview","volume":"35","author":"Plotkin","year":"2017","journal-title":"Vaccine"},{"key":"10.1016\/j.celrep.2026.117329_bib49","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.51804","article-title":"Repression of viral gene expression and replication by the unfolded protein response effector XBP1u","volume":"9","author":"Hinte","year":"2020","journal-title":"eLife"},{"key":"10.1016\/j.celrep.2026.117329_bib50","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1003266","article-title":"PKR-like endoplasmic reticulum kinase is necessary for lipogenic activation during HCMV infection","volume":"9","author":"Yu","year":"2013","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.celrep.2026.117329_bib51","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1016\/j.molcel.2017.06.002","article-title":"The EGLN-HIF O(2)-Sensing System: Multiple Inputs and Feedbacks","volume":"66","author":"Ivan","year":"2017","journal-title":"Mol. Cell"},{"key":"10.1016\/j.celrep.2026.117329_bib52","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.ccr.2005.06.015","article-title":"Neuronal apoptosis linked to EglN3 prolyl hydroxylase and familial pheochromocytoma genes: developmental culling and cancer","volume":"8","author":"Lee","year":"2005","journal-title":"Cancer Cell"},{"key":"10.1016\/j.celrep.2026.117329_bib53","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1016\/j.molcel.2016.08.014","article-title":"PHD3 Loss in Cancer Enables Metabolic Reliance on Fatty Acid Oxidation via Deactivation of ACC2","volume":"63","author":"German","year":"2016","journal-title":"Mol. Cell"},{"key":"10.1016\/j.celrep.2026.117329_bib54","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1101\/gad.242131.114","article-title":"Prolyl hydroxylation by EglN2 destabilizes FOXO3a by blocking its interaction with the USP9x deubiquitinase","volume":"28","author":"Zheng","year":"2014","journal-title":"Genes Dev."},{"key":"10.1016\/j.celrep.2026.117329_bib55","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1126\/science.aad5755","article-title":"pVHL suppresses kinase activity of Akt in a proline-hydroxylation-dependent manner","volume":"353","author":"Guo","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.celrep.2026.117329_bib56","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/j.cell.2015.03.011","article-title":"A lactate-induced response to hypoxia","volume":"161","author":"Lee","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2026.117329_bib57","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1084\/jem.93.6.635","article-title":"The relation of the Krebs cycle to viral synthesis. II. The effect of sodium fluoroacetate on the propagation of influenza virus in mice","volume":"93","author":"Ackermann","year":"1951","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.celrep.2026.117329_bib58","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/S0021-9258(18)56133-0","article-title":"Concerning the relation of the Krebs cycle to virus propagation","volume":"189","author":"Ackermann","year":"1951","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.celrep.2026.117329_bib59","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1128\/am.18.4.660-667.1969","article-title":"Antiviral and antitumor antibiotics. XX. Effects of rotenone, deguelin, and related compounds on animal and plant viruses","volume":"18","author":"Takatsuki","year":"1969","journal-title":"Appl. Microbiol."},{"key":"10.1016\/j.celrep.2026.117329_bib60","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1128\/jvi.55.3.601-610.1985","article-title":"Degradation of cellular mRNAs induced by a virion-associated factor during herpes simplex virus infection of Vero cells","volume":"55","author":"Schek","year":"1985","journal-title":"J. Virol."},{"key":"10.1016\/j.celrep.2026.117329_bib61","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1038\/sj.embor.7400878","article-title":"Herpes simplex virus eliminates host mitochondrial DNA","volume":"8","author":"Saffran","year":"2007","journal-title":"EMBO Rep."},{"key":"10.1016\/j.celrep.2026.117329_bib62","doi-asserted-by":"crossref","first-page":"3665","DOI":"10.1038\/s41388-022-02378-8","article-title":"The multifaceted role of EGLN family prolyl hydroxylases in cancer: going beyond HIF regulation","volume":"41","author":"Strocchi","year":"2022","journal-title":"Oncogene"},{"key":"10.1016\/j.celrep.2026.117329_bib63","doi-asserted-by":"crossref","first-page":"2327","DOI":"10.1158\/0008-5472.CAN-18-1785","article-title":"Selective EGLN Inhibition Enables Ablative Radiotherapy and Improves Survival in Unresectable Pancreatic Cancer","volume":"79","author":"Fujimoto","year":"2019","journal-title":"Cancer Res."},{"key":"10.1016\/j.celrep.2026.117329_bib64","doi-asserted-by":"crossref","DOI":"10.1242\/dev.200030","article-title":"Oxygen-sensing mechanisms in development and tissue repair","volume":"148","author":"Jiang","year":"2021","journal-title":"Development"},{"key":"10.1016\/j.celrep.2026.117329_bib65","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.afos.2022.03.001","article-title":"Role of prolyl hydroxylase domain proteins in bone metabolism","volume":"8","author":"Wolf","year":"2022","journal-title":"Osteoporos. Sarcopenia"},{"key":"10.1016\/j.celrep.2026.117329_bib66","doi-asserted-by":"crossref","first-page":"347","DOI":"10.3109\/15376516.2012.673088","article-title":"HIF-prolyl hydroxylases and cardiovascular diseases","volume":"22","author":"Sen Banerjee","year":"2012","journal-title":"Toxicol. Mech. Methods"},{"key":"10.1016\/j.celrep.2026.117329_bib67","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1053\/j.ajkd.2015.12.020","article-title":"Roxadustat (FG-4592) Versus Epoetin Alfa for Anemia in Patients Receiving Maintenance Hemodialysis: A Phase 2, Randomized, 6- to 19-Week, Open-Label, Active-Comparator, Dose-Ranging, Safety and Exploratory Efficacy Study","volume":"67","author":"Provenzano","year":"2016","journal-title":"Am. J. Kidney Dis."},{"key":"10.1016\/j.celrep.2026.117329_bib68","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.837249","article-title":"Clinical Potential of Hypoxia Inducible Factors Prolyl Hydroxylase Inhibitors in Treating Nonanemic Diseases","volume":"13","author":"Miao","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.celrep.2026.117329_bib69","doi-asserted-by":"crossref","first-page":"3533","DOI":"10.1038\/s41467-024-47814-3","article-title":"Oxygen enhances antiviral innate immunity through maintenance of EGLN1-catalyzed proline hydroxylation of IRF3","volume":"15","author":"Liu","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2026.117329_bib77","doi-asserted-by":"crossref","first-page":"7960","DOI":"10.1128\/jvi.69.12.7960-7970.1995","article-title":"Human cytomegalovirus IE1 and IE2 proteins block apoptosis","volume":"69","author":"Zhu","year":"1995","journal-title":"J. Virol."},{"key":"10.1016\/j.celrep.2026.117329_bib78","doi-asserted-by":"crossref","first-page":"10594","DOI":"10.1128\/JVI.77.19.10594-10605.2003","article-title":"Human cytomegalovirus UL99-encoded pp28 is required for the cytoplasmic envelopment of tegument-associated capsids","volume":"77","author":"Silva","year":"2003","journal-title":"J. Virol."},{"key":"10.1016\/j.celrep.2026.117329_bib79","doi-asserted-by":"crossref","first-page":"3541","DOI":"10.1128\/JVI.80.7.3541-3548.2006","article-title":"UL26-deficient human cytomegalovirus produces virions with hypophosphorylated pp28 tegument protein that is unstable within newly infected cells","volume":"80","author":"Munger","year":"2006","journal-title":"J. Virol."},{"key":"10.1016\/j.celrep.2026.117329_bib73","doi-asserted-by":"crossref","first-page":"10330","DOI":"10.1128\/JVI.79.16.10330-10338.2005","article-title":"Human cytomegalovirus UL131 open reading frame is required for epithelial cell tropism","volume":"79","author":"Wang","year":"2005","journal-title":"J. Virol."},{"key":"10.1016\/j.celrep.2026.117329_bib74","doi-asserted-by":"crossref","first-page":"3700","DOI":"10.1128\/JVI.02442-10","article-title":"Human cytomegalovirus pUS27 G protein-coupled receptor homologue is required for efficient spread by the extracellular route but not for direct cell-to-cell spread","volume":"85","author":"O'Connor","year":"2011","journal-title":"J. Virol."},{"key":"10.1016\/j.celrep.2026.117329_bib70","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.jviromet.2016.12.012","article-title":"Visualization of herpes simplex virus type 1 virions using fluorescent colors","volume":"241","author":"Etienne","year":"2017","journal-title":"J. Virol. Methods"},{"key":"10.1016\/j.celrep.2026.117329_bib71","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1012058","article-title":"A UL26-PIAS1 complex antagonizes anti-viral gene expression during Human Cytomegalovirus infection","volume":"20","author":"Ciesla","year":"2024","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.celrep.2026.117329_bib75","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1021\/bi00647a029","article-title":"Mechanism of phosphonoacetate inhibition of herpesvirus-induced DNA polymerase","volume":"15","author":"Leinbach","year":"1976","journal-title":"Biochemistry"},{"key":"10.1016\/j.celrep.2026.117329_bib76","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1007569","article-title":"The Human Cytomegalovirus UL38 protein drives mTOR-independent metabolic flux reprogramming by inhibiting TSC2","volume":"15","author":"Rodr\u00edguez-S\u00e1nchez","year":"2019","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.celrep.2026.117329_bib80","doi-asserted-by":"crossref","first-page":"D543","DOI":"10.1093\/nar\/gkae1011","article-title":"The PRIDE database at 20 years: 2025 update","volume":"53","author":"Perez-Riverol","year":"2025","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.celrep.2026.117329_bib81","doi-asserted-by":"crossref","first-page":"8207","DOI":"10.1021\/ac060923y","article-title":"ChromAlign: A Two-Step Algorithmic Procedure for Time Alignment of Three-Dimensional LC\u2212MS Chromatographic Surfaces","volume":"78","author":"Sadygov","year":"2006","journal-title":"Anal. Chem."},{"key":"10.1016\/j.celrep.2026.117329_bib82","doi-asserted-by":"crossref","first-page":"D463","DOI":"10.1093\/nar\/gkv1042","article-title":"Metabolomics Workbench: An international repository for metabolomics data and metadata, metabolite standards, protocols, tutorials and training, and analysis tools","volume":"44","author":"Sud","year":"2016","journal-title":"Nucleic Acids Res."}],"container-title":["Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124726004079?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124726004079?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T12:38:48Z","timestamp":1783082328000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211124726004079"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":82,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["S2211124726004079"],"URL":"https:\/\/doi.org\/10.1016\/j.celrep.2026.117329","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2025.10.31.685607","asserted-by":"object"}]},"ISSN":["2211-1247"],"issn-type":[{"value":"2211-1247","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"HCMV infection depends on EGLN1-mediated mitochondrial activation to increase dNTP pools for viral DNA replication","name":"articletitle","label":"Article Title"},{"value":"Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.celrep.2026.117329","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"117329"}}