{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T00:26:06Z","timestamp":1783124766377,"version":"3.54.6"},"reference-count":78,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T00:00:00Z","timestamp":1775779200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012232","name":"National Key Clinical Specialty Discipline Construction Program of China","doi-asserted-by":"publisher","award":["CZXM-ZK-47"],"award-info":[{"award-number":["CZXM-ZK-47"]}],"id":[{"id":"10.13039\/501100012232","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["92359304"],"award-info":[{"award-number":["92359304"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82403065"],"award-info":[{"award-number":["82403065"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008081","name":"Southeast University","doi-asserted-by":"publisher","award":["CXJU_SEU 24228"],"award-info":[{"award-number":["CXJU_SEU 24228"]}],"id":[{"id":"10.13039\/501100008081","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008081","name":"Southeast University","doi-asserted-by":"publisher","award":["GSP-JCYJ05"],"award-info":[{"award-number":["GSP-JCYJ05"]}],"id":[{"id":"10.13039\/501100008081","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["zdlyg01"],"award-info":[{"award-number":["zdlyg01"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["BK20252098"],"award-info":[{"award-number":["BK20252098"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Reports"],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1016\/j.celrep.2026.117330","type":"journal-article","created":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T12:38:09Z","timestamp":1778762289000},"page":"117330","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["HOXD11-NMDAR signaling drives neuroendocrine prostate cancer and enables potential therapeutic intervention as a target of memantine"],"prefix":"10.1016","volume":"45","author":[{"given":"Tiange","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Song","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Likai","family":"Mao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruixin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enyao","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Can","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengrong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haowen","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caichen","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yurui","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifei","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianyi","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangyu","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziqi","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zonghao","family":"You","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunlai","family":"Zhi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiejunhao","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tian","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Congbin","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Na","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gao-Jun","family":"Teng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yini","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenchao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4993-0500","authenticated-orcid":false,"given":"Bin","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.celrep.2026.117330_bib1","doi-asserted-by":"crossref","first-page":"e386","DOI":"10.1200\/JCO.2011.41.5166","article-title":"Challenges in recognizing treatment-related neuroendocrine prostate cancer","volume":"30","author":"Beltran","year":"2012","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.celrep.2026.117330_bib2","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/S0090-4295(97)00684-5","article-title":"Neuroendocrine differentiation in prostatic carcinoma during hormonal treatment","volume":"51","author":"Jiborn","year":"1998","journal-title":"Urology"},{"key":"10.1016\/j.celrep.2026.117330_bib3","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1158\/2159-8290.CD-16-1174","article-title":"Transdifferentiation as a Mechanism of Treatment Resistance in a Mouse Model of Castration-Resistant Prostate Cancer","volume":"7","author":"Zou","year":"2017","journal-title":"Cancer Discov."},{"key":"10.1016\/j.celrep.2026.117330_bib4","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1126\/science.aah4307","article-title":"SOX2 promotes lineage plasticity and antiandrogen resistance in TP53- and RB1-deficient prostate cancer","volume":"355","author":"Mu","year":"2017","journal-title":"Science"},{"key":"10.1016\/j.celrep.2026.117330_bib5","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1158\/2159-8290.CD-11-0130","article-title":"Molecular characterization of neuroendocrine prostate cancer and identification of new drug targets","volume":"1","author":"Beltran","year":"2011","journal-title":"Cancer Discov."},{"key":"10.1016\/j.celrep.2026.117330_bib6","doi-asserted-by":"crossref","first-page":"2492","DOI":"10.1200\/JCO.2017.77.6880","article-title":"Clinical and Genomic Characterization of Treatment-Emergent Small-Cell Neuroendocrine Prostate Cancer: A Multi-institutional Prospective Study","volume":"36","author":"Aggarwal","year":"2018","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.celrep.2026.117330_bib7","article-title":"Single-cell transcriptional regulation and genetic evolution of neuroendocrine prostate cancer","volume":"25","author":"Wang","year":"2022","journal-title":"iScience"},{"key":"10.1016\/j.celrep.2026.117330_bib8","doi-asserted-by":"crossref","first-page":"R187","DOI":"10.1530\/ERC-12-0085","article-title":"The reactive stroma microenvironment and prostate cancer progression","volume":"19","author":"Barron","year":"2012","journal-title":"Endocr. Relat. Cancer"},{"key":"10.1016\/j.celrep.2026.117330_bib9","doi-asserted-by":"crossref","first-page":"3522","DOI":"10.1158\/0008-5472.CAN-24-1388","article-title":"Neuroendocrine Differentiation in Prostate Cancer Requires ASCL1","volume":"84","author":"Rodarte","year":"2024","journal-title":"Cancer Res."},{"key":"10.1016\/j.celrep.2026.117330_bib10","doi-asserted-by":"crossref","first-page":"2282","DOI":"10.1038\/s41467-022-29963-5","article-title":"ASCL1 activates neuronal stem cell-like lineage programming through remodeling of the chromatin landscape in prostate cancer","volume":"13","author":"Nouruzi","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2026.117330_bib11","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1038\/nm.4045","article-title":"Divergent clonal evolution of castration-resistant neuroendocrine prostate cancer","volume":"22","author":"Beltran","year":"2016","journal-title":"Nat. Med."},{"key":"10.1016\/j.celrep.2026.117330_bib12","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1126\/science.aah4199","article-title":"Rb1 and Trp53 cooperate to suppress prostate cancer lineage plasticity, metastasis, and antiandrogen resistance","volume":"355","author":"Ku","year":"2017","journal-title":"Science"},{"key":"10.1016\/j.celrep.2026.117330_bib13","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1038\/s41467-021-27322-4","article-title":"Single-cell analysis of human primary prostate cancer reveals the heterogeneity of tumor-associated epithelial cell states","volume":"13","author":"Song","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2026.117330_bib14","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1016\/j.ccell.2022.10.011","article-title":"FOXA2 drives lineage plasticity and KIT pathway activation in neuroendocrine prostate cancer","volume":"40","author":"Han","year":"2022","journal-title":"Cancer Cell"},{"key":"10.1016\/j.celrep.2026.117330_bib15","article-title":"New insights into markers for distinguishing neuroendocrine prostate cancer: evidence from single-cell analysis","volume":"16","author":"Luo","year":"2025","journal-title":"Front. Immunol."},{"key":"10.1016\/j.celrep.2026.117330_bib16","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1038\/s41418-024-01295-5","article-title":"Zeb1-controlled metabolic plasticity enables remodeling of chromatin accessibility in the development of neuroendocrine prostate cancer","volume":"31","author":"Wang","year":"2024","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.celrep.2026.117330_bib17","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.adf7006","article-title":"Exportin 1 inhibition prevents neuroendocrine transformation through SOX2 down-regulation in lung and prostate cancers","volume":"15","author":"Quintanal-Villalonga","year":"2023","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.celrep.2026.117330_bib18","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1016\/j.ccell.2016.03.001","article-title":"N-Myc Drives Neuroendocrine Prostate Cancer Initiated from Human Prostate Epithelial Cells","volume":"29","author":"Lee","year":"2016","journal-title":"Cancer Cell"},{"key":"10.1016\/j.celrep.2026.117330_bib19","first-page":"3325","article-title":"Characterization of prostatic epithelial cell lines derived from transgenic adenocarcinoma of the mouse prostate (TRAMP) model","volume":"57","author":"Foster","year":"1997","journal-title":"Cancer Res."},{"key":"10.1016\/j.celrep.2026.117330_bib20","doi-asserted-by":"crossref","first-page":"236","DOI":"10.2353\/ajpath.2008.070602","article-title":"Dissociation of epithelial and neuroendocrine carcinoma lineages in the transgenic adenocarcinoma of mouse prostate model of prostate cancer","volume":"172","author":"Chiaverotti","year":"2008","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.celrep.2026.117330_bib21","doi-asserted-by":"crossref","first-page":"3439","DOI":"10.1073\/pnas.92.8.3439","article-title":"Prostate cancer in a transgenic mouse","volume":"92","author":"Greenberg","year":"1995","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2026.117330_bib22","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1093\/carcin\/bgw044","article-title":"Icaritin suppresses development of neuroendocrine differentiation of prostate cancer through inhibition of IL-6\/STAT3 and Aurora kinase A pathways in TRAMP mice","volume":"37","author":"Sun","year":"2016","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.celrep.2026.117330_bib23","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.ccr.2010.05.024","article-title":"Siah2-dependent concerted activity of HIF and FoxA2 regulates formation of neuroendocrine phenotype and neuroendocrine prostate tumors","volume":"18","author":"Qi","year":"2010","journal-title":"Cancer Cell"},{"key":"10.1016\/j.celrep.2026.117330_bib24","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1038\/nrn3504","article-title":"NMDA receptor subunit diversity: impact on receptor properties, synaptic plasticity and disease","volume":"14","author":"Paoletti","year":"2013","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.celrep.2026.117330_bib25","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1038\/nrn.2016.92","article-title":"Emerging roles of GluN3-containing NMDA receptors in the CNS","volume":"17","author":"P\u00e9rez-Ota\u00f1o","year":"2016","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.celrep.2026.117330_bib26","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1007\/s00418-009-0613-1","article-title":"Expression of glutamate receptor subunits in human cancers","volume":"132","author":"Stepulak","year":"2009","journal-title":"Histochem. Cell Biol."},{"key":"10.1016\/j.celrep.2026.117330_bib27","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2302126120","article-title":"NMDAR antagonists suppress tumor progression by regulating tumor-associated macrophages","volume":"120","author":"Yuan","year":"2023","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2026.117330_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.ccell.2025.09.003","article-title":"Sensory neurons drive pancreatic cancer progression through glutamatergic neuron-cancer pseudo-synapses","author":"Ren","year":"2025","journal-title":"Cancer Cell"},{"key":"10.1016\/j.celrep.2026.117330_bib29","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.cell.2013.02.051","article-title":"Hijacking the neuronal NMDAR signaling circuit to promote tumor growth and invasion","volume":"153","author":"Li","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2026.117330_bib30","doi-asserted-by":"crossref","first-page":"4240","DOI":"10.1158\/1078-0432.CCR-11-1217","article-title":"Molecular pathways: dysregulated glutamatergic signaling pathways in cancer","volume":"18","author":"Prickett","year":"2012","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.celrep.2026.117330_bib31","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1126\/science.abn0478","article-title":"Lineage plasticity in prostate cancer depends on JAK\/STAT inflammatory signaling","volume":"377","author":"Chan","year":"2022","journal-title":"Science"},{"key":"10.1016\/j.celrep.2026.117330_bib32","doi-asserted-by":"crossref","first-page":"3530","DOI":"10.1016\/j.celrep.2018.11.086","article-title":"A Cellular Anatomy of the Normal Adult Human Prostate and Prostatic Urethra","volume":"25","author":"Henry","year":"2018","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2026.117330_bib33","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1038\/s41422-019-0149-4","article-title":"Neuroendocrine prostate carcinoma cells originate from the p63-expressing basal cells but not the pre-existing adenocarcinoma cells in mice","volume":"29","author":"Lee","year":"2019","journal-title":"Cell Res."},{"key":"10.1016\/j.celrep.2026.117330_bib34","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.ebiom.2019.07.002","article-title":"Intergrated analysis of ELMO1, serves as a link between tumour mutation burden and epithelial-mesenchymal transition in hepatocellular carcinoma","volume":"46","author":"Peng","year":"2019","journal-title":"EBioMedicine"},{"key":"10.1016\/j.celrep.2026.117330_bib35","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1182\/blood.2021012091","article-title":"PEG10 amplification at 7q21.3 potentiates large-cell transformation in cutaneous T-cell lymphoma","volume":"139","author":"Liu","year":"2022","journal-title":"Blood"},{"key":"10.1016\/j.celrep.2026.117330_bib36","doi-asserted-by":"crossref","first-page":"4012","DOI":"10.1038\/onc.2011.569","article-title":"The insulin resistance Grb14 adaptor protein promotes thyroid cancer ret signaling and progression","volume":"31","author":"Balogh","year":"2012","journal-title":"Oncogene"},{"key":"10.1016\/j.celrep.2026.117330_bib37","doi-asserted-by":"crossref","first-page":"7203","DOI":"10.1158\/0008-5472.CAN-07-0473","article-title":"ELMO1 and Dock180, a bipartite Rac1 guanine nucleotide exchange factor, promote human glioma cell invasion","volume":"67","author":"Jarzynka","year":"2007","journal-title":"Cancer Res."},{"key":"10.1016\/j.celrep.2026.117330_bib38","article-title":"Prediction of relapse and prognosis by expression levels of long noncoding RNA PEG10 in glioma patients","volume":"98","author":"Xiao","year":"2019","journal-title":"Medicine (Baltim.)"},{"key":"10.1016\/j.celrep.2026.117330_bib39","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.7150\/ijbs.57168","article-title":"Identification of low-dose radiation-induced exosomal circ-METRN and miR-4709-3p\/GRB14\/PDGFR\u03b1 pathway as a key regulatory mechanism in Glioblastoma progression and radioresistance: Functional validation and clinical theranostic significance","volume":"17","author":"Wang","year":"2021","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.celrep.2026.117330_bib40","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1016\/j.celrep.2015.07.012","article-title":"The Placental Gene PEG10 Promotes Progression of Neuroendocrine Prostate Cancer","volume":"12","author":"Akamatsu","year":"2015","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2026.117330_bib41","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1530\/JME-18-0226","article-title":"PEG10 is associated with treatment-induced neuroendocrine prostate cancer","volume":"63","author":"Kim","year":"2019","journal-title":"J. Mol. Endocrinol."},{"key":"10.1016\/j.celrep.2026.117330_bib42","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24108955","article-title":"Spatial Gene Expression Analysis Reveals Characteristic Gene Expression Patterns of De Novo Neuroendocrine Prostate Cancer Coexisting with Androgen Receptor Pathway Prostate Cancer","volume":"24","author":"Watanabe","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.celrep.2026.117330_bib43","doi-asserted-by":"crossref","first-page":"4492","DOI":"10.1172\/JCI128212","article-title":"Molecular profiling stratifies diverse phenotypes of treatment-refractory metastatic castration-resistant prostate cancer","volume":"129","author":"Labrecque","year":"2019","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.celrep.2026.117330_bib44","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1038\/nm.4053","article-title":"Substantial interindividual and limited intraindividual genomic diversity among tumors from men with metastatic prostate cancer","volume":"22","author":"Kumar","year":"2016","journal-title":"Nat. Med."},{"key":"10.1016\/j.celrep.2026.117330_bib45","doi-asserted-by":"crossref","first-page":"11428","DOI":"10.1073\/pnas.1902651116","article-title":"Genomic correlates of clinical outcome in advanced prostate cancer","volume":"116","author":"Abida","year":"2019","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2026.117330_bib46","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1038\/nmeth.4463","article-title":"SCENIC: single-cell regulatory network inference and clustering","volume":"14","author":"Aibar","year":"2017","journal-title":"Nat. Methods"},{"key":"10.1016\/j.celrep.2026.117330_bib47","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.1038\/s43018-024-00838-6","article-title":"The neuroendocrine transition in prostate cancer is dynamic and dependent on ASCL1","volume":"5","author":"Romero","year":"2024","journal-title":"Nat. Cancer"},{"key":"10.1016\/j.celrep.2026.117330_bib48","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1038\/s41698-024-00667-x","article-title":"Unveiling novel double-negative prostate cancer subtypes through single-cell RNA sequencing analysis","volume":"8","author":"Cheng","year":"2024","journal-title":"npj Precis. Oncol."},{"key":"10.1016\/j.celrep.2026.117330_bib49","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1093\/bioinformatics\/btq064","article-title":"GOSemSim: an R package for measuring semantic similarity among GO terms and gene products","volume":"26","author":"Yu","year":"2010","journal-title":"Bioinformatics"},{"key":"10.1016\/j.celrep.2026.117330_bib50","doi-asserted-by":"crossref","DOI":"10.1016\/j.ctrv.2025.102941","article-title":"Current and future directions in theranostics for neuroendocrine prostate cancer","volume":"136","author":"Belge Bilgin","year":"2025","journal-title":"Cancer Treat Rev."},{"key":"10.1016\/j.celrep.2026.117330_bib51","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1593\/neo.121550","article-title":"Concurrent AURKA and MYCN gene amplifications are harbingers of lethal treatment-related neuroendocrine prostate cancer","volume":"15","author":"Mosquera","year":"2013","journal-title":"Neoplasia"},{"key":"10.1016\/j.celrep.2026.117330_bib52","doi-asserted-by":"crossref","first-page":"6532","DOI":"10.1158\/1078-0432.CCR-19-0498","article-title":"BRN4 Is a Novel Driver of Neuroendocrine Differentiation in Castration-Resistant Prostate Cancer and Is Selectively Released in Extracellular Vesicles with BRN2","volume":"25","author":"Bhagirath","year":"2019","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.celrep.2026.117330_bib53","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.1016\/j.ccell.2022.10.010","article-title":"KIT as a therapeutic target in neuroendocrine prostate cancer","volume":"40","author":"Azad","year":"2022","journal-title":"Cancer Cell"},{"key":"10.1016\/j.celrep.2026.117330_bib54","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.adm7098","article-title":"Identification of an anaplastic subtype of prostate cancer amenable to therapies targeting SP1 or translation elongation","volume":"10","author":"Zou","year":"2024","journal-title":"Sci. Adv."},{"key":"10.1016\/j.celrep.2026.117330_bib55","doi-asserted-by":"crossref","DOI":"10.1016\/j.bmc.2024.117894","article-title":"Advancements in platinum-based anticancer drug development: A comprehensive review of strategies, discoveries, and future perspectives","volume":"112","author":"Sahoo","year":"2024","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.celrep.2026.117330_bib56","doi-asserted-by":"crossref","first-page":"2010","DOI":"10.1016\/j.ejca.2014.04.014","article-title":"Review of therapeutic drug monitoring of anticancer drugs part 1--cytotoxics","volume":"50","author":"Paci","year":"2014","journal-title":"Eur. J. Cancer"},{"key":"10.1016\/j.celrep.2026.117330_bib57","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1038\/s41586-020-03170-y","article-title":"Elevated NSD3 histone methylation activity drives squamous cell lung cancer","volume":"590","author":"Yuan","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2026.117330_bib58","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1038\/s41586-020-03069-8","article-title":"Molecular basis of nucleosomal H3K36 methylation by NSD methyltransferases","volume":"590","author":"Li","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2026.117330_bib59","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1038\/s41392-021-00616-1","article-title":"Targeting H3K36 methyltransferases NSDs: a promising strategy for tumor targeted therapy","volume":"6","author":"Peng","year":"2021","journal-title":"Signal Transduct. Targeted Ther."},{"key":"10.1016\/j.celrep.2026.117330_bib60","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1016\/j.molcel.2015.10.033","article-title":"NSD3-Short Is an Adaptor Protein that Couples BRD4 to the CHD8 Chromatin Remodeler","volume":"60","author":"Shen","year":"2015","journal-title":"Mol. Cell"},{"key":"10.1016\/j.celrep.2026.117330_bib61","article-title":"The OncoPPi network of cancer-focused protein-protein interactions to inform biological insights and therapeutic strategies","volume":"8","author":"Li","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2026.117330_bib62","doi-asserted-by":"crossref","first-page":"2673","DOI":"10.1016\/j.molcel.2025.06.004","article-title":"Isoform-specific function of NSD3 in DNA replication stress confers resistance to PARP inhibitors in prostate cancer","volume":"85","author":"Zhu","year":"2025","journal-title":"Mol. Cell"},{"key":"10.1016\/j.celrep.2026.117330_bib63","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2022-006020","article-title":"YY1 complex in M2 macrophage promotes prostate cancer progression by upregulating IL-6","volume":"11","author":"Chen","year":"2023","journal-title":"J. Immunother. Cancer"},{"key":"10.1016\/j.celrep.2026.117330_bib64","doi-asserted-by":"crossref","first-page":"6261","DOI":"10.1038\/s41467-025-61560-0","article-title":"YY1 enhances HIF-1\u03b1 stability in tumor-associated macrophages to suppress anti-tumor immunity of prostate cancer in mice","volume":"16","author":"Li","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2026.117330_bib65","doi-asserted-by":"crossref","DOI":"10.1172\/JCI183544","article-title":"5-HT orchestrates histone serotonylation and citrullination to drive neutrophil extracellular traps and liver metastasis","volume":"135","author":"Liu","year":"2025","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.celrep.2026.117330_bib66","doi-asserted-by":"crossref","DOI":"10.1172\/JCI191687","article-title":"Serotonin sets up neutrophil extracellular traps to promote neuroendocrine prostate cancer metastasis in the liver","volume":"135","author":"Tang","year":"2025","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.celrep.2026.117330_bib67","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1038\/s41586-025-09492-z","article-title":"Neuronal activity-dependent mechanisms of small cell lung cancer pathogenesis","volume":"646","author":"Savchuk","year":"2025","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2026.117330_bib68","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1007\/s00232-005-0777-0","article-title":"N-methyl-D-aspartate receptor in human prostate cancer","volume":"205","author":"Abdul","year":"2005","journal-title":"J. Membr. Biol."},{"key":"10.1016\/j.celrep.2026.117330_bib69","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1177\/0960327117747025","article-title":"Memantine induces apoptosis and inhibits cell cycle progression in LNCaP prostate cancer cells","volume":"37","author":"Albayrak","year":"2018","journal-title":"Hum. Exp. Toxicol."},{"key":"10.1016\/j.celrep.2026.117330_bib70","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1016\/j.ccell.2018.02.011","article-title":"GKAP Acts as a Genetic Modulator of NMDAR Signaling to Govern Invasive Tumor Growth","volume":"33","author":"Li","year":"2018","journal-title":"Cancer Cell"},{"key":"10.1016\/j.celrep.2026.117330_bib71","first-page":"31","article-title":"NMDA receptors are expressed by small-cell lung cancer and are potential targets for effective treatment","volume":"2","author":"North","year":"2010","journal-title":"Clin. Pharmacol."},{"key":"10.1016\/j.celrep.2026.117330_bib72","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1007\/s10549-009-0556-1","article-title":"Breast cancer expresses functional NMDA receptors","volume":"122","author":"North","year":"2010","journal-title":"Breast Cancer Res. Treat."},{"key":"10.1016\/j.celrep.2026.117330_bib73","doi-asserted-by":"crossref","DOI":"10.1186\/s12964-018-0317-z","article-title":"Memantine potentiates cytarabine-induced cell death of acute leukemia correlating with inhibition of K(v)1.3 potassium channels, AKT and ERK1\/2 signaling","volume":"17","author":"Lowinus","year":"2019","journal-title":"Cell Commun. Signal."},{"key":"10.1016\/j.celrep.2026.117330_bib74","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.cell.2014.08.017","article-title":"Identification of multipotent luminal progenitor cells in human prostate organoid cultures","volume":"159","author":"Karthaus","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2026.117330_bib75","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1038\/nprot.2016.006","article-title":"Organoid culture systems for prostate epithelial and cancer tissue","volume":"11","author":"Drost","year":"2016","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.celrep.2026.117330_bib76","doi-asserted-by":"crossref","DOI":"10.1016\/j.canlet.2024.217214","article-title":"Inhibition of PRMT5 moderately suppresses prostate cancer growth in vivo but enhances its response to immunotherapy","volume":"602","author":"He","year":"2024","journal-title":"Cancer Lett."},{"key":"10.1016\/j.celrep.2026.117330_bib77","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1038\/s41586-018-0414-6","article-title":"RNA velocity of single cells","volume":"560","author":"La Manno","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2026.117330_bib78","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1038\/s41587-020-0591-3","article-title":"Generalizing RNA velocity to transient cell states through dynamical modeling","volume":"38","author":"Bergen","year":"2020","journal-title":"Nat. Biotechnol."}],"container-title":["Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124726004080?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124726004080?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T00:11:10Z","timestamp":1783123870000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211124726004080"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":78,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["S2211124726004080"],"URL":"https:\/\/doi.org\/10.1016\/j.celrep.2026.117330","relation":{},"ISSN":["2211-1247"],"issn-type":[{"value":"2211-1247","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"HOXD11-NMDAR signaling drives neuroendocrine prostate cancer and enables potential therapeutic intervention as a target of memantine","name":"articletitle","label":"Article Title"},{"value":"Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.celrep.2026.117330","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"117330"}}