{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T07:12:44Z","timestamp":1790838764825,"version":"4.1.0"},"reference-count":66,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T00:00:00Z","timestamp":1776384000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000245","name":"Michael Smith Health Research BC","doi-asserted-by":"publisher","award":["RT-2022-2726"],"award-info":[{"award-number":["RT-2022-2726"]}],"id":[{"id":"10.13039\/501100000245","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["FDN-159908"],"award-info":[{"award-number":["FDN-159908"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Reports"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.celrep.2026.117362","type":"journal-article","created":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T13:06:54Z","timestamp":1779368814000},"page":"117362","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Cachexia-induced alterations of miR-27a-3p drive cell-type specific effects in FAPs and tumor cells that coincide with muscle wasting"],"prefix":"10.1016","volume":"45","author":[{"given":"Ashok","family":"Narasimhan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun Wai","family":"Cheung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nasim","family":"Kajabadi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin Wei","family":"Tung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chihkai","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0368-2620","authenticated-orcid":false,"given":"Fabio M.V.","family":"Rossi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.celrep.2026.117362_bib1","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/S1470-2045(10)70218-7","article-title":"Definition and classification of cancer cachexia: an international con sensus","volume":"12","author":"Fearon","year":"2011","journal-title":"Lancet Oncol."},{"key":"10.1016\/j.celrep.2026.117362_bib2","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1200\/JCO.2014.56.1894","article-title":"Diagnostic criteria for the classification of cancer-associated weight loss","volume":"33","author":"Martin","year":"2015","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.celrep.2026.117362_bib3","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1097\/MPA.0000000000000898","article-title":"Predictors of Pancreatic Cancer-Associated Weight Loss and Nutritional Interventions","volume":"46","author":"Nemer","year":"2017","journal-title":"Pancreas"},{"key":"10.1016\/j.celrep.2026.117362_bib4","doi-asserted-by":"crossref","first-page":"17","DOI":"10.21037\/jgo.2017.11.10","article-title":"Cachexia, and not obesity, prior to pancreatic cancer diagnosis worsens survival and is negated by chemotherapy","volume":"9","author":"Hendifar","year":"2018","journal-title":"J. Gastrointest. Oncol."},{"key":"10.1016\/j.celrep.2026.117362_bib5","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20190450","article-title":"Tumor-derived IL-6 and trans-signaling among tumor, fat, and muscle me diate pancreatic cancer cachexia","volume":"218","author":"Rupert","year":"2021","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.celrep.2026.117362_bib6","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aay9592","article-title":"Perturbed BMP signaling and denervation promote muscle wasting in cancer cachexia","volume":"13","author":"Sartori","year":"2021","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.celrep.2026.117362_bib7","doi-asserted-by":"crossref","DOI":"10.1038\/nrdp.2017.105","article-title":"Cancer-associated cachexia","volume":"4","author":"Baracos","year":"2018","journal-title":"Nat. Rev. Dis. Primers"},{"key":"10.1016\/j.celrep.2026.117362_bib8","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1038\/s41536-022-00204-z","article-title":"The jam session between muscle stem cells and the extracellular matrix in the tissue microenvironment","volume":"7","author":"Loreti","year":"2022","journal-title":"npj Regen. Med."},{"key":"10.1016\/j.celrep.2026.117362_bib9","doi-asserted-by":"crossref","first-page":"6374","DOI":"10.1038\/s41467-020-20063-w","article-title":"Single-nucleus RNA-seq identifies transcriptional heterogeneity in multinucleated skeletal myofibers","volume":"11","author":"Petrany","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2026.117362_bib10","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1038\/ncb2015","article-title":"Muscle injury activates resident fibro\/adipogenic progenitors that facilitate myogenesis","volume":"12","author":"Joe","year":"2010","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.celrep.2026.117362_bib11","doi-asserted-by":"crossref","first-page":"2029","DOI":"10.1016\/j.celrep.2019.04.074","article-title":"Mesenchymal Stromal Cells Are Required for Regeneration and Homeostatic Maintenance of Skeletal Muscle","volume":"27","author":"Wosczyna","year":"2019","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2026.117362_bib12","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1038\/nm.3869","article-title":"Nilotinib reduces muscle fibrosis in chronic muscle injury by promoting TNF-mediated apoptosis of fibro\/adipogenic progenitors","volume":"21","author":"Lemos","year":"2015","journal-title":"Nat. Med."},{"key":"10.1016\/j.celrep.2026.117362_bib13","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1038\/ncb2014","article-title":"Mesenchymal progenitors distinct from satellite cells contribute to ectopic fat cell formation in skeletal muscle","volume":"12","author":"Uezumi","year":"2010","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.celrep.2026.117362_bib14","doi-asserted-by":"crossref","first-page":"2430","DOI":"10.1038\/s41467-019-10438-z","article-title":"Fibroadipogenic progenitors are responsible for muscle loss in limb girdle muscular dystrophy 2B","volume":"10","author":"Hogarth","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2026.117362_bib15","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0196235","article-title":"Sarcopenia and myosteatosis are accompanied by distinct biological profiles in patients with pancreatic and periampullary adenocarcinomas","volume":"13","author":"Stretch","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.celrep.2026.117362_bib16","doi-asserted-by":"crossref","first-page":"pky043","DOI":"10.1093\/jncics\/pky043","article-title":"Skeletal Muscle Fibrosis in Pancreatic Cancer Patients with Respect to Survival","volume":"2","author":"Judge","year":"2018","journal-title":"JNCI Cancer Spectr."},{"key":"10.1016\/j.celrep.2026.117362_bib17","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1002\/jcsm.12575","article-title":"Prognostic impact of myosteatosis in patients with colorectal cancer: a systematic review and meta-analysis","volume":"11","author":"Lee","year":"2020","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"10.1016\/j.celrep.2026.117362_bib18","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1002\/jcsm.12307","article-title":"Three cachexia phenotypes and the impact of fat-only loss on survival in FOLFIRINOX therapy for pancreatic cancer","volume":"9","author":"Kays","year":"2018","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"10.1016\/j.celrep.2026.117362_bib19","article-title":"Pathophysiological remodeling of the skeletal muscle microenvironment in patients with lung cancer","author":"Battey","year":"2025","journal-title":"bioRxiv"},{"key":"10.1016\/j.celrep.2026.117362_bib20","doi-asserted-by":"crossref","first-page":"C1283","DOI":"10.1152\/ajpcell.00448.2025","article-title":"Pro-Fibrotic Immune Cells and Fibro-Adipogenic Progenitors Contribute to Skeletal Muscle Extracellular Matrix Remodeling and Fibrosis in Cancer Cachexia","volume":"329","author":"Cardaci","year":"2025","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.celrep.2026.117362_bib21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ydbio.2015.12.013","article-title":"Muscle-specific microRNAs in skeletal muscle development","volume":"410","author":"Horak","year":"2016","journal-title":"Dev. Biol."},{"key":"10.1016\/j.celrep.2026.117362_bib22","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1016\/j.stem.2021.04.008","article-title":"Targeting microRNA-mediated gene repression limits adipogenic conversi on of skeletal muscle mesenchymal stromal cells","volume":"28","author":"Wosczyna","year":"2021","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.celrep.2026.117362_bib23","doi-asserted-by":"crossref","first-page":"415","DOI":"10.3390\/ijms26010415","article-title":"Dual Roles of miR-10a-5p and miR-10b-5p as Tumor Suppressors and Oncogenes in Diverse Cancers","volume":"26","author":"Singh","year":"2025","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.celrep.2026.117362_bib24","doi-asserted-by":"crossref","first-page":"4821","DOI":"10.1172\/JCI68523","article-title":"NF-\u03baB\u2013mediated Pax7 dysregulation in the muscle microenvironment promotes cancer cachexia","volume":"123","author":"He","year":"2013","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.celrep.2026.117362_bib25","article-title":"A molecular pathway for cancer cachexia-induced muscle atrophy revealed at single-nucleus resolution","volume":"43","author":"Zhang","year":"2024","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2026.117362_bib26","doi-asserted-by":"crossref","first-page":"1898","DOI":"10.1002\/jcsm.13540","article-title":"Tumour-induced alterations in single-nucleus transcriptome of atrophying muscles indicate enhanced protein degradation and reduced oxidative metabolism","volume":"15","author":"Agca","year":"2024","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"10.1016\/j.celrep.2026.117362_bib27","article-title":"Pancreatic Cancer Induces Population-Specific Switching of Myosin Isoforms and Discrete Activation of Cachexia Genes in","author":"Counts","year":"2025","journal-title":"bioRxiv"},{"key":"10.1016\/j.celrep.2026.117362_bib28","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1038\/s41597-024-03399-6","article-title":"Direct comparison of mass cytometry and single-cell RNA sequencing of human peripheral blood mononuclear cells","volume":"11","author":"Su","year":"2024","journal-title":"Sci. Data"},{"key":"10.1016\/j.celrep.2026.117362_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.cyto.2022.155972","article-title":"Exogenous Oncostatin M induces Cardiac Dysfunction, Musculoskeletal Atrophy, and Fibrosis","volume":"159","author":"Jengelley","year":"2022","journal-title":"Cytokine"},{"key":"10.1016\/j.celrep.2026.117362_bib30","article-title":"Oncostatin M signaling drives cancer-associated skeletal muscle wasting","volume":"5","author":"Domaniku-Waraich","year":"2024","journal-title":"Cell Rep. Med."},{"key":"10.1016\/j.celrep.2026.117362_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2024.114925","article-title":"Muscle inflammation is regulated by NF-\u03baB from multiple cells to control distinct states of wasting in cancer cachexia","volume":"43","author":"Pryce","year":"2024","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2026.117362_bib32","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/j.devcel.2023.02.009","article-title":"Activation of \u03b2-catenin in mesenchymal progenitors leads to muscle mas s loss","volume":"58","author":"Kajabadi","year":"2023","journal-title":"Dev. Cell"},{"key":"10.1016\/j.celrep.2026.117362_bib33","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0167825","article-title":"Transcriptome and Metabolome Analyses in Exogenous FABP4- and FABP5-Treated Adipose-Derived Stem Cells","volume":"11","author":"Yamamoto","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.celrep.2026.117362_bib34","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1016\/j.bbagen.2012.04.001","article-title":"CD36 promotes adipocyte differentiation and adipogenesis","volume":"1820","author":"Christiaens","year":"2012","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.celrep.2026.117362_bib35","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1038\/s41597-024-03114-5","article-title":"Integrative cross-species analysis reveals conserved and unique signatures in fatty skeletal muscles","volume":"11","author":"Wang","year":"2024","journal-title":"Sci. Data"},{"key":"10.1016\/j.celrep.2026.117362_bib36","doi-asserted-by":"crossref","first-page":"2053","DOI":"10.1038\/s41590-023-01669-w","article-title":"A discrete \u2018early-responder\u2019 stromal-cell subtype orchestrates immunocyte recruitment to injured tissue","volume":"24","author":"Yaghi","year":"2023","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.celrep.2026.117362_bib37","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1186\/1471-2407-14-997","article-title":"Genome-wide identification of FoxO-dependent gene networks in skeletal muscle during C26 cancer cachexia","volume":"14","author":"Judge","year":"2014","journal-title":"BMC Cancer"},{"key":"10.1016\/j.celrep.2026.117362_bib38","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1016\/j.stem.2019.11.004","article-title":"Hic1 Defines Quiescent Mesenchymal Progenitor Subpopulations with Dist inct Functions and Fates in Skeletal Muscle Regeneration","volume":"25","author":"Scott","year":"2019","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.celrep.2026.117362_bib39","doi-asserted-by":"crossref","first-page":"3205","DOI":"10.3390\/cells10113205","article-title":"microRNA-27a-3p but Not -5p Is a Crucial Mediator of Human Adipogenesis","volume":"10","author":"Wu","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.celrep.2026.117362_bib40","article-title":"MicroRNA-27a regulates hepatic lipid metabolism and alleviates NAFLD via repressing FAS and SCD1","volume":"7","author":"Zhang","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.celrep.2026.117362_bib41","doi-asserted-by":"crossref","DOI":"10.1126\/science.aav1741","article-title":"The biochemical basis of microRNA targeting efficacy","volume":"366","author":"McGeary","year":"2019","journal-title":"Science"},{"key":"10.1016\/j.celrep.2026.117362_bib42","doi-asserted-by":"crossref","first-page":"D147","DOI":"10.1093\/nar\/gkae1072","article-title":"miRTarBase 2025: updates to the collection of experimentally validated microRNA\u2013target interactions","volume":"53","author":"Cui","year":"2024","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.celrep.2026.117362_bib43","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1002\/cbf.3736","article-title":"MiR-27a downregulates 14-3-3\u03b8, RUNX1, AF4, and MLL-AF4, crucial drivers of blast transformation in t(4;11) leukemia cells","volume":"40","author":"Fioretti","year":"2022","journal-title":"Cell Biochem. Funct."},{"key":"10.1016\/j.celrep.2026.117362_bib44","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1093\/nar\/gkt848","article-title":"A regulatory circuit comprising GATA1\/2 switch and microRNA-27a\/24 promotes erythropoiesis","volume":"42","author":"Wang","year":"2014","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.celrep.2026.117362_bib45","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.ccr.2009.07.016","article-title":"FKBP51 affects cancer cell response to chemotherapy by negatively regulating Akt","volume":"16","author":"Pei","year":"2009","journal-title":"Cancer Cell"},{"key":"10.1016\/j.celrep.2026.117362_bib46","article-title":"Cholesterol metabolism in pancreatic cancer and associated therapeutic strategies","volume":"1870","author":"Daya","year":"2025","journal-title":"Biochim. Biophys. Acta. Mol. Cell Biol. Lipids"},{"key":"10.1016\/j.celrep.2026.117362_bib47","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1158\/1535-7163.MCT-10-0802","article-title":"Lipoprotein lipase links dietary fat to solid tumor cell proliferation","volume":"10","author":"Kuemmerle","year":"2011","journal-title":"Mol. Cancer Ther."},{"key":"10.1016\/j.celrep.2026.117362_bib48","doi-asserted-by":"crossref","first-page":"2057","DOI":"10.1038\/s41467-021-22361-3","article-title":"Lipocalin 2 mediates appetite suppression during pancreatic cancer cachexia","volume":"12","author":"Olson","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2026.117362_bib49","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1002\/jcsm.12377","article-title":"MyD88 signalling is critical in the development of pancreatic cancer cachexia","volume":"10","author":"Zhu","year":"2019","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"10.1016\/j.celrep.2026.117362_bib50","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1007\/s10753-021-01429-8","article-title":"The Emerging Role of Interleukin 1\u03b2 (IL-1\u03b2) in Cancer Cachexia","volume":"44","author":"Laird","year":"2021","journal-title":"Inflammation"},{"key":"10.1016\/j.celrep.2026.117362_bib51","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1002\/jcsm.12461","article-title":"The systemic activin response to pancreatic cancer: implications for effective cancer cachexia therapy","volume":"10","author":"Zhong","year":"2019","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"10.1016\/j.celrep.2026.117362_bib52","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1152\/physiolgenomics.00061.2018","article-title":"Transcriptomic analysis of the development of skeletal muscle atrophy in cancer-cachexia in tumor-bearing mice","volume":"50","author":"Blackwell","year":"2018","journal-title":"Physiol. Genomics"},{"key":"10.1016\/j.celrep.2026.117362_bib53","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.3389\/fphys.2019.01074","article-title":"Fibro-Adipogenic Progenitors Cross-Talk in Skeletal Muscle: The Social Network","volume":"10","author":"Biferali","year":"2019","journal-title":"Front. Physiol."},{"key":"10.1016\/j.celrep.2026.117362_bib54","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2316544121","article-title":"Reciprocal communication between FAPs and muscle cells via distinct extracellular vesicle miRNAs in muscle regeneration","volume":"121","author":"Yu","year":"2024","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2026.117362_bib55","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1016\/j.celrep.2018.09.086","article-title":"Sox9-Meis1 Inactivation Is Required for Adipogenesis, Advancing Pref-1+ to PDGFR\u03b1+ Cells","volume":"25","author":"Gulyaeva","year":"2018","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2026.117362_bib56","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.ccr.2006.01.025","article-title":"Unique microRNA molecular profiles in lung cancer diagnosis and prognosis","volume":"9","author":"Yanaihara","year":"2006","journal-title":"Cancer Cell"},{"key":"10.1016\/j.celrep.2026.117362_bib57","article-title":"miR-29b contributes to multiple types of muscle atrophy","volume":"8","author":"Li","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2026.117362_bib58","doi-asserted-by":"crossref","DOI":"10.1172\/JCI139617","article-title":"Mesenchymal Bmp3b expression maintains skeletal muscle integrity and decreases in age-related sarcopenia","volume":"131","author":"Uezumi","year":"2021","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.celrep.2026.117362_bib59","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.neo.2022.01.001","article-title":"UALCAN: An update to the integrated cancer data analysis platform","volume":"25","author":"Chandrashekar","year":"2022","journal-title":"Neoplasia"},{"key":"10.1016\/j.celrep.2026.117362_bib60","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1038\/nbt.4096","article-title":"Integrating single-cell transcriptomic data across different conditions, technologies, and species","volume":"36","author":"Butler","year":"2018","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.celrep.2026.117362_bib61","first-page":"329","article-title":"DoubletFinder: Doublet Detection in Single-Cell RNA Sequencing Data Using Artificial Nearest Neighbors","volume":"8","author":"McGinnis","year":"2019","journal-title":"cels"},{"key":"10.1016\/j.celrep.2026.117362_bib62","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol."},{"key":"10.1016\/j.celrep.2026.117362_bib63","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/nmeth.2019","article-title":"Fiji: an open-source platform for biological-image analysis","volume":"9","author":"Schindelin","year":"2012","journal-title":"Nat. Methods"},{"key":"10.1016\/j.celrep.2026.117362_bib64","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.immuni.2018.06.006","article-title":"Tumor Cell-Intrinsic Factors Underlie Heterogeneity of Immune Cell Infiltration and Response to Immunotherapy","volume":"49","author":"Li","year":"2018","journal-title":"Immunity"},{"key":"10.1016\/j.celrep.2026.117362_bib65","article-title":"The ARRIVE guidelines 2.0: Updated guidelines for reporting animal research","volume":"18","author":"Percie du Sert","year":"2020","journal-title":"PLoS Biol."},{"key":"10.1016\/j.celrep.2026.117362_bib66","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1038\/nprot.2013.055","article-title":"Imaging of neutral lipids by oil red O for analyzing the metabolic status in health and disease","volume":"8","author":"Mehlem","year":"2013","journal-title":"Nat. Protoc."}],"container-title":["Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124726004407?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124726004407?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T04:35:50Z","timestamp":1790310950000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211124726004407"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":66,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["S2211124726004407"],"URL":"https:\/\/doi.org\/10.1016\/j.celrep.2026.117362","relation":{},"ISSN":["2211-1247"],"issn-type":[{"value":"2211-1247","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cachexia-induced alterations of miR-27a-3p drive cell-type specific effects in FAPs and tumor cells that coincide with muscle wasting","name":"articletitle","label":"Article Title"},{"value":"Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.celrep.2026.117362","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"117362"}}