{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T19:00:46Z","timestamp":1791658846972,"version":"4.3.4"},"reference-count":60,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T00:00:00Z","timestamp":1776643200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100012545","name":"The Foundation for Research in Science and the Humanities at the University of Zurich","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012545","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006447","name":"Universit\u00e4t Z\u00fcrich","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006447","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008481","name":"Kurt und Senta Herrmann Stiftung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008481","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008273","name":"Novartis International AG","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008273","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100024370","name":"Ministero dell'Istruzione dell'Universit\u00e0 e della Ricerca","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100024370","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008464","name":"Emdo Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008464","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Swiss National Science Foundation","doi-asserted-by":"publisher","award":["310030_197557"],"award-info":[{"award-number":["310030_197557"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Swiss National Science Foundation","doi-asserted-by":"publisher","award":["320030-236150"],"award-info":[{"award-number":["320030-236150"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008578","name":"Anniversary Foundation of the Swiss Life and Pension Institute for Public Health and Medical Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008578","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013161","name":"Swiss Life Stiftung f\u00fcr Chancenreichtum und Zukunft","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013161","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004362","name":"Schweizerische Herzstiftung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004362","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012654","name":"Olga Mayenfisch Stiftung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012654","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018872","name":"Italian Society of Arterial Hypertension","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100018872","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017295","name":"Holcim Stiftung zur Forderung der wissenschaftlichen Fortbildung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100017295","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Reports"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.celrep.2026.117365","type":"journal-article","created":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T19:18:40Z","timestamp":1780427920000},"page":"117365","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["BET-induced metabolic reprogramming fuels inflammation at the vascular-fat interface in mice and patients with cardiometabolic disease"],"prefix":"10.1016","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2834-9725","authenticated-orcid":false,"given":"Alessandro","family":"Mengozzi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Costantino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessia","family":"Mongelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emiliano","family":"Duranti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shafeeq A.","family":"Mohammed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Era","family":"Gorica","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Cappelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marialucia","family":"Telesca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Armenia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thorsten","family":"Hornemann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Hulsmeier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina","family":"de Ciuceis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Agabiti-Rosei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Ippolito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosario","family":"Bellini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola Riccardo","family":"Pugliese","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian M.","family":"Matter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omer","family":"Dzemali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Masi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Taddei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Ruschitzka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agostino","family":"Virdis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Paneni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.celrep.2026.117365_bib2","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.1097\/HJH.0000000000003503","article-title":"The importance of microvascular inflammation in ageing and age-related diseases: a position paper from the ESH working group on small arteries, section of microvascular inflammation","volume":"41","author":"Mengozzi","year":"2023","journal-title":"J. Hypertens."},{"key":"10.1016\/j.celrep.2026.117365_bib30","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1016\/S0140-6736(25)00355-1","article-title":"Global, regional, and national prevalence of adult overweight and obesity, 1990-2021, with forecasts to 2050: a forecasting study for the Global Burden of Disease Study 2021","volume":"405","author":"Ng","year":"2025","journal-title":"The Lancet"},{"key":"10.1016\/j.celrep.2026.117365_bib3","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1161\/CIRCRESAHA.122.320888","article-title":"Targeting SIRT1 Rescues Age- and Obesity-Induced Microvascular Dysfunction in Ex Vivo Human Vessels","volume":"131","author":"Mengozzi","year":"2022","journal-title":"Circ. Res."},{"key":"10.1016\/j.celrep.2026.117365_bib4","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.1038\/s41591-022-01890-4","article-title":"Modeling global 80-80-80 blood pressure targets and cardiovascular outcomes","volume":"28","author":"Pickersgill","year":"2022","journal-title":"Nat. Med."},{"key":"10.1016\/j.celrep.2026.117365_bib5","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1161\/HYPERTENSIONAHA.123.22483","article-title":"Mechanisms of Vascular Inflammation and Potential Therapeutic Targets: A Position Paper From the ESH Working Group on Small Arteries","volume":"81","author":"Rios","year":"2024","journal-title":"Hypertension"},{"key":"10.1016\/j.celrep.2026.117365_bib6","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1161\/HYPERTENSIONAHA.123.19437","article-title":"Influence of Perivascular Adipose Tissue on Microcirculation: A Link Between Hypertension and Obesity","volume":"81","author":"Agabiti-Rosei","year":"2024","journal-title":"Hypertension"},{"key":"10.1016\/j.celrep.2026.117365_bib7","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1210\/endrev\/bnaa025","article-title":"Microvascular Dysfunction in Diabetes Mellitus and Cardiometabolic Disease","volume":"42","author":"Horton","year":"2021","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.celrep.2026.117365_bib8","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1093\/eurheartj\/ehu072","article-title":"Tumour necrosis factor-alpha participates on the endothelin-1\/nitric oxide imbalance in small arteries from obese patients: role of perivascular adipose tissue","volume":"36","author":"Virdis","year":"2015","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.celrep.2026.117365_bib9","doi-asserted-by":"crossref","first-page":"3827","DOI":"10.1093\/eurheartj\/ehad484","article-title":"Perivascular adipose tissue as a source of therapeutic targets and clinical biomarkers: A clinical consensus statement from the European Society of Cardiology Working Group on Coronary Pathophysiology and Micro-circulation","volume":"44","author":"Antoniades","year":"2023","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.celrep.2026.117365_bib10","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1093\/eurheartj\/ehad486","article-title":"Inflammation in acute myocardial infarction: the good, the bad and the ugly","volume":"45","author":"Matter","year":"2024","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.celrep.2026.117365_bib11","doi-asserted-by":"crossref","first-page":"2698","DOI":"10.1093\/eurheartj\/ehad361","article-title":"Subclinical atherosclerosis and accelerated epigenetic age mediated by inflammation: a multi-omics study","volume":"44","author":"S\u00e1nchez-Cabo","year":"2023","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.celrep.2026.117365_bib12","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1016\/j.molcel.2014.05.016","article-title":"The Mechanisms behind the Therapeutic Activity of BET Bromodomain Inhibition","volume":"54","author":"Shi","year":"2014","journal-title":"Mol. Cell"},{"key":"10.1016\/j.celrep.2026.117365_bib13","doi-asserted-by":"crossref","first-page":"2167","DOI":"10.1016\/j.cell.2021.03.026","article-title":"BET inhibition blocks inflammation-induced cardiac dysfunction and SARS-CoV-2 infection","volume":"184","author":"Mills","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2026.117365_bib14","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1186\/s13148-019-0696-z","article-title":"Apabetalone (RVX-208) reduces vascular inflammation in vitro and in CVD patients by a BET-dependent epigenetic mechanism","volume":"11","author":"Tsujikawa","year":"2019","journal-title":"Clin. Epigenetics"},{"key":"10.1016\/j.celrep.2026.117365_bib15","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/s12933-020-01199-x","article-title":"Apabetalone and hospitalization for heart failure in patients following an acute coronary syndrome: a prespecified analysis of the BETonMACE study","volume":"20","author":"Nicholls","year":"2021","journal-title":"Cardiovasc. Diabetol."},{"key":"10.1016\/j.celrep.2026.117365_bib16","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1001\/jama.2020.3308","article-title":"Effect of Apabetalone Added to Standard Therapy on Major Adverse Cardiovascular Events in Patients With Recent Acute Coronary Syndrome and Type 2 Diabetes: A Randomized Clinical Trial","volume":"323","author":"Ray","year":"2020","journal-title":"JAMA"},{"key":"10.1016\/j.celrep.2026.117365_bib17","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1161\/01.HYP.0000034738.79310.06","article-title":"Spironolactone improves angiotensin-induced vascular changes and oxidative stress","volume":"40","author":"Virdis","year":"2002","journal-title":"Hypertension"},{"key":"10.1016\/j.celrep.2026.117365_bib18","doi-asserted-by":"crossref","first-page":"3827","DOI":"10.1093\/eurheartj\/ehad484","article-title":"Perivascular adipose tissue as a source of therapeutic targets and clinical biomarkers","volume":"44","author":"Antoniades","year":"2023","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.celrep.2026.117365_bib19","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1038\/s41586-019-1100-z","article-title":"Nitrosative stress drives heart failure with preserved ejection fraction","volume":"568","author":"Schiattarella","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2026.117365_bib20","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1016\/j.ekir.2024.11.022","article-title":"The Bromodomain and Extraterminal Protein Inhibitor Apabetalone Ameliorates Kidney Injury in Diabetes by Regulating Cholesterol Accumulation and Modulating the Gut Microbiota","volume":"10","author":"Wang","year":"2025","journal-title":"Kidney Int. Rep."},{"key":"10.1016\/j.celrep.2026.117365_bib21","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/s40256-015-0146-z","article-title":"Effect of the BET Protein Inhibitor, RVX-208, on Progression of Coronary Atherosclerosis: Results of the Phase 2b, Randomized, Double-Blind, Multicenter, ASSURE Trial","volume":"16","author":"Nicholls","year":"2016","journal-title":"Am. J. Cardiovasc. Drugs"},{"key":"10.1016\/j.celrep.2026.117365_bib22","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1007\/s40256-017-0250-3","article-title":"Selective BET Protein Inhibition with Apabetalone and Cardiovascular Events: A Pooled Analysis of Trials in Patients with Coronary Artery Disease","volume":"18","author":"Nicholls","year":"2018","journal-title":"Am. J. Cardiovasc. Drugs"},{"key":"10.1016\/j.celrep.2026.117365_bib23","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1007\/s40292-025-00739-4","article-title":"Targeting the Epigenetic Remodeler GCN5 Prevents Vascular Oxidative Stress and Endothelial Dysfunction in Obesity: Insights in Patients with Cardiometabolic Disease","volume":"32","author":"Costantino","year":"2025","journal-title":"High Blood Press. Cardiovasc. Prev."},{"key":"10.1016\/j.celrep.2026.117365_bib24","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/j.cmet.2017.08.006","article-title":"Global Analysis of Plasma Lipids Identifies Liver-Derived Acylcarnitines as a Fuel Source for Brown Fat Thermogenesis","volume":"26","author":"Simcox","year":"2017","journal-title":"Cell Metab."},{"key":"10.1016\/j.celrep.2026.117365_bib25","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1016\/j.cmet.2018.11.017","article-title":"Inhibition of Mevalonate Pathway Prevents Adipocyte Browning in Mice and Men by Affecting Protein Prenylation","volume":"29","author":"Balaz","year":"2019","journal-title":"Cell Metab."},{"key":"10.1016\/j.celrep.2026.117365_bib26","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.1161\/HYPERTENSIONAHA.123.22649","article-title":"Interplay Between Plasma Glycine and Branched-Chain Amino Acids Contributes to the Development of Hypertension and Coronary Heart Disease","volume":"81","author":"Dziedzic","year":"2024","journal-title":"Hypertension"},{"key":"10.1016\/j.celrep.2026.117365_bib27","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1016\/j.molmet.2016.04.006","article-title":"Branched-chain amino acid restriction in Zucker-fatty rats improves muscle insulin sensitivity by enhancing efficiency of fatty acid oxidation and acyl-glycine export","volume":"5","author":"White","year":"2016","journal-title":"Mol. Metab."},{"key":"10.1016\/j.celrep.2026.117365_bib28","doi-asserted-by":"crossref","first-page":"H1252","DOI":"10.1152\/ajpheart.00040.2024","article-title":"A cell atlas of thoracic aortic perivascular adipose tissue: a focus on mechanotransducers","volume":"326","author":"Thompson","year":"2024","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.celrep.2026.117365_bib29","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1038\/s41586-022-04518-2","article-title":"A single-cell atlas of human and mouse white adipose tissue","volume":"603","author":"Emont","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2026.117365_bib31","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1161\/CIRCRESAHA.121.318093","article-title":"Obesity, Adipose Tissue and Vascular Dysfunction","volume":"128","author":"Koenen","year":"2021","journal-title":"Circ. Res."},{"key":"10.1016\/j.celrep.2026.117365_bib32","doi-asserted-by":"crossref","first-page":"3434","DOI":"10.1093\/cvr\/cvac120","article-title":"Obesity and heart failure with preserved ejection fraction: new insights and pathophysiological targets","volume":"118","author":"Borlaug","year":"2023","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.celrep.2026.117365_bib33","doi-asserted-by":"crossref","first-page":"1940","DOI":"10.1093\/eurheartj\/ehab197","article-title":"Leveraging clinical epigenetics in heart failure with preserved ejection fraction: a call for individualized therapies","volume":"42","author":"Hamdani","year":"2021","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.celrep.2026.117365_bib34","doi-asserted-by":"crossref","first-page":"705","DOI":"10.2215\/CJN.16751020","article-title":"Effect of Apabetalone on Cardiovascular Events in Diabetes, CKD, and Recent Acute Coronary Syndrome: Results from the BETonMACE Randomized Controlled Trial","volume":"16","author":"Kalantar-Zadeh","year":"2021","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"10.1016\/j.celrep.2026.117365_bib35","doi-asserted-by":"crossref","first-page":"4359","DOI":"10.1093\/eurheartj\/ehaf190","article-title":"Focused Update of the 2019 ESC\/EAS Guidelines for the management of dyslipidaemias: Developed by the task force for the management of dyslipidaemias of the European Society of Cardiology (ESC) and the European Atherosclerosis Society (EAS)","volume":"46","author":"Mach","year":"2025","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.celrep.2026.117365_bib36","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.ccr.2013.06.014","article-title":"Hexokinase 2 is required for tumor initiation and maintenance and its systemic deletion is therapeutic in mouse models of cancer","volume":"24","author":"Patra","year":"2013","journal-title":"Cancer Cell"},{"key":"10.1016\/j.celrep.2026.117365_bib37","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/s40170-018-0184-5","article-title":"Hexokinase 2 is dispensable for T cell-dependent immunity","volume":"6","author":"Mehta","year":"2018","journal-title":"Cancer Metab."},{"key":"10.1016\/j.celrep.2026.117365_bib38","doi-asserted-by":"crossref","DOI":"10.15252\/embr.201949117","article-title":"Hexokinase 2 displacement from mitochondria-associated membranes prompts Ca 2+ -dependent death of cancer cells","volume":"21","author":"Ciscato","year":"2020","journal-title":"EMBO Rep."},{"key":"10.1016\/j.celrep.2026.117365_bib39","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.85103","article-title":"Diet-induced loss of adipose hexokinase 2 correlates with hyperglycemia","volume":"12","author":"Shimobayashi","year":"2023","journal-title":"Elife"},{"key":"10.1016\/j.celrep.2026.117365_bib40","doi-asserted-by":"crossref","first-page":"2453","DOI":"10.3390\/ijms23052453","article-title":"Emerging Glycation-Based Therapeutics\u2014Glyoxalase 1 Inducers and Glyoxalase 1 Inhibitors","volume":"23","author":"Rabbani","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.celrep.2026.117365_bib41","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.tem.2019.04.011","article-title":"Hexokinase-2 Glycolytic Overload in Diabetes and Ischemia\u2013Reperfusion Injury","volume":"30","author":"Rabbani","year":"2019","journal-title":"Trends Endocrinol. Metab."},{"key":"10.1016\/j.celrep.2026.117365_bib42","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2022.113757","article-title":"SIRT1 regulated hexokinase-2 promoting glycolysis is involved in hydroquinone-enhanced malignant progression in human lymphoblastoid TK6 cells","volume":"241","author":"Chen","year":"2022","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.celrep.2026.117365_bib43","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/j.bcp.2018.02.001","article-title":"Leptin induces SIRT1 expression through activation of NF-E2-related factor 2: Implications for obesity-associated colon carcinogenesis","volume":"153","author":"Song","year":"2018","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.celrep.2026.117365_bib44","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1186\/s12974-021-02187-y","article-title":"Early glycolytic reprogramming controls microglial inflammatory activation","volume":"18","author":"Cheng","year":"2021","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.celrep.2026.117365_bib45","article-title":"Nuclear and chromatin rearrangement associate to epigenome and gene expression changes in a model of in vitro adipogenesis and hypertrophy","volume":"1868","author":"Baldini","year":"2023","journal-title":"Biochim. Biophys. Acta. Mol. Cell Biol. Lipids"},{"key":"10.1016\/j.celrep.2026.117365_bib46","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1161\/CIRCRESAHA.123.322676","article-title":"Cardiac Aging Is Promoted by Pseudohypoxia Increasing p300-Induced Glycolysis","volume":"133","author":"Serio","year":"2023","journal-title":"Circ. Res."},{"key":"10.1016\/j.celrep.2026.117365_bib47","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.atherosclerosis.2022.11.015","article-title":"Epigenetic BET reader inhibitor apabetalone (RVX-208) counters proinflammatory aortic gene expression in a diet induced obesity mouse model and in human endothelial cells","volume":"364","author":"Wasiak","year":"2023","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.celrep.2026.117365_bib48","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1016\/j.jacbts.2022.12.010","article-title":"Immunometabolism at the Heart of Cardiovascular Disease","volume":"8","author":"DeBerge","year":"2023","journal-title":"JACC. Basic Transl. Sci."},{"key":"10.1016\/j.celrep.2026.117365_bib49","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1016\/j.immuni.2023.01.011","article-title":"Oxidative phosphorylation selectively orchestrates tissue macrophage homeostasis","volume":"56","author":"Wculek","year":"2023","journal-title":"Immunity"},{"key":"10.1016\/j.celrep.2026.117365_bib50","doi-asserted-by":"crossref","first-page":"1795","DOI":"10.1038\/s41591-018-0271-8","article-title":"The emerging link between cancer, metabolism, and circadian rhythms","volume":"24","author":"Masri","year":"2018","journal-title":"Nat. Med."},{"key":"10.1016\/j.celrep.2026.117365_bib51","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.metabol.2018.12.001","article-title":"Childhood obesity: increased risk for cardiometabolic disease and cancer in adulthood","volume":"92","author":"Weihrauch-Bl\u00fcher","year":"2019","journal-title":"Metabolism."},{"key":"10.1016\/j.celrep.2026.117365_bib52","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2020.105367","article-title":"Novel selective hexokinase 2 inhibitor Benitrobenrazide blocks cancer cells growth by targeting glycolysis","volume":"164","author":"Zheng","year":"2021","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.celrep.2026.117365_bib53","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.1038\/s41467-017-01645-7","article-title":"Epigenetic targeting of bromodomain protein BRD4 counteracts cancer cachexia and prolongs survival","volume":"8","author":"Segatto","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2026.117365_bib54","article-title":"Hexokinase 2-mediated metabolic stress and inflammation burden of liver macrophages via histone lactylation in MASLD","volume":"44","author":"Li","year":"2025","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2026.117365_bib55","doi-asserted-by":"crossref","first-page":"H77","DOI":"10.1152\/ajpheart.01021.2020","article-title":"Guidelines for the measurement of vascular function and structure in isolated arteries and veins","volume":"321","author":"Wenceslau","year":"2021","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.celrep.2026.117365_bib56","doi-asserted-by":"crossref","first-page":"2590","DOI":"10.1093\/eurheartj\/ehaa857","article-title":"Assessment and pathophysiology of microvascular disease: recent progress and clinical implications","volume":"42","author":"Masi","year":"2021","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.celrep.2026.117365_bib57","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1161\/HYPERTENSIONAHA.121.17954","article-title":"New Noninvasive Methods to Evaluate Microvascular Structure and Function","volume":"79","author":"Rizzoni","year":"2022","journal-title":"Hypertension"},{"key":"10.1016\/j.celrep.2026.117365_bib58","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1152\/japplphysiol.00595.2024","article-title":"Sexual dimorphism in animal models of heart failure with preserved ejection fraction","volume":"138","author":"Bauer","year":"2025","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.celrep.2026.117365_bib59","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1186\/s12933-023-02057-2","article-title":"Treatment with recombinant Sirt1 rewires the cardiac lipidome and rescues diabetes-related metabolic cardiomyopathy","volume":"22","author":"Costantino","year":"2023","journal-title":"Cardiovasc. Diabetol."},{"key":"10.1016\/j.celrep.2026.117365_bib60","doi-asserted-by":"crossref","first-page":"2144","DOI":"10.1073\/pnas.1711155115","article-title":"BET bromodomain proteins regulate enhancer function during adipogenesis","volume":"115","author":"Brown","year":"2018","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2026.117365_bib61","doi-asserted-by":"crossref","first-page":"1874","DOI":"10.1097\/HJH.0000000000003480","volume":"41","author":"Mancia","year":"2023","journal-title":"J Hypertens"}],"container-title":["Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124726004432?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124726004432?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T04:54:46Z","timestamp":1790312086000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211124726004432"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":60,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["S2211124726004432"],"URL":"https:\/\/doi.org\/10.1016\/j.celrep.2026.117365","relation":{},"ISSN":["2211-1247"],"issn-type":[{"value":"2211-1247","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"BET-induced metabolic reprogramming fuels inflammation at the vascular-fat interface in mice and patients with cardiometabolic disease","name":"articletitle","label":"Article Title"},{"value":"Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.celrep.2026.117365","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"117365"}}