{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T05:01:20Z","timestamp":1790312480542,"version":"4.1.0"},"reference-count":74,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T00:00:00Z","timestamp":1776816000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000016","name":"U.S. Department of Health and Human Services","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000016","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["NIA U54 AG079779"],"award-info":[{"award-number":["NIA U54 AG079779"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HF-GRO-23-1199068-44"],"award-info":[{"award-number":["HF-GRO-23-1199068-44"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Reports"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.celrep.2026.117389","type":"journal-article","created":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T14:47:52Z","timestamp":1781189272000},"page":"117389","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["Circulating cell type senescence signatures track distinct dimensions of health status and trajectories in human longitudinal cohorts"],"prefix":"10.1016","volume":"45","author":[{"given":"Bradley","family":"Olinger","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Anerillas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allison B.","family":"Herman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitrios","family":"Tsitsipatis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reema","family":"Banarjee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiko","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julian","family":"Candia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manolis","family":"Maragkakis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefania","family":"Bandinelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keenan A.","family":"Walker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleanor M.","family":"Simonsick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue A.","family":"Qi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"Ferrucci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myriam","family":"Gorospe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan","family":"Basisty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.celrep.2026.117389_bib1","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1038\/nrm2233","article-title":"Cellular senescence: when bad things happen to good cells","volume":"8","author":"Campisi","year":"2007","journal-title":"Nat Rev Mol Cell Bio"},{"key":"10.1016\/j.celrep.2026.117389_bib2","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1146\/annurev-pathol-121808-102144","article-title":"The senescence-associated secretory phenotype: the dark side of tumor suppression","volume":"5","author":"Copp\u00e9","year":"2010","journal-title":"Annu. Rev. Pathol."},{"key":"10.1016\/j.celrep.2026.117389_bib3","doi-asserted-by":"crossref","first-page":"2853","DOI":"10.1371\/journal.pbio.0060301","article-title":"Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor","volume":"6","author":"Copp\u00e9","year":"2008","journal-title":"PLoS Biol."},{"key":"10.1016\/j.celrep.2026.117389_bib4","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1080\/14789450.2020.1766976","article-title":"The power of proteomics to monitor senescence-associated secretory phenotypes and beyond: toward clinical applications","volume":"17","author":"Basisty","year":"2020","journal-title":"Expert Rev. Proteomics"},{"key":"10.1016\/j.celrep.2026.117389_bib5","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.3000599","article-title":"A proteomic atlas of senescence-associated secretomes for aging biomarker development","volume":"18","author":"Basisty","year":"2020","journal-title":"PLoS Biol."},{"key":"10.1016\/j.celrep.2026.117389_bib6","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.133668","article-title":"The senescence-associated secretome as an indicator of age and medical risk","volume":"5","author":"Schafer","year":"2020","journal-title":"JCI Insight"},{"key":"10.1016\/j.celrep.2026.117389_bib7","doi-asserted-by":"crossref","DOI":"10.3389\/fmed.2021.600626","article-title":"Transcriptional and Proteomic Characterization of Telomere-Induced Senescence in a Human Alveolar Epithelial Cell Line","volume":"8","author":"Sullivan","year":"2021","journal-title":"Front. Med."},{"key":"10.1016\/j.celrep.2026.117389_bib8","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2014.489","article-title":"Characterization of novel markers of senescence and their prognostic potential in cancer","volume":"5","author":"Althubiti","year":"2014","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.celrep.2026.117389_bib9","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.1038\/s43587-025-00877-3","article-title":"The secretome of senescent monocytes predicts age-related clinical outcomes in humans","volume":"5","author":"Olinger","year":"2025","journal-title":"Nat. Aging"},{"key":"10.1016\/j.celrep.2026.117389_bib10","doi-asserted-by":"crossref","DOI":"10.1111\/acel.12799","article-title":"Plasma proteomic signature of age in healthy humans","volume":"17","author":"Tanaka","year":"2018","journal-title":"Aging Cell"},{"key":"10.1016\/j.celrep.2026.117389_bib11","doi-asserted-by":"crossref","DOI":"10.1111\/acel.14006","article-title":"Biomarkers of cellular senescence and risk of death in humans","volume":"22","author":"St Sauver","year":"2023","journal-title":"Aging Cell"},{"key":"10.1016\/j.celrep.2026.117389_bib12","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.freeradbiomed.2020.01.007","article-title":"Older adults with frailty syndrome present an altered platelet function and an increased level of circulating oxidative stress and mitochondrial dysfunction biomarker GDF-15","volume":"149","author":"Arauna","year":"2020","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.celrep.2026.117389_bib13","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.61073","article-title":"Plasma proteomic biomarker signature of age predicts health and life span","volume":"9","author":"Tanaka","year":"2020","journal-title":"eLife"},{"key":"10.1016\/j.celrep.2026.117389_bib14","doi-asserted-by":"crossref","DOI":"10.1111\/acel.13132","article-title":"Plasma proteomic signature of the risk of developing mobility disability: A 9-year follow-up","volume":"19","author":"Osawa","year":"2020","journal-title":"Aging Cell"},{"key":"10.1016\/j.celrep.2026.117389_bib15","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1186\/s13195-021-00845-0","article-title":"Association of accelerated long-term forgetting and senescence-related blood-borne factors in asymptomatic individuals from families with autosomal dominant Alzheimer's disease","volume":"13","author":"Yang","year":"2021","journal-title":"Alzheimers Res. Ther."},{"key":"10.1016\/j.celrep.2026.117389_bib16","doi-asserted-by":"crossref","first-page":"2045","DOI":"10.3389\/fimmu.2020.02045","article-title":"Cognition Is Associated With Peripheral Immune Molecules in Healthy Older Adults: A Cross-Sectional Study","volume":"11","author":"Serre-Miranda","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.celrep.2026.117389_bib17","doi-asserted-by":"crossref","first-page":"3409","DOI":"10.1007\/s11357-023-00906-2","article-title":"Association between aging-related biomarkers and longitudinal trajectories of intrinsic capacity in older adults","volume":"45","author":"Lu","year":"2023","journal-title":"GeroScience"},{"key":"10.1016\/j.celrep.2026.117389_bib18","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1002\/acn3.52047","article-title":"A multi-omics study to monitor senescence-associated secretory phenotypes of Alzheimer's disease","volume":"11","author":"Yang","year":"2024","journal-title":"Ann. Clin. Transl. Neurol."},{"key":"10.1016\/j.celrep.2026.117389_bib19","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1038\/s41380-021-01339-z","article-title":"Multi-omics of human plasma reveals molecular features of dysregulated inflammation and accelerated aging in schizophrenia","volume":"27","author":"Campeau","year":"2022","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.celrep.2026.117389_bib20","doi-asserted-by":"crossref","first-page":"2505","DOI":"10.1097\/QAD.0000000000000471","article-title":"Relationships of pulmonary function, inflammation, and T-cell activation and senescence in an HIV-infected cohort","volume":"28","author":"Fitzpatrick","year":"2014","journal-title":"AIDS"},{"key":"10.1016\/j.celrep.2026.117389_bib21","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1186\/s12931-023-02403-8","article-title":"Biomarkers of cellular senescence in idiopathic pulmonary fibrosis","volume":"24","author":"Aversa","year":"2023","journal-title":"Respir. Res."},{"key":"10.1016\/j.celrep.2026.117389_bib22","doi-asserted-by":"crossref","DOI":"10.1136\/bmjdrc-2019-000720","article-title":"Senescence marker activin A is increased in human diabetic kidney disease: association with kidney function and potential implications for therapy","volume":"7","author":"Bian","year":"2019","journal-title":"BMJ Open Diabetes Res. Care"},{"key":"10.1016\/j.celrep.2026.117389_bib23","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1093\/gerona\/glaa324","article-title":"Elevated Plasma Growth and Differentiation Factor 15 Predicts Incident Anemia in Older Adults Aged 60 Years and Older","volume":"76","author":"Yamaguchi","year":"2021","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"key":"10.1016\/j.celrep.2026.117389_bib24","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23084168","article-title":"Cellular Senescence: Molecular Targets, Biomarkers, and Senolytic Drugs","volume":"23","author":"Kudlova","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.celrep.2026.117389_bib25","doi-asserted-by":"crossref","first-page":"2481","DOI":"10.1038\/s41591-023-02543-w","article-title":"Senolytic therapy in mild Alzheimer's disease: a phase 1 feasibility trial","volume":"29","author":"Gonzales","year":"2023","journal-title":"Nat. Med."},{"key":"10.1016\/j.celrep.2026.117389_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2025.105612","article-title":"A pilot study of senolytics to improve cognition and mobility in older adults at risk for Alzheimer's disease","volume":"113","author":"Millar","year":"2025","journal-title":"EBioMedicine"},{"key":"10.1016\/j.celrep.2026.117389_bib27","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1017\/S0007114515002950","article-title":"Effects of a quercetin-rich onion skin extract on 24 h ambulatory blood pressure and endothelial function in overweight-to-obese patients with (pre-)hypertension: a randomised double-blinded placebo-controlled cross-over trial","volume":"114","author":"Br\u00fcll","year":"2015","journal-title":"Br. J. Nutr."},{"key":"10.1016\/j.celrep.2026.117389_bib28","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1016\/j.ebiom.2018.12.052","article-title":"Senolytics in idiopathic pulmonary fibrosis: Results from a first-in-human, open-label, pilot study","volume":"40","author":"Justice","year":"2019","journal-title":"EBioMedicine"},{"key":"10.1016\/j.celrep.2026.117389_bib29","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.nutres.2018.02.005","article-title":"A diet high in carotenoid-rich vegetables and fruits favorably impacts inflammation status by increasing plasma concentrations of IFN-alpha2 and decreasing MIP-1beta and TNF-alpha in healthy individuals during a controlled feeding trial","volume":"52","author":"Jahns","year":"2018","journal-title":"Nutr. Res."},{"key":"10.1016\/j.celrep.2026.117389_bib30","doi-asserted-by":"crossref","DOI":"10.1093\/gerona\/glad214","article-title":"Caloric Restriction Intervention Alters Specific Circulating Biomarkers of the Senescence-Associated Secretome in Middle-Aged and Older Adults With Obesity and Prediabetes in an 18-Week Randomized Controlled Trial","volume":"79","author":"Justice","year":"2024","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"key":"10.1016\/j.celrep.2026.117389_bib31","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1093\/gerona\/glv057","article-title":"A 2-Year Randomized Controlled Trial of Human Caloric Restriction: Feasibility and Effects on Predictors of Health Span and Longevity","volume":"70","author":"Ravussin","year":"2015","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"key":"10.1016\/j.celrep.2026.117389_bib32","doi-asserted-by":"crossref","first-page":"2804","DOI":"10.1007\/s11695-018-3247-3","article-title":"Reduction of Premature Aging Markers After Gastric Bypass Surgery in Morbidly Obese Patients","volume":"28","author":"Hohensinner","year":"2018","journal-title":"Obes. Surg."},{"key":"10.1016\/j.celrep.2026.117389_bib33","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1093\/gerona\/glaa271","article-title":"Horticultural Therapy Reduces Biomarkers of Immunosenescence and Inflammaging in Community-Dwelling Older Adults: A Feasibility Pilot Randomized Controlled Trial","volume":"76","author":"Wong","year":"2021","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"key":"10.1016\/j.celrep.2026.117389_bib34","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1038\/s41586-023-06802-1","article-title":"Organ aging signatures in the plasma proteome track health and disease","volume":"624","author":"Oh","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2026.117389_bib35","doi-asserted-by":"crossref","first-page":"1843","DOI":"10.1038\/s41591-019-0673-2","article-title":"Undulating changes in human plasma proteome profiles across the lifespan","volume":"25","author":"Lehallier","year":"2019","journal-title":"Nat. Med."},{"key":"10.1016\/j.celrep.2026.117389_bib36","author":"Lehallier"},{"key":"10.1016\/j.celrep.2026.117389_bib37","doi-asserted-by":"crossref","first-page":"E361","DOI":"10.1503\/cmaj.200484","article-title":"Sex differences in mortality: results from a population-based study of 12 longitudinal cohorts","volume":"193","author":"Wu","year":"2021","journal-title":"CMAJ (Can. Med. Assoc. J.)"},{"key":"10.1016\/j.celrep.2026.117389_bib38","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1007\/s00125-023-05891-x","article-title":"Sex differences in type 2 diabetes","volume":"66","author":"Kautzky-Willer","year":"2023","journal-title":"Diabetologia"},{"key":"10.1016\/j.celrep.2026.117389_bib39","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.neurobiolaging.2022.08.014","article-title":"Evidence of sex differences in cellular senescence","volume":"120","author":"Ng","year":"2022","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.celrep.2026.117389_bib40","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1007\/s00592-024-02325-x","article-title":"Silencing the FABP3 gene in insulin-secreting cells reduces fatty acid uptake and protects against lipotoxicity","volume":"61","author":"Hyder","year":"2024","journal-title":"Acta Diabetol."},{"key":"10.1016\/j.celrep.2026.117389_bib41","doi-asserted-by":"crossref","first-page":"645","DOI":"10.3390\/antiox12030645","article-title":"Fatty Acid Binding Proteins 3 and 4 Predict Both All-Cause and Cardiovascular Mortality in Subjects with Chronic Heart Failure and Type 2 Diabetes Mellitus","volume":"12","author":"Rodriguez-Calvo","year":"2023","journal-title":"Antioxidants"},{"key":"10.1016\/j.celrep.2026.117389_bib42","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1111\/cei.13344","article-title":"Type 2 diabetes is associated with the accumulation of senescent T cells","volume":"197","author":"Lau","year":"2019","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.celrep.2026.117389_bib43","article-title":"The Bidirectional Link Between Diabetes and Kidney Disease: Mechanisms and Management","volume":"15","author":"Kumar","year":"2023","journal-title":"Cureus"},{"key":"10.1016\/j.celrep.2026.117389_bib44","doi-asserted-by":"crossref","first-page":"2757","DOI":"10.1038\/s41467-019-10688-x","article-title":"Reduced subcutaneous adipogenesis in human hypertrophic obesity is linked to senescent precursor cells","volume":"10","author":"Gustafson","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2026.117389_bib45","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1007\/s11892-022-01493-w","article-title":"Cellular Senescence in Obesity and Associated Complications: a New Therapeutic Target","volume":"22","author":"Narasimhan","year":"2022","journal-title":"Curr. Diab. Rep."},{"key":"10.1016\/j.celrep.2026.117389_bib46","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1038\/ijo.2008.41","article-title":"Decorin is a secreted protein associated with obesity and type 2 diabetes","volume":"32","author":"Bolton","year":"2008","journal-title":"Int. J. Obes."},{"key":"10.1016\/j.celrep.2026.117389_bib47","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/j.atherosclerosis.2015.02.017","article-title":"Elevated baseline plasma phospholipid protein (PLTP) levels are an independent predictor of long-term all-cause mortality in patients with diabetes mellitus and known or suspected coronary artery disease","volume":"239","author":"Cavusoglu","year":"2015","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.celrep.2026.117389_bib48","article-title":"Cellular Senescence in Sarcopenia: Possible Mechanisms and Therapeutic Potential","volume":"9","author":"He","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.celrep.2026.117389_bib49","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1038\/nature13013","article-title":"Geriatric muscle stem cells switch reversible quiescence into senescence","volume":"506","author":"Sousa-Victor","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2026.117389_bib50","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1038\/nature16187","article-title":"Autophagy maintains stemness by preventing senescence","volume":"529","author":"Garc\u00eda-Prat","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2026.117389_bib51","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1186\/s13195-023-01217-6","article-title":"Plasma beta(2)-microglobulin and cerebrospinal fluid biomarkers of Alzheimer's disease pathology in cognitively intact older adults: the CABLE study","volume":"15","author":"Huang","year":"2023","journal-title":"Alzheimers Res. Ther."},{"key":"10.1016\/j.celrep.2026.117389_bib52","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.21037\/atm-22-4405","article-title":"Immunosenescence is a therapeutic target for frailty in older adults: a narrative review","volume":"10","author":"Jia","year":"2022","journal-title":"Ann. Transl. Med."},{"key":"10.1016\/j.celrep.2026.117389_bib53","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1038\/s41392-023-01451-2","article-title":"Immunosenescence: molecular mechanisms and diseases","volume":"8","author":"Liu","year":"2023","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.celrep.2026.117389_bib54","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1038\/s41586-021-03547-7","article-title":"An aged immune system drives senescence and ageing of solid organs","volume":"594","author":"Yousefzadeh","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2026.117389_bib55","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1038\/s41419-018-0327-1","article-title":"The pro-inflammatory phenotype of the human non-classical monocyte subset is attributed to senescence","volume":"9","author":"Ong","year":"2018","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.celrep.2026.117389_bib56","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23169387","article-title":"Senescence Markers in Peripheral Blood Mononuclear Cells in Amnestic Mild Cognitive Impairment and Alzheimer's Disease","volume":"23","author":"Salech","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.celrep.2026.117389_bib57","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1080\/23744235.2022.2113135","article-title":"Markers of cellular senescence is associated with persistent pulmonary pathology after COVID-19 infection","volume":"54","author":"Lekva","year":"2022","journal-title":"Infect. Dis."},{"key":"10.1016\/j.celrep.2026.117389_bib58","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhlto.2024.100199","article-title":"T cell immune senescence is associated with frailty and sarcopenia in lung transplant candidates","volume":"7","author":"Schaenman","year":"2025","journal-title":"JHLT Open"},{"key":"10.1016\/j.celrep.2026.117389_bib59","doi-asserted-by":"crossref","first-page":"1699","DOI":"10.1097\/01.hjh.0000176788.12376.20","article-title":"Estrogen reduces endothelial progenitor cell senescence through augmentation of telomerase activity","volume":"23","author":"Imanishi","year":"2005","journal-title":"J. Hypertens."},{"key":"10.1016\/j.celrep.2026.117389_bib60","doi-asserted-by":"crossref","DOI":"10.14814\/phy2.14535","article-title":"Effect of menopausal hormone therapy on proteins associated with senescence and inflammation","volume":"8","author":"Faubion","year":"2020","journal-title":"Physiol. Rep."},{"key":"10.1016\/j.celrep.2026.117389_bib61","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2023216118","article-title":"Effects of sex and aging on the immune cell landscape as assessed by single-cell transcriptomic analysis","volume":"118","author":"Huang","year":"2021","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2026.117389_bib62","author":"Olinger"},{"key":"10.1016\/j.celrep.2026.117389_bib76","first-page":"86","article-title":"SenCat: Cataloging human cell senescence through multiomic profiling of multiple senescent primary cell types","author":"Anerillas","year":"2026","journal-title":"Mol. Cell."},{"key":"10.1016\/j.celrep.2026.117389_bib63","doi-asserted-by":"crossref","first-page":"1","DOI":"10.18637\/jss.v033.i01","article-title":"Regularization Paths for Generalized Linear Models via Coordinate Descent","volume":"33","author":"Friedman","year":"2010","journal-title":"J. Stat. Softw."},{"key":"10.1016\/j.celrep.2026.117389_bib64","author":"Therneau"},{"key":"10.1016\/j.celrep.2026.117389_bib65","doi-asserted-by":"crossref","first-page":"1","DOI":"10.18637\/jss.v059.i05","article-title":"Mediation: R Package for Causal Mediation Analysis","volume":"59","author":"Tingley","year":"2014","journal-title":"J. Stat. Softw."},{"key":"10.1016\/j.celrep.2026.117389_bib66","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.1093\/gerona\/63.12.1416","article-title":"The Baltimore Longitudinal Study of Aging (BLSA): a 50-year-long journey and plans for the future","volume":"63","author":"Ferrucci","year":"2008","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"key":"10.1016\/j.celrep.2026.117389_bib67","doi-asserted-by":"crossref","DOI":"10.3390\/nu14235072","article-title":"Quality Specific Associations of Carbohydrate Consumption and Frailty Index","volume":"14","author":"Tanaka","year":"2022","journal-title":"Nutrients"},{"key":"10.1016\/j.celrep.2026.117389_bib68","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1016\/j.neurobiolaging.2004.09.002","article-title":"Vitamin E levels, cognitive impairment and dementia in older persons: the InCHIANTI study","volume":"26","author":"Cherubini","year":"2005","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.celrep.2026.117389_bib69","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-022-22116-0","article-title":"Assessment of variability in the plasma 7k SomaScan proteomics assay","volume":"12","author":"Candia","year":"2022","journal-title":"Sci. Rep."},{"key":"10.1016\/j.celrep.2026.117389_bib70","article-title":"A fully automated FAIMS-DIA mass spectrometry-based proteomic pipeline","volume":"3","author":"Reilly","year":"2023","journal-title":"Cell Rep. Methods"},{"key":"10.1016\/j.celrep.2026.117389_bib71","doi-asserted-by":"crossref","DOI":"10.1093\/gpbjnl\/qzae083","article-title":"ProtPipe: A Multifunctional Data Analysis Pipeline for Proteomics and Peptidomics","volume":"22","author":"Li","year":"2025","journal-title":"Genom. Proteom. Bioinform."},{"key":"10.1016\/j.celrep.2026.117389_bib74","first-page":"1","article-title":"Relative Importance for Linear Regression in R: The Package relaimpo","volume":"17","author":"Groemping","year":"2006","journal-title":"J. Stat. Software"},{"key":"10.1016\/j.celrep.2026.117389_bib75","article-title":"clusterProfiler 4.0: A universal enrichment tool for interpreting omics data","volume":"2","author":"Wu","year":"2021","journal-title":"Innovation"}],"container-title":["Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124726004675?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124726004675?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T04:55:00Z","timestamp":1790312100000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211124726004675"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":74,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["S2211124726004675"],"URL":"https:\/\/doi.org\/10.1016\/j.celrep.2026.117389","relation":{},"ISSN":["2211-1247"],"issn-type":[{"value":"2211-1247","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Circulating cell type senescence signatures track distinct dimensions of health status and trajectories in human longitudinal cohorts","name":"articletitle","label":"Article Title"},{"value":"Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.celrep.2026.117389","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"https:\/\/doi.org\/10.1016\/j.molcel.2026.05.017","name":"associatedlink","label":"CrossRef DOI link to the associated document"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"117389"}}