{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T01:11:17Z","timestamp":1792717877274,"version":"4.5.0"},"reference-count":56,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T00:00:00Z","timestamp":1776816000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82401587"],"award-info":[{"award-number":["82401587"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82401565"],"award-info":[{"award-number":["82401565"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["92248304"],"award-info":[{"award-number":["92248304"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82371404"],"award-info":[{"award-number":["82371404"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82301510"],"award-info":[{"award-number":["82301510"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82471353"],"award-info":[{"award-number":["82471353"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82271341"],"award-info":[{"award-number":["82271341"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["YCJJ20252405"],"award-info":[{"award-number":["YCJJ20252405"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["2022ZD0204700"],"award-info":[{"award-number":["2022ZD0204700"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Reports"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.celrep.2026.117398","type":"journal-article","created":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T19:19:07Z","timestamp":1781032747000},"page":"117398","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["Bilirubin mitigates ischemic white matter injury by targeting transferrin-receptor-mediated B cell immunometabolism"],"prefix":"10.1016","volume":"45","author":[{"given":"Lian","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Wei","family":"Pang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi-Cheng","family":"Mei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun-Hui","family":"Chu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng-Lu","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Fang","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luo-Qi","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming-Hao","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Shang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian-Ke","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dai-Shi","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5162-3150","authenticated-orcid":false,"given":"Chuan","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.celrep.2026.117398_bib1","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1161\/CIRCRESAHA.122.319951","article-title":"Post-Stroke Cognitive Impairment and Dementia","volume":"130","author":"Rost","year":"2022","journal-title":"Circ. Res."},{"key":"10.1016\/j.celrep.2026.117398_bib2","doi-asserted-by":"crossref","first-page":"983","DOI":"10.3233\/JAD-215644","article-title":"Post-Stroke Cognitive Impairment: Epidemiology, Risk Factors, and Management","volume":"86","author":"Huang","year":"2022","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.celrep.2026.117398_bib3","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.immuni.2024.12.008","article-title":"The immunology of stroke and dementia","volume":"58","author":"Iadecola","year":"2025","journal-title":"Immunity"},{"key":"10.1016\/j.celrep.2026.117398_bib4","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1016\/j.molmed.2016.07.004","article-title":"A Novel Perspective on the Biology of Bilirubin in Health and Disease","volume":"22","author":"Gazzin","year":"2016","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.celrep.2026.117398_bib5","doi-asserted-by":"crossref","DOI":"10.3390\/antiox9090900","article-title":"The Role of Bilirubin and the Other \u201cYellow Players\u201d in Neurodegenerative Diseases","volume":"9","author":"Jayanti","year":"2020","journal-title":"Antioxidants"},{"key":"10.1016\/j.celrep.2026.117398_bib6","doi-asserted-by":"crossref","first-page":"5483","DOI":"10.1007\/s12035-018-1440-y","article-title":"Bilirubin and Ischemic Stroke: Rendering the Current Paradigm to Better Understand the Protective Effects of Bilirubin","volume":"56","author":"Thakkar","year":"2019","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.celrep.2026.117398_bib7","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1016\/j.ijdevneu.2013.08.002","article-title":"Elevated bilirubin after acute ischemic stroke linked to the stroke severity","volume":"31","author":"Luo","year":"2013","journal-title":"Int. J. Dev. Neurosci."},{"key":"10.1016\/j.celrep.2026.117398_bib8","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1186\/s12883-021-02398-z","article-title":"Serum bilirubin levels are associated with poor functional outcomes in patients with acute ischemic stroke or transient ischemic attack","volume":"21","author":"Ouyang","year":"2021","journal-title":"BMC Neurol."},{"key":"10.1016\/j.celrep.2026.117398_bib9","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1016\/j.neuroimage.2012.03.072","article-title":"NODDI: practical in vivo neurite orientation dispersion and density imaging of the human brain","volume":"61","author":"Zhang","year":"2012","journal-title":"Neuroimage"},{"key":"10.1016\/j.celrep.2026.117398_bib10","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1515\/cmble-2015-0012","article-title":"The pharmacological features of bilirubin: the question of the century","volume":"20","author":"Zahir","year":"2015","journal-title":"Cell. Mol. Biol. Lett."},{"key":"10.1016\/j.celrep.2026.117398_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2020.118032","article-title":"Bilirubin in metabolic syndrome and associated inflammatory diseases: New perspectives","volume":"257","author":"Nov\u00e1k","year":"2020","journal-title":"Life Sci."},{"key":"10.1016\/j.celrep.2026.117398_bib12","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.trre.2018.06.003","article-title":"Bilirubin, a new therapeutic for kidney transplant?","volume":"32","author":"Sundararaghavan","year":"2018","journal-title":"Transplant. Rev."},{"key":"10.1016\/j.celrep.2026.117398_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.parkreldis.2023.105890","article-title":"Abnormal immune function of B lymphocyte in peripheral blood of Parkinson's disease","volume":"116","author":"Zhang","year":"2023","journal-title":"Parkinsonism Relat. Disord."},{"key":"10.1016\/j.celrep.2026.117398_bib14","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.2147\/JIR.S399021","article-title":"Circulating Leukocyte as an Inflammatory Biomarker: Association with Fibrinogen and Neuronal Damage in Acute Ischemic Stroke","volume":"16","author":"Han","year":"2023","journal-title":"J. Inflamm. Res."},{"key":"10.1016\/j.celrep.2026.117398_bib15","doi-asserted-by":"crossref","DOI":"10.3390\/ijms25105323","article-title":"Bilirubin Exerts Protective Effects on Alveolar Type II Pneumocytes in an In Vitro Model of Oxidative Stress","volume":"25","author":"Endesfelder","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.celrep.2026.117398_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbo.2023.100472","article-title":"Indirect bilirubin impairs invasion of osteosarcoma cells via inhibiting the PI3K\/AKT\/MMP-2 signaling pathway by suppressing intracellular ROS","volume":"39","author":"Yuan","year":"2023","journal-title":"J. Bone Oncol."},{"key":"10.1016\/j.celrep.2026.117398_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.mcn.2023.103850","article-title":"Bilirubin induces microglial NLRP3 inflammasome activation in vitro and in vivo","volume":"125","author":"Ercan","year":"2023","journal-title":"Mol. Cell. Neurosci."},{"key":"10.1016\/j.celrep.2026.117398_bib18","doi-asserted-by":"crossref","first-page":"4411","DOI":"10.1007\/s11033-023-08339-y","article-title":"Ameliorative effects of bilirubin on cell culture model of non-alcoholic fatty liver disease","volume":"50","author":"Vakili","year":"2023","journal-title":"Mol. Biol. Rep."},{"key":"10.1016\/j.celrep.2026.117398_bib19","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1038\/s41467-025-67523-9","article-title":"AAK1 activation-mediated iron trafficking drives ferroptotic cell death","volume":"17","author":"Li","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2026.117398_bib20","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1186\/s12974-023-02907-6","article-title":"Receptor-interacting protein kinase 2 (RIPK2) profoundly contributes to post-stroke neuroinflammation and behavioral deficits with microglia as unique perpetrators","volume":"20","author":"Larochelle","year":"2023","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.celrep.2026.117398_bib21","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1111\/j.1478-3231.2008.01716.x","article-title":"Bilirubin in clinical practice: a review","volume":"28","author":"Fevery","year":"2008","journal-title":"Liver Int."},{"key":"10.1016\/j.celrep.2026.117398_bib22","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1136\/svn-2019-000289","article-title":"Serum bilirubin and ischaemic stroke: a review of literature","volume":"5","author":"Wang","year":"2020","journal-title":"Stroke Vasc. Neurol."},{"key":"10.1016\/j.celrep.2026.117398_bib23","doi-asserted-by":"crossref","first-page":"6473","DOI":"10.1038\/s41598-018-24917-8","article-title":"Low Bilirubin Levels Indicate a High Risk of Cerebral Deep White Matter Lesions in Apparently Healthy Subjects","volume":"8","author":"Higuchi","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.celrep.2026.117398_bib24","doi-asserted-by":"crossref","first-page":"1780","DOI":"10.1002\/glia.22722","article-title":"White matter injury: Ischemic and nonischemic","volume":"62","author":"Fern","year":"2014","journal-title":"Glia"},{"key":"10.1016\/j.celrep.2026.117398_bib25","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1016\/j.arcmed.2014.11.015","article-title":"Blood-brain barrier and bilirubin: clinical aspects and experimental data","volume":"45","author":"Brito","year":"2014","journal-title":"Arch. Med. Res."},{"key":"10.1016\/j.celrep.2026.117398_bib26","doi-asserted-by":"crossref","first-page":"22","DOI":"10.3389\/fncel.2012.00022","article-title":"Time-dependent dual effects of high levels of unconjugated bilirubin on the human blood-brain barrier lining","volume":"6","author":"Palmela","year":"2012","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.celrep.2026.117398_bib27","doi-asserted-by":"crossref","first-page":"8556","DOI":"10.1523\/JNEUROSCI.1623-11.2011","article-title":"Regulatory B cells limit CNS inflammation and neurologic deficits in murine experimental stroke","volume":"31","author":"Ren","year":"2011","journal-title":"J. Neurosci."},{"key":"10.1016\/j.celrep.2026.117398_bib28","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1186\/s12974-017-1017-0","article-title":"Infiltration and persistence of lymphocytes during late-stage cerebral ischemia in middle cerebral artery occlusion and photothrombotic stroke models","volume":"14","author":"Feng","year":"2017","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.celrep.2026.117398_bib29","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bbi.2016.08.009","article-title":"Does B lymphocyte-mediated autoimmunity contribute to post-stroke dementia?","volume":"64","author":"Doyle","year":"2017","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.celrep.2026.117398_bib30","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.adi0295","article-title":"B cell depletion with anti-CD20 promotes neuroprotection in a BAFF-dependent manner in mice and humans","volume":"16","author":"Wang","year":"2024","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.celrep.2026.117398_bib31","doi-asserted-by":"crossref","first-page":"1887","DOI":"10.4049\/jimmunol.181.3.1887","article-title":"Bilirubin possesses powerful immunomodulatory activity and suppresses experimental autoimmune encephalomyelitis","volume":"181","author":"Liu","year":"2008","journal-title":"J. Immunol."},{"key":"10.1016\/j.celrep.2026.117398_bib32","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1189\/jlb.0211070","article-title":"Immunomodulatory and immunotoxic effects of bilirubin: molecular mechanisms","volume":"90","author":"Khan","year":"2011","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.celrep.2026.117398_bib33","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1016\/j.neuron.2023.02.022","article-title":"Bilirubin gates the TRPM2 channel as a direct agonist to exacerbate ischemic brain damage","volume":"111","author":"Liu","year":"2023","journal-title":"Neuron"},{"key":"10.1016\/j.celrep.2026.117398_bib34","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2021.615372","article-title":"Ferroptosis and Its Multifaceted Roles in Cerebral Stroke","volume":"15","author":"Zhang","year":"2021","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.celrep.2026.117398_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2022.102475","article-title":"Mitochondrial ferritin alleviates apoptosis by enhancing mitochondrial bioenergetics and stimulating glucose metabolism in cerebral ischemia reperfusion","volume":"57","author":"Wang","year":"2022","journal-title":"Redox Biol."},{"key":"10.1016\/j.celrep.2026.117398_bib36","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1038\/s41419-022-05027-w","article-title":"TFRC upregulation promotes ferroptosis in CVB3 infection via nucleus recruitment of Sp1","volume":"13","author":"Yi","year":"2022","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.celrep.2026.117398_bib37","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/j.celrep.2015.09.023","article-title":"Lethal Cardiomyopathy in Mice Lacking Transferrin Receptor in the Heart","volume":"13","author":"Xu","year":"2015","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2026.117398_bib38","doi-asserted-by":"crossref","DOI":"10.1042\/BSR20212835","article-title":"A ferroptosis-related gene signature for overall survival prediction and immune infiltration in lung squamous cell carcinoma","volume":"42","author":"Miao","year":"2022","journal-title":"Biosci. Rep."},{"key":"10.1016\/j.celrep.2026.117398_bib39","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1007\/s12264-019-00388-3","article-title":"Dual Functions of Microglia in Ischemic Stroke","volume":"35","author":"Qin","year":"2019","journal-title":"Neurosci. Bull."},{"key":"10.1016\/j.celrep.2026.117398_bib40","doi-asserted-by":"crossref","first-page":"288","DOI":"10.4049\/jimmunol.2100884","article-title":"CD11b(high) B Cells Increase after Stroke and Regulate Microglia","volume":"209","author":"Korf","year":"2022","journal-title":"J. Immunol."},{"key":"10.1016\/j.celrep.2026.117398_bib41","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1186\/s12974-024-03267-5","article-title":"Fenebrutinib, a Bruton's tyrosine kinase inhibitor, blocks distinct human microglial signaling pathways","volume":"21","author":"Langlois","year":"2024","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.celrep.2026.117398_bib42","doi-asserted-by":"crossref","first-page":"351","DOI":"10.2214\/ajr.149.2.351","article-title":"MR signal abnormalities at 1.5 T in Alzheimer's dementia and normal aging","volume":"149","author":"Fazekas","year":"1987","journal-title":"AJR Am. J. Roentgenol."},{"key":"10.1016\/j.celrep.2026.117398_bib43","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1249\/01.MSS.0000078924.61453.FB","article-title":"International physical activity questionnaire: 12-country reliability and validity","volume":"35","author":"Craig","year":"2003","journal-title":"Med. Sci. Sports Exerc."},{"key":"10.1016\/j.celrep.2026.117398_bib44","doi-asserted-by":"crossref","first-page":"4343","DOI":"10.1038\/s41380-022-01655-y","article-title":"Sleep, physical activity, sedentary behavior, and risk of incident dementia: a prospective cohort study of 431,924 UK Biobank participants","volume":"27","author":"Huang","year":"2022","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.celrep.2026.117398_bib45","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1001779","article-title":"UK biobank: an open access resource for identifying the causes of a wide range of complex diseases of middle and old age","volume":"12","author":"Sudlow","year":"2015","journal-title":"PLoS Med."},{"key":"10.1016\/j.celrep.2026.117398_bib46","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1038\/s41593-021-00826-4","article-title":"An expanded set of genome-wide association studies of brain imaging phenotypes in UK Biobank","volume":"24","author":"Smith","year":"2021","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.celrep.2026.117398_bib47","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1186\/s12916-023-02982-9","article-title":"Assessment of bidirectional relationships between brain imaging-derived phenotypes and stroke: a Mendelian randomization study","volume":"21","author":"Yu","year":"2023","journal-title":"BMC Med."},{"key":"10.1016\/j.celrep.2026.117398_bib48","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1002\/jrsm.1346","article-title":"Meta-analysis and Mendelian randomization: A review","volume":"10","author":"Bowden","year":"2019","journal-title":"Res. Synth. Methods"},{"key":"10.1016\/j.celrep.2026.117398_bib49","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1038\/s41392-021-00802-1","article-title":"FSAP aggravated endothelial dysfunction and neurological deficits in acute ischemic stroke due to large vessel occlusion","volume":"7","author":"Tian","year":"2022","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.celrep.2026.117398_bib50","article-title":"TREM2-IGF1 Mediated Glucometabolic Enhancement Underlies Microglial Neuroprotective Properties During Ischemic Stroke","volume":"11","author":"Yang","year":"2024","journal-title":"Adv. Sci."},{"key":"10.1016\/j.celrep.2026.117398_bib51","doi-asserted-by":"crossref","first-page":"2598","DOI":"10.1161\/01.STR.0000143725.19053.60","article-title":"White matter lesions and glial activation in a novel mouse model of chronic cerebral hypoperfusion","volume":"35","author":"Shibata","year":"2004","journal-title":"Stroke"},{"key":"10.1016\/j.celrep.2026.117398_bib52","doi-asserted-by":"crossref","first-page":"6943","DOI":"10.1038\/s41467-021-27248-x","article-title":"Stroke subtype-dependent synapse elimination by reactive gliosis in mice","volume":"12","author":"Shi","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2026.117398_bib53","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1093\/brain\/awad321","article-title":"Soluble TREM2 triggers microglial dysfunction in neuromyelitis optica spectrum disorders","volume":"147","author":"Qin","year":"2024","journal-title":"Brain"},{"key":"10.1016\/j.celrep.2026.117398_bib54","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1111\/jnc.15987","article-title":"Trem2 deficiency attenuates microglial phagocytosis and autophagic-lysosomal activation in white matter hypoperfusion","volume":"167","author":"Pang","year":"2023","journal-title":"J. Neurochem."},{"key":"10.1016\/j.celrep.2026.117398_bib55","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1038\/nbt.4096","article-title":"Integrating single-cell transcriptomic data across different conditions, technologies, and species","volume":"36","author":"Butler","year":"2018","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.celrep.2026.117398_bib56","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1038\/s43587-022-00196-x","article-title":"Limited Proteolysis-Mass Spectrometry Reveals Aging-Associated Changes in Cerebrospinal Fluid Protein Abundances and Structures","volume":"2","author":"Shuken","year":"2022","journal-title":"Nat. Aging"}],"container-title":["Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124726004766?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124726004766?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T04:40:34Z","timestamp":1790311234000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211124726004766"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":56,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["S2211124726004766"],"URL":"https:\/\/doi.org\/10.1016\/j.celrep.2026.117398","relation":{},"ISSN":["2211-1247"],"issn-type":[{"value":"2211-1247","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Bilirubin mitigates ischemic white matter injury by targeting transferrin-receptor-mediated B cell immunometabolism","name":"articletitle","label":"Article Title"},{"value":"Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.celrep.2026.117398","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"117398"}}