{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T05:00:26Z","timestamp":1790312426645,"version":"4.1.0"},"reference-count":23,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T00:00:00Z","timestamp":1777334400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012165","name":"Key Technologies Research and Development Program","doi-asserted-by":"publisher","award":["2022YFA1304000"],"award-info":[{"award-number":["2022YFA1304000"]}],"id":[{"id":"10.13039\/501100012165","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003392","name":"Fujian Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["2022J05299"],"award-info":[{"award-number":["2022J05299"]}],"id":[{"id":"10.13039\/501100003392","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003392","name":"Fujian Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["2021J011338"],"award-info":[{"award-number":["2021J011338"]}],"id":[{"id":"10.13039\/501100003392","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82303109"],"award-info":[{"award-number":["82303109"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Reports"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.celrep.2026.117413","type":"journal-article","created":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T16:29:39Z","timestamp":1780072179000},"page":"117413","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Integrative analysis reveals intra-tumoral microbial enterotypes shape host transcriptomes in colorectal cancer"],"prefix":"10.1016","volume":"45","author":[{"given":"Kai","family":"Yuan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifan","family":"Lian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pingmei","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoning","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yapi","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luyao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhijian","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinggui","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinbo","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sibo","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanyun","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuntian","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianlin","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongzhi","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.celrep.2026.117413_bib1","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1038\/s41392-023-01693-0","article-title":"Intratumoural microbiota: a new frontier in cancer development and therapy","volume":"9","author":"Cao","year":"2024","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.celrep.2026.117413_bib2","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.chom.2018.01.007","article-title":"Bacteroides fragilis Toxin Coordinates a Pro-carcinogenic Inflammatory Cascade via Targeting of Colonic Epithelial Cells","volume":"23","author":"Chung","year":"2018","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.celrep.2026.117413_bib3","doi-asserted-by":"crossref","DOI":"10.1080\/19490976.2021.1987780","article-title":"Fusobacterium nucleatum drives a pro-inflammatory intestinal microenvironment through metabolite receptor-dependent modulation of IL-17 expression","volume":"13","author":"Brennan","year":"2021","journal-title":"Gut Microbes"},{"key":"10.1016\/j.celrep.2026.117413_bib4","doi-asserted-by":"crossref","DOI":"10.1186\/s43556-025-00248-9","article-title":"Tumor microbiome: roles in tumor initiation, progression, and therapy","volume":"6","author":"Zhang","year":"2025","journal-title":"Mol. Biomed."},{"key":"10.1016\/j.celrep.2026.117413_bib5","doi-asserted-by":"crossref","first-page":"2395","DOI":"10.1053\/j.gastro.2021.02.020","article-title":"Microbial Community Heterogeneity Within Colorectal Neoplasia and its Correlation With Colorectal Carcinogenesis","volume":"160","author":"Liu","year":"2021","journal-title":"Gastroenterology"},{"key":"10.1016\/j.celrep.2026.117413_bib6","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1038\/s41571-023-00766-x","article-title":"Gut microbiota in colorectal cancer development and therapy","volume":"20","author":"Wong","year":"2023","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.celrep.2026.117413_bib7","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1186\/s13073-024-01344-1","article-title":"Colorectal cancer microbiome programs DNA methylation of host cells by affecting methyl donor metabolism","volume":"16","author":"Liu","year":"2024","journal-title":"Genome Med."},{"key":"10.1016\/j.celrep.2026.117413_bib8","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1016\/j.cell.2024.01.027","article-title":"Pan-cancer proteogenomics characterization of tumor immunity","volume":"187","author":"Petralia","year":"2024","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2026.117413_bib9","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1038\/s41586-024-07182-w","article-title":"A distinct Fusobacterium nucleatum clade dominates the colorectal cancer niche","volume":"628","author":"Zepeda-Rivera","year":"2024","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2026.117413_bib10","doi-asserted-by":"crossref","first-page":"2129","DOI":"10.3390\/microorganisms10112129","article-title":"Host Genetics and Microbiota Interactions in Colorectal Cancer: Shared or Independent Risk?","volume":"10","author":"Romero-Garmendia","year":"2022","journal-title":"Microorganisms"},{"key":"10.1016\/j.celrep.2026.117413_bib11","doi-asserted-by":"crossref","DOI":"10.1128\/msystems.00043-25","article-title":"Fecal bacterial biomarkers and blood biochemical indicators as potential key factors in the development of colorectal cancer","volume":"10","author":"Cai","year":"2025","journal-title":"mSystems"},{"key":"10.1016\/j.celrep.2026.117413_bib12","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1016\/j.chom.2025.05.004","article-title":"Bacteroides fragilis promotes chemoresistance in colorectal cancer, and its elimination by phage VA7 restores chemosensitivity","volume":"33","author":"Ding","year":"2025","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.celrep.2026.117413_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2025.114283","article-title":"Long non-coding RNA UCA1 modulates SMARCA2-containing SWI\/SNF chromatin remodeling complexes in human colorectal cancer","volume":"29","author":"Neve","year":"2026","journal-title":"iScience"},{"key":"10.1016\/j.celrep.2026.117413_bib14","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1186\/s12967-024-05720-8","article-title":"Parvimonas micra forms a distinct bacterial network with oral pathobionts in colorectal cancer patients","volume":"22","author":"L\u00f6wenmark","year":"2024","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.celrep.2026.117413_bib15","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1016\/j.chom.2024.07.001","article-title":"Peptostreptococcus stomatis promotes colonic tumorigenesis and receptor tyrosine kinase inhibitor resistance by activating ERBB2-MAPK","volume":"32","author":"Huang","year":"2024","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.celrep.2026.117413_bib16","doi-asserted-by":"crossref","DOI":"10.1186\/s13046-021-02073-8","article-title":"Neuromedin U induces an invasive phenotype in CRC cells expressing the NMUR2 receptor","volume":"40","author":"Przygodzka","year":"2021","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"10.1016\/j.celrep.2026.117413_bib17","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-025-59588-3","article-title":"Ligand-activated EGFR\/MAPK signaling but not PI3K, are key resistance mechanisms to EGFR-therapy in colorectal cancer","volume":"16","author":"Qu","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2026.117413_bib18","doi-asserted-by":"crossref","DOI":"10.1038\/s41419-023-06151-x","article-title":"Knockdown of ANXA10 induces ferroptosis by inhibiting autophagy-mediated TFRC degradation in colorectal cancer","volume":"14","author":"Wang","year":"2023","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.celrep.2026.117413_bib19","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1038\/nm.3967","article-title":"The consensus molecular subtypes of colorectal cancer","volume":"21","author":"Guinney","year":"2015","journal-title":"Nat. Med."},{"key":"10.1016\/j.celrep.2026.117413_bib20","doi-asserted-by":"crossref","DOI":"10.1038\/s41419-024-06697-4","article-title":"Modulating extracellular matrix stiffness: a strategic approach to boost cancer immunotherapy","volume":"15","author":"Mai","year":"2024","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.celrep.2026.117413_bib21","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1093\/cvr\/cvz182","article-title":"HAND1 loss-of-function within the embryonic myocardium reveals survivable congenital cardiac defects and adult heart failure","volume":"116","author":"Firulli","year":"2020","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.celrep.2026.117413_bib22","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1038\/s41423-023-00974-6","article-title":"The chemokines CXCL8 and CXCL12: molecular and functional properties, role in disease and efforts towards pharmacological intervention","volume":"20","author":"Cambier","year":"2023","journal-title":"Cell. Mol. Immunol."},{"key":"10.1016\/j.celrep.2026.117413_bib23","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1186\/s12885-021-09110-x","article-title":"High frequency of enterotoxigenic Bacteroides fragilis and Enterococcus faecalis in the paraffin-embedded tissues of Iranian colorectal cancer patients","volume":"21","author":"Khodaverdi","year":"2021","journal-title":"BMC Cancer"}],"container-title":["Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124726004912?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124726004912?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T04:31:11Z","timestamp":1790310671000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211124726004912"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":23,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["S2211124726004912"],"URL":"https:\/\/doi.org\/10.1016\/j.celrep.2026.117413","relation":{},"ISSN":["2211-1247"],"issn-type":[{"value":"2211-1247","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Integrative analysis reveals intra-tumoral microbial enterotypes shape host transcriptomes in colorectal cancer","name":"articletitle","label":"Article Title"},{"value":"Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.celrep.2026.117413","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"117413"}}