{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T05:00:14Z","timestamp":1790312414814,"version":"4.1.0"},"reference-count":67,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T00:00:00Z","timestamp":1778025600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFC3401500"],"award-info":[{"award-number":["2022YFC3401500"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2025YFC3409700"],"award-info":[{"award-number":["2025YFC3409700"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFA1302800"],"award-info":[{"award-number":["2022YFA1302800"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013061","name":"Jilin Scientific and Technological Development Program","doi-asserted-by":"publisher","award":["20250204064YY"],"award-info":[{"award-number":["20250204064YY"]}],"id":[{"id":"10.13039\/501100013061","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32150014"],"award-info":[{"award-number":["32150014"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32470771"],"award-info":[{"award-number":["32470771"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["319707340"],"award-info":[{"award-number":["319707340"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32170614"],"award-info":[{"award-number":["32170614"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People's Republic of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009539","name":"Life Sciences Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009539","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Reports"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.celrep.2026.117449","type":"journal-article","created":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T21:53:19Z","timestamp":1780005199000},"page":"117449","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["Enhanced formaldehyde clearance ameliorates differentiation-induced genotoxicity in Fanconi anemia mutant cells"],"prefix":"10.1016","volume":"45","author":[{"given":"Jinghang","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaotong","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siqian","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Landing","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhilin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Can","family":"Yi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuejia","family":"Duan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yajing","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sirui","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianghuijun","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinxin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianping","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shixian","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liangyu","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1196-6372","authenticated-orcid":false,"given":"Lei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.celrep.2026.117449_bib1","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/j.cell.2014.12.031","article-title":"SnapShot: Fanconi anemia and associated proteins","volume":"160","author":"Wang","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2026.117449_bib2","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1038\/nrc.2017.116","article-title":"Fanconi anaemia and cancer: an intricate relationship","volume":"18","author":"Nalepa","year":"2018","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.celrep.2026.117449_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.blre.2024.101225","article-title":"Longitudinal clinical manifestations of Fanconi anemia: A systematized review","volume":"68","author":"Hoover","year":"2024","journal-title":"Blood Rev."},{"key":"10.1016\/j.celrep.2026.117449_bib4","doi-asserted-by":"crossref","DOI":"10.1172\/JCI187323","article-title":"Genetic inactivation of FAAP100 causes Fanconi anemia due to disruption of the monoubiquitin ligase core complex","volume":"135","author":"Kuehl","year":"2025","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.celrep.2026.117449_bib5","first-page":"457","article-title":"The Fanconi Anemia Pathway in Cancer","volume":"Vol 3","author":"Niraj","year":"2019"},{"key":"10.1016\/j.celrep.2026.117449_bib6","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1038\/nature11863","article-title":"Fanconi anaemia and the repair of Watson and Crick DNA crosslinks","volume":"493","author":"Kottemann","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2026.117449_bib7","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/j.trecan.2022.01.015","article-title":"Fanconi anemia proteins and genome fragility: unraveling replication defects for cancer therapy","volume":"8","author":"Badra Fajardo","year":"2022","journal-title":"Trends Cancer"},{"key":"10.1016\/j.celrep.2026.117449_bib8","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/nrm.2016.48","article-title":"The Fanconi anaemia pathway: new players and new functions","volume":"17","author":"Ceccaldi","year":"2016","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.celrep.2026.117449_bib9","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1038\/s41586-019-1703-4","article-title":"Structure of the Fanconi anaemia monoubiquitin ligase complex","volume":"575","author":"Shakeel","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2026.117449_bib10","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1016\/j.molcel.2014.03.015","article-title":"XPF-ERCC1 acts in Unhooking DNA interstrand crosslinks in cooperation with FANCD2 and FANCP\/SLX4","volume":"54","author":"Klein Douwel","year":"2014","journal-title":"Mol. Cell"},{"key":"10.1016\/j.celrep.2026.117449_bib11","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1126\/science.1192656","article-title":"FAN1 acts with FANCI-FANCD2 to promote DNA interstrand cross-link repair","volume":"329","author":"Liu","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.celrep.2026.117449_bib12","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1038\/s41594-020-0380-1","article-title":"FANCD2-FANCI is a clamp stabilized on DNA by monoubiquitination of FANCD2 during DNA repair","volume":"27","author":"Alc\u00f3n","year":"2020","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.celrep.2026.117449_bib13","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1016\/j.molcel.2020.11.040","article-title":"A Surge of DNA Damage Links Transcriptional Reprogramming and Hematopoietic Deficit in Fanconi Anemia","volume":"80","author":"Shen","year":"2020","journal-title":"Mol. Cell"},{"key":"10.1016\/j.celrep.2026.117449_bib14","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1038\/nature25154","article-title":"Alcohol and endogenous aldehydes damage chromosomes and mutate stem cells","volume":"553","author":"Garaycoechea","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2026.117449_bib15","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1016\/j.molcel.2020.10.012","article-title":"Two Aldehyde Clearance Systems Are Essential to Prevent Lethal Formaldehyde Accumulation in Mice and Humans","volume":"80","author":"Dingler","year":"2020","journal-title":"Mol. Cell"},{"key":"10.1016\/j.celrep.2026.117449_bib16","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1016\/j.cell.2004.12.012","article-title":"Histone demethylation mediated by the nuclear amine oxidase homolog LSD1","volume":"119","author":"Shi","year":"2004","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2026.117449_bib17","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1038\/nature04433","article-title":"Histone demethylation by a family of JmjC domain-containing proteins","volume":"439","author":"Tsukada","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2026.117449_bib18","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1038\/nature04837","article-title":"The putative oncogene GASC1 demethylates tri- and dimethylated lysine 9 on histone H3","volume":"442","author":"Cloos","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2026.117449_bib19","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abd7197","article-title":"Digenic mutations in ALDH2 and ADH5 impair formaldehyde clearance and cause a multisystem disorder, AMeD syndrome","volume":"6","author":"Oka","year":"2020","journal-title":"Sci. Adv."},{"key":"10.1016\/j.celrep.2026.117449_bib20","doi-asserted-by":"crossref","first-page":"2021","DOI":"10.1182\/blood.2020009111","article-title":"Analysis of disease model iPSCs derived from patients with a novel Fanconi anemia-like IBMFS ADH5\/ALDH2 deficiency","volume":"137","author":"Mu","year":"2021","journal-title":"Blood"},{"key":"10.1016\/j.celrep.2026.117449_bib21","doi-asserted-by":"crossref","first-page":"1909","DOI":"10.1056\/NEJMra0809889","article-title":"Susceptibility pathways in Fanconi's anemia and breast cancer","volume":"362","author":"D'Andrea","year":"2010","journal-title":"N. Engl. J. Med."},{"issue":"Suppl 2","key":"10.1016\/j.celrep.2026.117449_bib22","doi-asserted-by":"crossref","first-page":"S51","DOI":"10.1038\/bmt.2008.284","article-title":"HSCT for Fanconi anemia in children: factors that influence early and late results","volume":"42","author":"Dalle","year":"2008","journal-title":"Bone Marrow Transplant."},{"key":"10.1016\/j.celrep.2026.117449_bib23","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1111\/bjh.15006","article-title":"Transplant results in adults with Fanconi anaemia","volume":"180","author":"Bierings","year":"2018","journal-title":"Br. J. Haematol."},{"key":"10.1016\/j.celrep.2026.117449_bib24","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.1016\/j.celrep.2014.04.029","article-title":"Modularized functions of the Fanconi anemia core complex","volume":"7","author":"Huang","year":"2014","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2026.117449_bib25","doi-asserted-by":"crossref","first-page":"20184","DOI":"10.1074\/jbc.M117.814780","article-title":"Constitutive role of the Fanconi anemia D2 gene in the replication stress response","volume":"292","author":"Tian","year":"2017","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.celrep.2026.117449_bib26","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/0145-2126(90)90002-Q","article-title":"Induced differentiation of K562 leukemia cells: a model for studies of gene expression in early megakaryoblasts","volume":"14","author":"Alitalo","year":"1990","journal-title":"Leuk. Res."},{"key":"10.1016\/j.celrep.2026.117449_bib27","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1517\/17425255.4.6.697","article-title":"Non-P450 aldehyde oxidizing enzymes: the aldehyde dehydrogenase superfamily","volume":"4","author":"Marchitti","year":"2008","journal-title":"Expert Opin. Drug Metab. Toxicol."},{"key":"10.1016\/j.celrep.2026.117449_bib28","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1186\/1479-7364-5-4-283","article-title":"Update on the aldehyde dehydrogenase gene (ALDH) superfamily","volume":"5","author":"Jackson","year":"2011","journal-title":"Hum. Genomics"},{"key":"10.1016\/j.celrep.2026.117449_bib29","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1038\/s41467-022-28242-7","article-title":"Endogenous formaldehyde scavenges cellular glutathione resulting in redox disruption and cytotoxicity","volume":"13","author":"Umansky","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2026.117449_bib30","doi-asserted-by":"crossref","first-page":"10720","DOI":"10.1021\/bi9929711","article-title":"Kinetic mechanism of human glutathione-dependent formaldehyde dehydrogenase","volume":"39","author":"Sanghani","year":"2000","journal-title":"Biochemistry"},{"key":"10.1016\/j.celrep.2026.117449_bib31","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1006\/jmbi.1996.0731","article-title":"Structure of human \u03c7\u03c7 alcohol dehydrogenase: a glutathione-dependent formaldehyde dehydrogenase11Edited by I","volume":"265","author":"Yang","year":"1997","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.celrep.2026.117449_bib32","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1038\/nrm3719","article-title":"Double-strand break repair: 53BP1 comes into focus","volume":"15","author":"Panier","year":"2014","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.celrep.2026.117449_bib33","doi-asserted-by":"crossref","first-page":"4073","DOI":"10.1039\/C7SC00748E","article-title":"A 2-aza-Cope reactivity-based platform for ratiometric fluorescence imaging of formaldehyde in living cells","volume":"8","author":"Brewer","year":"2017","journal-title":"Chem. Sci."},{"key":"10.1016\/j.celrep.2026.117449_bib34","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1016\/j.celrep.2019.12.067","article-title":"The ARK Assay Is a Sensitive and Versatile Method for the Global Detection of DNA-Protein Crosslinks","volume":"30","author":"Hu","year":"2020","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2026.117449_bib35","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1016\/0006-291X(91)91045-E","article-title":"Human liver class III alcohol and glutathione dependent formaldehyde dehydrogenase are the same enzyme","volume":"178","author":"Vallee","year":"1991","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.celrep.2026.117449_bib36","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/0014-5793(89)81797-1","article-title":"Evidence for the identity of glutathione-dependent formaldehyde dehydrogenase and class III alcohol dehydrogenase","volume":"257","author":"Koivusalo","year":"1989","journal-title":"FEBS Lett."},{"key":"10.1016\/j.celrep.2026.117449_bib37","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.cbi.2008.10.050","article-title":"The Janus face of alcohol dehydrogenase 3","volume":"178","author":"Staab","year":"2009","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.celrep.2026.117449_bib38","doi-asserted-by":"crossref","first-page":"7653","DOI":"10.1016\/S0021-9258(19)81287-5","article-title":"Formaldehyde Dehydrogenase from Human Liver","volume":"249","author":"Uotila","year":"1974","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.celrep.2026.117449_bib39","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1016\/0006-2952(84)90526-4","article-title":"Oxidation of formaldehyde and acetaldehyde by NAD+-dependent dehydrogenases in rat nasal mucosal homogenates","volume":"33","author":"Casanova-Schmitz","year":"1984","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.celrep.2026.117449_bib40","doi-asserted-by":"crossref","first-page":"2784","DOI":"10.1110\/ps.8.12.2784","article-title":"Human liver mitochondrial aldehyde dehydrogenase: Three-dimensional structure and the restoration of solubility and activity of chimeric forms","volume":"8","author":"Ni","year":"1999","journal-title":"Protein Sci."},{"key":"10.1016\/j.celrep.2026.117449_bib41","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.jmb.2012.04.010","article-title":"The Three-Dimensional Structural Basis of Type II Hyperprolinemia","volume":"420","author":"Srivastava","year":"2012","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.celrep.2026.117449_bib42","doi-asserted-by":"crossref","first-page":"5513","DOI":"10.1021\/acs.biochem.5b00754","article-title":"Structural Basis of Substrate Recognition by Aldehyde Dehydrogenase 7A1","volume":"54","author":"Luo","year":"2015","journal-title":"Biochemistry"},{"key":"10.1016\/j.celrep.2026.117449_bib43","doi-asserted-by":"crossref","first-page":"W324","DOI":"10.1093\/nar\/gkae300","article-title":"SwissDock 2024: major enhancements for small-molecule docking with Attracting Cavities and AutoDock Vina","volume":"52","author":"Bugnon","year":"2024","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.celrep.2026.117449_bib44","doi-asserted-by":"crossref","first-page":"3925","DOI":"10.1021\/acs.jcim.3c00054","article-title":"Attracting Cavities 2.0: Improving the Flexibility and Robustness for Small-Molecule Docking","volume":"63","author":"R\u00f6hrig","year":"2023","journal-title":"J. Chem. Inf. Model."},{"key":"10.1016\/j.celrep.2026.117449_bib45","doi-asserted-by":"crossref","first-page":"3891","DOI":"10.1021\/acs.jcim.1c00203","article-title":"AutoDock Vina 1.2.0: New Docking Methods, Expanded Force Field, and Python Bindings","volume":"61","author":"Eberhardt","year":"2021","journal-title":"J. Chem. Inf. Model."},{"key":"10.1016\/j.celrep.2026.117449_bib46","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1038\/nri1375","article-title":"Adhesion mechanisms regulating the migration of monocytes","volume":"4","author":"Imhof","year":"2004","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.celrep.2026.117449_bib47","doi-asserted-by":"crossref","first-page":"2378","DOI":"10.1172\/JCI116470","article-title":"Characterization of adhesive interactions between human endothelial cells and megakaryocytes","volume":"91","author":"Avraham","year":"1993","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.celrep.2026.117449_bib48","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1038\/1821373a0","article-title":"Detection of H\u00e6moglobin, H\u00e6moglobin\u2013Haptoglobin Complexes and other Substances with Peroxidase Activity after Zone Electrophoresis","volume":"182","author":"Owen","year":"1958","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2026.117449_bib49","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1038\/nprot.2017.016","article-title":"Genome-scale CRISPR-Cas9 knockout and transcriptional activation screening","volume":"12","author":"Joung","year":"2017","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.celrep.2026.117449_bib50","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1161\/CIRCRESAHA.123.322654","article-title":"Mitochondrial GSNOR Alleviates Cardiac Dysfunction via ANT1 Denitrosylation","volume":"133","author":"Tang","year":"2023","journal-title":"Circ. Res."},{"key":"10.1016\/j.celrep.2026.117449_bib51","doi-asserted-by":"crossref","first-page":"2068","DOI":"10.1016\/j.molcel.2025.04.018","article-title":"Emerging mechanisms underlying formaldehyde toxicity and response","volume":"85","author":"Valverde-Santiago","year":"2025","journal-title":"Mol. Cell"},{"key":"10.1016\/j.celrep.2026.117449_bib52","doi-asserted-by":"crossref","DOI":"10.1083\/jcb.202407141","article-title":"ALDH9A1 deficiency as a source of endogenous DNA damage that requires repair by the Fanconi anemia pathway","volume":"224","author":"Jung","year":"2025","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.celrep.2026.117449_bib53","first-page":"2372","article-title":"DNA polymerase theta protects leukemia cells from metabolically induced DNA damage","volume":"141","author":"Vekariya","year":"2023","journal-title":"Blood"},{"key":"10.1016\/j.celrep.2026.117449_bib54","doi-asserted-by":"crossref","first-page":"2152","DOI":"10.1038\/s41375-025-02687-3","article-title":"ADH5\/ALDH2 dehydrogenases and DNA polymerase theta protect normal and malignant hematopoietic cells from formaldehyde challenge: therapeutic implications","volume":"39","author":"Atkins","year":"2025","journal-title":"Leukemia"},{"key":"10.1016\/j.celrep.2026.117449_bib55","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2023.112428","article-title":"Fanconi anemia-associated chromosomal radial formation is dependent on POLtheta-mediated alternative end joining","volume":"42","author":"Rogers","year":"2023","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2026.117449_bib56","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1074\/mcp.M113.035600","article-title":"Analysis of the human tissue-specific expression by genome-wide integration of transcriptomics and antibody-based proteomics","volume":"13","author":"Fagerberg","year":"2014","journal-title":"Mol. Cell. Proteomics"},{"key":"10.1016\/j.celrep.2026.117449_bib57","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1126\/science.aaz1776","article-title":"The GTEx Consortium atlas of genetic regulatory effects across human tissues","volume":"369","author":"Consortium","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.celrep.2026.117449_bib58","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1126\/science.1211053","article-title":"Correction of sickle cell disease in adult mice by interference with fetal hemoglobin silencing","volume":"334","author":"Xu","year":"2011","journal-title":"Science"},{"key":"10.1016\/j.celrep.2026.117449_bib59","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1056\/NEJMoa2031054","article-title":"CRISPR-Cas9 Gene Editing for Sickle Cell Disease and \u03b2-Thalassemia","volume":"384","author":"Frangoul","year":"2021","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.celrep.2026.117449_bib60","doi-asserted-by":"crossref","first-page":"9594","DOI":"10.1074\/jbc.RA118.003320","article-title":"Reassignment of the human aldehyde dehydrogenase ALDH8A1 (ALDH12) to the kynurenine pathway in tryptophan catabolism","volume":"293","author":"Davis","year":"2018","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.celrep.2026.117449_bib61","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1126\/science.1247005","article-title":"Genome-Scale CRISPR-Cas9 Knockout Screening in Human Cells","volume":"343","author":"Shalem","year":"2014","journal-title":"Science"},{"key":"10.1016\/j.celrep.2026.117449_bib62","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1038\/nmeth.3047","article-title":"Improved vectors and genome-wide libraries for CRISPR screening","volume":"11","author":"Sanjana","year":"2014","journal-title":"Nat. Methods"},{"key":"10.1016\/j.celrep.2026.117449_bib63","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1186\/s12859-021-04344-9","article-title":"CellProfiler 4: improvements in speed, utility and usability","volume":"22","author":"Stirling","year":"2021","journal-title":"BMC Bioinf."},{"key":"10.1016\/j.celrep.2026.117449_bib64","doi-asserted-by":"crossref","first-page":"10118","DOI":"10.1128\/MCB.24.23.10118-10125.2004","article-title":"Ski negatively regulates erythroid differentiation through its interaction with GATA1","volume":"24","author":"Ueki","year":"2004","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.celrep.2026.117449_bib65","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1038\/cr.2007.72","article-title":"A critical role for the co-repressor N-CoR in erythroid differentiation and heme synthesis","volume":"17","author":"Zhang","year":"2007","journal-title":"Cell Res."},{"key":"10.1016\/j.celrep.2026.117449_bib66","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1038\/s41586-024-07487-w","article-title":"Accurate structure prediction of biomolecular interactions with AlphaFold 3","volume":"630","author":"Abramson","year":"2024","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2026.117449_bib67","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1002\/pro.3943","article-title":"UCSF ChimeraX: Structure visualization for researchers, educators, and developers","volume":"30","author":"Pettersen","year":"2021","journal-title":"Protein Sci."}],"container-title":["Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124726005279?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124726005279?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T04:29:18Z","timestamp":1790310558000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211124726005279"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":67,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["S2211124726005279"],"URL":"https:\/\/doi.org\/10.1016\/j.celrep.2026.117449","relation":{},"ISSN":["2211-1247"],"issn-type":[{"value":"2211-1247","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Enhanced formaldehyde clearance ameliorates differentiation-induced genotoxicity in Fanconi anemia mutant cells","name":"articletitle","label":"Article Title"},{"value":"Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.celrep.2026.117449","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"117449"}}