{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T05:00:56Z","timestamp":1790312456823,"version":"4.1.0"},"reference-count":89,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T00:00:00Z","timestamp":1778457600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["5U19MH114830-03"],"award-info":[{"award-number":["5U19MH114830-03"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["STI (Science, Technology, and Innovation) 2030-Major Projects ( 2021ZD0201002 )"],"award-info":[{"award-number":["STI (Science, Technology, and Innovation) 2030-Major Projects ( 2021ZD0201002 )"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100019274","name":"National Institute of Mental Health and Neurosciences","doi-asserted-by":"publisher","award":["5U19MH114830-03"],"award-info":[{"award-number":["5U19MH114830-03"]}],"id":[{"id":"10.13039\/100019274","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007835","name":"Wenzhou Medical University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007835","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017008","name":"Allen Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100017008","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001703","name":"Swiss Federal Institute of Technology Lausanne","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001703","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Reports"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.celrep.2026.117469","type":"journal-article","created":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T12:05:29Z","timestamp":1781611529000},"page":"117469","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Whole-neuron morphology and genetic identity define cell types and reveal principles of brain-wide connectivity"],"prefix":"10.1016","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5501-8433","authenticated-orcid":false,"given":"Yun","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsien-Chi","family":"Kuo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuli","family":"Kuang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shenqin","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phil","family":"Lesnar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lydia","family":"Ng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaoyao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laila","family":"El-Hifnawi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalie","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kasey","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric M.","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoav","family":"Ben-Simon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Song-Lin","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quanxin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Totte","family":"Karlsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Dalley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grace","family":"Williams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zili","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi-Feng","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Jie","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leila","family":"Ahmadinia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Walling-Bell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Andrade","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga","family":"Gliko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matt","family":"Mallory","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colin","family":"Farrel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ben","family":"Sutton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zizhen","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carliana","family":"Halterman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kara","family":"Ronellenfitch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luke","family":"Esposito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Sunkin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren","family":"Kruse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingming","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangning","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Qu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Mihalas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Zhuang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Staci","family":"Sorensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.celrep.2026.117469_bib1","doi-asserted-by":"crossref","first-page":"8441","DOI":"10.1523\/JNEUROSCI.1400-04.2004","article-title":"A quantitative map of the circuit of cat primary visual cortex","volume":"24","author":"Binzegger","year":"2004","journal-title":"J. Neurosci."},{"key":"10.1016\/j.celrep.2026.117469_bib2","doi-asserted-by":"crossref","first-page":"11174","DOI":"10.1523\/JNEUROSCI.2093-08.2008","article-title":"Excitatory local connections of superficial neurons in rat auditory cortex","volume":"28","author":"Barbour","year":"2008","journal-title":"J. Neurosci."},{"key":"10.1016\/j.celrep.2026.117469_bib3","volume":"2","author":"Ram\u00f3n y Cajal","year":"1911"},{"key":"10.1016\/j.celrep.2026.117469_bib4","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/0301-0082(92)90015-7","article-title":"The pyramidal neuron of the cerebral cortex: morphological and chemical characteristics of the synaptic inputs","volume":"39","author":"DeFelipe","year":"1992","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.celrep.2026.117469_bib5","first-page":"201","volume":"1","author":"Fair\u00e9n","year":"1984"},{"key":"10.1016\/j.celrep.2026.117469_bib6","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/j.cell.2015.09.029","article-title":"Reconstruction and Simulation of Neocortical Microcircuitry","volume":"163","author":"Markram","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2026.117469_bib7","doi-asserted-by":"crossref","first-page":"19","DOI":"10.3389\/neuro.01.1.1.002.2007","article-title":"Functional Maps of Neocortical Local Circuitry","volume":"1","author":"Thomson","year":"2007","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.celrep.2026.117469_bib8","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.ibror.2018.10.001","article-title":"A simplified morphological classification scheme for pyramidal cells in six layers of primary somatosensory cortex of juvenile rats","volume":"5","author":"Wang","year":"2018","journal-title":"IBRO Rep."},{"key":"10.1016\/j.celrep.2026.117469_bib9","doi-asserted-by":"crossref","first-page":"486","DOI":"10.4161\/cib.15670","article-title":"Semi-automated three-dimensional reconstructions of individual neurons reveal cell type-specific circuits in cortex","volume":"4","author":"Boudewijns","year":"2011","journal-title":"Commun. Integr. Biol."},{"key":"10.1016\/j.celrep.2026.117469_bib10","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1016\/j.neuron.2015.11.002","article-title":"Three Types of Cortical Layer 5 Neurons That Differ in Brain-wide Connectivity and Function","volume":"88","author":"Kim","year":"2015","journal-title":"Neuron"},{"key":"10.1016\/j.celrep.2026.117469_bib11","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1038\/nn1670","article-title":"Heterogeneity in the pyramidal network of the medial prefrontal cortex","volume":"9","author":"Wang","year":"2006","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.celrep.2026.117469_bib12","doi-asserted-by":"crossref","first-page":"1257803","DOI":"10.3389\/fncel.2023.1257803","article-title":"Structure and function of neocortical layer 6b","volume":"17","author":"Feldmeyer","year":"2023","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.celrep.2026.117469_bib13","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1111\/j.1469-7580.2007.00779.x","article-title":"The underside of the cerebral cortex: layer V\/VI spiny inverted neurons","volume":"211","author":"Mendizabal-Zubiaga","year":"2007","journal-title":"J. Anat."},{"key":"10.1016\/j.celrep.2026.117469_bib14","article-title":"Neocortical Layer 6, A Review","volume":"4","author":"Thomson","year":"2010","journal-title":"Front. Neuroanat."},{"key":"10.1016\/j.celrep.2026.117469_bib15","first-page":"41","article-title":"La corteza cerebral del rat\u00f3n (Primera contribuci\u00f3n: la corteza ac\u00fastica)","volume":"20","author":"Lorente de N\u00f3","year":"1922","journal-title":"Trab. Lab. Invest. Biol."},{"key":"10.1016\/j.celrep.2026.117469_bib16","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.neuron.2025.10.019","article-title":"Integrative analysis of single-neuron projectomes links connectome, transcriptome, and function in the mouse cortex","volume":"114","author":"Gao","year":"2026","journal-title":"Neuron"},{"key":"10.1016\/j.celrep.2026.117469_bib17","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1038\/s41593-022-01041-5","article-title":"Single-neuron projectome of mouse prefrontal cortex","volume":"25","author":"Gao","year":"2022","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.celrep.2026.117469_bib18","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1038\/s41592-025-02621-6","article-title":"Connectivity of single neurons classifies cell subtypes in mouse brains","volume":"22","author":"Liu","year":"2025","journal-title":"Nat. Methods"},{"key":"10.1016\/j.celrep.2026.117469_bib19","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.cell.2019.07.042","article-title":"Reconstruction of 1,000 Projection Neurons Reveals New Cell Types and Organization of Long-Range Connectivity in the Mouse Brain","volume":"179","author":"Winnubst","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2026.117469_bib20","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1038\/s41586-018-0654-5","article-title":"Shared and distinct transcriptomic cell types across neocortical areas","volume":"563","author":"Tasic","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2026.117469_bib21","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1038\/s41586-023-06823-w","article-title":"Brain-wide correspondence of neuronal epigenomics and distant projections","volume":"624","author":"Zhou","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2026.117469_bib22","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1038\/s41586-021-03500-8","article-title":"A transcriptomic and epigenomic cell atlas of the mouse primary motor cortex","volume":"598","author":"Yao","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2026.117469_bib23","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1038\/s41593-023-01339-y","article-title":"Single-neuron analysis of dendrites and axons reveals the network organization in mouse prefrontal cortex","volume":"26","author":"Gao","year":"2023","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.celrep.2026.117469_bib24","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1038\/s41586-023-06812-z","article-title":"A high-resolution transcriptomic and spatial atlas of cell types in the whole mouse brain","volume":"624","author":"Yao","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2026.117469_bib25","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1038\/s41586-021-03941-1","article-title":"Morphological diversity of single neurons in molecularly defined cell types","volume":"598","author":"Peng","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2026.117469_bib26","doi-asserted-by":"crossref","first-page":"1811","DOI":"10.1007\/s00429-022-02603-w","article-title":"Characterizing functional modules in the human thalamus: coactivation-based parcellation and systems-level functional decoding","volume":"228","author":"Boeken","year":"2023","journal-title":"Brain Struct. Funct."},{"key":"10.1016\/j.celrep.2026.117469_bib27","doi-asserted-by":"crossref","first-page":"41","DOI":"10.3389\/fnsys.2018.00041","article-title":"Functional Diversity of Thalamic Reticular Subnetworks","volume":"12","author":"Crabtree","year":"2018","journal-title":"Front. Syst. Neurosci."},{"key":"10.1016\/j.celrep.2026.117469_bib28","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1016\/j.tins.2016.08.001","article-title":"Thalamic Inhibition: Diverse Sources, Diverse Scales","volume":"39","author":"Halassa","year":"2016","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.celrep.2026.117469_bib29","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1038\/nn.3780","article-title":"A comprehensive thalamocortical projection map at the mesoscopic level","volume":"17","author":"Hunnicutt","year":"2014","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.celrep.2026.117469_bib30","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1146\/annurev.neuro.23.1.315","article-title":"Mechanisms of visual attention in the human cortex","volume":"23","author":"Kastner","year":"2000","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/j.celrep.2026.117469_bib31","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.neubiorev.2015.03.001","article-title":"The mediodorsal thalamus as a higher order thalamic relay nucleus important for learning and decision-making","volume":"54","author":"Mitchell","year":"2015","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.celrep.2026.117469_bib32","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1016\/j.neuron.2013.01.038","article-title":"Inhibition of mediodorsal thalamus disrupts thalamofrontal connectivity and cognition","volume":"77","author":"Parnaudeau","year":"2013","journal-title":"Neuron"},{"key":"10.1016\/j.celrep.2026.117469_bib33","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.brainresrev.2004.04.008","article-title":"The thalamic reticular nucleus: structure, function and concept","volume":"46","author":"Pinault","year":"2004","journal-title":"Brain Res. Brain Res. Rev."},{"key":"10.1016\/j.celrep.2026.117469_bib34","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1038\/s41593-021-00996-1","article-title":"Thalamic subnetworks as units of function","volume":"25","author":"Roy","year":"2022","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.celrep.2026.117469_bib35","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.1098\/rstb.2002.1161","article-title":"The role of the thalamus in the flow of information to the cortex","volume":"357","author":"Sherman","year":"2002","journal-title":"Philos. Trans. R. Soc. Lond. B Biol. Sci."},{"key":"10.1016\/j.celrep.2026.117469_bib36","doi-asserted-by":"crossref","first-page":"18156","DOI":"10.1073\/pnas.1114828108","article-title":"Properties of the thalamic projection from the posterior medial nucleus to primary and secondary somatosensory cortices in the mouse","volume":"108","author":"Viaene","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2026.117469_bib37","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.neuroscience.2024.10.034","article-title":"Thalamus and its functional connections with cortical regions contribute to complexity-dependent cognitive reasoning","volume":"562","author":"Wang","year":"2024","journal-title":"Neuroscience"},{"key":"10.1016\/j.celrep.2026.117469_bib38","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/S0165-0173(02)00181-9","article-title":"The intralaminar and midline nuclei of the thalamus. Anatomical and functional evidence for participation in processes of arousal and awareness","volume":"39","author":"Van der Werf","year":"2002","journal-title":"Brain Res. Brain Res. Rev."},{"key":"10.1016\/j.celrep.2026.117469_bib39","doi-asserted-by":"crossref","DOI":"10.1523\/JNEUROSCI.0909-24.2024","article-title":"Transthalamic Pathways for Cortical Function","volume":"44","author":"Sherman","year":"2024","journal-title":"J. Neurosci."},{"key":"10.1016\/j.celrep.2026.117469_bib40","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1016\/j.neuron.2019.06.005","article-title":"Thalamocortical Circuit Motifs: A General Framework","volume":"103","author":"Halassa","year":"2019","journal-title":"Neuron"},{"key":"10.1016\/j.celrep.2026.117469_bib41","doi-asserted-by":"crossref","first-page":"4317","DOI":"10.1038\/s41467-018-06928-1","article-title":"Author Correction: Topographic precision in sensory and motor corticostriatal projections varies across cell type and cortical area","volume":"9","author":"Hooks","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2026.117469_bib42","doi-asserted-by":"crossref","first-page":"4689","DOI":"10.1073\/pnas.1814144116","article-title":"Multimodal gradients across mouse cortex","volume":"116","author":"Fulcher","year":"2019","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2026.117469_bib43","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1038\/s41586-019-1716-z","article-title":"Hierarchical organization of cortical and thalamic connectivity","volume":"575","author":"Harris","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2026.117469_bib44","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1038\/s42003-023-05629-w","article-title":"Mapping and comparing fMRI connectivity networks across species","volume":"6","author":"Pagani","year":"2023","journal-title":"Commun. Biol."},{"key":"10.1016\/j.celrep.2026.117469_bib45","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/cercor\/1.1.1","article-title":"Distributed hierarchical processing in the primate cerebral cortex","volume":"1","author":"Felleman","year":"1991","journal-title":"Cereb. Cortex"},{"key":"10.1016\/j.celrep.2026.117469_bib46","doi-asserted-by":"crossref","DOI":"10.1098\/rstb.2019.0319","article-title":"'Hierarchy' in the organization of brain networks","volume":"375","author":"Hilgetag","year":"2020","journal-title":"Philos. Trans. R. Soc. Lond. B Biol. Sci."},{"key":"10.1016\/j.celrep.2026.117469_bib47","doi-asserted-by":"crossref","first-page":"4607","DOI":"10.1093\/cercor\/bhaa063","article-title":"Hierarchy of Connectivity-Function Relationship of the Human Cortex Revealed through Predicting Activity across Functional Domains","volume":"30","author":"Wu","year":"2020","journal-title":"Cereb. Cortex"},{"key":"10.1016\/j.celrep.2026.117469_bib48","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1038\/s41593-022-01219-x","article-title":"A whole-brain monosynaptic input connectome to neuron classes in mouse visual cortex","volume":"26","author":"Yao","year":"2023","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.celrep.2026.117469_bib49","article-title":"Regional and cell-type-specific afferent and efferent projections of the mouse claustrum","volume":"42","author":"Wang","year":"2023","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2026.117469_bib50","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2023.1194299","article-title":"Possible rodent equivalent of the posterior cingulate cortex (area 23) interconnects with multimodal cortical and subcortical regions","volume":"17","author":"Xiang","year":"2023","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.celrep.2026.117469_bib51","doi-asserted-by":"crossref","first-page":"0470","DOI":"10.34133\/research.0470","article-title":"From Individual to Population: Circuit Organization of Pyramidal Tract and Intratelencephalic Neurons in Mouse Sensorimotor Cortex","volume":"7","author":"Yao","year":"2024","journal-title":"Research"},{"key":"10.1016\/j.celrep.2026.117469_bib52","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1038\/s41586-023-06569-5","article-title":"Spatial atlas of the mouse central nervous system at molecular resolution","volume":"622","author":"Shi","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2026.117469_bib53","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1038\/nature05453","article-title":"Genome-wide atlas of gene expression in the adult mouse brain","volume":"445","author":"Lein","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2026.117469_bib54","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1146\/annurev.neuro.27.070203.144152","article-title":"Neuronal circuits of the neocortex","volume":"27","author":"Douglas","year":"2004","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/j.celrep.2026.117469_bib55","doi-asserted-by":"crossref","first-page":"1622","DOI":"10.1126\/science.1124593","article-title":"Cortex is driven by weak but synchronously active thalamocortical synapses","volume":"312","author":"Bruno","year":"2006","journal-title":"Science"},{"key":"10.1016\/j.celrep.2026.117469_bib56","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1038\/nature12654","article-title":"Cortical connectivity and sensory coding","volume":"503","author":"Harris","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2026.117469_bib57","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1038\/nature10835","article-title":"Gain control by layer six in cortical circuits of vision","volume":"483","author":"Olsen","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2026.117469_bib58","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1146\/annurev-vision-101322-012348","article-title":"The Role of Layer 6 Corticothalamic Circuits in Vision: Plasticity, Sensory Processing, and Behavior","volume":"11","author":"Katzner","year":"2025","journal-title":"Annu. Rev. Vis. Sci."},{"key":"10.1016\/j.celrep.2026.117469_bib59","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.neuron.2011.06.027","article-title":"Cognitive and Perceptual Functions of the Visual Thalamus","volume":"71","author":"Saalmann","year":"2011","journal-title":"Neuron"},{"key":"10.1016\/j.celrep.2026.117469_bib60","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1016\/j.neuron.2012.10.038","article-title":"Canonical microcircuits for predictive coding","volume":"76","author":"Bastos","year":"2012","journal-title":"Neuron"},{"key":"10.1016\/j.celrep.2026.117469_bib61","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/bs.irn.2020.11.008","article-title":"Secondary motor cortex: Broadcasting and biasing animal's decisions through long-range circuits","volume":"158","author":"Yang","year":"2021","journal-title":"Int. Rev. Neurobiol."},{"key":"10.1016\/j.celrep.2026.117469_bib62","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1038\/nn.4332","article-title":"The mouse cortico-striatal projectome","volume":"19","author":"Hintiryan","year":"2016","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.celrep.2026.117469_bib63","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1016\/j.cell.2014.02.023","article-title":"Neural networks of the mouse neocortex","volume":"156","author":"Zingg","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2026.117469_bib64","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.neuron.2013.10.020","article-title":"Flow of cortical activity underlying a tactile decision in mice","volume":"81","author":"Guo","year":"2014","journal-title":"Neuron"},{"key":"10.1016\/j.celrep.2026.117469_bib65","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1038\/nature14178","article-title":"A motor cortex circuit for motor planning and movement","volume":"519","author":"Li","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2026.117469_bib66","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.19103","article-title":"A comprehensive excitatory input map of the striatum reveals novel functional organization","volume":"5","author":"Hunnicutt","year":"2016","journal-title":"eLife"},{"key":"10.1016\/j.celrep.2026.117469_bib67","article-title":"Whole-brain mapping of inputs to projection neurons and cholinergic interneurons in the dorsal striatum","volume":"10","author":"Guo","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.celrep.2026.117469_bib68","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/S0006-8993(00)02905-X","article-title":"Cerebral hemisphere regulation of motivated behavior","volume":"886","author":"Swanson","year":"2000","journal-title":"Brain Res."},{"key":"10.1016\/j.celrep.2026.117469_bib69","doi-asserted-by":"crossref","first-page":"5112","DOI":"10.1038\/s41467-025-60078-9","article-title":"Concept transfer of synaptic diversity from biological to artificial neural networks","volume":"16","author":"Hofmann","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2026.117469_bib70","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1038\/s41586-024-07939-3","article-title":"Connectome-constrained networks predict neural activity across the fly visual system","volume":"634","author":"Lappalainen","year":"2024","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2026.117469_bib71","doi-asserted-by":"crossref","DOI":"10.1016\/j.neubiorev.2025.106524","article-title":"On biological and artificial consciousness: A case for biological computationalism","volume":"181","author":"Milinkovic","year":"2026","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.celrep.2026.117469_bib72","doi-asserted-by":"crossref","DOI":"10.3389\/fncom.2023.1092185","article-title":"Distinctive properties of biological neural networks and recent advances in bottom-up approaches toward a better biologically plausible neural network","volume":"17","author":"Jeon","year":"2023","journal-title":"Front. Comput. Neurosci."},{"key":"10.1016\/j.celrep.2026.117469_bib73","doi-asserted-by":"crossref","first-page":"e68","DOI":"10.1371\/journal.pbio.0030068","article-title":"Highly nonrandom features of synaptic connectivity in local cortical circuits","volume":"3","author":"Song","year":"2005","journal-title":"PLoS Biol."},{"key":"10.1016\/j.celrep.2026.117469_bib74","doi-asserted-by":"crossref","first-page":"5419","DOI":"10.1073\/pnas.1016051108","article-title":"A synaptic organizing principle for cortical neuronal groups","volume":"108","author":"Perin","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2026.117469_bib75","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1523\/JNEUROSCI.03-05-01116.1983","article-title":"Clustered intrinsic connections in cat visual cortex","volume":"3","author":"Gilbert","year":"1983","journal-title":"J. Neurosci."},{"key":"10.1016\/j.celrep.2026.117469_bib76","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1093\/cercor\/13.1.5","article-title":"Interlaminar connections in the neocortex","volume":"13","author":"Thomson","year":"2003","journal-title":"Cereb. Cortex"},{"key":"10.1016\/j.celrep.2026.117469_bib77","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1152\/jn.1998.79.2.567","article-title":"Sharp, local synchrony among putative feed-forward inhibitory interneurons of rabbit somatosensory cortex","volume":"79","author":"Swadlow","year":"1998","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.celrep.2026.117469_bib78","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/S0165-0270(97)00176-3","article-title":"Neocortical efferent neurons with very slowly conducting axons: strategies for reliable antidromic identification","volume":"79","author":"Swadlow","year":"1998","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.celrep.2026.117469_bib79","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1093\/cercor\/bhs358","article-title":"The cell-type specific cortical microcircuit: relating structure and activity in a full-scale spiking network model","volume":"24","author":"Potjans","year":"2014","journal-title":"Cereb. Cortex"},{"key":"10.1016\/j.celrep.2026.117469_bib80","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/j.neuron.2020.01.040","article-title":"Systematic Integration of Structural and Functional Data into Multi-scale Models of Mouse Primary Visual Cortex","volume":"106","author":"Billeh","year":"2020","journal-title":"Neuron"},{"key":"10.1016\/j.celrep.2026.117469_bib81","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1016\/j.neuron.2021.03.011","article-title":"Enhancer viruses for combinatorial cell-subclass-specific labeling","volume":"109","author":"Graybuck","year":"2021","journal-title":"Neuron"},{"key":"10.1016\/j.celrep.2026.117469_bib82","article-title":"Connecting single-cell transcriptomes to projectomes in mouse visual cortex","author":"Sorensen","year":"2023","journal-title":"bioRxiv"},{"key":"10.1016\/j.celrep.2026.117469_bib83","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2021.108709","article-title":"Chemical sectioning fluorescence tomography: high-throughput, high-contrast, multicolor, whole-brain imaging at subcellular resolution","volume":"34","author":"Wang","year":"2021","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2026.117469_bib84","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.68967","article-title":"Spatially patterned excitatory neuron subtypes and projections of the claustrum","volume":"10","author":"Erwin","year":"2021","journal-title":"eLife"},{"key":"10.1016\/j.celrep.2026.117469_bib85","doi-asserted-by":"crossref","first-page":"7830","DOI":"10.1038\/s41467-025-63138-2","article-title":"A spatial single-cell atlas of the claustro-insular region uncovers key regulators of neuronal identity and excitability","volume":"16","author":"Fodoulian","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2026.117469_bib86","doi-asserted-by":"crossref","first-page":"2139","DOI":"10.1038\/s41598-020-59042-y","article-title":"A Robust Image Registration Interface for Large Volume Brain Atlas","volume":"10","author":"Ni","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.celrep.2026.117469_bib87","series-title":"Physics augmented Classification of fNIRS Signals 375-405","author":"Orihuela-Espina","year":"2022"},{"key":"10.1016\/j.celrep.2026.117469_bib88","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1146\/annurev-neuro-071714-033936","article-title":"General cortical and special prefrontal connections: principles from structure to function","volume":"38","author":"Barbas","year":"2015","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/j.celrep.2026.117469_bib89","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1038\/nrn2286","article-title":"Pyramidal neurons: dendritic structure and synaptic integration","volume":"9","author":"Spruston","year":"2008","journal-title":"Nat. Rev. Neurosci."}],"container-title":["Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124726005474?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124726005474?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T04:48:21Z","timestamp":1790311701000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211124726005474"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":89,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["S2211124726005474"],"URL":"https:\/\/doi.org\/10.1016\/j.celrep.2026.117469","relation":{},"ISSN":["2211-1247"],"issn-type":[{"value":"2211-1247","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Whole-neuron morphology and genetic identity define cell types and reveal principles of brain-wide connectivity","name":"articletitle","label":"Article Title"},{"value":"Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.celrep.2026.117469","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"117469"}}