{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T05:58:32Z","timestamp":1790315912400,"version":"4.1.0"},"reference-count":49,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T00:00:00Z","timestamp":1778716800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82573026"],"award-info":[{"award-number":["82573026"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82273223"],"award-info":[{"award-number":["82273223"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32270798"],"award-info":[{"award-number":["32270798"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003347","name":"Fudan University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFC3603300"],"award-info":[{"award-number":["2023YFC3603300"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFA1103900"],"award-info":[{"award-number":["2022YFA1103900"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Reports"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.celrep.2026.117487","type":"journal-article","created":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T19:18:40Z","timestamp":1780427920000},"page":"117487","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["LKB1 inactivation elicits an NNMT-mediated methyl sink and confers dependence on PRMT5 in lung cancer"],"prefix":"10.1016","volume":"45","author":[{"given":"Wen","family":"Mi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyi","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Xue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liucheng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xincheng","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinlei","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yijia","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingzhi","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guanlin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongbin","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyuan","family":"Tong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pingyu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2603-1548","authenticated-orcid":false,"given":"Fuming","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.celrep.2026.117487_bib1","first-page":"12","article-title":"Cancer statistics, 2024","volume":"74","author":"Siegel","year":"2024","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.celrep.2026.117487_bib2","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1038\/nature13385","article-title":"Comprehensive molecular profiling of lung adenocarcinoma","volume":"511","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2026.117487_bib3","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1038\/nature06030","article-title":"LKB1 modulates lung cancer differentiation and metastasis","volume":"448","author":"Ji","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2026.117487_bib4","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1016\/j.ccell.2015.04.001","article-title":"LKB1 Inactivation Elicits a Redox Imbalance to Modulate Non-small Cell Lung Cancer Plasticity and Therapeutic Response","volume":"27","author":"Li","year":"2015","journal-title":"Cancer Cell"},{"key":"10.1016\/j.celrep.2026.117487_bib5","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1038\/nature10937","article-title":"A murine lung cancer co-clinical trial identifies genetic modifiers of therapeutic response","volume":"483","author":"Chen","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2026.117487_bib6","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.ccell.2024.01.012","article-title":"Adeno-to-squamous transition drives resistance to KRAS inhibition in LKB1 mutant lung cancer","volume":"42","author":"Tong","year":"2024","journal-title":"Cancer Cell"},{"key":"10.1016\/j.celrep.2026.117487_bib7","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1158\/2159-8290.CD-14-1236","article-title":"Co-occurring genomic alterations define major subsets of KRAS-mutant lung adenocarcinoma with distinct biology, immune profiles, and therapeutic vulnerabilities","volume":"5","author":"Skoulidis","year":"2015","journal-title":"Cancer Discov."},{"key":"10.1016\/j.celrep.2026.117487_bib8","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1158\/2159-8290.CD-18-0099","article-title":"STK11\/LKB1 Mutations and PD-1 Inhibitor Resistance in KRAS-Mutant Lung Adenocarcinoma","volume":"8","author":"Skoulidis","year":"2018","journal-title":"Cancer Discov."},{"key":"10.1016\/j.celrep.2026.117487_bib9","doi-asserted-by":"crossref","first-page":"6502","DOI":"10.1158\/0008-5472.CAN-12-1909","article-title":"The CRTC1-NEDD9 signaling axis mediates lung cancer progression caused by LKB1 loss","volume":"72","author":"Feng","year":"2012","journal-title":"Cancer Res."},{"key":"10.1016\/j.celrep.2026.117487_bib10","doi-asserted-by":"crossref","first-page":"18892","DOI":"10.1073\/pnas.1004952107","article-title":"LKB1 inhibits lung cancer progression through lysyl oxidase and extracellular matrix remodeling","volume":"107","author":"Gao","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2026.117487_bib11","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1038\/nrc2676","article-title":"The LKB1-AMPK pathway: metabolism and growth control in tumour suppression","volume":"9","author":"Shackelford","year":"2009","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.celrep.2026.117487_bib12","doi-asserted-by":"crossref","first-page":"2554","DOI":"10.1073\/pnas.1312570111","article-title":"Loss of the tumor suppressor LKB1 promotes metabolic reprogramming of cancer cells via HIF-1alpha","volume":"111","author":"Faubert","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2026.117487_bib13","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.ccr.2012.12.008","article-title":"LKB1 inactivation dictates therapeutic response of non-small cell lung cancer to the metabolism drug phenformin","volume":"23","author":"Shackelford","year":"2013","journal-title":"Cancer Cell"},{"key":"10.1016\/j.celrep.2026.117487_bib14","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1038\/nature11066","article-title":"AMPK regulates NADPH homeostasis to promote tumour cell survival during energy stress","volume":"485","author":"Jeon","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2026.117487_bib15","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1038\/nature22359","article-title":"CPS1 maintains pyrimidine pools and DNA synthesis in KRAS\/LKB1-mutant lung cancer cells","volume":"546","author":"Kim","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2026.117487_bib16","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1038\/s42255-020-00316-0","article-title":"The hexosamine biosynthesis pathway is a targetable liability in KRAS\/LKB1 mutant lung cancer","volume":"2","author":"Kim","year":"2020","journal-title":"Nat. Metab."},{"key":"10.1016\/j.celrep.2026.117487_bib17","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1038\/s42255-024-01066-z","article-title":"Concurrent loss of LKB1 and KEAP1 enhances SHMT-mediated antioxidant defence in KRAS-mutant lung cancer","volume":"6","author":"Lee","year":"2024","journal-title":"Nat. Metab."},{"key":"10.1016\/j.celrep.2026.117487_bib18","doi-asserted-by":"crossref","first-page":"199","DOI":"10.15698\/cst2020.08.228","article-title":"PRMT5 function and targeting in cancer","volume":"4","author":"Kim","year":"2020","journal-title":"Cell Stress"},{"key":"10.1016\/j.celrep.2026.117487_bib19","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1126\/science.aad5944","article-title":"Disordered methionine metabolism in MTAP\/CDKN2A-deleted cancers leads to dependence on PRMT5","volume":"351","author":"Mavrakis","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.celrep.2026.117487_bib20","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1126\/science.aad5214","article-title":"MTAP deletion confers enhanced dependency on the PRMT5 arginine methyltransferase in cancer cells","volume":"351","author":"Kryukov","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.celrep.2026.117487_bib21","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1016\/j.celrep.2016.03.043","article-title":"MTAP Deletions in Cancer Create Vulnerability to Targeting of the MAT2A\/PRMT5\/RIOK1 Axis","volume":"15","author":"Marjon","year":"2016","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2026.117487_bib22","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1038\/nchembio.1204","article-title":"NNMT promotes epigenetic remodeling in cancer by creating a metabolic methylation sink","volume":"9","author":"Ulanovskaya","year":"2013","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.celrep.2026.117487_bib23","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1038\/s43018-021-00259-9","article-title":"Proteogenomics of non-small cell lung cancer reveals molecular subtypes associated with specific therapeutic targets and immune evasion mechanisms","volume":"2","author":"Lehti\u00f6","year":"2021","journal-title":"Nat. Cancer"},{"key":"10.1016\/j.celrep.2026.117487_bib24","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.cell.2020.06.012","article-title":"Proteogenomics of Non-smoking Lung Cancer in East Asia Delineates Molecular Signatures of Pathogenesis and Progression","volume":"182","author":"Chen","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2026.117487_bib25","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.aaw6455","article-title":"The CREB coactivator CRTC2 promotes oncogenesis in LKB1-mutant non-small cell lung cancer","volume":"5","author":"Rod\u00f3n","year":"2019","journal-title":"Sci. Adv."},{"key":"10.1016\/j.celrep.2026.117487_bib26","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1038\/s41467-021-21204-5","article-title":"PRMT5 inhibition disrupts splicing and stemness in glioblastoma","volume":"12","author":"Sachamitr","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2026.117487_bib27","doi-asserted-by":"crossref","first-page":"2643","DOI":"10.1016\/j.celrep.2018.08.002","article-title":"PRMT5 Regulates DNA Repair by Controlling the Alternative Splicing of Histone-Modifying Enzymes","volume":"24","author":"Hamard","year":"2018","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2026.117487_bib28","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1038\/s43018-023-00671-3","article-title":"Blocking methionine catabolism induces senescence and confers vulnerability to GSK3 inhibition in liver cancer","volume":"5","author":"Li","year":"2024","journal-title":"Nat. Cancer"},{"key":"10.1016\/j.celrep.2026.117487_bib29","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1038\/s41586-019-1607-3","article-title":"Inducing and exploiting vulnerabilities for the treatment of liver cancer","volume":"574","author":"Wang","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2026.117487_bib30","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1038\/s41586-018-0543-y","article-title":"Clearance of senescent glial cells prevents tau-dependent pathology and cognitive decline","volume":"562","author":"Bussian","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2026.117487_bib31","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1111\/acel.12445","article-title":"Identification of a novel senolytic agent, navitoclax, targeting the Bcl-2 family of anti-apoptotic factors","volume":"15","author":"Zhu","year":"2016","journal-title":"Aging Cell"},{"key":"10.1016\/j.celrep.2026.117487_bib32","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1038\/s43018-021-00208-6","article-title":"ULK1 inhibition overcomes compromised antigen presentation and restores antitumor immunity in LKB1 mutant lung cancer","volume":"2","author":"Deng","year":"2021","journal-title":"Nat. Cancer"},{"key":"10.1016\/j.celrep.2026.117487_bib33","doi-asserted-by":"crossref","first-page":"1942","DOI":"10.1016\/j.chembiol.2024.08.003","article-title":"A chemical screen identifies PRMT5 as a therapeutic vulnerability for paclitaxel-resistant triple-negative breast cancer","volume":"31","author":"Zhang","year":"2024","journal-title":"Cell Chem. Biol."},{"key":"10.1016\/j.celrep.2026.117487_bib34","doi-asserted-by":"crossref","DOI":"10.1172\/JCI175023","article-title":"PRMT5-mediated FUBP1 methylation accelerates prostate cancer progression","volume":"134","author":"Yan","year":"2024","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.celrep.2026.117487_bib35","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1136\/gutjnl-2024-332998","article-title":"Identification of PRMT5 as a therapeutic target in cholangiocarcinoma","volume":"74","author":"Elurbide","year":"2024","journal-title":"Gut"},{"key":"10.1016\/j.celrep.2026.117487_bib36","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1038\/s41556-025-01610-3","article-title":"PRMT5-mediated arginine methylation stabilizes GPX4 to suppress ferroptosis in cancer","volume":"27","author":"Fan","year":"2025","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.celrep.2026.117487_bib37","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1158\/2159-8290.CD-24-0887","article-title":"AMG 193, a Clinical Stage MTA-Cooperative PRMT5 Inhibitor, Drives Antitumor Activity Preclinically and in Patients With MTAP-Deleted Cancers","volume":"15","author":"Belmontes","year":"2025","journal-title":"Cancer Discov."},{"key":"10.1016\/j.celrep.2026.117487_bib38","doi-asserted-by":"crossref","first-page":"2412","DOI":"10.1158\/2159-8290.CD-23-0669","article-title":"MRTX1719 Is an MTA-Cooperative PRMT5 Inhibitor That Exhibits Synthetic Lethality in Preclinical Models and Patients with MTAP-Deleted Cancer","volume":"13","author":"Engstrom","year":"2023","journal-title":"Cancer Discov."},{"key":"10.1016\/j.celrep.2026.117487_bib39","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1002\/ijc.31909","article-title":"LKB1 regulates PRMT5 activity in breast cancer","volume":"144","author":"Lattouf","year":"2019","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.celrep.2026.117487_bib40","doi-asserted-by":"crossref","first-page":"2287","DOI":"10.1038\/s41467-024-46495-2","article-title":"PRMT5 is an actionable therapeutic target in CDK4\/6 inhibitor-resistant ER+\/RB-deficient breast cancer","volume":"15","author":"Lin","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2026.117487_bib41","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1038\/s41586-025-09303-5","article-title":"NNMT inhibition in cancer-associated fibroblasts restores antitumour immunity","volume":"645","author":"Heide","year":"2025","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2026.117487_bib42","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1038\/s41586-019-1173-8","article-title":"Proteomics reveals NNMT as a master metabolic regulator of cancer-associated fibroblasts","volume":"569","author":"Eckert","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2026.117487_bib43","article-title":"PRMT blockade induces defective DNA replication stress response and synergizes with PARP inhibition","volume":"4","author":"Li","year":"2023","journal-title":"Cell Rep. Med."},{"key":"10.1016\/j.celrep.2026.117487_bib44","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aaz5683","article-title":"PRMT5 control of cGAS\/STING and NLRC5 pathways defines melanoma response to antitumor immunity","volume":"12","author":"Kim","year":"2020","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.celrep.2026.117487_bib45","article-title":"BET inhibition induces GDH1-dependent glutamine metabolic remodeling and vulnerability in liver cancer","volume":"3","author":"Mi Wen","year":"2024","journal-title":"Life Metabolism"},{"key":"10.1016\/j.celrep.2026.117487_bib46","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.molcel.2025.12.001","article-title":"Mitochondrial glutamine import sustains electron transport chain integrity independently of glutaminolysis in cancer","volume":"86","author":"Zhu","year":"2026","journal-title":"Mol. Cell"},{"key":"10.1016\/j.celrep.2026.117487_bib47","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1038\/s42255-026-01455-6","article-title":"SLC6A6 imports taurine into mitochondria to sustain mitochondrial translation and tumour growth","volume":"8","author":"Li","year":"2026","journal-title":"Nat. Metab."},{"key":"10.1016\/j.celrep.2026.117487_bib48","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1038\/s41589-025-02013-z","article-title":"alpha-Ketoglutarate dictates AMPK protein synthesis for energy sensing in human cancers","volume":"22","author":"Mi","year":"2025","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.celrep.2026.117487_bib49","doi-asserted-by":"crossref","first-page":"2071","DOI":"10.1038\/s41467-025-57334-3","article-title":"ACSS2 drives senescence-associated secretory phenotype by limiting purine biosynthesis through PAICS acetylation","volume":"16","author":"Yang","year":"2025","journal-title":"Nat. Commun."}],"container-title":["Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124726005656?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124726005656?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T04:59:48Z","timestamp":1790312388000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211124726005656"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":49,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["S2211124726005656"],"URL":"https:\/\/doi.org\/10.1016\/j.celrep.2026.117487","relation":{},"ISSN":["2211-1247"],"issn-type":[{"value":"2211-1247","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"LKB1 inactivation elicits an NNMT-mediated methyl sink and confers dependence on PRMT5 in lung cancer","name":"articletitle","label":"Article Title"},{"value":"Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.celrep.2026.117487","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"117487"}}