{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T22:09:59Z","timestamp":1791497399063,"version":"4.3.4"},"reference-count":47,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T00:00:00Z","timestamp":1780012800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000009","name":"Foundation for the National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["5R01CA258427-02"],"award-info":[{"award-number":["5R01CA258427-02"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DP2CA228044"],"award-info":[{"award-number":["DP2CA228044"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005492","name":"Stanford University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005492","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100032560","name":"Arc Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100032560","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Reports"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.celrep.2026.117580","type":"journal-article","created":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T12:06:44Z","timestamp":1782130004000},"page":"117580","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Activation-induced SLC7A1 expression enhances T cell sensitivity to cGAMP-mediated STING signaling"],"prefix":"10.1016","volume":"45","author":[{"given":"Valentino","family":"Sudaryo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dayanne R.","family":"Carvalho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacqueline A.","family":"Carozza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xujun","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Courtney","family":"Kernick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony F.","family":"Cordova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Michelle","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theodore L.","family":"Roth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4386-7926","authenticated-orcid":false,"given":"Lingyin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.celrep.2026.117580_bib1","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1038\/nature25432","article-title":"Chromosomal Instability Drives Metastasis through a Cytosolic DNA Response","volume":"553","author":"Bakhoum","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2026.117580_bib2","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.immuni.2017.07.016","article-title":"Dendritic Cells but Not Macrophages Sense Tumor Mitochondrial DNA for Cross-Priming through Signal Regulatory Protein \u03b1 Signaling","volume":"47","author":"Xu","year":"2017","journal-title":"Immunity"},{"key":"10.1016\/j.celrep.2026.117580_bib3","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1038\/s41586-019-1763-5","article-title":"Circular ecDNA Promotes Accessible Chromatin and High Oncogene Expression","volume":"575","author":"Wu","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2026.117580_bib4","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2103585118","article-title":"Chromatin Bridges, Not Micronuclei, Activate cGAS after Drug-Induced Mitotic Errors in Human Cells","volume":"118","author":"Flynn","year":"2021","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2026.117580_bib5","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1146\/annurev-biochem-040320-101629","article-title":"Biochemistry, Cell Biology, and Pathophysiology of the Innate Immune cGAS-cGAMP-STING Pathway","volume":"91","author":"Ritchie","year":"2022","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.celrep.2026.117580_bib6","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1038\/s43018-020-0028-4","article-title":"Extracellular cGAMP Is a Cancer-Cell-Produced Immunotransmitter Involved in Radiation-Induced Anticancer Immunity","volume":"1","author":"Carozza","year":"2020","journal-title":"Nat. Cancer"},{"key":"10.1016\/j.celrep.2026.117580_bib7","doi-asserted-by":"crossref","first-page":"1799","DOI":"10.1016\/j.immuni.2022.08.006","article-title":"ABCC1 Transporter Exports the Immunostimulatory Cyclic Dinucleotide cGAMP","volume":"55","author":"Maltbaek","year":"2022","journal-title":"Immunity"},{"key":"10.1016\/j.celrep.2026.117580_bib8","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1016\/j.molcel.2020.10.021","article-title":"LRRC8A:C\/E Heteromeric Channels Are Ubiquitous Transporters of cGAMP","volume":"80","author":"Lahey","year":"2020","journal-title":"Mol. Cell"},{"key":"10.1016\/j.celrep.2026.117580_bib9","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1021\/acscentsci.1c00440","article-title":"Human SLC46A2 Is the Dominant cGAMP Importer in Extracellular cGAMP-Sensing Macrophages and Monocytes","volume":"7","author":"Cordova","year":"2021","journal-title":"ACS Cent. Sci."},{"key":"10.1016\/j.celrep.2026.117580_bib10","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2313693120","article-title":"ENPP1 Is an Innate Immune Checkpoint of the Anticancer cGAMP\u2013STING Pathway in Breast Cancer","volume":"120","author":"Wang","year":"2023","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2026.117580_bib11","doi-asserted-by":"crossref","first-page":"15408","DOI":"10.1073\/pnas.1512832112","article-title":"STING Activation of Tumor Endothelial Cells Initiates Spontaneous and Therapeutic Antitumor Immunity","volume":"112","author":"Demaria","year":"2015","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2026.117580_bib12","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1007\/s00262-017-1975-1","article-title":"Intratumoral Administration of cGAMP Transiently Accumulates Potent Macrophages for Anti-Tumor Immunity at a Mouse Tumor Site","volume":"66","author":"Ohkuri","year":"2017","journal-title":"Cancer Immunol. Immunother."},{"key":"10.1016\/j.celrep.2026.117580_bib13","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1038\/nchembio.1661","article-title":"Hydrolysis of 2\u20323\u2032-cGAMP by ENPP1 and Design of Non-Hydrolyzable Analogs","volume":"10","author":"Li","year":"2014","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.celrep.2026.117580_bib14","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1016\/j.celrep.2015.04.031","article-title":"Direct Activation of STING in the Tumor Microenvironment Leads to Potent and Systemic Tumor Regression and Immunity","volume":"11","author":"Corrales","year":"2015","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2026.117580_bib15","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1038\/s41586-018-0705-y","article-title":"Design of Amidobenzimidazole STING Receptor Agonists with Systemic Activity","volume":"564","author":"Ramanjulu","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2026.117580_bib16","doi-asserted-by":"crossref","DOI":"10.1126\/science.aba6098","article-title":"An Orally Available Non-Nucleotide STING Agonist with Antitumor Activity","volume":"369","author":"Pan","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.celrep.2026.117580_bib17","doi-asserted-by":"crossref","first-page":"3074","DOI":"10.1016\/j.celrep.2018.11.047","article-title":"Magnitude of Therapeutic STING Activation Determines CD8+ T Cell-Mediated Anti-Tumor Immunity","volume":"25","author":"Sivick","year":"2018","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2026.117580_bib18","doi-asserted-by":"crossref","first-page":"397","DOI":"10.4049\/jimmunol.1601999","article-title":"Activation of STING in T Cells Induces Type I IFN Responses and Cell Death","volume":"199","author":"Larkin","year":"2017","journal-title":"J. Immunol."},{"key":"10.1016\/j.celrep.2026.117580_bib19","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.immuni.2020.06.009","article-title":"Interferon-Independent Activities of Mammalian STING Mediate Antiviral Response and Tumor Immune Evasion","volume":"53","author":"Wu","year":"2020","journal-title":"Immunity"},{"key":"10.1016\/j.celrep.2026.117580_bib20","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1038\/s41590-021-01105-x","article-title":"The Volume-Regulated Anion Channel LRRC8C Suppresses T Cell Function by Regulating Cyclic Dinucleotide Transport and STING\u2013P53 Signaling","volume":"23","author":"Concepcion","year":"2022","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.celrep.2026.117580_bib21","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2022-005151","article-title":"Cell-Intrinsic STING Signaling Promotes Regulatory T Cell Induction and Immunosuppression by Upregulating FOXP3 Transcription in Cervical Cancer","volume":"10","author":"Ni","year":"2022","journal-title":"J. Immunother. Cancer"},{"key":"10.1016\/j.celrep.2026.117580_bib22","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2205049120","article-title":"STING Controls T Cell Memory Fitness during Infection through T Cell-Intrinsic and IDO-Dependent Mechanisms","volume":"120","author":"Quaney","year":"2023","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2026.117580_bib23","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1038\/s41467-017-00573-w","article-title":"Signalling Strength Determines Proapoptotic Functions of STING","volume":"8","author":"Gulen","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2026.117580_bib24","doi-asserted-by":"crossref","first-page":"1769","DOI":"10.1084\/jem.20161674","article-title":"Intrinsic Antiproliferative Activity of the Innate Sensor STING in T Lymphocytes","volume":"214","author":"Cerboni","year":"2017","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.celrep.2026.117580_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2025.115510","article-title":"Cancer-Cell-Derived cGAMP Limits the Activity of Tumor-Associated CD8+ T Cells","volume":"44","author":"Herbst","year":"2025","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2026.117580_bib26","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.abn6612","article-title":"Selective STING Stimulation in Dendritic Cells Primes Antitumor T Cell Responses","volume":"8","author":"Jneid","year":"2023","journal-title":"Sci. Immunol."},{"key":"10.1016\/j.celrep.2026.117580_bib27","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1038\/nature10429","article-title":"STING Is a Direct Innate Immune Sensor of Cyclic Di-GMP","volume":"478","author":"Burdette","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2026.117580_bib28","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.1021\/cb400264n","article-title":"Anticancer Flavonoids Are Mouse-Selective STING Agonists","volume":"8","author":"Kim","year":"2013","journal-title":"ACS Chem. Biol."},{"key":"10.1016\/j.celrep.2026.117580_bib29","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1016\/j.immuni.2020.03.016","article-title":"Transfer of cGAMP into Bystander Cells via LRRC8 Volume-Regulated Anion Channels Augments STING-Mediated Interferon Responses and Anti-Viral Immunity","volume":"52","author":"Zhou","year":"2020","journal-title":"Immunity"},{"key":"10.1016\/j.celrep.2026.117580_bib30","doi-asserted-by":"crossref","first-page":"eadn1630","DOI":"10.1126\/sciimmunol.adn1630","article-title":"Radiotherapy Enhances Anticancer CD8 T Cell Responses by cGAMP Transfer through LRRC8A\/C Volume-Regulated Anion Channels","volume":"10","author":"Cao","year":"2025","journal-title":"Sci. Immunol."},{"key":"10.1016\/j.celrep.2026.117580_bib31","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/j.molcel.2019.05.006","article-title":"SLC19A1 Is an Importer of the Immunotransmitter cGAMP","volume":"75","author":"Ritchie","year":"2019","journal-title":"Mol. Cell"},{"key":"10.1016\/j.celrep.2026.117580_bib32","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1038\/s41586-019-1553-0","article-title":"SLC19A1 Transports Immunoreactive Cyclic Dinucleotides","volume":"573","author":"Luteijn","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2026.117580_bib33","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1016\/j.cell.2018.10.022","article-title":"Impact of Genetic Polymorphisms on Human Immune Cell Gene Expression","volume":"175","author":"Schmiedel","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2026.117580_bib34","doi-asserted-by":"crossref","first-page":"2752S","DOI":"10.1093\/jn\/134.10.2752S","article-title":"Plasma Membrane Transporters for Arginine","volume":"134","author":"Closs","year":"2004","journal-title":"J. Nutr."},{"key":"10.1016\/j.celrep.2026.117580_bib35","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1007\/s00232-006-0875-7","article-title":"Structure and Function of Cationic Amino Acid Transporters (CATs)","volume":"213","author":"Closs","year":"2006","journal-title":"J. Membr. Biol."},{"key":"10.1016\/j.celrep.2026.117580_bib36","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1016\/j.cell.2016.09.031","article-title":"Arginine Modulates T Cell Metabolism and Enhances Survival and Anti-Tumor Activity","volume":"167","author":"Geiger","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2026.117580_bib37","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-018-03066-6","article-title":"Structural Basis for Amino Acid Transport by the CAT Family of SLC7 Transporters","volume":"9","author":"Jungnickel","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2026.117580_bib38","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1016\/j.chembiol.2020.07.007","article-title":"Structure-Aided Development of Small-Molecule Inhibitors of ENPP1, the Extracellular Phosphodiesterase of the Immunotransmitter cGAMP","volume":"27","author":"Carozza","year":"2020","journal-title":"Cell Chem. Biol."},{"key":"10.1016\/j.celrep.2026.117580_bib39","doi-asserted-by":"crossref","first-page":"1801","DOI":"10.1038\/s41467-020-15543-y","article-title":"Single-Cell Transcriptomics Identifies an Effectorness Gradient Shaping the Response of CD4+ T Cells to Cytokines","volume":"11","author":"Cano-Gamez","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2026.117580_bib40","doi-asserted-by":"crossref","first-page":"5417","DOI":"10.1038\/s41467-023-41132-w","article-title":"Systematic Transcriptional Analysis of Human Cell Lines for Gene Expression Landscape and Tumor Representation","volume":"14","author":"Jin","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2026.117580_bib41","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1038\/s41586-021-03819-2","article-title":"Highly Accurate Protein Structure Prediction with AlphaFold","volume":"596","author":"Jumper","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2026.117580_bib42","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1038\/d41573-020-00056-6","article-title":"The RESOLUTE Consortium: Unlocking SLC Transporters for Drug Discovery","volume":"19","author":"Superti-Furga","year":"2020","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.celrep.2026.117580_bib43","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1038\/nmeth.3047","article-title":"Improved Vectors and Genome-Wide Libraries for CRISPR Screening","volume":"11","author":"Sanjana","year":"2014","journal-title":"Nat. Methods"},{"key":"10.1016\/j.celrep.2026.117580_bib44","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1038\/nbt.3834","article-title":"Synergistic Drug Combinations for Cancer Identified in a CRISPR Screen for Pairwise Genetic Interactions","volume":"35","author":"Han","year":"2017","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.celrep.2026.117580_bib45","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/nmeth.2019","article-title":"Fiji: An Open-Source Platform for Biological-Image Analysis","volume":"9","author":"Schindelin","year":"2012","journal-title":"Nat. Methods"},{"key":"10.1016\/j.celrep.2026.117580_bib46","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated Estimation of Fold Change and Dispersion for RNA-Seq Data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol."},{"key":"10.1016\/j.celrep.2026.117580_bib47","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1038\/nbt.3567","article-title":"Systematic Comparison of CRISPR\/Cas9 and RNAi Screens for Essential Genes","volume":"34","author":"Morgens","year":"2016","journal-title":"Nat. Biotechnol."}],"container-title":["Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124726006583?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124726006583?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T20:49:10Z","timestamp":1791233350000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211124726006583"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":47,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["S2211124726006583"],"URL":"https:\/\/doi.org\/10.1016\/j.celrep.2026.117580","relation":{},"ISSN":["2211-1247"],"issn-type":[{"value":"2211-1247","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Activation-induced SLC7A1 expression enhances T cell sensitivity to cGAMP-mediated STING signaling","name":"articletitle","label":"Article Title"},{"value":"Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.celrep.2026.117580","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"117580"}}