{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T20:59:50Z","timestamp":1791233990776,"version":"4.1.0"},"reference-count":64,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100013365","name":"West China Hospital, Sichuan University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013365","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004572","name":"National Health Commission of the People's Republic of China","doi-asserted-by":"publisher","award":["2025ZD0552310"],"award-info":[{"award-number":["2025ZD0552310"]}],"id":[{"id":"10.13039\/501100004572","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004912","name":"Sichuan University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004912","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Reports"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.celrep.2026.117583","type":"journal-article","created":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T03:38:56Z","timestamp":1781926736000},"page":"117583","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Dual blockade of PD-1 and NKG2A prevents NK cell senescence and reprograms the immunosuppressive microenvironment in pancreatic cancer"],"prefix":"10.1016","volume":"45","author":[{"given":"Yu","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueyan","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhao","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunuo","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huan","family":"Tong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zedong","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangqi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuting","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaomeng","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shen","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lusi","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haorui","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianlong","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jieping","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingwen","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keqin","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqian","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renwei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaqing","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiyi","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengxin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jifeng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuelei","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.celrep.2026.117583_bib1","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1038\/s41568-021-00418-1","article-title":"Pancreatic cancer evolution and heterogeneity: integrating omics and clinical data","volume":"22","author":"Connor","year":"2022","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.celrep.2026.117583_bib2","first-page":"12","article-title":"Cancer statistics, 2024","volume":"74","author":"Siegel","year":"2024","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.celrep.2026.117583_bib3","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1016\/S0140-6736(25)00261-2","article-title":"Pancreatic cancer","volume":"405","author":"Stoop","year":"2025","journal-title":"Lancet"},{"key":"10.1016\/j.celrep.2026.117583_bib4","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/s13045-020-01030-w","article-title":"Targeting hypoxic tumor microenvironment in pancreatic cancer","volume":"14","author":"Tao","year":"2021","journal-title":"J. Hematol. Oncol."},{"key":"10.1016\/j.celrep.2026.117583_bib5","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/s13045-024-01561-6","article-title":"Current and future immunotherapeutic approaches in pancreatic cancer treatment","volume":"17","author":"Farhangnia","year":"2024","journal-title":"J. Hematol. Oncol."},{"key":"10.1016\/j.celrep.2026.117583_bib6","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1038\/s41573-021-00345-8","article-title":"The foundations of immune checkpoint blockade and the ipilimumab approval decennial","volume":"21","author":"Korman","year":"2022","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.celrep.2026.117583_bib7","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1016\/S1470-2045(24)00263-8","article-title":"Combining CD40 agonist mitazalimab with mFOLFIRINOX in previously untreated metastatic pancreatic ductal adenocarcinoma (OPTIMIZE-1): a single-arm, multicentre phase 1b\/2 study","volume":"25","author":"Van Laethem","year":"2024","journal-title":"Lancet Oncol."},{"key":"10.1016\/j.celrep.2026.117583_bib8","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1038\/s41590-022-01315-x","article-title":"In vivo CRISPR screens reveal the landscape of immune evasion pathways across cancer","volume":"23","author":"Dubrot","year":"2022","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.celrep.2026.117583_bib9","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1038\/s41423-021-00735-3","article-title":"IFN\u03b3 signaling integrity in colorectal cancer immunity and immunotherapy","volume":"19","author":"Du","year":"2022","journal-title":"Cell. Mol. Immunol."},{"key":"10.1016\/j.celrep.2026.117583_bib10","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1038\/35869","article-title":"HLA-E binds to natural killer cell receptors CD94\/NKG2A, B and C","volume":"391","author":"Braud","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2026.117583_bib11","doi-asserted-by":"crossref","first-page":"3903","DOI":"10.1016\/j.cell.2023.07.016","article-title":"A membrane-associated MHC-I inhibitory axis for cancer immune evasion","volume":"186","author":"Chen","year":"2023","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2026.117583_bib12","doi-asserted-by":"crossref","first-page":"5199","DOI":"10.1073\/pnas.95.9.5199","article-title":"HLA-E is a major ligand for the natural killer inhibitory receptor CD94\/NKG2A","volume":"95","author":"Lee","year":"1998","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2026.117583_bib13","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1016\/j.cell.2018.10.014","article-title":"Anti-NKG2A mAb Is a Checkpoint Inhibitor that Promotes Anti-tumor Immunity by Unleashing Both T and NK Cells","volume":"175","author":"Andr\u00e9","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2026.117583_bib14","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1158\/2159-8290.CD-23-0519","article-title":"NKG2A Is a Therapeutic Vulnerability in Immunotherapy Resistant MHC-I Heterogeneous Triple-Negative Breast Cancer","volume":"14","author":"Taylor","year":"2024","journal-title":"Cancer Discov."},{"key":"10.1016\/j.celrep.2026.117583_bib15","doi-asserted-by":"crossref","first-page":"1744","DOI":"10.1016\/j.cell.2018.10.028","article-title":"NKG2A Blockade Potentiates CD8 T Cell Immunity Induced by Cancer Vaccines","volume":"175","author":"van Montfoort","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2026.117583_bib16","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2023-007340","article-title":"Phase 1\/2 study of monalizumab plus durvalumab in patients with advanced solid tumors","volume":"12","author":"Patel","year":"2024","journal-title":"J. Immunother. Cancer"},{"key":"10.1016\/j.celrep.2026.117583_bib17","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1146\/annurev-immunol-101921-044122","article-title":"Designing Cancer Immunotherapies That Engage T Cells and NK Cells","volume":"41","author":"Kyrysyuk","year":"2023","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.celrep.2026.117583_bib18","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/s12943-023-01737-7","article-title":"NK cells are never alone: crosstalk and communication in tumour microenvironments","volume":"22","author":"Zhou","year":"2023","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.celrep.2026.117583_bib19","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.adm7269","article-title":"Tumor extracellular vesicle-derived PD-L1 promotes T cell senescence through lipid metabolism reprogramming","volume":"17","author":"Ma","year":"2025","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.celrep.2026.117583_bib20","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1186\/s13045-020-00986-z","article-title":"Immunosenescence: a key player in cancer development","volume":"13","author":"Lian","year":"2020","journal-title":"J. Hematol. Oncol."},{"key":"10.1016\/j.celrep.2026.117583_bib21","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.molcel.2023.10.006","article-title":"Stress, epigenetics, and aging: Unraveling the intricate crosstalk","volume":"84","author":"Wu","year":"2024","journal-title":"Mol. Cell"},{"key":"10.1016\/j.celrep.2026.117583_bib22","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.15252\/emmm.201403918","article-title":"TLR8 signaling enhances tumor immunity by preventing tumor-induced T-cell senescence","volume":"6","author":"Ye","year":"2014","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/j.celrep.2026.117583_bib23","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1038\/s41577-022-00732-1","article-title":"Roles of natural killer cells in immunity to cancer, and applications to immunotherapy","volume":"23","author":"Wolf","year":"2023","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.celrep.2026.117583_bib24","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1056\/NEJMoa1604958","article-title":"Mutations Associated with Acquired Resistance to PD-1 Blockade in Melanoma","volume":"375","author":"Zaretsky","year":"2016","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.celrep.2026.117583_bib25","doi-asserted-by":"crossref","first-page":"3364","DOI":"10.1038\/s41467-023-38578-3","article-title":"Transcriptional control of pancreatic cancer immunosuppression by metabolic enzyme CD73 in a tumor-autonomous and -autocrine manner","volume":"14","author":"Tang","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2026.117583_bib26","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1038\/s41423-025-01260-3","article-title":"GLP1 alleviates oleic acid-propelled lipocalin-2 generation by tumor-infiltrating CD8(+) T cells to reduce polymorphonuclear MDSC recruitment and enhances viral immunotherapy in pancreatic cancer","volume":"22","author":"Wu","year":"2025","journal-title":"Cell. Mol. Immunol."},{"key":"10.1016\/j.celrep.2026.117583_bib27","doi-asserted-by":"crossref","first-page":"1859","DOI":"10.1136\/gutjnl-2024-334361","article-title":"Histone lactylation-driven feedback loop modulates cholesterol-linked immunosuppression in pancreatic cancer","volume":"74","author":"Yang","year":"2025","journal-title":"Gut"},{"key":"10.1016\/j.celrep.2026.117583_bib28","doi-asserted-by":"crossref","first-page":"6162","DOI":"10.1038\/s41467-024-50441-7","article-title":"Senescent cancer-associated fibroblasts in pancreatic adenocarcinoma restrict CD8(+) T cell activation and limit responsiveness to immunotherapy in mice","volume":"15","author":"Assouline","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2026.117583_bib29","doi-asserted-by":"crossref","DOI":"10.1126\/science.abe6474","article-title":"Pan-cancer single-cell landscape of tumor-infiltrating T cells","volume":"374","author":"Zheng","year":"2021","journal-title":"Science"},{"key":"10.1016\/j.celrep.2026.117583_bib30","doi-asserted-by":"crossref","first-page":"4235","DOI":"10.1016\/j.cell.2023.07.034","article-title":"A pan-cancer single-cell panorama of human natural killer cells","volume":"186","author":"Tang","year":"2023","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2026.117583_bib31","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1038\/s41586-022-05388-4","article-title":"Blocking PD-L1-PD-1 improves senescence surveillance and ageing phenotypes","volume":"611","author":"Wang","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2026.117583_bib32","doi-asserted-by":"crossref","DOI":"10.1111\/acel.13338","article-title":"Cellular aging beyond cellular senescence: Markers of senescence prior to cell cycle arrest in vitro and in vivo","volume":"20","author":"Ogrodnik","year":"2021","journal-title":"Aging Cell"},{"key":"10.1016\/j.celrep.2026.117583_bib33","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1038\/s41580-024-00727-x","article-title":"The senescence-associated secretory phenotype and its physiological and pathological implications","volume":"25","author":"Wang","year":"2024","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.celrep.2026.117583_bib34","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1038\/s41467-017-02689-5","article-title":"Regulatory T cells trigger effector T cell DNA damage and senescence caused by metabolic competition","volume":"9","author":"Liu","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2026.117583_bib35","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1164\/rccm.201810-1975TR","article-title":"Cellular Senescence as a Mechanism and Target in Chronic Lung Diseases","volume":"200","author":"Barnes","year":"2019","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.celrep.2026.117583_bib36","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.adk8823","article-title":"A diet of oxidative stress-adapted bacteria improves stress resistance and lifespan in C. elegans via p38-MAPK","volume":"10","author":"Bhat","year":"2024","journal-title":"Sci. Adv."},{"key":"10.1016\/j.celrep.2026.117583_bib37","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/s11010-011-1197-3","article-title":"STAT1 mediates cellular senescence induced by angiotensin II and H2O2 in human glomerular mesangial cells","volume":"365","author":"Jiao","year":"2012","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.celrep.2026.117583_bib38","doi-asserted-by":"crossref","first-page":"1675","DOI":"10.1038\/srep01675","article-title":"Radiation-induced senescence in securin-deficient cancer cells promotes cell invasion involving the IL-6\/STAT3 and PDGF-BB\/PDGFR pathways","volume":"3","author":"Yu","year":"2013","journal-title":"Sci. Rep."},{"key":"10.1016\/j.celrep.2026.117583_bib39","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1038\/s41423-022-00925-7","article-title":"Serine metabolism orchestrates macrophage polarization by regulating the IGF1-p38 axis","volume":"19","author":"Shan","year":"2022","journal-title":"Cell. Mol. Immunol."},{"key":"10.1016\/j.celrep.2026.117583_bib40","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1038\/s41580-020-00314-w","article-title":"Cellular senescence in ageing: from mechanisms to therapeutic opportunities","volume":"22","author":"Di Micco","year":"2021","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.celrep.2026.117583_bib41","doi-asserted-by":"crossref","first-page":"2435","DOI":"10.1038\/s41467-024-46769-9","article-title":"Senescence drives immunotherapy resistance by inducing an immunosuppressive tumor microenvironment","volume":"15","author":"Maggiorani","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2026.117583_bib42","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1038\/s41568-022-00450-9","article-title":"Exploiting senescence for the treatment of cancer","volume":"22","author":"Wang","year":"2022","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.celrep.2026.117583_bib43","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1038\/nm.4010","article-title":"Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice","volume":"22","author":"Chang","year":"2016","journal-title":"Nat. Med."},{"key":"10.1016\/j.celrep.2026.117583_bib44","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1038\/s41577-018-0029-z","article-title":"IFN\u03b3: signalling, epigenetics and roles in immunity, metabolism, disease and cancer immunotherapy","volume":"18","author":"Ivashkiv","year":"2018","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.celrep.2026.117583_bib45","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1038\/s41392-025-02228-5","article-title":"Overexpressing natural killer group 2 member A drives natural killer cell exhaustion in relapsed acute myeloid leukemia","volume":"10","author":"Xie","year":"2025","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.celrep.2026.117583_bib63","doi-asserted-by":"crossref","first-page":"qzaf072","DOI":"10.1093\/gpbjnl\/qzaf072","article-title":"The GSA Family in 2025: A Broadened Sharing Platform for Multi-Omics and Multimodal Data","volume":"23","author":"Zhang","year":"2025","journal-title":"Genom. Proteom. Bioinform."},{"key":"10.1016\/j.celrep.2026.117583_bib64","doi-asserted-by":"crossref","first-page":"D28","DOI":"10.1093\/nar\/gkaf1172","article-title":"Database Resources of the National Genomics Data Center, China National Center for Bioinformation in 2026","volume":"54","author":"Bao","year":"2026","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.celrep.2026.117583_bib46","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20211631","article-title":"CCR2\/CCR5 inhibitor permits the radiation-induced effector T cell infiltration in pancreatic adenocarcinoma","volume":"219","author":"Wang","year":"2022","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.celrep.2026.117583_bib47","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1158\/2326-6066.CIR-23-1073","article-title":"Blockade of IL1\u03b2 and PD1 with Combination Chemotherapy Reduces Systemic Myeloid Suppression in Metastatic Pancreatic Cancer with Heterogeneous Effects in the Tumor","volume":"12","author":"Oberstein","year":"2024","journal-title":"Cancer Immunol. Res."},{"key":"10.1016\/j.celrep.2026.117583_bib48","doi-asserted-by":"crossref","first-page":"2212","DOI":"10.1158\/2159-8290.CD-22-0851","article-title":"Dual Immune Checkpoint Blockade Induces Analogous Alterations in the Dysfunctional CD8+ T-cell and Activated Treg Compartment","volume":"13","author":"van der Leun","year":"2023","journal-title":"Cancer Discov."},{"key":"10.1016\/j.celrep.2026.117583_bib49","doi-asserted-by":"crossref","first-page":"2094","DOI":"10.1158\/1078-0432.CCR-21-3570","article-title":"Immunostimulatory Cancer-Associated Fibroblast Subpopulations Can Predict Immunotherapy Response in Head and Neck Cancer","volume":"28","author":"Obradovic","year":"2022","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.celrep.2026.117583_bib50","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1038\/s42003-020-01625-6","article-title":"Mapping the immune environment in clear cell renal carcinoma by single-cell genomics","volume":"4","author":"Borcherding","year":"2021","journal-title":"Commun. Biol."},{"key":"10.1016\/j.celrep.2026.117583_bib51","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.1016\/j.ccell.2021.10.001","article-title":"Determinants of anti-PD-1 response and resistance in clear cell renal cell carcinoma","volume":"39","author":"Au","year":"2021","journal-title":"Cancer Cell"},{"key":"10.1016\/j.celrep.2026.117583_bib52","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2024-009210","article-title":"NKG2C\/KLRC2 tumor cell expression enhances immunotherapeutic efficacy against glioblastoma","volume":"12","author":"de Dios","year":"2024","journal-title":"J. Immunother. Cancer"},{"key":"10.1016\/j.celrep.2026.117583_bib53","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1016\/j.ccell.2023.04.011","article-title":"Remodeling of the immune and stromal cell compartment by PD-1 blockade in mismatch repair-deficient colorectal cancer","volume":"41","author":"Li","year":"2023","journal-title":"Cancer Cell"},{"key":"10.1016\/j.celrep.2026.117583_bib54","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1016\/j.ccell.2025.01.007","article-title":"Distinct cellular mechanisms underlie chemotherapies and PD-L1 blockade combinations in triple-negative breast cancer","volume":"43","author":"Zhang","year":"2025","journal-title":"Cancer Cell"},{"key":"10.1016\/j.celrep.2026.117583_bib55","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.ccell.2025.01.001","article-title":"Contrasting cytotoxic and regulatory T cell responses underlying distinct clinical outcomes to anti-PD-1 plus lenvatinib therapy in cancer","volume":"43","author":"Guo","year":"2025","journal-title":"Cancer Cell"},{"key":"10.1016\/j.celrep.2026.117583_bib56","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/s13073-023-01164-9","article-title":"Tumor microenvironment remodeling after neoadjuvant immunotherapy in non-small cell lung cancer revealed by single-cell RNA sequencing","volume":"15","author":"Hu","year":"2023","journal-title":"Genome Med."},{"key":"10.1016\/j.celrep.2026.117583_bib57","doi-asserted-by":"crossref","first-page":"3131","DOI":"10.1158\/0008-5472.CAN-22-2593","article-title":"Intratumoral Microbiota Composition Regulates Chemoimmunotherapy Response in Esophageal Squamous Cell Carcinoma","volume":"83","author":"Wu","year":"2023","journal-title":"Cancer Res."},{"key":"10.1016\/j.celrep.2026.117583_bib58","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-17204-5","article-title":"QuPath: Open source software for digital pathology image analysis","volume":"7","author":"Bankhead","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.celrep.2026.117583_bib59","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2019-000155","article-title":"The Society for Immunotherapy of Cancer statement on best practices for multiplex immunohistochemistry (IHC) and immunofluorescence (IF) staining and validation","volume":"8","author":"Taube","year":"2020","journal-title":"J. Immunother. Cancer"},{"key":"10.1016\/j.celrep.2026.117583_bib60","doi-asserted-by":"crossref","DOI":"10.1016\/j.xpro.2024.103270","article-title":"Protocol for whole-slide image analysis of human multiplexed tumor tissues using QuPath and R","volume":"5","author":"Franken","year":"2024","journal-title":"STAR Protoc."},{"key":"10.1016\/j.celrep.2026.117583_bib61","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/j.immuni.2024.02.007","article-title":"CD4(+) T cell activation distinguishes response to anti-PD-L1+anti-CTLA4 therapy from anti-PD-L1 monotherapy","volume":"57","author":"Franken","year":"2024","journal-title":"Immunity"},{"key":"10.1016\/j.celrep.2026.117583_bib62","doi-asserted-by":"crossref","DOI":"10.1002\/imt2.70018","article-title":"Tidyplots empowers life scientists with easy code-based data visualization","volume":"4","author":"Engler","year":"2025","journal-title":"iMeta"}],"container-title":["Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124726006613?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124726006613?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T20:47:45Z","timestamp":1791233265000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211124726006613"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":64,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["S2211124726006613"],"URL":"https:\/\/doi.org\/10.1016\/j.celrep.2026.117583","relation":{},"ISSN":["2211-1247"],"issn-type":[{"value":"2211-1247","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dual blockade of PD-1 and NKG2A prevents NK cell senescence and reprograms the immunosuppressive microenvironment in pancreatic cancer","name":"articletitle","label":"Article Title"},{"value":"Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.celrep.2026.117583","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"117583"}}