{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T05:31:15Z","timestamp":1793856675728,"version":"4.6.1"},"reference-count":88,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T00:00:00Z","timestamp":1781481600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100012538","name":"Swedish Cancer Foundation","doi-asserted-by":"publisher","award":["25 4525 Pj,22 2461 Pj 01H"],"award-info":[{"award-number":["25 4525 Pj,22 2461 Pj 01H"]}],"id":[{"id":"10.13039\/100012538","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012538","name":"Swedish Cancer Foundation","doi-asserted-by":"publisher","award":["CAN 23 3096 Pj"],"award-info":[{"award-number":["CAN 23 3096 Pj"]}],"id":[{"id":"10.13039\/100012538","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005760","name":"G\u00f6teborgs Universitet","doi-asserted-by":"publisher","award":["VR-RFI 2019-00217"],"award-info":[{"award-number":["VR-RFI 2019-00217"]}],"id":[{"id":"10.13039\/501100005760","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Swedish Research Council","doi-asserted-by":"publisher","award":["2023-01962"],"award-info":[{"award-number":["2023-01962"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Swedish Research Council","doi-asserted-by":"publisher","award":["2016-00890"],"award-info":[{"award-number":["2016-00890"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Swedish Research Council","doi-asserted-by":"publisher","award":["2022-01308_3"],"award-info":[{"award-number":["2022-01308_3"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002794","name":"Swedish Cancer Society","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002794","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003243","name":"Ministerstvo Zdravotnictv\u00ed Cesk\u00e9 Republiky","doi-asserted-by":"publisher","award":["00179906"],"award-info":[{"award-number":["00179906"]}],"id":[{"id":"10.13039\/501100003243","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004063","name":"Knut and Alice Wallenberg Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004063","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Reports"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.celrep.2026.117640","type":"journal-article","created":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T08:55:51Z","timestamp":1783068951000},"page":"117640","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["STING-dependent peripheral inflammaging drives neurodegeneration via extracellular vesicles"],"prefix":"10.1016","volume":"45","author":[{"given":"Maria","family":"\u00d6berg","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caitlyn","family":"Myers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Najmeh","family":"Saffarzadeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivana","family":"Maric","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mateo","family":"Murillo-Le\u00f3n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anneli","family":"Str\u00f6mberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Fabrikova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivo","family":"Fabrik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laia","family":"Rivas-Galvez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meghshree Vinod","family":"Deshmukh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josue","family":"Enriquez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin X.","family":"Ali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rossella","family":"Crescitelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davide","family":"Angeletti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Volkan I.","family":"Sayin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karim","family":"Rafie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karolina P.","family":"Skibicka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marzena","family":"Kurzawa-Akanbi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gesine","family":"Paul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nelson O.","family":"Gekara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8152-4361","authenticated-orcid":false,"given":"Anetta","family":"H\u00e4rtlova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.celrep.2026.117640_bib1","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1038\/s41586-023-06802-1","article-title":"Organ aging signatures in the plasma proteome track health and disease","volume":"624","author":"Oh","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2026.117640_bib2","doi-asserted-by":"crossref","first-page":"1614","DOI":"10.3390\/cells9071614","article-title":"Neurovascular Inflammaging in Health and Disease","volume":"9","author":"M\u00e9sz\u00e1ros","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.celrep.2026.117640_bib3","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.31157","article-title":"Naked Mole-Rat mortality rates defy gompertzian laws by not increasing with age","volume":"7","author":"Ruby","year":"2018","journal-title":"eLife"},{"key":"10.1016\/j.celrep.2026.117640_bib4","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1038\/s41586-020-2499-y","article-title":"Ageing hallmarks exhibit organ-specific temporal signatures","volume":"583","author":"Schaum","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2026.117640_bib5","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1038\/s41586-022-04461-2","article-title":"Molecular hallmarks of heterochronic parabiosis at single-cell resolution","volume":"603","author":"P\u00e1lovics","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2026.117640_bib6","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1038\/s41467-018-02926-5","article-title":"A transcriptomic atlas of aged human microglia","volume":"9","author":"Olah","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2026.117640_bib7","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.immuni.2018.11.004","article-title":"Single-Cell RNA Sequencing of Microglia throughout the Mouse Lifespan and in the Injured Brain Reveals Complex Cell-State Changes","volume":"50","author":"Hammond","year":"2019","journal-title":"Immunity"},{"key":"10.1016\/j.celrep.2026.117640_bib8","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1038\/s41586-020-2496-1","article-title":"A single-cell transcriptomic atlas characterizes ageing tissues in the mouse","volume":"583","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2026.117640_bib9","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1126\/science.1252945","article-title":"Aging. Aging-induced type I interferon response at the choroid plexus negatively affects brain function","volume":"346","author":"Baruch","year":"2014","journal-title":"Science"},{"key":"10.1016\/j.celrep.2026.117640_bib10","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1101\/gr.240093.118","article-title":"Remodeling of epigenome and transcriptome landscapes with aging in mice reveals widespread induction of inflammatory responses","volume":"29","author":"Benayoun","year":"2019","journal-title":"Genome Res."},{"key":"10.1016\/j.celrep.2026.117640_bib11","doi-asserted-by":"crossref","first-page":"3263","DOI":"10.1016\/j.celrep.2019.08.043","article-title":"Age-Related Gene Expression Signature in Rats Demonstrate Early, Late, and Linear Transcriptional Changes from Multiple Tissues","volume":"28","author":"Shavlakadze","year":"2019","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2026.117640_bib12","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1038\/s43587-022-00337-2","article-title":"Activation of innate immune cGAS-STING pathway contributes to Alzheimer's pathogenesis in 5\u00d7FAD mice","volume":"3","author":"Xie","year":"2023","journal-title":"Nat. Aging"},{"key":"10.1016\/j.celrep.2026.117640_bib13","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1038\/s41586-018-0448-9","article-title":"Parkin and PINK1 mitigate STING-induced inflammation","volume":"561","author":"Sliter","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2026.117640_bib14","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1038\/s41586-023-06373-1","article-title":"cGAS-STING drives ageing-related inflammation and neurodegeneration","volume":"620","author":"Gulen","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2026.117640_bib15","doi-asserted-by":"crossref","first-page":"eadk3225","DOI":"10.1126\/scitranslmed.adk3225","article-title":"Central and peripheral innate and adaptive immunity in Parkinson's disease","volume":"15","author":"Harms","year":"2023","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.celrep.2026.117640_bib16","doi-asserted-by":"crossref","first-page":"1822","DOI":"10.1038\/s41591-019-0675-0","article-title":"Chronic inflammation in the etiology of disease across the life span","volume":"25","author":"Furman","year":"2019","journal-title":"Nat. Med."},{"key":"10.1016\/j.celrep.2026.117640_bib17","doi-asserted-by":"crossref","DOI":"10.1111\/sji.13022","article-title":"The role of innate immunity and inflammation in Parkinson s disease","volume":"93","author":"\u00d6berg","year":"2021","journal-title":"Scand. J. Immunol."},{"key":"10.1016\/j.celrep.2026.117640_bib18","doi-asserted-by":"crossref","first-page":"1752","DOI":"10.1212\/WNL.0b013e3181c34af5","article-title":"Medical records documentation of constipation preceding Parkinson disease: A case-control study","volume":"73","author":"Savica","year":"2009","journal-title":"Neurology"},{"key":"10.1016\/j.celrep.2026.117640_bib19","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0047387","article-title":"Non-motor symptoms in patients with Parkinson's disease - correlations with inflammatory cytokines in serum","volume":"7","author":"Lindqvist","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.celrep.2026.117640_bib20","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1002\/ana.23687","article-title":"Meta-analysis of early nonmotor features and risk factors for Parkinson disease","volume":"72","author":"Noyce","year":"2012","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.celrep.2026.117640_bib21","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S0197-4580(02)00065-9","article-title":"Staging of brain pathology related to sporadic Parkinson's disease","volume":"24","author":"Braak","year":"2003","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.celrep.2026.117640_bib22","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1038\/s41531-021-00156-z","article-title":"Meta-analysis of the Parkinson's disease gut microbiome suggests alterations linked to intestinal inflammation","volume":"7","author":"Romano","year":"2021","journal-title":"NPJ Parkinson's Dis."},{"key":"10.1016\/j.celrep.2026.117640_bib23","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1038\/s41531-016-0002-0","article-title":"The gut-brain axis: is intestinal inflammation a silent driver of Parkinson's disease pathogenesis?","volume":"3","author":"Houser","year":"2017","journal-title":"NPJ Parkinson's Dis."},{"key":"10.1016\/j.celrep.2026.117640_bib24","doi-asserted-by":"crossref","first-page":"R48","DOI":"10.1093\/hmg\/ddp012","article-title":"Parkinson's disease: from monogenic forms to genetic susceptibility factors","volume":"18","author":"Lesage","year":"2009","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.celrep.2026.117640_bib25","doi-asserted-by":"crossref","DOI":"10.15252\/embj.201798694","article-title":"LRRK2 is a negative regulator of Mycobacterium tuberculosis phagosome maturation in macrophages","volume":"37","author":"H\u00e4rtlova","year":"2018","journal-title":"EMBO J."},{"key":"10.1016\/j.celrep.2026.117640_bib26","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/j.yexcr.2009.09.014","article-title":"LRRK2 enhances oxidative stress-induced neurotoxicity via its kinase activity","volume":"316","author":"Heo","year":"2010","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.celrep.2026.117640_bib27","doi-asserted-by":"crossref","first-page":"e2006265","DOI":"10.1371\/journal.pbio.2006265","article-title":"Lrrk promotes tau neurotoxicity through dysregulation of actin and mitochondrial dynamics","volume":"16","author":"Bardai","year":"2018","journal-title":"PLoS Biol."},{"key":"10.1016\/j.celrep.2026.117640_bib28","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2303809120","article-title":"Astrocyte-targeting therapy rescues cognitive impairment caused by neuroinflammation via the Nrf2 pathway","volume":"120","author":"Nakano-Kobayashi","year":"2023","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2026.117640_bib29","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1038\/s41586-020-2681-2","article-title":"The innate immunity protein IFITM3 modulates gamma-secretase in Alzheimer's disease","volume":"586","author":"Hur","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2026.117640_bib30","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.celrep.2018.09.003","article-title":"Type I Interferon Receptor Signaling of Neurons and Astrocytes Regulates Microglia Activation during Viral Encephalitis","volume":"25","author":"Chhatbar","year":"2018","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2026.117640_bib31","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms11295","article-title":"Untangling the brain's neuroinflammatory and neurodegenerative transcriptional responses","volume":"7","author":"Srinivasan","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2026.117640_bib32","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1016\/j.neuron.2017.11.032","article-title":"Activation of the STING-Dependent Type I Interferon Response Reduces Microglial Reactivity and Neuroinflammation","volume":"96","author":"Mathur","year":"2017","journal-title":"Neuron"},{"key":"10.1016\/j.celrep.2026.117640_bib33","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1016\/j.immuni.2022.03.018","article-title":"Concerted type I interferon signaling in microglia and neural cells promotes memory impairment associated with amyloid \u03b2 plaques","volume":"55","author":"Roy","year":"2022","journal-title":"Immunity"},{"key":"10.1016\/j.celrep.2026.117640_bib34","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1038\/nrneurol.2015.143","article-title":"Type I interferon dysregulation and neurological disease","volume":"11","author":"McGlasson","year":"2015","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.celrep.2026.117640_bib35","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1002\/glia.23154","article-title":"Type I interferon pathway in CNS homeostasis and neurological disorders","volume":"65","author":"Blank","year":"2017","journal-title":"Glia"},{"key":"10.1016\/j.celrep.2026.117640_bib36","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.mad.2006.11.016","article-title":"Inflammaging and anti-inflammaging: a systemic perspective on aging and longevity emerged from studies in humans","volume":"128","author":"Franceschi","year":"2007","journal-title":"Mech. Ageing Dev."},{"key":"10.1016\/j.celrep.2026.117640_bib37","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1126\/science.1232458","article-title":"Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway","volume":"339","author":"Sun","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.celrep.2026.117640_bib38","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1038\/nature12306","article-title":"cGAS produces a 2'-5'-linked cyclic dinucleotide second messenger that activates STING","volume":"498","author":"Ablasser","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2026.117640_bib39","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1016\/j.celrep.2013.05.009","article-title":"The innate immune DNA sensor cGAS produces a noncanonical cyclic dinucleotide that activates human STING","volume":"3","author":"Diner","year":"2013","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2026.117640_bib40","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.immuni.2006.08.009","article-title":"Type I interferon [corrected] gene induction by the interferon regulatory factor family of transcription factors","volume":"25","author":"Honda","year":"2006","journal-title":"Immunity"},{"key":"10.1016\/j.celrep.2026.117640_bib41","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1038\/nature07317","article-title":"STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling","volume":"455","author":"Ishikawa","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2026.117640_bib42","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.immuni.2015.01.012","article-title":"DNA damage primes the type I interferon system via the cytosolic DNA sensor STING to promote anti-microbial innate immunity","volume":"42","author":"H\u00e4rtlova","year":"2015","journal-title":"Immunity"},{"key":"10.1016\/j.celrep.2026.117640_bib43","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1038\/s41586-023-06621-4","article-title":"Apoptotic stress causes mtDNA release during senescence and drives the SASP","volume":"622","author":"Victorelli","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2026.117640_bib44","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1016\/j.cell.2020.09.020","article-title":"TDP-43 Triggers Mitochondrial DNA Release via mPTP to Activate cGAS\/STING in ALS","volume":"183","author":"Yu","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2026.117640_bib45","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.51071","article-title":"LRRK2 maintains mitochondrial homeostasis and regulates innate immune responses to Mycobacterium tuberculosis","volume":"9","author":"Weindel","year":"2020","journal-title":"eLife"},{"key":"10.1016\/j.celrep.2026.117640_bib46","doi-asserted-by":"crossref","first-page":"E4612","DOI":"10.1073\/pnas.1705499114","article-title":"cGAS is essential for cellular senescence","volume":"114","author":"Yang","year":"2017","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2026.117640_bib47","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1038\/s41577-022-00751-y","article-title":"DNA damage and repair in age-related inflammation","volume":"23","author":"Zhao","year":"2023","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.celrep.2026.117640_bib48","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1084\/jem.20180139","article-title":"The cGAS-cGAMP-STING pathway connects DNA damage to inflammation, senescence, and cancer","volume":"215","author":"Li","year":"2018","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.celrep.2026.117640_bib49","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1038\/cr.2014.44","article-title":"Double-stranded DNA in exosomes: a novel biomarker in cancer detection","volume":"24","author":"Thakur","year":"2014","journal-title":"Cell Res."},{"key":"10.1016\/j.celrep.2026.117640_bib50","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms13588","article-title":"ISGylation controls exosome secretion by promoting lysosomal degradation of MVB proteins","volume":"7","author":"Villarroya-Beltri","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2026.117640_bib51","doi-asserted-by":"crossref","DOI":"10.1002\/jev2.12146","article-title":"Hypoxia-stimulated ATM activation regulates autophagy-associated exosome release from cancer-associated fibroblasts to promote cancer cell invasion","volume":"10","author":"Xi","year":"2021","journal-title":"J. Extracell. Vesicles"},{"key":"10.1016\/j.celrep.2026.117640_bib52","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1080\/15548627.2019.1635383","article-title":"Disrupting the TRIB3-SQSTM1 interaction reduces liver fibrosis by restoring autophagy and suppressing exosome-mediated HSC activation","volume":"16","author":"Zhang","year":"2020","journal-title":"Autophagy"},{"key":"10.1016\/j.celrep.2026.117640_bib53","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1111\/cas.15288","article-title":"MEK\/ERK-mediated oncogenic signals promote secretion of extracellular vesicles by controlling lysosome function","volume":"113","author":"Hikita","year":"2022","journal-title":"Cancer Sci."},{"key":"10.1016\/j.celrep.2026.117640_bib54","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.1016\/j.yexcr.2008.09.020","article-title":"Trafficking and function of the tetraspanin CD63","volume":"315","author":"Pols","year":"2009","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.celrep.2026.117640_bib55","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1016\/j.devcel.2011.08.019","article-title":"The tetraspanin CD63 regulates ESCRT-independent and -dependent endosomal sorting during melanogenesis","volume":"21","author":"van Niel","year":"2011","journal-title":"Dev. Cell"},{"key":"10.1016\/j.celrep.2026.117640_bib56","doi-asserted-by":"crossref","DOI":"10.1002\/jev2.12295","article-title":"Retinal pigment epithelium extracellular vesicles are potent inducers of age-related macular degeneration disease phenotype in the outer retina","volume":"11","author":"Kurzawa-Akanbi","year":"2022","journal-title":"J. Extracell. Vesicles"},{"key":"10.1016\/j.celrep.2026.117640_bib57","doi-asserted-by":"crossref","first-page":"eadi9156","DOI":"10.1126\/sciadv.adi9156","article-title":"Endocytosis blocks the vesicular secretion of exosome marker proteins","volume":"10","author":"Ai","year":"2024","journal-title":"Sci. Adv."},{"key":"10.1016\/j.celrep.2026.117640_bib58","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1038\/s41586-022-05354-0","article-title":"Clathrin-associated AP-1 controls termination of STING signalling","volume":"610","author":"Liu","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2026.117640_bib59","doi-asserted-by":"crossref","first-page":"6770","DOI":"10.1038\/s41467-023-42150-4","article-title":"ARF1 prevents aberrant type I interferon induction by regulating STING activation and recycling","volume":"14","author":"Hirschenberger","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2026.117640_bib60","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1038\/s41556-023-01098-9","article-title":"STING signalling is terminated through ESCRT-dependent microautophagy of vesicles originating from recycling endosomes","volume":"25","author":"Kuchitsu","year":"2023","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.celrep.2026.117640_bib61","doi-asserted-by":"crossref","first-page":"2671","DOI":"10.1042\/BCJ20160557","article-title":"Phos-tag analysis of Rab10 phosphorylation by LRRK2: a powerful assay for assessing kinase function and inhibitors","volume":"473","author":"Ito","year":"2016","journal-title":"Biochem. J."},{"key":"10.1016\/j.celrep.2026.117640_bib62","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.31012","article-title":"Systematic proteomic analysis of LRRK2-mediated Rab GTPase phosphorylation establishes a connection to ciliogenesis","volume":"6","author":"Steger","year":"2017","journal-title":"eLife"},{"key":"10.1016\/j.celrep.2026.117640_bib63","doi-asserted-by":"crossref","first-page":"E9115","DOI":"10.1073\/pnas.1812196115","article-title":"LRRK2 and its substrate Rab GTPases are sequentially targeted onto stressed lysosomes and maintain their homeostasis","volume":"115","author":"Eguchi","year":"2018","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2026.117640_bib64","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1038\/nn.3489","article-title":"The Parkinson's disease-linked proteins Fbxo7 and Parkin interact to mediate mitophagy","volume":"16","author":"Burchell","year":"2013","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.celrep.2026.117640_bib65","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1038\/33416","article-title":"Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism","volume":"392","author":"Kitada","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2026.117640_bib66","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.semcdb.2015.03.005","article-title":"Autophagy in neurodegenerative diseases: From pathogenic dysfunction to therapeutic modulation","volume":"40","author":"Martinez-Vicente","year":"2015","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.celrep.2026.117640_bib67","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.ajhg.2011.07.018","article-title":"VPS35 mutations in Parkinson disease","volume":"89","author":"Vilari\u00f1o-G\u00fcell","year":"2011","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.celrep.2026.117640_bib68","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1001\/archneur.65.10.1353","article-title":"The spectrum of parkinsonian manifestations associated with glucocerebrosidase mutations","volume":"65","author":"Goker-Alpan","year":"2008","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.celrep.2026.117640_bib69","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1038\/s41467-017-02593-y","article-title":"Synaptotagmin-11 is a critical mediator of parkin-linked neurotoxicity and Parkinson's disease-like pathology","volume":"9","author":"Wang","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2026.117640_bib70","doi-asserted-by":"crossref","first-page":"1656","DOI":"10.1002\/glia.23186","article-title":"Synaptotagmin-11 inhibits cytokine secretion and phagocytosis in microglia","volume":"65","author":"Du","year":"2017","journal-title":"Glia"},{"key":"10.1016\/j.celrep.2026.117640_bib71","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms11803","article-title":"The Parkinson's disease-associated genes ATP13A2 and SYT11 regulate autophagy via a common pathway","volume":"7","author":"Bento","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2026.117640_bib72","doi-asserted-by":"crossref","first-page":"4240","DOI":"10.1523\/JNEUROSCI.5575-11.2012","article-title":"Deficiency of ATP13A2 leads to lysosomal dysfunction, \u03b1-synuclein accumulation, and neurotoxicity","volume":"32","author":"Usenovic","year":"2012","journal-title":"J. Neurosci."},{"key":"10.1016\/j.celrep.2026.117640_bib73","doi-asserted-by":"crossref","first-page":"9611","DOI":"10.1073\/pnas.1112368109","article-title":"Loss of P-type ATPase ATP13A2\/PARK9 function induces general lysosomal deficiency and leads to Parkinson disease neurodegeneration","volume":"109","author":"Dehay","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2026.117640_bib74","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1038\/nature23269","article-title":"The lysosomal potassium channel TMEM175 adopts a novel tetrameric architecture","volume":"547","author":"Lee","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2026.117640_bib75","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1016\/j.cell.2015.08.002","article-title":"TMEM175 Is an Organelle K(+) Channel Regulating Lysosomal Function","volume":"162","author":"Cang","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2026.117640_bib76","doi-asserted-by":"crossref","first-page":"2517","DOI":"10.1038\/s41418-021-00767-2","article-title":"The DJ1-Nrf2-STING axis mediates the neuroprotective effects of Withaferin A in Parkinson's disease","volume":"28","author":"Zhao","year":"2021","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.celrep.2026.117640_bib77","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2118819119","article-title":"STING mediates neurodegeneration and neuroinflammation in nigrostriatal \u03b1-synucleinopathy","volume":"119","author":"Hinkle","year":"2022","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2026.117640_bib78","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.81943","article-title":"Constitutively active STING causes neuroinflammation and degeneration of dopaminergic neurons in mice","volume":"11","author":"Szego","year":"2022","journal-title":"eLife"},{"key":"10.1016\/j.celrep.2026.117640_bib79","doi-asserted-by":"crossref","first-page":"2989","DOI":"10.1038\/s41418-020-00624-8","article-title":"Crosstalk between cGAS-STING signaling and cell death","volume":"27","author":"Murthy","year":"2020","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.celrep.2026.117640_bib80","doi-asserted-by":"crossref","first-page":"e2350386","DOI":"10.1002\/eji.202350386","article-title":"cGAS-STING signaling in cell death: Mechanisms of action and implications in pathologies","volume":"53","author":"Xu","year":"2023","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.celrep.2026.117640_bib81","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1038\/s41392-021-00613-4","article-title":"The STING1 network regulates autophagy and cell death","volume":"6","author":"Zhang","year":"2021","journal-title":"Signal Transduct. Targeted Ther."},{"key":"10.1016\/j.celrep.2026.117640_bib82","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1038\/s41467-017-00573-w","article-title":"Signalling strength determines proapoptotic functions of STING","volume":"8","author":"Gulen","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2026.117640_bib83","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/j.cell.2019.05.035","article-title":"The Cytoplasmic DNA Sensor cGAS Promotes Mitotic Cell Death","volume":"178","author":"Zierhut","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2026.117640_bib84","doi-asserted-by":"crossref","first-page":"6339","DOI":"10.1038\/s41467-020-20154-8","article-title":"Ferroptotic damage promotes pancreatic tumorigenesis through a TMEM173\/STING-dependent DNA sensor pathway","volume":"11","author":"Dai","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2026.117640_bib85","doi-asserted-by":"crossref","first-page":"4043","DOI":"10.1016\/j.cell.2024.05.031","article-title":"STING orchestrates the neuronal inflammatory stress response in multiple sclerosis","volume":"187","author":"Woo","year":"2024","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2026.117640_bib86","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1016\/j.immuni.2022.04.006","article-title":"The gut microbiota prime systemic antiviral immunity via the cGAS-STING-IFN-I axis","volume":"55","author":"Erttmann","year":"2022","journal-title":"Immunity"},{"key":"10.1016\/j.celrep.2026.117640_bib87","first-page":"56774","article-title":"An Improved Method for Collection of Cerebrospinal Fluid from Anesthetized Mice","author":"Lim","year":"2018","journal-title":"J. Vis. Exp."},{"key":"10.1016\/j.celrep.2026.117640_bib88","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1007\/s00401-021-02367-3","article-title":"Altered ceramide metabolism is a feature in the extracellular vesicle-mediated spread of alpha-synuclein in Lewy body disorders","volume":"142","author":"Kurzawa-Akanbi","year":"2021","journal-title":"Acta Neuropathol."}],"container-title":["Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124726007187?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124726007187?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T05:22:01Z","timestamp":1793856121000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211124726007187"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":88,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["S2211124726007187"],"URL":"https:\/\/doi.org\/10.1016\/j.celrep.2026.117640","relation":{},"ISSN":["2211-1247"],"issn-type":[{"value":"2211-1247","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"STING-dependent peripheral inflammaging drives neurodegeneration via extracellular vesicles","name":"articletitle","label":"Article Title"},{"value":"Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.celrep.2026.117640","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"117640"}}