{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T21:50:48Z","timestamp":1791237048964,"version":"4.1.0"},"reference-count":75,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T00:00:00Z","timestamp":1781827200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100019018","name":"Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences","doi-asserted-by":"publisher","award":["2021-I2M-1-064"],"award-info":[{"award-number":["2021-I2M-1-064"]}],"id":[{"id":"10.13039\/501100019018","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004826","name":"Beijing Natural Science Foundation","doi-asserted-by":"publisher","award":["Z240015"],"award-info":[{"award-number":["Z240015"]}],"id":[{"id":"10.13039\/501100004826","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004826","name":"Beijing Natural Science Foundation","doi-asserted-by":"publisher","award":["L248046"],"award-info":[{"award-number":["L248046"]}],"id":[{"id":"10.13039\/501100004826","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["823B2007"],"award-info":[{"award-number":["823B2007"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018597","name":"Ministry of Education of the People's Republic of China Cultivation Fund of the Key Scientific and Technical Innovation Project","doi-asserted-by":"publisher","award":["2025YFKT-PT-01"],"award-info":[{"award-number":["2025YFKT-PT-01"]}],"id":[{"id":"10.13039\/501100018597","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011635","name":"Fuwai Hospital, Chinese Academy of Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011635","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005153","name":"National Science Fund for Distinguished Young Scholars","doi-asserted-by":"publisher","award":["82125004"],"award-info":[{"award-number":["82125004"]}],"id":[{"id":"10.13039\/501100005153","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005150","name":"Chinese Academy of Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005150","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Reports"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.celrep.2026.117666","type":"journal-article","created":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T09:15:38Z","timestamp":1783502138000},"page":"117666","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Time-resolved proteolipidomics of the human aorta identifies stage-specific lipid-protein modules across development and aging"],"prefix":"10.1016","volume":"45","author":[{"given":"Hao","family":"Cui","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sin Man","family":"Lam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiqi","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengda","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingkang","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ningning","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongxing","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiumeng","family":"Hua","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han","family":"Mo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guanghou","family":"Shui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9488-7823","authenticated-orcid":false,"given":"Jiangping","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.celrep.2026.117666_bib1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jacc.2006.12.050","article-title":"Mechanical factors in arterial aging: a clinical perspective","volume":"50","author":"O'Rourke","year":"2007","journal-title":"Journal of the American College of Cardiology"},{"key":"10.1016\/j.celrep.2026.117666_bib2","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCIMAGING.117.005617","article-title":"Imaging Insights on the Aorta in Aging","volume":"11","author":"Ohyama","year":"2018","journal-title":"Circ Cardiovasc Imaging"},{"key":"10.1016\/j.celrep.2026.117666_bib3","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/S0002-8703(99)70313-3","article-title":"Influence of arterial pulse and reflected waves on blood pressure and cardiac function","volume":"138","author":"London","year":"1999","journal-title":"Am. Heart J."},{"key":"10.1016\/j.celrep.2026.117666_bib4","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1152\/physiol.00035.2021","article-title":"Is It Good to Have a Stiff Aorta with Aging? Causes and Consequences","volume":"37","author":"Pierce","year":"2022","journal-title":"Physiology"},{"key":"10.1016\/j.celrep.2026.117666_bib5","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1016\/j.jacc.2019.07.012","article-title":"Large-Artery Stiffness in Health and Disease: JACC State-of-the-Art Review","volume":"74","author":"Chirinos","year":"2019","journal-title":"Journal of the American College of Cardiology"},{"key":"10.1016\/j.celrep.2026.117666_bib6","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1161\/CIRCRESAHA.121.318061","article-title":"Arterial Stiffness and Cardiovascular Risk in Hypertension","volume":"128","author":"Boutouyrie","year":"2021","journal-title":"Circ. Res."},{"key":"10.1016\/j.celrep.2026.117666_bib7","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1161\/CIRCULATIONAHA.109.914507","article-title":"Hemodynamic correlates of blood pressure across the adult age spectrum: noninvasive evaluation in the Framingham Heart Study","volume":"122","author":"Mitchell","year":"2010","journal-title":"Circulation"},{"key":"10.1016\/j.celrep.2026.117666_bib8","doi-asserted-by":"crossref","DOI":"10.1126\/science.abc8479","article-title":"Counteracting age-related VEGF signaling insufficiency promotes healthy aging and extends life span","volume":"373","author":"Grunewald","year":"2021","journal-title":"Science"},{"key":"10.1016\/j.celrep.2026.117666_bib9","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1093\/gerona\/glq135","article-title":"A vascular theory of aging","volume":"65A","author":"Le Couteur","year":"2010","journal-title":"The Journals of Gerontology Series A: Biological Sciences and Medical Sciences"},{"key":"10.1016\/j.celrep.2026.117666_bib10","doi-asserted-by":"crossref","first-page":"2109","DOI":"10.1177\/2047487319865054","article-title":"Aortic stiffening is associated with increased left ventricular mass in women but not in men","volume":"27","author":"Papaioannou","year":"2020","journal-title":"Eur. J. Prev. Cardiol."},{"key":"10.1016\/j.celrep.2026.117666_bib11","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1161\/HYPERTENSIONAHA.115.06610","article-title":"Association of Aortic Stiffness With Cognition and Brain Aging in Young and Middle-Aged Adults: The Framingham Third Generation Cohort Study","volume":"67","author":"Pase","year":"2016","journal-title":"Hypertension"},{"key":"10.1016\/j.celrep.2026.117666_bib12","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1038\/s42003-022-03563-x","article-title":"Progressive aortic stiffness in aging C57Bl\/6 mice displays altered contractile behaviour and extracellular matrix changes","volume":"5","author":"De Moudt","year":"2022","journal-title":"Commun. Biol."},{"key":"10.1016\/j.celrep.2026.117666_bib13","doi-asserted-by":"crossref","first-page":"H893","DOI":"10.1152\/ajpheart.00120.2023","article-title":"Female C57BL\/6N mice are a viable model of aortic aging in women","volume":"324","author":"Longtine","year":"2023","journal-title":"American Journal of Physiology-Heart and Circulatory Physiology"},{"key":"10.1016\/j.celrep.2026.117666_bib14","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1161\/ATVBAHA.121.316883","article-title":"Single-Cell RNA Sequencing and Assay for Transposase-Accessible Chromatin Using Sequencing Reveals Cellular and Molecular Dynamics of Aortic Aging in Mice","volume":"42","author":"Xie","year":"2022","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.celrep.2026.117666_bib15","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1161\/CIRCRESAHA.110.221846","article-title":"Short communication: vascular smooth muscle cell stiffness as a mechanism for increased aortic stiffness with aging","volume":"107","author":"Qiu","year":"2010","journal-title":"Circ. Res."},{"key":"10.1016\/j.celrep.2026.117666_bib16","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1038\/s41569-023-00881-3","article-title":"Hallmarks of cardiovascular ageing","volume":"20","author":"Abdellatif","year":"2023","journal-title":"Nat. Rev. Cardiol."},{"key":"10.1016\/j.celrep.2026.117666_bib17","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1093\/eurheartj\/ehac757","article-title":"Acute aortic dissection: evidence, uncertainties, and future therapies","volume":"44","author":"Rylski","year":"2023","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.celrep.2026.117666_bib18","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1161\/ATVBAHA.122.317643","article-title":"Aging Alters the Aortic Proteome in Health and Thoracic Aortic Aneurysm","volume":"42","author":"Tyrrell","year":"2022","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.celrep.2026.117666_bib19","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1007\/s10741-007-9034-1","article-title":"Return to the fetal gene program protects the stressed heart: a strong hypothesis","volume":"12","author":"Rajabi","year":"2007","journal-title":"Heart Fail. Rev."},{"key":"10.1016\/j.celrep.2026.117666_bib20","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1038\/s42003-024-06111-x","article-title":"A single-cell atlas of lung homeostasis reveals dynamic changes during development and aging","volume":"7","author":"Jia","year":"2024","journal-title":"Commun. Biol."},{"key":"10.1016\/j.celrep.2026.117666_bib21","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1161\/ATVBAHA.120.315373","article-title":"Single-Cell Transcriptomic Atlas of Different Human Cardiac Arteries Identifies Cell Types Associated With Vascular Physiology","volume":"41","author":"Hu","year":"2021","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.celrep.2026.117666_bib22","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1038\/s42255-021-00425-4","article-title":"A multi-omics investigation of the composition and function of extracellular vesicles along the temporal trajectory of COVID-19","volume":"3","author":"Lam","year":"2021","journal-title":"Nat. Metab."},{"key":"10.1016\/j.celrep.2026.117666_bib23","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.cmet.2024.09.009","article-title":"Non-invasive lipid panel of MASLD fibrosis transition underscores the role of lipoprotein sulfatides in hepatic immunomodulation","volume":"37","author":"Lam","year":"2025","journal-title":"Cell Metab."},{"key":"10.1016\/j.celrep.2026.117666_bib24","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1038\/s41467-017-01747-2","article-title":"Region and cell-type resolved quantitative proteomic map of the human heart","volume":"8","author":"Doll","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2026.117666_bib25","doi-asserted-by":"crossref","first-page":"H1247","DOI":"10.1152\/ajpheart.1990.259.4.H1247","article-title":"Perinatal aortic growth in lambs: relation to blood flow changes at birth","volume":"259","author":"Langille","year":"1990","journal-title":"American Journal of Physiology-Heart and Circulatory Physiology"},{"key":"10.1016\/j.celrep.2026.117666_bib26","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1159\/000356704","article-title":"Measuring physiological changes during the transition to life after birth","volume":"105","author":"van Vonderen","year":"2014","journal-title":"Neonatology"},{"key":"10.1016\/j.celrep.2026.117666_bib27","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1111\/j.1749-6632.2009.05100.x","article-title":"Return to the fetal gene program: a suggested metabolic link to gene expression in the heart","volume":"1188","author":"Taegtmeyer","year":"2010","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.celrep.2026.117666_bib28","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1038\/s41569-022-00760-3","article-title":"Branched-chain amino acids in cardiovascular disease","volume":"20","author":"McGarrah","year":"2023","journal-title":"Nat. Rev. Cardiol."},{"key":"10.1016\/j.celrep.2026.117666_bib29","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.freeradbiomed.2023.11.002","article-title":"Branched-chain amino acid catabolic defect in vascular smooth muscle cells drives thoracic aortic dissection via mTOR hyperactivation","volume":"210","author":"Yu","year":"2024","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.celrep.2026.117666_bib30","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1007\/BF03085963","article-title":"Regulation and characteristics of vascular smooth muscle cell phenotypic diversity","volume":"15","author":"Rensen","year":"2007","journal-title":"Neth. Heart J."},{"key":"10.1016\/j.celrep.2026.117666_bib31","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1007\/BF00295949","article-title":"Calcification of the human thoracic aorta during aging","volume":"54","author":"Elliott","year":"1994","journal-title":"Calcif. Tissue Int."},{"key":"10.1016\/j.celrep.2026.117666_bib32","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1016\/S0008-6363(01)00547-8","article-title":"Vitronectin is up-regulated after vascular injury and vitronectin blockade prevents neointima formation","volume":"53","author":"Dufourcq","year":"2002","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.celrep.2026.117666_bib33","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1016\/S0955-0674(97)80126-3","article-title":"Plasminogen activators, integrins, and the coordinated regulation of cell adhesion and migration","volume":"9","author":"Chapman","year":"1997","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.celrep.2026.117666_bib34","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1023\/A:1020224016830","article-title":"Ganglioside function in calcium homeostasis and signaling","volume":"27","author":"Ledeen","year":"2002","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.celrep.2026.117666_bib35","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1161\/CIRCRESAHA.125.326064","article-title":"Mineral Stress and Vascular Aging: Decoding the Epigenetic Connection to Slow the Clock","volume":"136","author":"Li","year":"2025","journal-title":"Circ. Res."},{"key":"10.1016\/j.celrep.2026.117666_bib36","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1161\/CIRCRESAHA.109.208801","article-title":"Sent to destroy: the ubiquitin proteasome system regulates cell signaling and protein quality control in cardiovascular development and disease","volume":"106","author":"Willis","year":"2010","journal-title":"Circ. Res."},{"key":"10.1016\/j.celrep.2026.117666_bib37","doi-asserted-by":"crossref","first-page":"3013","DOI":"10.1113\/JP270033","article-title":"Origin and differentiation of vascular smooth muscle cells","volume":"593","author":"Wang","year":"2015","journal-title":"J. Physiol."},{"key":"10.1016\/j.celrep.2026.117666_bib38","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1146\/annurev-physiol-012110-142315","article-title":"Epigenetic control of smooth muscle cell differentiation and phenotypic switching in vascular development and disease","volume":"74","author":"Alexander","year":"2012","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.celrep.2026.117666_bib39","first-page":"1077","article-title":"Effects of proteasome and calpain inhibitors on the structural reorganization and proliferation of vascular smooth muscle cells in primary culture","volume":"79","author":"Thyberg","year":"1999","journal-title":"Lab Invest"},{"key":"10.1016\/j.celrep.2026.117666_bib40","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1093\/cvr\/cvs128","article-title":"Physiological and pathological role of the ubiquitin-proteasome system in the vascular smooth muscle cell","volume":"95","author":"Demasi","year":"2012","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.celrep.2026.117666_bib41","doi-asserted-by":"crossref","first-page":"3304","DOI":"10.1111\/febs.15903","article-title":"Histone degradation by the proteasome regulates chromatin and cellular plasticity","volume":"289","author":"Shmueli","year":"2022","journal-title":"Febs j"},{"key":"10.1016\/j.celrep.2026.117666_bib42","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.neuron.2015.06.014","article-title":"Critical Role of Histone Turnover in Neuronal Transcription and Plasticity","volume":"87","author":"Maze","year":"2015","journal-title":"Neuron"},{"key":"10.1016\/j.celrep.2026.117666_bib43","doi-asserted-by":"crossref","first-page":"1808","DOI":"10.1128\/MCB.23.5.1808-1816.2003","article-title":"Cascade of distinct histone modifications during collagenase gene activation","volume":"23","author":"Martens","year":"2003","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.celrep.2026.117666_bib44","doi-asserted-by":"crossref","first-page":"9272","DOI":"10.1093\/nar\/gkx696","article-title":"Accumulation of histone variant H3.3 with age is associated with profound changes in the histone methylation landscape","volume":"45","author":"Tvardovskiy","year":"2017","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.celrep.2026.117666_bib45","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.molcel.2017.02.026","article-title":"A Metabolic Function for Phospholipid and Histone Methylation","volume":"66","author":"Ye","year":"2017","journal-title":"Mol. Cell"},{"key":"10.1016\/j.celrep.2026.117666_bib46","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.1161\/01.RES.0000266448.30370.a0","article-title":"Programming smooth muscle plasticity with chromatin dynamics","volume":"100","author":"McDonald","year":"2007","journal-title":"Circ. Res."},{"key":"10.1016\/j.celrep.2026.117666_bib47","doi-asserted-by":"crossref","first-page":"2765","DOI":"10.1016\/j.devcel.2021.09.001","article-title":"H3K4 di-methylation governs smooth muscle lineage identity and promotes vascular homeostasis by restraining plasticity","volume":"56","author":"Liu","year":"2021","journal-title":"Dev. Cell"},{"key":"10.1016\/j.celrep.2026.117666_bib48","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1016\/0006-291X(79)91283-X","article-title":"The effects of phospholipid and factor Va on the inhibition of factor Xa by antithrombin III","volume":"90","author":"Walker","year":"1979","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.celrep.2026.117666_bib49","doi-asserted-by":"crossref","first-page":"3532","DOI":"10.1074\/jbc.M109.079566","article-title":"Identification of human plasma proteins as major clients for the extracellular chaperone clusterin","volume":"285","author":"Wyatt","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.celrep.2026.117666_bib50","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1042\/bj3310231","article-title":"(clusterin) induces cholesterol export from macrophage-foam cells: a potential anti-atherogenic function?","volume":"331","author":"Gelissen","year":"1998","journal-title":"Biochem J"},{"key":"10.1016\/j.celrep.2026.117666_bib51","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.cmet.2018.10.013","article-title":"Quantitative Analysis of the Whole-Body Metabolic Fate of Branched-Chain Amino Acids","volume":"29","author":"Neinast","year":"2019","journal-title":"Cell Metab."},{"key":"10.1016\/j.celrep.2026.117666_bib52","doi-asserted-by":"crossref","DOI":"10.3389\/fnut.2024.1450386","article-title":"Branched-chain amino acid supplementation and voluntary running have distinct effects on the serum metabolome of rats with high or low intrinsic aerobic capacity","volume":"11","author":"Karvinen","year":"2024","journal-title":"Front. Nutr."},{"key":"10.1016\/j.celrep.2026.117666_bib53","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.21873\/invivo.12410","article-title":"Higher Branched-chain Amino Acids and Lower Serine Exist in the Plasma of Nondiabetic Mice: A Comparison Between High- and Low-protein Diet Conditions","volume":"35","author":"Arimura","year":"2021","journal-title":"In Vivo"},{"key":"10.1016\/j.celrep.2026.117666_bib54","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1007\/BF02532637","article-title":"Changes in phospholipid composition of human aorta with age","volume":"4","author":"Rouser","year":"1969","journal-title":"Lipids"},{"key":"10.1016\/j.celrep.2026.117666_bib55","doi-asserted-by":"crossref","first-page":"590","DOI":"10.14336\/AD.2017.0430","article-title":"Age-related Impairment of Vascular Structure and Functions","volume":"8","author":"Xu","year":"2017","journal-title":"Aging Dis."},{"key":"10.1016\/j.celrep.2026.117666_bib56","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1016\/j.bbamem.2014.01.003","article-title":"Effects of gangliosides on the activity of the plasma membrane Ca2+-ATPase","volume":"1838","author":"Jiang","year":"2014","journal-title":"Biochimica et Biophysica Acta (BBA) - Biomembranes"},{"key":"10.1016\/j.celrep.2026.117666_bib57","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1016\/S0140-6736(86)90530-1","article-title":"Aortic calcification as a predictor of cardiovascular mortality","volume":"328","author":"Witteman","year":"1986","journal-title":"The Lancet"},{"key":"10.1016\/j.celrep.2026.117666_bib58","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1161\/CIRCRESAHA.110.238808","article-title":"Calcium regulates key components of vascular smooth muscle cell-derived matrix vesicles to enhance mineralization","volume":"109","author":"Kapustin","year":"2011","journal-title":"Circ. Res."},{"key":"10.1016\/j.celrep.2026.117666_bib59","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.atherosclerosis.2015.11.005","article-title":"A novel organ culture model of aorta for vascular calcification","volume":"244","author":"Akiyoshi","year":"2016","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.celrep.2026.117666_bib60","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1055\/s-0031-1276590","article-title":"Vitronectin in vascular context: facets of a multitalented matricellular protein","volume":"37","author":"Preissner","year":"2011","journal-title":"Semin. Thromb. Hemost."},{"key":"10.1016\/j.celrep.2026.117666_bib61","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1073\/pnas.1524523113","article-title":"Activation of integrin \u03b15 mediated by flow requires its translocation to membrane lipid rafts in vascular endothelial cells","volume":"113","author":"Sun","year":"2016","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2026.117666_bib62","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.chemphyslip.2018.08.003","article-title":"Sphingolipids and lipid rafts: Novel concepts and methods of analysis","volume":"216","author":"Bieberich","year":"2018","journal-title":"Chem. Phys. Lipids"},{"key":"10.1016\/j.celrep.2026.117666_bib63","doi-asserted-by":"crossref","DOI":"10.1074\/mcp.M111.008128","article-title":"Extracellular Matrix Composition and Remodeling in Human Abdominal Aortic Aneurysms: A Proteomics Approach","volume":"10","author":"Didangelos","year":"2011","journal-title":"Mol. Cell. Proteomics"},{"key":"10.1016\/j.celrep.2026.117666_bib64","doi-asserted-by":"crossref","first-page":"e47","DOI":"10.1093\/nar\/gkv007","article-title":"limma powers differential expression analyses for RNA-sequencing and microarray studies","volume":"43","author":"Ritchie","year":"2015","journal-title":"Nucleic Acids Research"},{"key":"10.1016\/j.celrep.2026.117666_bib65","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1142\/S0219720005001375","article-title":"Noise robust clustering of gene expression time-course data","volume":"03","author":"Futschik","year":"2005","journal-title":"Journal of Bioinformatics and Computational Biology"},{"key":"10.1016\/j.celrep.2026.117666_bib66","doi-asserted-by":"crossref","DOI":"10.1016\/j.xinn.2021.100141","article-title":"clusterProfiler 4.0: A universal enrichment tool for interpreting omics data","volume":"2","author":"Wu","year":"2021","journal-title":"The Innovation"},{"key":"10.1016\/j.celrep.2026.117666_bib67","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/1471-2105-13-20","article-title":"graphite - a Bioconductor package to convert pathway topology to gene network","volume":"13","author":"Sales","year":"2012","journal-title":"BMC Bioinformatics"},{"key":"10.1016\/j.celrep.2026.117666_bib68","series-title":"ggplot2: Elegant Graphics for Data Analysis","first-page":"189","article-title":"Data Analysis","author":"Wickham","year":"2016"},{"key":"10.1016\/j.celrep.2026.117666_bib69","doi-asserted-by":"crossref","first-page":"2811","DOI":"10.1093\/bioinformatics\/btu393","article-title":"circlize implements and enhances circular visualization in R","volume":"30","author":"Gu","year":"2014","journal-title":"Bioinformatics"},{"key":"10.1016\/j.celrep.2026.117666_bib70","doi-asserted-by":"crossref","first-page":"1","DOI":"10.18637\/jss.v025.i01","article-title":"FactoMineR: An R Package for Multivariate Analysis","volume":"25","author":"L\u00ea","year":"2008","journal-title":"Journal of Statistical Software"},{"key":"10.1016\/j.celrep.2026.117666_bib71","volume":"2022","author":"Miao","year":"2022"},{"key":"10.1016\/j.celrep.2026.117666_bib72","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1039\/B913353D","article-title":"Toward one step analysis of cellular lipidomes using liquid chromatography coupled with mass spectrometry: application to Saccharomyces cerevisiae and Schizosaccharomyces pombe lipidomics","volume":"6","author":"Shui","year":"2010","journal-title":"Mol. Biosyst."},{"key":"10.1016\/j.celrep.2026.117666_bib73","doi-asserted-by":"crossref","DOI":"10.1016\/j.jprot.2020.103848","article-title":"Proteomics analysis reveals the effect of Aeromonas hydrophila sirtuin CobB on biological functions","volume":"225","author":"Wang","year":"2020","journal-title":"J. Proteomics"},{"key":"10.1016\/j.celrep.2026.117666_bib74","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1007\/978-1-0716-1641-3_6","article-title":"Data Processing and Analysis for DIA-Based Phosphoproteomics Using Spectronaut","volume":"2361","author":"Martinez-Val","year":"2021","journal-title":"Methods Mol Biol"},{"key":"10.1016\/j.celrep.2026.117666_bib75","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1161\/CIRCULATIONAHA.123.066110","article-title":"Ganglioside GM3 Protects Against Abdominal Aortic Aneurysm by Suppressing Ferroptosis","volume":"149","author":"Zhang","year":"2024","journal-title":"Circulation"}],"container-title":["Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124726007448?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124726007448?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T20:54:28Z","timestamp":1791233668000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211124726007448"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":75,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["S2211124726007448"],"URL":"https:\/\/doi.org\/10.1016\/j.celrep.2026.117666","relation":{},"ISSN":["2211-1247"],"issn-type":[{"value":"2211-1247","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Time-resolved proteolipidomics of the human aorta identifies stage-specific lipid-protein modules across development and aging","name":"articletitle","label":"Article Title"},{"value":"Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.celrep.2026.117666","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"117666"}}