{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T20:59:32Z","timestamp":1791233972518,"version":"4.1.0"},"reference-count":66,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T00:00:00Z","timestamp":1782691200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007038","name":"Lung Cancer Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007038","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Institutes of Health National Cancer Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014228","name":"Duke Cancer Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014228","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Reports"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.celrep.2026.117699","type":"journal-article","created":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T19:05:05Z","timestamp":1784142305000},"page":"117699","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["ABL kinase inactivation induces transcription-replication conflicts and impairs replication fork progression in metastatic small cell lung cancer"],"prefix":"10.1016","volume":"45","author":[{"given":"Jing Jin","family":"Gu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin M.","family":"Scott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arijit","family":"Ghosh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto H.","family":"Barbier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas C.","family":"Rouse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob P.","family":"Hoj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael W.","family":"Caminear","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengqi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boya","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret W.","family":"Barbier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lee","family":"Zou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Lan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1250-6880","authenticated-orcid":false,"given":"Ann Marie","family":"Pendergast","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.celrep.2026.117699_bib1","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1038\/s41572-020-00235-0","article-title":"Small-cell lung cancer","volume":"7","author":"Rudin","year":"2021","journal-title":"Nat. Rev. Dis. Primers"},{"key":"10.1016\/j.celrep.2026.117699_bib2","doi-asserted-by":"crossref","DOI":"10.15252\/emmm.202013122","article-title":"Mechanisms of small cell lung cancer metastasis","volume":"13","author":"Ko","year":"2021","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/j.celrep.2026.117699_bib3","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.3389\/fonc.2020.01074","article-title":"Update on the Biology, Management, and Treatment of Small Cell Lung Cancer (SCLC)","volume":"10","author":"Saltos","year":"2020","journal-title":"Front. Oncol."},{"key":"10.1016\/j.celrep.2026.117699_bib4","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1038\/s41568-019-0133-9","article-title":"Molecular subtypes of small cell lung cancer: a synthesis of human and mouse model data","volume":"19","author":"Rudin","year":"2019","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.celrep.2026.117699_bib5","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1101\/gad.349359.122","article-title":"Killing SCLC: insights into how to target a shapeshifting tumor","volume":"36","author":"Sutherland","year":"2022","journal-title":"Genes Dev."},{"key":"10.1016\/j.celrep.2026.117699_bib6","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/j.ccell.2020.12.014","article-title":"Patterns of transcription factor programs and immune pathway activation define four major subtypes of SCLC with distinct therapeutic vulnerabilities","volume":"39","author":"Gay","year":"2021","journal-title":"Cancer Cell"},{"key":"10.1016\/j.celrep.2026.117699_bib7","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/j.ccell.2024.01.010","article-title":"Immune heterogeneity in small-cell lung cancer and vulnerability to immune checkpoint blockade","volume":"42","author":"Nabet","year":"2024","journal-title":"Cancer Cell"},{"key":"10.1016\/j.celrep.2026.117699_bib8","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aaf6282","article-title":"Small cell lung cancer: Time to revisit DNA-damaging chemotherapy","volume":"8","author":"Thomas","year":"2016","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.celrep.2026.117699_bib9","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1038\/s41580-022-00474-x","article-title":"Sources, resolution and physiological relevance of R-loops and RNA-DNA hybrids","volume":"23","author":"Petermann","year":"2022","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.celrep.2026.117699_bib10","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1038\/nrm.2016.88","article-title":"Transcription-replication conflicts: how they occur and how they are resolved","volume":"17","author":"Garc\u00eda-Muse","year":"2016","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.celrep.2026.117699_bib11","doi-asserted-by":"crossref","first-page":"637","DOI":"10.3390\/life11070637","article-title":"Consequences and Resolution of Transcription-Replication Conflicts","volume":"11","author":"Lalonde","year":"2021","journal-title":"Life"},{"key":"10.1016\/j.celrep.2026.117699_bib12","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.89647","article-title":"Inactivation of ABL kinases suppresses non-small cell lung cancer metastasis","volume":"1","author":"Gu","year":"2016","journal-title":"JCI Insight"},{"key":"10.1016\/j.celrep.2026.117699_bib13","doi-asserted-by":"crossref","first-page":"3421","DOI":"10.1016\/j.celrep.2019.11.018","article-title":"A TAZ-AXL-ABL2 Feed-Forward Signaling Axis Promotes Lung Adenocarcinoma Brain Metastasis","volume":"29","author":"Hoj","year":"2019","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2026.117699_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2021.109880","article-title":"ABL allosteric inhibitors synergize with statins to enhance apoptosis of metastatic lung cancer cells","volume":"37","author":"Luttman","year":"2021","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2026.117699_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.111268","article-title":"ABL kinases regulate translation in HER2+ cells through Y-box-binding protein 1 to facilitate colonization of the brain","volume":"40","author":"McKernan","year":"2022","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2026.117699_bib16","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1038\/nrc3563","article-title":"Role of ABL family kinases in cancer: from leukaemia to solid tumours","volume":"13","author":"Greuber","year":"2013","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.celrep.2026.117699_bib17","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2210418120","article-title":"ABL kinases regulate the stabilization of HIF-1alpha and MYC through CPSF1","volume":"120","author":"Mayro","year":"2023","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2026.117699_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbadis.2022.166557","article-title":"Small-cell lung cancer brain metastasis: From molecular mechanisms to diagnosis and treatment","volume":"1868","author":"Zhu","year":"2022","journal-title":"Biochim. Biophys. Acta. Mol. Basis Dis."},{"key":"10.1016\/j.celrep.2026.117699_bib19","doi-asserted-by":"crossref","first-page":"1874","DOI":"10.18632\/oncotarget.26740","article-title":"ABL kinase inhibition sensitizes primary lung adenocarcinomas to chemotherapy by promoting tumor cell differentiation","volume":"10","author":"Khatri","year":"2019","journal-title":"Oncotarget"},{"key":"10.1016\/j.celrep.2026.117699_bib20","doi-asserted-by":"crossref","first-page":"4744","DOI":"10.1158\/0008-5472.CAN-19-1236","article-title":"Targeting BCR-ABL1 in Chronic Myeloid Leukemia by PROTAC-Mediated Targeted Protein Degradation","volume":"79","author":"Burslem","year":"2019","journal-title":"Cancer Res."},{"key":"10.1016\/j.celrep.2026.117699_bib21","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1038\/nature21702","article-title":"The allosteric inhibitor ABL001 enables dual targeting of BCR-ABL1","volume":"543","author":"Wylie","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2026.117699_bib22","doi-asserted-by":"crossref","first-page":"4115","DOI":"10.1038\/s41467-018-06586-3","article-title":"ROS-induced R loops trigger a transcription-coupled but BRCA1\/2-independent homologous recombination pathway through CSB","volume":"9","author":"Teng","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2026.117699_bib23","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1038\/s41586-021-03538-8","article-title":"RNA transcripts stimulate homologous recombination by forming DR-loops","volume":"594","author":"Ouyang","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2026.117699_bib24","doi-asserted-by":"crossref","first-page":"4590","DOI":"10.1093\/nar\/gkx126","article-title":"RAD51 interconnects between DNA replication, DNA repair and immunity","volume":"45","author":"Bhattacharya","year":"2017","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.celrep.2026.117699_bib25","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1016\/j.molcel.2016.02.001","article-title":"RNA Processing and Genome Stability: Cause and Consequence","volume":"61","author":"Wickramasinghe","year":"2016","journal-title":"Mol. Cell"},{"key":"10.1016\/j.celrep.2026.117699_bib26","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1146\/annurev-genet-080320-031523","article-title":"Transcription-Replication Conflicts as a Source of Genome Instability","volume":"57","author":"Goehring","year":"2023","journal-title":"Annu. Rev. Genet."},{"key":"10.1016\/j.celrep.2026.117699_bib27","doi-asserted-by":"crossref","first-page":"7776","DOI":"10.1038\/s41467-024-51784-x","article-title":"RAD52 resolves transcription-replication conflicts to mitigate R-loop induced genome instability","volume":"15","author":"Jalan","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2026.117699_bib28","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1007\/978-1-0716-2477-7_19","article-title":"Proximity Ligation Assay for Detection of R-Loop Complexes upon DNA Damage","volume":"2528","author":"Alagia","year":"2022","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.celrep.2026.117699_bib29","doi-asserted-by":"crossref","DOI":"10.1083\/jcb.202004079","article-title":"Recognition of RNA by the S9.6 antibody creates pervasive artifacts when imaging RNA:DNA hybrids","volume":"220","author":"Smolka","year":"2021","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.celrep.2026.117699_bib30","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.molcel.2012.04.009","article-title":"R loops: from transcription byproducts to threats to genome stability","volume":"46","author":"Aguilera","year":"2012","journal-title":"Mol. Cell"},{"key":"10.1016\/j.celrep.2026.117699_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2023.112792","article-title":"ATR protects ongoing and newly assembled DNA replication forks through distinct mechanisms","volume":"42","author":"Leung","year":"2023","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2026.117699_bib32","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/bs.mie.2017.03.019","article-title":"DNA Fiber Analysis: Mind the Gap","volume":"591","author":"Quinet","year":"2017","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.celrep.2026.117699_bib33","doi-asserted-by":"crossref","first-page":"E6045","DOI":"10.1073\/pnas.1604807113","article-title":"Tyrosine phosphorylation stimulates activity of human RAD51 recombinase through altered nucleoprotein filament dynamics","volume":"113","author":"Subramanyam","year":"2016","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2026.117699_bib34","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.bbrc.2009.03.020","article-title":"c-ABL tyrosine kinase stabilizes RAD51 chromatin association","volume":"382","author":"Shimizu","year":"2009","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.celrep.2026.117699_bib35","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/S1097-2765(01)00357-4","article-title":"BCR\/ABL regulates mammalian RecA homologs, resulting in drug resistance","volume":"8","author":"Slupianek","year":"2001","journal-title":"Mol. Cell"},{"key":"10.1016\/j.celrep.2026.117699_bib36","doi-asserted-by":"crossref","first-page":"48944","DOI":"10.1074\/jbc.M208151200","article-title":"Regulation of ionizing radiation-induced Rad52 nuclear foci formation by c-Abl-mediated phosphorylation","volume":"277","author":"Kitao","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.celrep.2026.117699_bib37","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1093\/embo-reports\/kvd002","article-title":"Coordinated response of mammalian Rad51 and Rad52 to DNA damage","volume":"1","author":"Liu","year":"2000","journal-title":"EMBO Rep."},{"key":"10.1016\/j.celrep.2026.117699_bib38","doi-asserted-by":"crossref","first-page":"2699","DOI":"10.1158\/0008-5472.CAN-07-6505","article-title":"Distinct RAD51 associations with RAD52 and BCCIP in response to DNA damage and replication stress","volume":"68","author":"Wray","year":"2008","journal-title":"Cancer Res."},{"key":"10.1016\/j.celrep.2026.117699_bib39","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkt1309","article-title":"Quantitation of DNA double-strand break resection intermediates in human cells","volume":"42","author":"Zhou","year":"2014","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.celrep.2026.117699_bib40","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0266645","article-title":"RAD51 is a druggable target that sustains replication fork progression upon DNA replication stress","volume":"17","author":"Feu","year":"2022","journal-title":"PLoS One"},{"key":"10.1016\/j.celrep.2026.117699_bib41","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1182\/blood-2010-09-307256","article-title":"Targeting RAD51 phosphotyrosine-315 to prevent unfaithful recombination repair in BCR-ABL1 leukemia","volume":"118","author":"Slupianek","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.celrep.2026.117699_bib42","doi-asserted-by":"crossref","first-page":"2298","DOI":"10.1016\/j.molcel.2022.05.004","article-title":"Hallmarks of DNA replication stress","volume":"82","author":"Saxena","year":"2022","journal-title":"Mol. Cell"},{"key":"10.1016\/j.celrep.2026.117699_bib43","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1158\/1535-7163.MCT-18-0972","article-title":"Inhibition of the Replication Stress Response Is a Synthetic Vulnerability in SCLC That Acts Synergistically in Combination with Cisplatin","volume":"18","author":"Nagel","year":"2019","journal-title":"Mol. Cancer Ther."},{"key":"10.1016\/j.celrep.2026.117699_bib44","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1016\/j.ccell.2021.02.014","article-title":"Therapeutic targeting of ATR yields durable regressions in small cell lung cancers with high replication stress","volume":"39","author":"Thomas","year":"2021","journal-title":"Cancer Cell"},{"key":"10.1016\/j.celrep.2026.117699_bib45","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.gde.2021.07.003","article-title":"An extending ATR-CHK1 circuitry: the replication stress response and beyond","volume":"71","author":"Simoneau","year":"2021","journal-title":"Curr. Opin. Genet. Dev."},{"key":"10.1016\/j.celrep.2026.117699_bib46","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.tibs.2010.09.005","article-title":"ATR: a master conductor of cellular responses to DNA replication stress","volume":"36","author":"Flynn","year":"2011","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.celrep.2026.117699_bib47","doi-asserted-by":"crossref","DOI":"10.1126\/scisignal.aad3210","article-title":"ABL kinases promote breast cancer osteolytic metastasis by modulating tumor-bone interactions through TAZ and STAT5 signaling","volume":"9","author":"Wang","year":"2016","journal-title":"Sci. Signal."},{"key":"10.1016\/j.celrep.2026.117699_bib48","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1038\/s41556-018-0138-8","article-title":"Pericyte-like spreading by disseminated cancer cells activates YAP and MRTF for metastatic colonization","volume":"20","author":"Er","year":"2018","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.celrep.2026.117699_bib49","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/S1470-2045(17)30230-9","article-title":"Prophylactic cranial irradiation versus observation in patients with extensive-disease small-cell lung cancer: a multicentre, randomised, open-label, phase 3 trial","volume":"18","author":"Takahashi","year":"2017","journal-title":"Lancet Oncol."},{"key":"10.1016\/j.celrep.2026.117699_bib50","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1200\/JCO.2017.75.9589","article-title":"Whole-Brain Radiotherapy for Brain Metastases: Evolution or Revolution?","volume":"36","author":"Brown","year":"2018","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.celrep.2026.117699_bib51","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1093\/neuonc\/nov266","article-title":"Different spatial distributions of brain metastases from lung cancer by histological subtype and mutation status of epidermal growth factor receptor","volume":"18","author":"Takano","year":"2016","journal-title":"Neuro Oncol."},{"key":"10.1016\/j.celrep.2026.117699_bib52","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/s40644-021-00410-w","article-title":"Exploration of spatial distribution of brain metastasis from small cell lung cancer and identification of metastatic risk level of brain regions: a multicenter, retrospective study","volume":"21","author":"Wang","year":"2021","journal-title":"Cancer Imaging"},{"key":"10.1016\/j.celrep.2026.117699_bib53","doi-asserted-by":"crossref","first-page":"15199","DOI":"10.1002\/cam4.6206","article-title":"Magnetic resonance imaging characteristics of brain metastases in small cell lung cancer","volume":"12","author":"Zhu","year":"2023","journal-title":"Cancer Med."},{"key":"10.1016\/j.celrep.2026.117699_bib54","doi-asserted-by":"crossref","first-page":"3467","DOI":"10.1093\/nar\/gkz024","article-title":"Tyrosine kinase c-Abl couples RNA polymerase II transcription to DNA double-strand breaks","volume":"47","author":"Burger","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.celrep.2026.117699_bib55","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2023.113489","article-title":"The phosphorylated trimeric SOSS1 complex and RNA polymerase II trigger liquid-liquid phase separation at double-strand breaks","volume":"42","author":"Long","year":"2023","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2026.117699_bib56","doi-asserted-by":"crossref","DOI":"10.1093\/narcan\/zcaf031","article-title":"ABL1-mediated tyrosine phosphorylation of SYCP2 contributes to transcription-coupled homologous recombination and platinum resistance in ovarian cancer","volume":"7","author":"Gao","year":"2025","journal-title":"NAR Cancer"},{"key":"10.1016\/j.celrep.2026.117699_bib57","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1056\/NEJMoa2400858","article-title":"Asciminib in Newly Diagnosed Chronic Myeloid Leukemia","volume":"391","author":"Hochhaus","year":"2024","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.celrep.2026.117699_bib58","doi-asserted-by":"crossref","DOI":"10.3390\/cancers14040953","article-title":"Everything Comes with a Price: The Toxicity Profile of DNA-Damage Response Targeting Agents","volume":"14","author":"Martorana","year":"2022","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.celrep.2026.117699_bib59","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1158\/2159-8290.CD-18-1020","article-title":"Targeting DNA Damage Response Promotes Antitumor Immunity through STING-Mediated T-cell Activation in Small Cell Lung Cancer","volume":"9","author":"Sen","year":"2019","journal-title":"Cancer Discov."},{"key":"10.1016\/j.celrep.2026.117699_bib60","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.ado4618","article-title":"ATR inhibition activates cancer cell cGAS\/STING-interferon signaling and promotes antitumor immunity in small-cell lung cancer","volume":"10","author":"Taniguchi","year":"2024","journal-title":"Sci. Adv."},{"key":"10.1016\/j.celrep.2026.117699_bib61","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1038\/s41587-019-0201-4","article-title":"Graph-based genome alignment and genotyping with HISAT2 and HISAT-genotype","volume":"37","author":"Kim","year":"2019","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.celrep.2026.117699_bib62","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1093\/bioinformatics\/btt656","article-title":"featureCounts: an efficient general purpose program for assigning sequence reads to genomic features","volume":"30","author":"Liao","year":"2014","journal-title":"Bioinformatics"},{"key":"10.1016\/j.celrep.2026.117699_bib63","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol."},{"key":"10.1016\/j.celrep.2026.117699_bib64","doi-asserted-by":"crossref","first-page":"15545","DOI":"10.1073\/pnas.0506580102","article-title":"Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles","volume":"102","author":"Subramanian","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2026.117699_bib65","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/nmeth.2019","article-title":"Fiji: an open-source platform for biological-image analysis","volume":"9","author":"Schindelin","year":"2012","journal-title":"Nat. Methods"},{"key":"10.1016\/j.celrep.2026.117699_bib66","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0082241","article-title":"Online survival analysis software to assess the prognostic value of biomarkers using transcriptomic data in non-small-cell lung cancer","volume":"8","author":"Gy\u0151rffy","year":"2013","journal-title":"PLoS One"}],"container-title":["Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124726007771?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124726007771?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T20:42:14Z","timestamp":1791232934000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211124726007771"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":66,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["S2211124726007771"],"URL":"https:\/\/doi.org\/10.1016\/j.celrep.2026.117699","relation":{},"ISSN":["2211-1247"],"issn-type":[{"value":"2211-1247","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"ABL kinase inactivation induces transcription-replication conflicts and impairs replication fork progression in metastatic small cell lung cancer","name":"articletitle","label":"Article Title"},{"value":"Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.celrep.2026.117699","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"117699"}}