{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T20:36:43Z","timestamp":1790800603340,"version":"4.1.0"},"reference-count":72,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T00:00:00Z","timestamp":1783296000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Institutes of Health National Cancer Institute","doi-asserted-by":"publisher","award":["ZIA BC 011975"],"award-info":[{"award-number":["ZIA BC 011975"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Institutes of Health National Cancer Institute","doi-asserted-by":"publisher","award":["HHSN26120150003I"],"award-info":[{"award-number":["HHSN26120150003I"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000016","name":"U.S. Department of Health and Human Services","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000016","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Reports"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.celrep.2026.117723","type":"journal-article","created":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T15:59:29Z","timestamp":1784995169000},"page":"117723","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Distributed clonal deletion prevents autoimmune disease progression"],"prefix":"10.1016","volume":"45","author":[{"given":"Anna M.","family":"Newen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uzair A.","family":"Ansari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikala J.","family":"Simpson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fiona","family":"Flynn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sukriti","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Ivanov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ishaan","family":"Antani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dylan","family":"Pfannenstiel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baktiar","family":"Karim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Bassel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Capaldo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingrong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daoud","family":"Meerzaman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Indu","family":"Raman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengsong","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cornelius Y.","family":"Taabazuing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamid","family":"Kashkar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0256-9650","authenticated-orcid":false,"given":"Christian T.","family":"Mayer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.celrep.2026.117723_bib1","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1126\/science.1086907","article-title":"Predominant autoantibody production by early human B cell precursors","volume":"301","author":"Wardemann","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.celrep.2026.117723_bib2","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.immuni.2007.01.009","article-title":"Autoreactivity in human IgG+ memory B cells","volume":"26","author":"Tiller","year":"2007","journal-title":"Immunity"},{"key":"10.1016\/j.celrep.2026.117723_bib3","doi-asserted-by":"crossref","first-page":"603","DOI":"10.3389\/fimmu.2017.00603","article-title":"Mechanisms of Autoantibody-Induced Pathology","volume":"8","author":"Ludwig","year":"2017","journal-title":"Front. Immunol."},{"key":"10.1016\/j.celrep.2026.117723_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.110873","article-title":"Serum autoantibodyome reveals that healthy individuals share common autoantibodies","volume":"39","author":"Shome","year":"2022","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2026.117723_bib5","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1136\/jcp.53.6.424","article-title":"The use of laboratory tests in the diagnosis of SLE","volume":"53","author":"Egner","year":"2000","journal-title":"J. Clin. Pathol."},{"key":"10.1016\/j.celrep.2026.117723_bib6","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1038\/nri3570","article-title":"Orchestrating B cell lymphopoiesis through interplay of IL-7 receptor and pre-B cell receptor signalling","volume":"14","author":"Clark","year":"2014","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.celrep.2026.117723_bib7","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1038\/nri2491","article-title":"Regulation of B-cell proliferation and differentiation by pre-B-cell receptor signalling","volume":"9","author":"Herzog","year":"2009","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.celrep.2026.117723_bib8","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1146\/annurev.immunol.19.1.595","article-title":"B cell development pathways","volume":"19","author":"Hardy","year":"2001","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.celrep.2026.117723_bib9","doi-asserted-by":"crossref","first-page":"6834","DOI":"10.4049\/jimmunol.167.12.6834","article-title":"Resolution of three nonproliferative immature splenic B cell subsets reveals multiple selection points during peripheral B cell maturation","volume":"167","author":"Allman","year":"2001","journal-title":"J. Immunol."},{"key":"10.1016\/j.celrep.2026.117723_bib10","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1084\/jem.190.1.75","article-title":"B cell development in the spleen takes place in discrete steps and is determined by the quality of B cell receptor-derived signals","volume":"190","author":"Loder","year":"1999","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.celrep.2026.117723_bib11","doi-asserted-by":"crossref","first-page":"4691","DOI":"10.1038\/s41467-024-49062-x","article-title":"Peripheral apoptosis and limited clonal deletion during physiologic murine B lymphocyte development","volume":"15","author":"Simpson","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2026.117723_bib12","doi-asserted-by":"crossref","first-page":"4431","DOI":"10.4049\/jimmunol.151.9.4431","article-title":"Peripheral B cell maturation. II. Heat-stable antigen(hi) splenic B cells are an immature developmental intermediate in the production of long-lived marrow-derived B cells","volume":"151","author":"Allman","year":"1993","journal-title":"J. Immunol."},{"key":"10.1016\/j.celrep.2026.117723_bib13","doi-asserted-by":"crossref","first-page":"3738","DOI":"10.1002\/(SICI)1521-4141(199811)28:11<3738::AID-IMMU3738>3.0.CO;2-Q","article-title":"Characterization of immature B cells by a novel monoclonal antibody, by turnover and by mitogen reactivity","volume":"28","author":"Rolink","year":"1998","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.celrep.2026.117723_bib14","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1146\/annurev-immunol-120419-022408","article-title":"Germinal Centers","volume":"40","author":"Victora","year":"2022","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.celrep.2026.117723_bib15","doi-asserted-by":"crossref","first-page":"1652","DOI":"10.1016\/j.immuni.2021.07.015","article-title":"The unique biology of germinal center B cells","volume":"54","author":"Young","year":"2021","journal-title":"Immunity"},{"key":"10.1016\/j.celrep.2026.117723_bib16","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.coi.2016.12.004","article-title":"Germinal centers: programmed for affinity maturation and antibody diversification","volume":"45","author":"Bannard","year":"2017","journal-title":"Curr. Opin. Immunol."},{"key":"10.1016\/j.celrep.2026.117723_bib17","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.immuni.2019.07.001","article-title":"Class-Switch Recombination Occurs Infrequently in Germinal Centers","volume":"51","author":"Roco","year":"2019","journal-title":"Immunity"},{"key":"10.1016\/j.celrep.2026.117723_bib18","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1038\/337562a0","article-title":"Clonal deletion of B lymphocytes in a transgenic mouse bearing anti-MHC class I antibody genes","volume":"337","author":"Nemazee","year":"1989","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2026.117723_bib19","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1038\/354308a0","article-title":"Peripheral deletion of self-reactive B cells","volume":"354","author":"Russell","year":"1991","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2026.117723_bib20","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1146\/annurev-immunol-051116-052510","article-title":"Self-Reactive B Cells in the Germinal Center Reaction","volume":"36","author":"Brink","year":"2018","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.celrep.2026.117723_bib21","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1084\/jem.20102265","article-title":"Liver-expressed Igkappa superantigen induces tolerance of polyclonal B cells by clonal deletion not kappa to lambda receptor editing","volume":"208","author":"Ota","year":"2011","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.celrep.2026.117723_bib22","doi-asserted-by":"crossref","first-page":"2065","DOI":"10.1084\/jem.20112272","article-title":"Deletion and anergy of polyclonal B cells specific for ubiquitous membrane-bound self-antigen","volume":"209","author":"Taylor","year":"2012","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.celrep.2026.117723_bib23","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.1084\/jem.182.6.1635","article-title":"In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. IV. Affinity-dependent, antigen-driven B cell apoptosis in germinal centers as a mechanism for maintaining self-tolerance","volume":"182","author":"Han","year":"1995","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.celrep.2026.117723_bib24","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1038\/375331a0","article-title":"Soluble antigen can cause enhanced apoptosis of germinal-centre B cells","volume":"375","author":"Pulendran","year":"1995","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2026.117723_bib25","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1038\/375334a0","article-title":"Antigen-induced B-cell death and elimination during germinal-centre immune responses","volume":"375","author":"Shokat","year":"1995","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2026.117723_bib26","doi-asserted-by":"crossref","first-page":"1735","DOI":"10.1126\/science.286.5445.1735","article-title":"Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity","volume":"286","author":"Bouillet","year":"1999","journal-title":"Science"},{"key":"10.1016\/j.celrep.2026.117723_bib27","doi-asserted-by":"crossref","first-page":"2276","DOI":"10.1182\/blood-2003-07-2469","article-title":"VavP-Bcl2 transgenic mice develop follicular lymphoma preceded by germinal center hyperplasia","volume":"103","author":"Egle","year":"2004","journal-title":"Blood"},{"key":"10.1016\/j.celrep.2026.117723_bib28","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2014.138","article-title":"Constitutive expression of murine c-FLIPR causes autoimmunity in aged mice","volume":"5","author":"Ewald","year":"2014","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.celrep.2026.117723_bib29","doi-asserted-by":"crossref","first-page":"8661","DOI":"10.1073\/pnas.88.19.8661","article-title":"Enforced BCL2 expression in B-lymphoid cells prolongs antibody responses and elicits autoimmune disease","volume":"88","author":"Strasser","year":"1991","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2026.117723_bib30","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.705307","article-title":"Impaired B Cell Apoptosis Results in Autoimmunity That Is Alleviated by Ablation of Btk","volume":"12","author":"Wright","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.celrep.2026.117723_bib31","doi-asserted-by":"crossref","first-page":"11272","DOI":"10.1073\/pnas.0504783102","article-title":"Essential role of BAX,BAK in B cell homeostasis and prevention of autoimmune disease","volume":"102","author":"Takeuchi","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2026.117723_bib32","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1038\/356314a0","article-title":"Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis","volume":"356","author":"Watanabe-Fukunaga","year":"1992","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2026.117723_bib33","doi-asserted-by":"crossref","first-page":"24957","DOI":"10.1073\/pnas.2015372117","article-title":"An apoptosis-dependent checkpoint for autoimmunity in memory B and plasma cells","volume":"117","author":"Mayer","year":"2020","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2026.117723_bib34","doi-asserted-by":"crossref","first-page":"25343","DOI":"10.1074\/jbc.M115.647008","article-title":"Functional Characterization of Autoantibodies against Complement Component C3 in Patients with Lupus Nephritis","volume":"290","author":"Vasilev","year":"2015","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.celrep.2026.117723_bib35","first-page":"241","article-title":"Autoantibody to proliferating cell nuclear antigen (PCNA) in SLE: a clinical and serological study","volume":"5","author":"Asero","year":"1987","journal-title":"Clin. Exp. Rheumatol."},{"key":"10.1016\/j.celrep.2026.117723_bib36","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1038\/s42003-021-01932-6","article-title":"Analysis of human total antibody repertoires in TIF1gamma autoantibody positive dermatomyositis","volume":"4","author":"Megremis","year":"2021","journal-title":"Commun. Biol."},{"key":"10.1016\/j.celrep.2026.117723_bib37","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1016\/j.cell.2004.05.014","article-title":"Survival of resting mature B lymphocytes depends on BCR signaling via the Igalpha\/beta heterodimer","volume":"117","author":"Kraus","year":"2004","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2026.117723_bib38","doi-asserted-by":"crossref","DOI":"10.1126\/science.aao2602","article-title":"The microanatomic segregation of selection by apoptosis in the germinal center","volume":"358","author":"Mayer","year":"2017","journal-title":"Science"},{"key":"10.1016\/j.celrep.2026.117723_bib39","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1038\/342929a0","article-title":"Mechanism of antigen-driven selection in germinal centres","volume":"342","author":"Liu","year":"1989","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2026.117723_bib40","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1093\/intimm\/10.11.1673","article-title":"B cell receptor-induced apoptosis in primary transitional murine B cells: signaling requirements and modulation by T cell help","volume":"10","author":"Sater","year":"1998","journal-title":"Int. Immunol."},{"key":"10.1016\/j.celrep.2026.117723_bib41","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1016\/j.immuni.2016.01.011","article-title":"Independent Roles of Switching and Hypermutation in the Development and Persistence of B Lymphocyte Memory","volume":"44","author":"Gitlin","year":"2016","journal-title":"Immunity"},{"key":"10.1016\/j.celrep.2026.117723_bib42","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1182\/hematology.2025000718","article-title":"Diagnosis and management of cold agglutinin disease","volume":"2025","author":"Berentsen","year":"2025","journal-title":"Hematol. Am Soc Hematol Educ Program"},{"key":"10.1016\/j.celrep.2026.117723_bib43","doi-asserted-by":"crossref","first-page":"148","DOI":"10.3109\/08916934.2012.750299","article-title":"Potential roles of activation-induced cytidine deaminase in promotion or prevention of autoimmunity in humans","volume":"46","author":"Durandy","year":"2013","journal-title":"Autoimmunity"},{"key":"10.1016\/j.celrep.2026.117723_bib44","doi-asserted-by":"crossref","first-page":"11560","DOI":"10.1073\/pnas.1102571108","article-title":"Activation-induced cytidine deaminase mediates central tolerance in B cells","volume":"108","author":"Kuraoka","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2026.117723_bib45","doi-asserted-by":"crossref","first-page":"1598","DOI":"10.1093\/brain\/awz106","article-title":"Early B cell tolerance defects in neuromyelitis optica favour anti-AQP4 autoantibody production","volume":"142","author":"Cotzomi","year":"2019","journal-title":"Brain"},{"key":"10.1016\/j.celrep.2026.117723_bib46","doi-asserted-by":"crossref","first-page":"9727","DOI":"10.1073\/pnas.0803644105","article-title":"Autoreactive IgG memory antibodies in patients with systemic lupus erythematosus arise from nonreactive and polyreactive precursors","volume":"105","author":"Mietzner","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2026.117723_bib47","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1111\/imr.12821","article-title":"Impaired B-cell tolerance checkpoints promote the development of autoimmune diseases and pathogenic autoantibodies","volume":"292","author":"Meffre","year":"2019","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.celrep.2026.117723_bib48","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1038\/s41590-018-0182-3","article-title":"Hyperactivated PI3Kdelta promotes self and commensal reactivity at the expense of optimal humoral immunity","volume":"19","author":"Preite","year":"2018","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.celrep.2026.117723_bib49","doi-asserted-by":"crossref","first-page":"4289","DOI":"10.1172\/JCI84645","article-title":"Decreased somatic hypermutation induces an impaired peripheral B cell tolerance checkpoint","volume":"126","author":"Cantaert","year":"2016","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.celrep.2026.117723_bib50","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1016\/j.immuni.2015.10.002","article-title":"Activation-Induced Cytidine Deaminase Expression in Human B Cell Precursors Is Essential for Central B Cell Tolerance","volume":"43","author":"Cantaert","year":"2015","journal-title":"Immunity"},{"key":"10.1016\/j.celrep.2026.117723_bib51","doi-asserted-by":"crossref","first-page":"11554","DOI":"10.1073\/pnas.1102600108","article-title":"Activation-induced cytidine deaminase (AID) is required for B-cell tolerance in humans","volume":"108","author":"Meyers","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2026.117723_bib52","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.4049\/jimmunol.1900501","article-title":"Abrogated AID Function Prolongs Survival and Diminishes Renal Pathology in the BXSB Mouse Model of Systemic Lupus Erythematosus","volume":"204","author":"Zhu","year":"2020","journal-title":"J. Immunol."},{"key":"10.1016\/j.celrep.2026.117723_bib53","doi-asserted-by":"crossref","first-page":"7422","DOI":"10.4049\/jimmunol.178.11.7422","article-title":"Abrogation of lupus nephritis in activation-induced deaminase-deficient MRL\/lpr mice","volume":"178","author":"Jiang","year":"2007","journal-title":"J. Immunol."},{"key":"10.1016\/j.celrep.2026.117723_bib54","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.95882","article-title":"Activation-induced cytidine deaminase deficiency accelerates autoimmune diabetes in NOD mice","volume":"3","author":"Tan","year":"2018","journal-title":"JCI Insight"},{"key":"10.1016\/j.celrep.2026.117723_bib55","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1111\/j.1365-2249.2009.04058.x","article-title":"Deficiency in activation-induced cytidine deaminase promotes systemic autoimmunity in lpr mice on a C57BL\/6 background","volume":"159","author":"Chen","year":"2009","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.celrep.2026.117723_bib56","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1126\/science.1077336","article-title":"Critical roles of activation-induced cytidine deaminase in the homeostasis of gut flora","volume":"298","author":"Fagarasan","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.celrep.2026.117723_bib57","doi-asserted-by":"crossref","first-page":"64","DOI":"10.3389\/fimmu.2019.00064","article-title":"Autoantibodies Against C3b-Functional Consequences and Disease Relevance","volume":"10","author":"Vasilev","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.celrep.2026.117723_bib58","doi-asserted-by":"crossref","first-page":"886","DOI":"10.3389\/fimmu.2019.00886","article-title":"Nephritic Factors: An Overview of Classification, Diagnostic Tools and Clinical Associations","volume":"10","author":"Corvillo","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.celrep.2026.117723_bib59","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1084\/jem.20041854","article-title":"An immunoglobulin C kappa-reactive single chain antibody fusion protein induces tolerance through receptor editing in a normal polyclonal immune system","volume":"201","author":"Ait-Azzouzene","year":"2005","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.celrep.2026.117723_bib60","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1038\/ni1076","article-title":"Receptor editing is the main mechanism of B cell tolerance toward membrane antigens","volume":"5","author":"Halverson","year":"2004","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.celrep.2026.117723_bib61","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1016\/j.cell.2008.09.062","article-title":"AID is required for the chromosomal breaks in c-myc that lead to c-myc\/IgH translocations","volume":"135","author":"Robbiani","year":"2008","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2026.117723_bib62","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/j.immuni.2017.03.016","article-title":"NAIP-NLRC4 Inflammasomes Coordinate Intestinal Epithelial Cell Expulsion with Eicosanoid and IL-18 Release via Activation of Caspase-1 and -8","volume":"46","author":"Rauch","year":"2017","journal-title":"Immunity"},{"key":"10.1016\/j.celrep.2026.117723_bib63","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1038\/nature22393","article-title":"Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin","volume":"547","author":"Wang","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2026.117723_bib64","doi-asserted-by":"crossref","first-page":"13789","DOI":"10.1073\/pnas.0605944103","article-title":"Testing gene function early in the B cell lineage in mb1-cre mice","volume":"103","author":"Hobeika","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2026.117723_bib65","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/S0092-8674(00)00078-7","article-title":"Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme","volume":"102","author":"Muramatsu","year":"2000","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2026.117723_bib66","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/j.immuni.2013.06.018","article-title":"The pseudokinase MLKL mediates necroptosis via a molecular switch mechanism","volume":"39","author":"Murphy","year":"2013","journal-title":"Immunity"},{"key":"10.1016\/j.celrep.2026.117723_bib67","doi-asserted-by":"crossref","first-page":"2732","DOI":"10.1182\/blood-2015-11-684183","article-title":"B-cell-specific conditional expression of Myd88p.L252P leads to the development of diffuse large B-cell lymphoma in mice","volume":"127","author":"Knittel","year":"2016","journal-title":"Blood"},{"key":"10.1016\/j.celrep.2026.117723_bib68","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkaf018","article-title":"edgeR v4: powerful differential analysis of sequencing data with expanded functionality and improved support for small counts and larger datasets","volume":"53","author":"Chen","year":"2025","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.celrep.2026.117723_bib69","doi-asserted-by":"crossref","first-page":"3292","DOI":"10.1038\/s41596-024-01020-z","article-title":"Using clusterProfiler to characterize multiomics data","volume":"19","author":"Xu","year":"2024","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.celrep.2026.117723_bib70","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.174976","article-title":"Validation of a murine proteome-wide phage display library for identification of autoantibody specificities","volume":"8","author":"Rackaityte","year":"2023","journal-title":"JCI Insight"},{"key":"10.1016\/j.celrep.2026.117723_bib71","doi-asserted-by":"crossref","first-page":"1958","DOI":"10.1038\/s41596-018-0025-6","article-title":"PhIP-Seq characterization of serum antibodies using oligonucleotide-encoded peptidomes","volume":"13","author":"Mohan","year":"2018","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.celrep.2026.117723_bib72","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1186\/s12864-022-08869-y","article-title":"Detecting antibody reactivities in Phage ImmunoPrecipitation Sequencing data","volume":"23","author":"Chen","year":"2022","journal-title":"BMC Genom."}],"container-title":["Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124726008016?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124726008016?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T04:57:50Z","timestamp":1789707470000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211124726008016"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":72,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["S2211124726008016"],"URL":"https:\/\/doi.org\/10.1016\/j.celrep.2026.117723","relation":{},"ISSN":["2211-1247"],"issn-type":[{"value":"2211-1247","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Distributed clonal deletion prevents autoimmune disease progression","name":"articletitle","label":"Article Title"},{"value":"Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.celrep.2026.117723","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"117723"}}