{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T05:06:40Z","timestamp":1789708000929,"version":"4.0.1"},"reference-count":90,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T00:00:00Z","timestamp":1783382400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002241","name":"Japan Science and Technology Agency","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002241","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008667","name":"SENSHIN Medical Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008667","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008608","name":"Sumitomo Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008608","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100024224","name":"Chemo-Sero-Therapeutic Research Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100024224","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007449","name":"Takeda Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007449","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003837","name":"Ichiro Kanehara Foundation for the Promotion of Medical Sciences and Medical Care","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003837","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005927","name":"Daiichi Sankyo Foundation of Life Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005927","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008801","name":"Senri Life Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008801","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004398","name":"Mitsubishi Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004398","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012630","name":"Life Science Foundation of Japan","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012630","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100002491","name":"Bristol-Myers Squibb","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100002491","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003485","name":"Heiwa Nakajima Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003485","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004330","name":"GlaxoSmithKline","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004330","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003844","name":"Inamori Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003844","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007428","name":"Naito Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007428","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013236","name":"MSD Life Science Foundation, Public Interest Incorporated Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013236","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007263","name":"Astellas Foundation for Research on Metabolic Disorders","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007263","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012832","name":"Okinaka Memorial Institute for Medical Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012832","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008880","name":"Kanae Foundation for the Promotion of Medical Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008880","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008042","name":"Obayashi Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008042","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008732","name":"Uehara Memorial Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008732","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020050","name":"Japan Intractable Diseases Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100020050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012626","name":"Japan Allergy Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012626","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005865","name":"Mochida Memorial Foundation for Medical and Pharmaceutical Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005865","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007451","name":"Cell Science Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007451","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004088","name":"Kowa Life Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004088","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100032149","name":"Harmonic Ito Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100032149","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008899","name":"Waksman Foundation of Japan","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008899","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016241","name":"Nakayama Foundation for Human Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016241","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Reports"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.celrep.2026.117745","type":"journal-article","created":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T00:30:32Z","timestamp":1785371432000},"page":"117745","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Circulating memory-phenotype CD4+ T cells rapidly accumulate in the ischemic gut to exacerbate tissue injury in an innate manner"],"prefix":"10.1016","volume":"45","author":[{"given":"Kosuke","family":"Sato","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunichi","family":"Tayama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihisa","family":"Kawajiri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziying","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryoji","family":"Mitsuwaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natsuki","family":"Asami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reoka","family":"Aoki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Nagashima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenshiro","family":"Matsuda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chigusa","family":"Nakahashi-Oda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoichiro","family":"Iwakura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Shibuya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Motoshi","family":"Wada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoto","family":"Ishii","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7173-4472","authenticated-orcid":false,"given":"Takeshi","family":"Kawabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.celrep.2026.117745_bib1","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1016\/j.immuni.2008.11.002","article-title":"Homeostasis of naive and memory T cells","volume":"29","author":"Surh","year":"2008","journal-title":"Immunity"},{"key":"10.1016\/j.celrep.2026.117745_bib2","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a037879","article-title":"Homeostasis of Naive and Memory T Lymphocytes","volume":"13","author":"Kawabe","year":"2021","journal-title":"Cold Spring Harbor Perspect. Biol."},{"key":"10.1016\/j.celrep.2026.117745_bib3","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1038\/ni.2018","article-title":"Normal T cell homeostasis: the conversion of naive cells into memory-phenotype cells","volume":"12","author":"Sprent","year":"2011","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.celrep.2026.117745_bib4","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1126\/science.aac5560","article-title":"Dietary antigens limit mucosal immunity by inducing regulatory T cells in the small intestine","volume":"351","author":"Kim","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.celrep.2026.117745_bib5","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.870542","article-title":"Redefining the Foreign Antigen and Self-Driven Memory CD4(+) T-Cell Compartments via Transcriptomic, Phenotypic, and Functional Analyses","volume":"13","author":"Kawabe","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.celrep.2026.117745_bib6","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.aam9304","article-title":"Memory-phenotype CD4(+) T cells spontaneously generated under steady-state conditions exert innate T(H)1-like effector function","volume":"2","author":"Kawabe","year":"2017","journal-title":"Sci. Immunol."},{"key":"10.1016\/j.celrep.2026.117745_bib7","doi-asserted-by":"crossref","first-page":"3366","DOI":"10.1038\/s41467-020-17136-1","article-title":"Requirements for the differentiation of innate T-bet(high) memory-phenotype CD4(+) T lymphocytes under steady state","volume":"11","author":"Kawabe","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2026.117745_bib8","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1038\/s41467-019-08482-w","article-title":"Pathogenic function of bystander-activated memory-like CD4(+) T cells in autoimmune encephalomyelitis","volume":"10","author":"Lee","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2026.117745_bib9","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1038\/s12276-023-00995-1","article-title":"Steady-state memory-phenotype conventional CD4(+) T cells exacerbate autoimmune neuroinflammation in a bystander manner via the Bhlhe40\/GM-CSF axis","volume":"55","author":"Cho","year":"2023","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.celrep.2026.117745_bib10","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1590\/S0102-86502005000400013","article-title":"Pathophysiology of mesenteric ischemia\/reperfusion: a review","volume":"20","author":"Cerqueira","year":"2005","journal-title":"Acta Cir. Bras."},{"key":"10.1016\/j.celrep.2026.117745_bib11","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1002\/bjs.4459","article-title":"Systematic review of survival after acute mesenteric ischaemia according to disease aetiology","volume":"91","author":"Schoots","year":"2004","journal-title":"Br. J. Surg."},{"key":"10.1016\/j.celrep.2026.117745_bib12","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1067\/mpd.2001.114481","article-title":"Nutritional and other postoperative management of neonates with short bowel syndrome correlates with clinical outcomes","volume":"139","author":"Andorsky","year":"2001","journal-title":"J. Pediatr."},{"key":"10.1016\/j.celrep.2026.117745_bib13","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1186\/s13017-022-00443-x","article-title":"Acute mesenteric ischemia: updated guidelines of the World Society of Emergency Surgery","volume":"17","author":"Bala","year":"2022","journal-title":"World J. Emerg. Surg."},{"key":"10.1016\/j.celrep.2026.117745_bib14","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1097\/SHK.0000000000000044","article-title":"Neutrophils--a key component of ischemia-reperfusion injury","volume":"40","author":"Schofield","year":"2013","journal-title":"Shock"},{"key":"10.1016\/j.celrep.2026.117745_bib15","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.3892\/etm.2013.1317","article-title":"Effect of dexmedetomidine pretreatment on lung injury following intestinal ischemia-reperfusion","volume":"6","author":"Shen","year":"2013","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.celrep.2026.117745_bib16","doi-asserted-by":"crossref","first-page":"2921","DOI":"10.4049\/jimmunol.1700655","article-title":"IL-17A Produced by Innate Lymphoid Cells Is Essential for Intestinal Ischemia-Reperfusion Injury","volume":"199","author":"Geha","year":"2017","journal-title":"J. Immunol."},{"key":"10.1016\/j.celrep.2026.117745_bib17","article-title":"Conventional alpha beta (alphabeta) T cells do not contribute to acute intestinal ischemia-reperfusion injury in mice","volume":"12","author":"Yu","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.celrep.2026.117745_bib18","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1080\/mic.9.2.99.109","article-title":"T-lymphocytes modulate the microvascular and inflammatory responses to intestinal ischemia-reperfusion","volume":"9","author":"Shigematsu","year":"2002","journal-title":"Microcirculation"},{"key":"10.1016\/j.celrep.2026.117745_bib19","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.clim.2008.09.019","article-title":"IL-17 producing CD4+ T cells mediate accelerated ischemia\/reperfusion-induced injury in autoimmunity-prone mice","volume":"130","author":"Edgerton","year":"2009","journal-title":"Clin. Immunol."},{"key":"10.1016\/j.celrep.2026.117745_bib20","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1002\/eji.201545907","article-title":"Mesenteric lymph nodes contribute to proinflammatory Th17-cell generation during inflammation of the small intestine in mice","volume":"46","author":"Kawabe","year":"2016","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.celrep.2026.117745_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.jff.2021.104361","article-title":"Oral zinc carnosine reduces multi-organ damage caused by gut ischemia\/reperfusion in mice","volume":"78","author":"Playford","year":"2021","journal-title":"J. Funct.Foods"},{"key":"10.1016\/j.celrep.2026.117745_bib22","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-021-96525-y","article-title":"Lack of gamma delta T cells ameliorates inflammatory response after acute intestinal ischemia reperfusion in mice","volume":"11","author":"Funken","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.celrep.2026.117745_bib23","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/j.molimm.2010.07.004","article-title":"Complement regulates TLR4-mediated inflammatory responses during intestinal ischemia reperfusion","volume":"48","author":"Pope","year":"2010","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.celrep.2026.117745_bib24","article-title":"Natural Killer Cells in Hepatic Ischemia-Reperfusion Injury","volume":"13","author":"Huang","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.celrep.2026.117745_bib25","doi-asserted-by":"crossref","DOI":"10.3390\/jcm6040041","article-title":"Natural Killer T Cells in Liver Ischemia-Reperfusion Injury","volume":"6","author":"Zimmerman","year":"2017","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.celrep.2026.117745_bib26","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.704836","article-title":"Gut Microbial Metabolite Pravastatin Attenuates Intestinal Ischemia\/Reperfusion Injury Through Promoting IL-13 Release From Type II Innate Lymphoid Cells via IL-33\/ST2 Signaling","volume":"12","author":"Deng","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.celrep.2026.117745_bib27","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.adq6618","article-title":"Naturally arising memory-phenotype CD4+ T lymphocytes contain an undifferentiated population that can generate TH1, TH17, and Treg cells","volume":"10","author":"Kawajiri","year":"2024","journal-title":"Sci. Adv."},{"key":"10.1016\/j.celrep.2026.117745_bib28","doi-asserted-by":"crossref","first-page":"1586","DOI":"10.1016\/j.immuni.2024.05.023","article-title":"The tissue-resident regulatory T cell pool is shaped by transient multi-tissue migration and a conserved residency program","volume":"57","author":"Burton","year":"2024","journal-title":"Immunity"},{"key":"10.1016\/j.celrep.2026.117745_bib29","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1038\/s41590-022-01387-9","article-title":"T(H)17 cell heterogeneity and its role in tissue inflammation","volume":"24","author":"Schnell","year":"2023","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.celrep.2026.117745_bib30","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1146\/annurev-immunol-082924-092651","article-title":"Tissue Regulatory T Cells","volume":"44","author":"Feuerer","year":"2026","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.celrep.2026.117745_bib31","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.immuni.2019.05.004","article-title":"The Intestine Harbors Functionally Distinct Homeostatic Tissue-Resident and Inflammatory Th17 Cells","volume":"51","author":"Omenetti","year":"2019","journal-title":"Immunity"},{"key":"10.1016\/j.celrep.2026.117745_bib32","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1126\/science.aad2035","article-title":"Hobit and Blimp1 instruct a universal transcriptional program of tissue residency in lymphocytes","volume":"352","author":"Mackay","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.celrep.2026.117745_bib33","doi-asserted-by":"crossref","first-page":"2234","DOI":"10.3389\/fimmu.2018.02234","article-title":"Mice Deficient in Nucleoporin Nup210 Develop Peripheral T Cell Alterations","volume":"9","author":"van Nieuwenhuijze","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.celrep.2026.117745_bib34","article-title":"Zbtb16 (PLZF) is stably suppressed and not inducible in non-innate T cells via T cell receptor-mediated signaling","volume":"5","author":"Zhang","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.celrep.2026.117745_bib35","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.713294","article-title":"ZBTB Transcription Factors: Key Regulators of the Development, Differentiation and Effector Function of T Cells","volume":"12","author":"Cheng","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.celrep.2026.117745_bib36","doi-asserted-by":"crossref","first-page":"2853","DOI":"10.4049\/jimmunol.152.6.2853","article-title":"Cyclosporin A inhibits positive selection and delays negative selection in alpha beta TCR transgenic mice","volume":"152","author":"Urdahl","year":"1994","journal-title":"J. Immunol."},{"key":"10.1016\/j.celrep.2026.117745_bib37","doi-asserted-by":"crossref","first-page":"1819","DOI":"10.1016\/j.intimp.2007.08.027","article-title":"Rapamycin inhibits differentiation of Th17 cells and promotes generation of FoxP3+ T regulatory cells","volume":"7","author":"Kopf","year":"2007","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.celrep.2026.117745_bib38","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.cyto.2008.03.006","article-title":"Cyclosporin A inhibits the production of IL-17 by memory Th17 cells from healthy individuals and patients with rheumatoid arthritis","volume":"42","author":"Zhang","year":"2008","journal-title":"Cytokine"},{"key":"10.1016\/j.celrep.2026.117745_bib39","doi-asserted-by":"crossref","first-page":"5788","DOI":"10.4049\/jimmunol.1203111","article-title":"Homeostatic proliferation of naive CD4+ T cells in mesenteric lymph nodes generates gut-tropic Th17 cells","volume":"190","author":"Kawabe","year":"2013","journal-title":"J. Immunol."},{"key":"10.1016\/j.celrep.2026.117745_bib40","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1038\/nature02284","article-title":"Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1","volume":"427","author":"Matloubian","year":"2004","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2026.117745_bib41","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1111\/j.1600-065X.2006.00482.x","article-title":"Generation of gut-homing T cells and their localization to the small intestinal mucosa","volume":"215","author":"Johansson-Lindbom","year":"2007","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.celrep.2026.117745_bib42","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1038\/sj.icb.7100112","article-title":"The correlation between proinflammatory cytokines, MAdCAM-1 and cellular infiltration in the inflamed colon from TNF-alpha gene knockout mice","volume":"85","author":"Xu","year":"2007","journal-title":"Immunol. Cell Biol."},{"key":"10.1016\/j.celrep.2026.117745_bib43","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1152\/ajpcell.2001.281.4.C1096","article-title":"Regulation and distribution of MAdCAM-1 in endothelial cells in vitro","volume":"281","author":"Oshima","year":"2001","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.celrep.2026.117745_bib44","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/1472-6793-7-10","article-title":"Inflammatory cytokines induce MAdCAM-1 in murine hepatic endothelial cells and mediate alpha-4 beta-7 integrin dependent lymphocyte endothelial adhesion in vitro","volume":"7","author":"Ando","year":"2007","journal-title":"BMC Physiol."},{"key":"10.1016\/j.celrep.2026.117745_bib45","doi-asserted-by":"crossref","first-page":"G659","DOI":"10.1152\/ajpgi.90495.2008","article-title":"Lymphocyte-derived interferon-gamma mediates ischemia-reperfusion-induced leukocyte and platelet adhesion in intestinal microcirculation","volume":"296","author":"Osman","year":"2009","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.celrep.2026.117745_bib46","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1038\/nri3399","article-title":"Neutrophil recruitment and function in health and inflammation","volume":"13","author":"Kolaczkowska","year":"2013","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.celrep.2026.117745_bib47","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1038\/sj.bjp.0705862","article-title":"Repertaxin, a novel inhibitor of rat CXCR2 function, inhibits inflammatory responses that follow intestinal ischaemia and reperfusion injury","volume":"143","author":"Souza","year":"2004","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.celrep.2026.117745_bib48","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.jss.2009.04.047","article-title":"A novel ELR-CXC chemokine antagonist reduces intestinal ischemia reperfusion-induced mortality, and local and remote organ injury","volume":"162","author":"Zhao","year":"2010","journal-title":"J. Surg. Res."},{"key":"10.1016\/j.celrep.2026.117745_bib49","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms11291","article-title":"Virtual memory T cells develop and mediate bystander protective immunity in an IL-15-dependent manner","volume":"7","author":"White","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2026.117745_bib50","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.abg9433","article-title":"Virtual memory T cells orchestrate extralymphoid responses conducive to resident memory","volume":"6","author":"Hou","year":"2021","journal-title":"Sci. Immunol."},{"key":"10.1016\/j.celrep.2026.117745_bib51","doi-asserted-by":"crossref","first-page":"6574","DOI":"10.1038\/s41467-025-61504-8","article-title":"Type 1 innate lymphoid cell-immature neutrophil axis suppresses acute tissue inflammation","volume":"16","author":"Matsuda","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2026.117745_bib52","doi-asserted-by":"crossref","first-page":"4711","DOI":"10.1182\/blood-2008-09-177287","article-title":"CXCR4 is a key regulator of neutrophil release from the bone marrow under basal and stress granulopoiesis conditions","volume":"113","author":"Eash","year":"2009","journal-title":"Blood"},{"key":"10.1016\/j.celrep.2026.117745_bib53","doi-asserted-by":"crossref","first-page":"2423","DOI":"10.1172\/JCI41649","article-title":"CXCR2 and CXCR4 antagonistically regulate neutrophil trafficking from murine bone marrow","volume":"120","author":"Eash","year":"2010","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.celrep.2026.117745_bib54","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/j.yexcr.2010.12.018","article-title":"CCR6 as a mediator of immunity in the lung and gut","volume":"317","author":"Ito","year":"2011","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.celrep.2026.117745_bib55","first-page":"18","article-title":"Tumor necrosis factor-alpha and its role as a mediator in myocardial infarction: A brief review","volume":"1","author":"Tian","year":"2015","journal-title":"Chronic Dis. Transl. Med."},{"key":"10.1016\/j.celrep.2026.117745_bib56","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1523\/JNEUROSCI.5505-08.2009","article-title":"Microglia protect neurons against ischemia by synthesis of tumor necrosis factor","volume":"29","author":"Lambertsen","year":"2009","journal-title":"J. Neurosci."},{"key":"10.1016\/j.celrep.2026.117745_bib57","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1186\/1742-2094-8-107","article-title":"The role of tumor necrosis factor-\u03b1 and TNF-\u03b1 receptors in cerebral arteries following cerebral ischemia in rat","volume":"8","author":"Maddahi","year":"2011","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.celrep.2026.117745_bib58","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1016\/j.jcmgh.2020.12.003","article-title":"MAdCAM-1\/alpha4beta7 Integrin-Mediated Lymphocyte\/Endothelium Interactions Exacerbate Acute Immune-Mediated Hepatitis in Mice","volume":"11","author":"Schippers","year":"2021","journal-title":"Cell. Mol. Gastroenterol. Hepatol."},{"key":"10.1016\/j.celrep.2026.117745_bib59","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1172\/JCI119533","article-title":"CD4(+) T-lymphocytes mediate ischemia\/reperfusion-induced inflammatory responses in mouse liver","volume":"100","author":"Zwacka","year":"1997","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.celrep.2026.117745_bib60","doi-asserted-by":"crossref","first-page":"1729","DOI":"10.1111\/j.1600-6143.2010.03205.x","article-title":"Alloimmune activation enhances innate tissue inflammation\/injury in a mouse model of liver ischemia\/reperfusion injury","volume":"10","author":"Shen","year":"2010","journal-title":"Am. J. Transplant."},{"key":"10.1016\/j.celrep.2026.117745_bib61","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1038\/s41423-018-0051-x","article-title":"Ag-specific CD4 T cells promote innate immune responses in liver ischemia reperfusion injury","volume":"16","author":"Rao","year":"2019","journal-title":"Cell. Mol. Immunol."},{"key":"10.1016\/j.celrep.2026.117745_bib62","doi-asserted-by":"crossref","first-page":"3098","DOI":"10.4049\/jimmunol.152.6.3098","article-title":"A novel subpopulation of primed T cells in the human fetus","volume":"152","author":"Byrne","year":"1994","journal-title":"J. Immunol."},{"key":"10.1016\/j.celrep.2026.117745_bib63","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1126\/scitranslmed.3008748","article-title":"CD4 T cells with effector memory phenotype and function develop in the sterile environment of the fetus","volume":"6","author":"Zhang","year":"2014","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.celrep.2026.117745_bib64","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1038\/s41590-018-0294-9","article-title":"Memory CD4+ T cells are generated in the human fetal intestine","volume":"20","author":"Li","year":"2019","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.celrep.2026.117745_bib65","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/j.autrev.2017.03.007","article-title":"Modulation of sphingosine-1-phosphate in inflammatory bowel disease","volume":"16","author":"Peyrin-Biroulet","year":"2017","journal-title":"Autoimmun. Rev."},{"key":"10.1016\/j.celrep.2026.117745_bib66","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines13112655","article-title":"Sphingosine-1-Phosphate (S1P) Receptor Modulators for the Treatment of Inflammatory Bowel Disease (IBD): Mechanisms, Clinical Evidence, and Practical Insights","volume":"13","author":"Shields","year":"2025","journal-title":"Biomedicines"},{"key":"10.1016\/j.celrep.2026.117745_bib67","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1093\/ecco-jcc\/jjw053","article-title":"Mechanism of Action of Anti-TNF Therapy in Inflammatory Bowel Disease","volume":"10","author":"Levin","year":"2016","journal-title":"J. Crohns Colitis"},{"key":"10.1016\/j.celrep.2026.117745_bib68","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1177\/2050640614550672","article-title":"Vedolizumab for inflammatory bowel disease: Changing the game, or more of the same?","volume":"2","author":"Raine","year":"2014","journal-title":"United Eur. Gastroenterol. J."},{"key":"10.1016\/j.celrep.2026.117745_bib69","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1038\/s41575-023-00768-1","article-title":"IL-12 and IL-23 pathway inhibition in inflammatory bowel disease","volume":"20","author":"Verstockt","year":"2023","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.celrep.2026.117745_bib70","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.4049\/jimmunol.159.3.1418","article-title":"Suppression of concanavalin A-induced hepatitis in IFN-gamma(-\/-) mice, but not in TNF-alpha(-\/-) mice: role for IFN-gamma in activating apoptosis of hepatocytes","volume":"159","author":"Tagawa","year":"1997","journal-title":"J. Immunol."},{"key":"10.1016\/j.celrep.2026.117745_bib71","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1016\/j.immuni.2012.09.007","article-title":"The transcription factor T-bet is induced by multiple pathways and prevents an endogenous Th2 cell program during Th1 cell responses","volume":"37","author":"Zhu","year":"2012","journal-title":"Immunity"},{"key":"10.1016\/j.celrep.2026.117745_bib72","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.freeradbiomed.2008.09.029","article-title":"Mouse model of liver ischemia and reperfusion injury: method for studying reactive oxygen and nitrogen metabolites in vivo","volume":"46","author":"Abe","year":"2009","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.celrep.2026.117745_bib73","doi-asserted-by":"crossref","first-page":"2513","DOI":"10.1038\/s41467-022-29772-w","article-title":"Protective effect of platinum nano-antioxidant and nitric oxide against hepatic ischemia-reperfusion injury","volume":"13","author":"Mu","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2026.117745_bib74","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1038\/s41419-022-04682-3","article-title":"Rubicon-deficiency sensitizes mice to mixed lineage kinase domain-like (MLKL)-mediated kidney ischemia-reperfusion injury","volume":"13","author":"Tonnus","year":"2022","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.celrep.2026.117745_bib75","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1038\/s41467-023-36664-0","article-title":"Polynucleotide phosphorylase protects against renal tubular injury via blocking mt-dsRNA-PKR-eIF2alpha axis","volume":"14","author":"Zhu","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2026.117745_bib76","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/j.jpedsurg.2004.11.045","article-title":"Ischemia\/reperfusion: a clinically relevant model of intestinal injury yielding systemic inflammation","volume":"40","author":"Stallion","year":"2005","journal-title":"J. Pediatr. Surg."},{"key":"10.1016\/j.celrep.2026.117745_bib77","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1097\/01.shk.0000101667.49265.fd","article-title":"Humane endpoints in shock research","volume":"21","author":"Nemzek","year":"2004","journal-title":"Shock"},{"key":"10.1016\/j.celrep.2026.117745_bib78","doi-asserted-by":"crossref","first-page":"G1020","DOI":"10.1152\/ajpgi.00239.2011","article-title":"Depletion of gut commensal bacteria attenuates intestinal ischemia\/reperfusion injury","volume":"301","author":"Yoshiya","year":"2011","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.celrep.2026.117745_bib79","doi-asserted-by":"crossref","first-page":"4230","DOI":"10.4049\/jimmunol.173.6.4230","article-title":"Accelerated ischemia\/reperfusion-induced injury in autoimmunity-prone mice","volume":"173","author":"Fleming","year":"2004","journal-title":"J. Immunol."},{"key":"10.1016\/j.celrep.2026.117745_bib80","doi-asserted-by":"crossref","first-page":"5186","DOI":"10.1096\/fj.201800195R","article-title":"Growth differentiation factor 11 worsens hepatocellular injury and liver regeneration after liver ischemia reperfusion injury","volume":"32","author":"Liu","year":"2018","journal-title":"FASEB J."},{"key":"10.1016\/j.celrep.2026.117745_bib81","doi-asserted-by":"crossref","first-page":"2202","DOI":"10.1111\/j.1523-1755.2004.66010.x","article-title":"Caspase-1-deficient mice are protected against cisplatin-induced apoptosis and acute tubular necrosis","volume":"66","author":"Faubel","year":"2004","journal-title":"Kidney Int."},{"key":"10.1016\/j.celrep.2026.117745_bib82","doi-asserted-by":"crossref","first-page":"3573","DOI":"10.1016\/j.cell.2021.04.048","article-title":"Integrated analysis of multimodal single-cell data","volume":"184","author":"Hao","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2026.117745_bib83","doi-asserted-by":"crossref","first-page":"515","DOI":"10.3389\/fimmu.2018.00515","article-title":"Tissue-Resident Memory CD8(+) T Cells: From Phenotype to Function","volume":"9","author":"Topham","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.celrep.2026.117745_bib84","doi-asserted-by":"crossref","first-page":"2921","DOI":"10.1016\/j.celrep.2017.08.078","article-title":"Human Tissue-Resident Memory T Cells Are Defined by Core Transcriptional and Functional Signatures in Lymphoid and Mucosal Sites","volume":"20","author":"Kumar","year":"2017","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2026.117745_bib85","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1093\/ecco-jcc\/jjz010","article-title":"CD4+ Tissue-resident Memory T Cells Expand and Are a Major Source of Mucosal Tumour Necrosis Factor alpha in Active Crohn's Disease","volume":"13","author":"Bishu","year":"2019","journal-title":"J. Crohns Colitis"},{"key":"10.1016\/j.celrep.2026.117745_bib86","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.abg3533","article-title":"Hobit identifies tissue-resident memory T cell precursors that are regulated by Eomes","volume":"6","author":"Parga-Vidal","year":"2021","journal-title":"Sci. Immunol."},{"key":"10.1016\/j.celrep.2026.117745_bib87","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.yexcr.2016.10.024","article-title":"An optimized method for mouse liver sinusoidal endothelial cell isolation","volume":"349","author":"Meyer","year":"2016","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.celrep.2026.117745_bib88","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1055\/s-0037-1617455","article-title":"Liver Sinusoidal Endothelial Cell: An Update","volume":"37","author":"DeLeve","year":"2017","journal-title":"Semin. Liver Dis."},{"key":"10.1016\/j.celrep.2026.117745_bib89","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1186\/s13578-023-01065-9","article-title":"CrebH protects against liver injury associated with colonic inflammation via modulation of exosomal miRNA","volume":"13","author":"Lee","year":"2023","journal-title":"Cell Biosci."},{"key":"10.1016\/j.celrep.2026.117745_bib90","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1038\/s42255-024-01053-4","article-title":"PNPO-PLP axis senses prolonged hypoxia in macrophages by regulating lysosomal activity","volume":"6","author":"Sekine","year":"2024","journal-title":"Nat. Metab."}],"container-title":["Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124726008235?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124726008235?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T04:49:20Z","timestamp":1789706960000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211124726008235"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":90,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["S2211124726008235"],"URL":"https:\/\/doi.org\/10.1016\/j.celrep.2026.117745","relation":{},"ISSN":["2211-1247"],"issn-type":[{"value":"2211-1247","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Circulating memory-phenotype CD4+ T cells rapidly accumulate in the ischemic gut to exacerbate tissue injury in an innate manner","name":"articletitle","label":"Article Title"},{"value":"Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.celrep.2026.117745","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"117745"}}