{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T05:04:56Z","timestamp":1789707896357,"version":"4.0.1"},"reference-count":62,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T00:00:00Z","timestamp":1784592000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People's Republic of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100016102","name":"Communist Party of China Central Committee","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100016102","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013076","name":"National Major Science and Technology Projects of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013076","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010120","name":"Huashan Hospital Fudan University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010120","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010097","name":"China Association for Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010097","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003395","name":"Shanghai Municipal Education Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003395","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Reports"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.celrep.2026.117800","type":"journal-article","created":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T16:37:35Z","timestamp":1786034255000},"page":"117800","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cholesterol enhances lysosome-autophagosome fusion for better \u03b1-synuclein clearance in GBA L444P-mutated Parkinson disease"],"prefix":"10.1016","volume":"45","author":[{"given":"Mingjia","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengtao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujie","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruibo","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linhua","family":"Gan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yimin","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuchen","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sisi","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenwei","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoting","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shun","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji","family":"Zuo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1551-9828","authenticated-orcid":false,"given":"Yunlong","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.celrep.2026.117800_bib1","doi-asserted-by":"crossref","first-page":"2133","DOI":"10.1016\/S0140-6736(24)00757-8","volume":"403","author":"Injuries","year":"2024","journal-title":"Lancet"},{"key":"10.1016\/j.celrep.2026.117800_bib2","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1016\/S1474-4422(18)30355-7","article-title":"The burden of Parkinson's disease: a worldwide perspective","volume":"17","author":"Rocca","year":"2018","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.celrep.2026.117800_bib3","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/S0140-6736(23)01419-8","article-title":"The epidemiology of Parkinson's disease","volume":"403","author":"Ben-Shlomo","year":"2024","journal-title":"Lancet"},{"key":"10.1016\/j.celrep.2026.117800_bib4","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1093\/bmb\/ldv022","article-title":"The genetics of Parkinson's disease","volume":"114","author":"Mullin","year":"2015","journal-title":"Br. Med. Bull."},{"key":"10.1016\/j.celrep.2026.117800_bib5","doi-asserted-by":"crossref","first-page":"2277","DOI":"10.1212\/01.wnl.0000304039.11891.29","article-title":"Genotype-phenotype correlations between GBA mutations and Parkinson disease risk and onset","volume":"70","author":"Gan-Or","year":"2008","journal-title":"Neurology"},{"key":"10.1016\/j.celrep.2026.117800_bib6","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1056\/NEJMoa0901281","article-title":"Multicenter analysis of glucocerebrosidase mutations in Parkinson's disease","volume":"361","author":"Sidransky","year":"2009","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.celrep.2026.117800_bib7","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1038\/s41531-023-00518-9","article-title":"The genetic spectrum of a cohort of patients clinically diagnosed as Parkinson's disease in mainland China","volume":"9","author":"Sun","year":"2023","journal-title":"npj Parkinson's Dis."},{"key":"10.1016\/j.celrep.2026.117800_bib8","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1001\/jamaneurol.2013.1274","article-title":"Clinical and biochemical differences in patients having Parkinson disease with vs without GBA mutations","volume":"70","author":"Chahine","year":"2013","journal-title":"JAMA Neurol."},{"key":"10.1016\/j.celrep.2026.117800_bib9","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1002\/mds.26071","article-title":"GBA-associated Parkinson's disease: reduced survival and more rapid progression in a prospective longitudinal study","volume":"30","author":"Brockmann","year":"2015","journal-title":"Mov. Disord."},{"key":"10.1016\/j.celrep.2026.117800_bib10","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1002\/acn3.228","article-title":"GBA mutations are associated with Rapid Eye Movement Sleep Behavior Disorder","volume":"2","author":"Gan-Or","year":"2015","journal-title":"Ann. Clin. Transl. Neurol."},{"key":"10.1016\/j.celrep.2026.117800_bib11","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1212\/WNL.0b013e318225ab77","article-title":"GBA-associated PD presents with nonmotor characteristics","volume":"77","author":"Brockmann","year":"2011","journal-title":"Neurology"},{"key":"10.1016\/j.celrep.2026.117800_bib12","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1016\/S1474-4422(12)70190-4","article-title":"The link between the GBA gene and parkinsonism","volume":"11","author":"Sidransky","year":"2012","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.celrep.2026.117800_bib13","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1093\/qjmed\/89.9.691","article-title":"Occurrence of Parkinson's syndrome in type I Gaucher disease","volume":"89","author":"Neudorfer","year":"1996","journal-title":"QJM"},{"key":"10.1016\/j.celrep.2026.117800_bib14","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1016\/j.cell.2007.10.018","article-title":"LIMP-2 is a receptor for lysosomal mannose-6-phosphate-independent targeting of beta-glucocerebrosidase","volume":"131","author":"Reczek","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2026.117800_bib15","doi-asserted-by":"crossref","first-page":"9617","DOI":"10.1523\/JNEUROSCI.1525-17.2017","article-title":"Glucosylsphingosine Promotes alpha-Synuclein Pathology in Mutant GBA-Associated Parkinson's Disease","volume":"37","author":"Taguchi","year":"2017","journal-title":"J. Neurosci."},{"key":"10.1016\/j.celrep.2026.117800_bib16","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abm6393","article-title":"Mutant glucocerebrosidase impairs alpha-synuclein degradation by blockade of chaperone-mediated autophagy","volume":"8","author":"Kuo","year":"2022","journal-title":"Sci. Adv."},{"key":"10.1016\/j.celrep.2026.117800_bib17","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1016\/j.cmet.2013.04.014","article-title":"Mitochondria and quality control defects in a mouse model of Gaucher disease--links to Parkinson's disease","volume":"17","author":"Osellame","year":"2013","journal-title":"Cell Metab."},{"key":"10.1016\/j.celrep.2026.117800_bib18","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.188413","article-title":"Stearoyl-CoA desaturase inhibition normalizes brain lipid saturation, alpha-synuclein homeostasis, and motor function in mutant Gba1-Parkinson mice","volume":"10","author":"Nuber","year":"2025","journal-title":"JCI Insight"},{"key":"10.1016\/j.celrep.2026.117800_bib19","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/S0166-2236(97)01213-7","article-title":"The synucleins: a family of proteins involved in synaptic function, plasticity, neurodegeneration and disease","volume":"21","author":"Clayton","year":"1998","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.celrep.2026.117800_bib20","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1038\/nn1443","article-title":"Alpha-synuclein phosphorylation controls neurotoxicity and inclusion formation in a Drosophila model of Parkinson disease","volume":"8","author":"Chen","year":"2005","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.celrep.2026.117800_bib21","doi-asserted-by":"crossref","first-page":"1969","DOI":"10.1093\/brain\/awm318","article-title":"The role of autophagy-lysosome pathway in neurodegeneration associated with Parkinson's disease","volume":"131","author":"Pan","year":"2008","journal-title":"Brain"},{"key":"10.1016\/j.celrep.2026.117800_bib22","doi-asserted-by":"crossref","first-page":"33855","DOI":"10.1074\/jbc.274.48.33855","article-title":"Degradation of alpha-synuclein by proteasome","volume":"274","author":"Bennett","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.celrep.2026.117800_bib23","doi-asserted-by":"crossref","first-page":"2209","DOI":"10.1007\/s12035-023-03212-2","article-title":"Interaction Between the Glymphatic System and alpha-Synuclein in Parkinson's Disease","volume":"60","author":"Zhang","year":"2023","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.celrep.2026.117800_bib24","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1194\/jlr.TR119000383","article-title":"The ins and outs of lipid rafts: functions in intracellular cholesterol homeostasis, microparticles, and cell membranes: Thematic Review Series: Biology of Lipid Rafts","volume":"61","author":"Ouweneel","year":"2020","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.celrep.2026.117800_bib25","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1038\/s41580-019-0190-7","article-title":"Mechanisms and regulation of cholesterol homeostasis","volume":"21","author":"Luo","year":"2020","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.celrep.2026.117800_bib26","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.tcb.2024.04.008","article-title":"Role of lipids in interorganelle communication","volume":"35","author":"Domingues","year":"2025","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.celrep.2026.117800_bib27","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1016\/j.tcb.2018.07.001","article-title":"Finding the Middle Ground for Autophagic Fusion Requirements","volume":"28","author":"Corona","year":"2018","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.celrep.2026.117800_bib28","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1186\/s12964-022-00942-z","article-title":"Intracellular cholesterol transport inhibition Impairs autophagy flux by decreasing autophagosome-lysosome fusion","volume":"20","author":"Maharjan","year":"2022","journal-title":"Cell Commun. Signal."},{"key":"10.1016\/j.celrep.2026.117800_bib29","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1038\/s41531-023-00571-4","article-title":"Mutational spectrum and clinical features of GBA1 variants in a Chinese cohort with Parkinson's disease","volume":"9","author":"Zhou","year":"2023","journal-title":"npj Parkinson's Dis."},{"key":"10.1016\/j.celrep.2026.117800_bib30","doi-asserted-by":"crossref","DOI":"10.3390\/ijms25031827","article-title":"A Comparative Biochemical and Pathological Evaluation of Brain Samples from Knock-In Murine Models of Gaucher Disease","volume":"25","author":"Furderer","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.celrep.2026.117800_bib31","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1016\/j.jmb.2008.03.017","article-title":"Characterization of conformational and dynamic properties of natively unfolded human and mouse alpha-synuclein ensembles by NMR: implication for aggregation","volume":"378","author":"Wu","year":"2008","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.celrep.2026.117800_bib32","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1093\/hmg\/ddq038","article-title":"Extensive enteric nervous system abnormalities in mice transgenic for artificial chromosomes containing Parkinson disease-associated alpha-synuclein gene mutations precede central nervous system changes","volume":"19","author":"Kuo","year":"2010","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.celrep.2026.117800_bib33","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.jocn.2015.12.004","article-title":"Glucocerebrosidase enzyme activity in GBA mutation Parkinson's disease","volume":"28","author":"Ortega","year":"2016","journal-title":"J. Clin. Neurosci."},{"key":"10.1016\/j.celrep.2026.117800_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.expneurol.2024.114959","article-title":"Viral overexpression of human alpha-synuclein in mouse substantia nigra dopamine neurons results in hyperdopaminergia but no neurodegeneration","volume":"382","author":"Garcia Moreno","year":"2024","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.celrep.2026.117800_bib35","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.neulet.2016.10.039","article-title":"Oligomeric alpha-synuclein and glucocerebrosidase activity levels in GBA-associated Parkinson's disease","volume":"636","author":"Pchelina","year":"2017","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.celrep.2026.117800_bib36","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.02783-18","article-title":"Infection by Anaplasma phagocytophilum Requires Recruitment of Low-Density Lipoprotein Cholesterol by Flotillins","volume":"10","author":"Xiong","year":"2019","journal-title":"mBio"},{"key":"10.1016\/j.celrep.2026.117800_bib37","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1016\/S0022-2275(20)39866-7","article-title":"Transgenic mice expressing both human apolipoprotein B and human CETP have a lipoprotein cholesterol distribution similar to that of normolipidemic humans","volume":"36","author":"Grass","year":"1995","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.celrep.2026.117800_bib38","doi-asserted-by":"crossref","first-page":"3052","DOI":"10.1096\/fj.09-144519","article-title":"Altered lipid content inhibits autophagic vesicular fusion","volume":"24","author":"Koga","year":"2010","journal-title":"FASEB J."},{"key":"10.1016\/j.celrep.2026.117800_bib39","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/S0140-6736(23)01478-2","article-title":"The pathogenesis of Parkinson's disease","volume":"403","author":"Morris","year":"2024","journal-title":"Lancet"},{"key":"10.1016\/j.celrep.2026.117800_bib40","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0187168","article-title":"Transcriptional and post-translational changes in the brain of mice deficient in cholesterol removal mediated by cytochrome P450 46A1 (CYP46A1)","volume":"12","author":"Mast","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.celrep.2026.117800_bib41","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.bbrc.2008.11.030","article-title":"Glycosphingolipid deficiency increases the sterol regulatory element-mediated gene transcription","volume":"378","author":"Ishitsuka","year":"2009","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.celrep.2026.117800_bib42","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.parkreldis.2017.08.026","article-title":"Serum lipid alterations in GBA-associated Parkinson's disease","volume":"44","author":"Guedes","year":"2017","journal-title":"Parkinsonism Relat. Disord."},{"key":"10.1016\/j.celrep.2026.117800_bib43","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1038\/s41531-021-00206-6","article-title":"Serum lipid profile among sporadic and familial forms of Parkinson's disease","volume":"7","author":"Mac\u00edas-Garc\u00eda","year":"2021","journal-title":"npj Parkinson's Dis."},{"key":"10.1016\/j.celrep.2026.117800_bib44","doi-asserted-by":"crossref","first-page":"597","DOI":"10.3389\/fneur.2020.00597","article-title":"Effects of Higher Serum Lipid Levels on the Risk of Parkinson's Disease: A Systematic Review and Meta-Analysis","volume":"11","author":"Jiang","year":"2020","journal-title":"Front. Neurol."},{"key":"10.1016\/j.celrep.2026.117800_bib45","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.1212\/01.wnl.0000286942.14552.51","article-title":"Statin use and the risk of Parkinson disease","volume":"70","author":"Wahner","year":"2008","journal-title":"Neurology"},{"key":"10.1016\/j.celrep.2026.117800_bib46","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202200212R","article-title":"Loss of Drosophila NUS1 results in cholesterol accumulation and Parkinson's disease-related neurodegeneration","volume":"36","author":"Xue","year":"2022","journal-title":"FASEB J."},{"key":"10.1016\/j.celrep.2026.117800_bib47","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/j.tins.2019.05.010","article-title":"Can GBA1-Associated Parkinson Disease Be Modeled in the Mouse?","volume":"42","author":"Farfel-Becker","year":"2019","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.celrep.2026.117800_bib48","doi-asserted-by":"crossref","DOI":"10.3390\/cells13060500","article-title":"Molecular Mechanism of Autophagosome-Lysosome Fusion in Mammalian Cells","volume":"13","author":"Ke","year":"2024","journal-title":"Cells"},{"key":"10.1016\/j.celrep.2026.117800_bib49","doi-asserted-by":"crossref","first-page":"2005","DOI":"10.1002\/mds.29577","article-title":"27-Hydroxycholesterol Drives the Spread of alpha-Synuclein Pathology in Parkinson's Disease","volume":"38","author":"Dai","year":"2023","journal-title":"Mov. Disord."},{"key":"10.1016\/j.celrep.2026.117800_bib50","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics13111980","article-title":"Modulating the Blood-Brain Barrier: A Comprehensive Review","volume":"13","author":"Whelan","year":"2021","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.celrep.2026.117800_bib51","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1021\/acschemneuro.9b00581","article-title":"Efficacy of Cholesterol Nose-to-Brain Delivery for Brain Targeting in Huntington's Disease","volume":"11","author":"Passoni","year":"2020","journal-title":"ACS Chem. Neurosci."},{"key":"10.1016\/j.celrep.2026.117800_bib52","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1212\/WNL.17.5.427","article-title":"Parkinsonism: onset, progression and mortality","volume":"17","author":"Hoehn","year":"1967","journal-title":"Neurology"},{"key":"10.1016\/j.celrep.2026.117800_bib53","doi-asserted-by":"crossref","first-page":"2129","DOI":"10.1002\/mds.22340","article-title":"Movement Disorder Society-sponsored revision of the Unified Parkinson's Disease Rating Scale (MDS-UPDRS): scale presentation and clinimetric testing results","volume":"23","author":"Goetz","year":"2008","journal-title":"Mov. Disord."},{"key":"10.1016\/j.celrep.2026.117800_bib54","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/0022-3956(75)90026-6","article-title":"\u201cMini-mental state\u201d. A practical method for grading the cognitive state of patients for the clinician","volume":"12","author":"Folstein","year":"1975","journal-title":"J. Psychiatr. Res."},{"key":"10.1016\/j.celrep.2026.117800_bib55","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1136\/jnnp.55.3.181","article-title":"Accuracy of clinical diagnosis of idiopathic Parkinson's disease: a clinico-pathological study of 100 cases","volume":"55","author":"Hughes","year":"1992","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.celrep.2026.117800_bib56","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1002\/mds.26424","article-title":"MDS clinical diagnostic criteria for Parkinson's disease","volume":"30","author":"Postuma","year":"2015","journal-title":"Mov. Disord."},{"key":"10.1016\/j.celrep.2026.117800_bib57","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1212\/WNL.0000000000001315","article-title":"Differential effects of severe vs mild GBA mutations on Parkinson disease","volume":"84","author":"Gan-Or","year":"2015","journal-title":"Neurology"},{"key":"10.1016\/j.celrep.2026.117800_bib58","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1006\/bcmd.1997.0114","article-title":"Hematologically important mutations: Gaucher disease","volume":"23","author":"Beutler","year":"1997","journal-title":"Blood Cells Mol. Dis."},{"key":"10.1016\/j.celrep.2026.117800_bib59","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2025.110659","article-title":"GLP-1 receptor agonist semaglutide ameliorates motor deficits and tau pathology in the rTg4510s mouse model","volume":"280","author":"Zhang","year":"2025","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.celrep.2026.117800_bib60","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/j.bbamem.2008.11.018","article-title":"Loss of membrane cholesterol influences lysosomal permeability to potassium ions and protons","volume":"1788","author":"Deng","year":"2009","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.celrep.2026.117800_bib61","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1002\/mds.27119","article-title":"N370S-GBA1 mutation causes lysosomal cholesterol accumulation in Parkinson's disease","volume":"32","author":"Garc\u00eda-Sanz","year":"2017","journal-title":"Mov. Disord."},{"key":"10.1016\/j.celrep.2026.117800_bib62","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1016\/j.neuron.2021.01.005","article-title":"Astrocytic ApoE reprograms neuronal cholesterol metabolism and histone-acetylation-mediated memory","volume":"109","author":"Li","year":"2021","journal-title":"Neuron"}],"container-title":["Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124726008788?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124726008788?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T04:28:47Z","timestamp":1789705727000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211124726008788"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":62,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["S2211124726008788"],"URL":"https:\/\/doi.org\/10.1016\/j.celrep.2026.117800","relation":{},"ISSN":["2211-1247"],"issn-type":[{"value":"2211-1247","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cholesterol enhances lysosome-autophagosome fusion for better \u03b1-synuclein clearance in GBA L444P-mutated Parkinson disease","name":"articletitle","label":"Article Title"},{"value":"Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.celrep.2026.117800","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"117800"}}