{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T21:38:51Z","timestamp":1792532331530,"version":"4.5.0"},"reference-count":74,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T00:00:00Z","timestamp":1784678400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32430016"],"award-info":[{"award-number":["32430016"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32300477"],"award-info":[{"award-number":["32300477"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2022A1515011174"],"award-info":[{"award-number":["2022A1515011174"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2021YFA1100300"],"award-info":[{"award-number":["2021YFA1100300"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Reports"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.celrep.2026.117813","type":"journal-article","created":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T16:32:50Z","timestamp":1787589170000},"page":"117813","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["The R-loop-SPT6-SETD2 axis safeguards H3K36me3 to prevent broad H3K4me3 invasion in mouse oocytes"],"prefix":"10.1016","volume":"45","author":[{"given":"Yingliang","family":"Sheng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianyan","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junzhi","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6430-3340","authenticated-orcid":false,"given":"Kui Ming","family":"Chan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangjin","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cizhong","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2144-0147","authenticated-orcid":false,"given":"Hongjie","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.celrep.2026.117813_bib1","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1101\/gad.331157.119","article-title":"The chromatin remodeler Snf2h is essential for oocyte meiotic cell cycle progression","volume":"34","author":"Zhang","year":"2020","journal-title":"Genes Dev."},{"key":"10.1016\/j.celrep.2026.117813_bib2","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1006\/dbio.2000.9947","article-title":"Transcriptional activity of the mouse oocyte genome: companion granulosa cells modulate transcription and chromatin remodeling","volume":"229","author":"De La Fuente","year":"2001","journal-title":"Dev. Biol."},{"key":"10.1016\/j.celrep.2026.117813_bib3","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1002\/mrd.1080250411","article-title":"Oogenesis: chromatin and microtubule dynamics during meiotic prophase","volume":"25","author":"Mattson","year":"1990","journal-title":"Mol. Reprod. Dev."},{"key":"10.1016\/j.celrep.2026.117813_bib4","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/0012-1606(91)90063-9","article-title":"Meiotic competence acquisition is associated with the appearance of M-phase characteristics in growing mouse oocytes","volume":"143","author":"Wickramasinghe","year":"1991","journal-title":"Dev. Biol."},{"key":"10.1016\/j.celrep.2026.117813_bib5","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1002\/mrd.1080360110","article-title":"Competent mouse oocytes isolated from antral follicles exhibit different chromatin organization and follow different maturation dynamics","volume":"36","author":"Debey","year":"1993","journal-title":"Mol. Reprod. Dev."},{"key":"10.1016\/j.celrep.2026.117813_bib6","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1002\/mrd.1080410410","article-title":"Chromatin organization during mouse oocyte growth","volume":"41","author":"Zuccotti","year":"1995","journal-title":"Mol. Reprod. Dev."},{"key":"10.1016\/j.celrep.2026.117813_bib7","doi-asserted-by":"crossref","first-page":"3285","DOI":"10.1016\/j.devcel.2025.08.005","article-title":"Preventing CpG hypermethylation in oocytes safeguards mouse development","volume":"60","author":"Kawamura","year":"2025","journal-title":"Dev. Cell"},{"key":"10.1016\/j.celrep.2026.117813_bib8","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1038\/s41594-017-0013-5","article-title":"MLL2 conveys transcription-independent H3K4 trimethylation in oocytes","volume":"25","author":"Hanna","year":"2018","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.celrep.2026.117813_bib9","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1007\/s13238-020-00757-z","article-title":"Insights into epigenetic patterns in mammalian early embryos","volume":"12","author":"Xu","year":"2021","journal-title":"Protein Cell"},{"key":"10.1016\/j.celrep.2026.117813_bib10","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1038\/nature23262","article-title":"Maternal H3K27me3 controls DNA methylation-independent imprinting","volume":"547","author":"Inoue","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2026.117813_bib11","doi-asserted-by":"crossref","first-page":"1927","DOI":"10.1101\/gad.304113.117","article-title":"Genomic imprinting of Xist by maternal H3K27me3","volume":"31","author":"Inoue","year":"2017","journal-title":"Genes Dev."},{"key":"10.1016\/j.celrep.2026.117813_bib12","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.aay7246","article-title":"Allelic H3K27me3 to allelic DNA methylation switch maintains noncanonical imprinting in extraembryonic cells","volume":"5","author":"Chen","year":"2019","journal-title":"Sci. Adv."},{"key":"10.1016\/j.celrep.2026.117813_bib13","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1038\/sj.emboj.7601967","article-title":"Dynamic histone H3 methylation during gene induction: HYPB\/Setd2 mediates all H3K36 trimethylation","volume":"27","author":"Edmunds","year":"2008","journal-title":"EMBO J."},{"key":"10.1016\/j.celrep.2026.117813_bib14","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.cell.2010.11.056","article-title":"Epigenetics in alternative pre-mRNA splicing","volume":"144","author":"Luco","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2026.117813_bib15","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/j.cell.2005.10.023","article-title":"Histone H3 methylation by Set2 directs deacetylation of coding regions by Rpd3S to suppress spurious intragenic transcription","volume":"123","author":"Carrozza","year":"2005","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2026.117813_bib16","doi-asserted-by":"crossref","first-page":"3305","DOI":"10.1128\/MCB.25.8.3305-3316.2005","article-title":"A novel domain in Set2 mediates RNA polymerase II interaction and couples histone H3 K36 methylation with transcript elongation","volume":"25","author":"Kizer","year":"2005","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.celrep.2026.117813_bib17","doi-asserted-by":"crossref","first-page":"4440","DOI":"10.1038\/s41467-022-32141-2","article-title":"Histone H3K36me2 and H3K36me3 form a chromatin platform essential for DNMT3A-dependent DNA methylation in mouse oocytes","volume":"13","author":"Yano","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2026.117813_bib18","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1038\/s41588-019-0398-7","article-title":"SETD2 regulates the maternal epigenome, genomic imprinting and embryonic development","volume":"51","author":"Xu","year":"2019","journal-title":"Nat. Genet."},{"key":"10.1016\/j.celrep.2026.117813_bib19","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1038\/s41580-019-0206-3","article-title":"Regulatory R-loops as facilitators of gene expression and genome stability","volume":"21","author":"Niehrs","year":"2020","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.celrep.2026.117813_bib20","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/j.molcel.2019.01.024","article-title":"R-Loops as Cellular Regulators and Genomic Threats","volume":"73","author":"Crossley","year":"2019","journal-title":"Mol. Cell"},{"key":"10.1016\/j.celrep.2026.117813_bib21","doi-asserted-by":"crossref","first-page":"1686","DOI":"10.1016\/j.molcel.2025.02.019","article-title":"Base-pair resolution reveals clustered R-loops and DNA damage-susceptible R-loops","volume":"85","author":"Li","year":"2025","journal-title":"Mol. Cell"},{"key":"10.1016\/j.celrep.2026.117813_bib22","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1016\/j.molcel.2012.01.017","article-title":"R-loop formation is a distinctive characteristic of unmethylated human CpG island promoters","volume":"45","author":"Ginno","year":"2012","journal-title":"Mol. Cell"},{"key":"10.1016\/j.celrep.2026.117813_bib23","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1038\/s41596-021-00647-6","article-title":"KAS-seq: genome-wide sequencing of single-stranded DNA by N(3)-kethoxal-assisted labeling","volume":"17","author":"Lyu","year":"2022","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.celrep.2026.117813_bib24","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/s13048-023-01342-8","article-title":"KAS-seq profiling captures transcription dynamics during oocyte maturation","volume":"17","author":"An","year":"2024","journal-title":"J. Ovarian Res."},{"key":"10.1016\/j.celrep.2026.117813_bib25","doi-asserted-by":"crossref","first-page":"1494","DOI":"10.1111\/j.1742-4658.2009.06908.x","article-title":"Ribonuclease H: the enzymes in eukaryotes","volume":"276","author":"Cerritelli","year":"2009","journal-title":"FEBS J."},{"key":"10.1016\/j.celrep.2026.117813_bib26","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1083\/jcb.201607062","article-title":"Meiotic spindle assembly and chromosome segregation in oocytes","volume":"215","author":"Bennabi","year":"2016","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.celrep.2026.117813_bib27","doi-asserted-by":"crossref","first-page":"8553","DOI":"10.1038\/ncomms9553","article-title":"DNA damage induces a meiotic arrest in mouse oocytes mediated by the spindle assembly checkpoint","volume":"6","author":"Collins","year":"2015","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2026.117813_bib28","doi-asserted-by":"crossref","DOI":"10.1111\/cpr.12809","article-title":"Metformin protects against mouse oocyte apoptosis defects induced by arecoline","volume":"53","author":"Li","year":"2020","journal-title":"Cell Prolif."},{"key":"10.1016\/j.celrep.2026.117813_bib29","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.molcel.2018.08.031","article-title":"Impeding DNA Break Repair Enables Oocyte Quality Control","volume":"72","author":"Qiao","year":"2018","journal-title":"Mol. Cell"},{"key":"10.1016\/j.celrep.2026.117813_bib30","doi-asserted-by":"crossref","DOI":"10.1242\/jcs.238105","article-title":"CENP-T regulates both the G2\/M transition and anaphase entry by acting through CDH1 in meiotic oocytes","volume":"133","author":"Wang","year":"2020","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.celrep.2026.117813_bib31","doi-asserted-by":"crossref","first-page":"6061","DOI":"10.1093\/emboj\/cdf626","article-title":"Dissection of c-MOS degron","volume":"21","author":"Sheng","year":"2002","journal-title":"EMBO J."},{"key":"10.1016\/j.celrep.2026.117813_bib32","doi-asserted-by":"crossref","first-page":"2536","DOI":"10.1126\/science.1065848","article-title":"Dnmt3L and the establishment of maternal genomic imprints","volume":"294","author":"Bourc'his","year":"2001","journal-title":"Science"},{"key":"10.1016\/j.celrep.2026.117813_bib33","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/s12861-014-0040-y","article-title":"Expression of maternally derived KHDC3, NLRP5, OOEP and TLE6 is associated with oocyte developmental competence in the ovine species","volume":"14","author":"Bebbere","year":"2014","journal-title":"BMC Dev. Biol."},{"key":"10.1016\/j.celrep.2026.117813_bib34","doi-asserted-by":"crossref","DOI":"10.1002\/bies.202200007","article-title":"Gene mutations impede oocyte maturation, fertilization, and early embryonic development","volume":"44","author":"Fei","year":"2022","journal-title":"Bioessays"},{"key":"10.1016\/j.celrep.2026.117813_bib35","doi-asserted-by":"crossref","first-page":"1947","DOI":"10.1126\/science.1103974","article-title":"The Gs-linked receptor GPR3 maintains meiotic arrest in mammalian oocytes","volume":"306","author":"Mehlmann","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.celrep.2026.117813_bib36","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1002\/mrd.22967","article-title":"Meeting the meiotic challenge: Specializations in mammalian oocyte spindle formation","volume":"85","author":"Severance","year":"2018","journal-title":"Mol. Reprod. Dev."},{"key":"10.1016\/j.celrep.2026.117813_bib37","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.tig.2017.03.005","article-title":"Specialize and Divide (Twice): Functions of Three Aurora Kinase Homologs in Mammalian Oocyte Meiotic Maturation","volume":"33","author":"Nguyen","year":"2017","journal-title":"Trends Genet."},{"key":"10.1016\/j.celrep.2026.117813_bib38","doi-asserted-by":"crossref","DOI":"10.1083\/jcb.201702123","article-title":"Tex19.1 inhibits the N-end rule pathway and maintains acetylated SMC3 cohesin and sister chromatid cohesion in oocytes","volume":"219","author":"Reichmann","year":"2020","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.celrep.2026.117813_bib39","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1009327","article-title":"Aurora kinase A is essential for meiosis in mouse oocytes","volume":"17","author":"Blengini","year":"2021","journal-title":"PLoS Genet."},{"key":"10.1016\/j.celrep.2026.117813_bib40","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1016\/j.molcel.2017.07.002","article-title":"Introns Protect Eukaryotic Genomes from Transcription-Associated Genetic Instability","volume":"67","author":"Bonnet","year":"2017","journal-title":"Mol. Cell"},{"key":"10.1016\/j.celrep.2026.117813_bib41","doi-asserted-by":"crossref","first-page":"2569","DOI":"10.1093\/nar\/gkab107","article-title":"Role of CxxC-finger protein 1 in establishing mouse oocyte epigenetic landscapes","volume":"49","author":"Sha","year":"2021","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.celrep.2026.117813_bib42","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1038\/s41422-025-01208-2","article-title":"R-loops orchestrate RNAPII transcriptional reprogramming for the maternal-to-zygotic transition","volume":"36","author":"Li","year":"2026","journal-title":"Cell Res."},{"key":"10.1016\/j.celrep.2026.117813_bib43","doi-asserted-by":"crossref","first-page":"3888","DOI":"10.1093\/nar\/gkz119","article-title":"A conserved genetic interaction between Spt6 and Set2 regulates H3K36 methylation","volume":"47","author":"Gopalakrishnan","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.celrep.2026.117813_bib44","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1093\/nar\/gkt1003","article-title":"A feed forward circuit comprising Spt6, Ctk1 and PAF regulates Pol II CTD phosphorylation and transcription elongation","volume":"42","author":"Dronamraju","year":"2014","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.celrep.2026.117813_bib45","doi-asserted-by":"crossref","first-page":"1869","DOI":"10.1242\/dev.035238","article-title":"Cyclic GMP from the surrounding somatic cells regulates cyclic AMP and meiosis in the mouse oocyte","volume":"136","author":"Norris","year":"2009","journal-title":"Development"},{"key":"10.1016\/j.celrep.2026.117813_bib46","doi-asserted-by":"crossref","DOI":"10.3791\/2851","article-title":"Mouse oocyte microinjection, maturation and ploidy assessment","author":"Stein","year":"2011","journal-title":"J. Vis. Exp."},{"key":"10.1016\/j.celrep.2026.117813_bib47","doi-asserted-by":"crossref","first-page":"3477","DOI":"10.1038\/s41467-018-05930-x","article-title":"CFP1 coordinates histone H3 lysine-4 trimethylation and meiotic cell cycle progression in mouse oocytes","volume":"9","author":"Sha","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2026.117813_bib48","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1095\/biolreprod.112.106450","article-title":"Melatonin prevents postovulatory oocyte aging in the mouse and extends the window for optimal fertilization in vitro","volume":"88","author":"Lord","year":"2013","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.celrep.2026.117813_bib49","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.1016\/j.molcel.2026.03.014","article-title":"H2AK119ub1-MLL2 counteraction underlies heritable H3K27me3 formation in oocytes","volume":"86","author":"Mei","year":"2026","journal-title":"Mol. Cell"},{"key":"10.1016\/j.celrep.2026.117813_bib50","doi-asserted-by":"crossref","first-page":"2190","DOI":"10.1002\/pmic.201400060","article-title":"Site-specific human histone H3 methylation stability: fast K4me3 turnover","volume":"14","author":"Zheng","year":"2014","journal-title":"Proteomics"},{"key":"10.1016\/j.celrep.2026.117813_bib51","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.gde.2007.12.003","article-title":"The emerging functions of histone demethylases","volume":"18","author":"Agger","year":"2008","journal-title":"Curr. Opin. Genet. Dev."},{"key":"10.1016\/j.celrep.2026.117813_bib52","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/s12860-024-00527-3","article-title":"Transcriptome and DNA methylation profiling during the NSN to SN transition in mouse oocytes","volume":"26","author":"Demond","year":"2025","journal-title":"BMC Mol. Cell Biol."},{"key":"10.1016\/j.celrep.2026.117813_bib53","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1038\/nature14176","article-title":"Genomic profiling of DNA methyltransferases reveals a role for DNMT3B in genic methylation","volume":"520","author":"Baubec","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2026.117813_bib54","doi-asserted-by":"crossref","first-page":"26114","DOI":"10.1074\/jbc.M109.089433","article-title":"The Dnmt3a PWWP domain reads histone 3 lysine 36 trimethylation and guides DNA methylation","volume":"285","author":"Dhayalan","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.celrep.2026.117813_bib55","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1101\/gr.266551.120","article-title":"Enzymatic methyl sequencing detects DNA methylation at single-base resolution from picograms of DNA","volume":"31","author":"Vaisvila","year":"2021","journal-title":"Genome Res."},{"key":"10.1016\/j.celrep.2026.117813_bib56","doi-asserted-by":"crossref","first-page":"3110","DOI":"10.1016\/j.molcel.2021.06.016","article-title":"Targeted protein degradation reveals a direct role of SPT6 in RNAPII elongation and termination","volume":"81","author":"Narain","year":"2021","journal-title":"Mol. Cell"},{"key":"10.1016\/j.celrep.2026.117813_bib57","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/j.molcel.2017.09.016","article-title":"The Elongation Factor Spt6 Maintains ESC Pluripotency by Controlling Super-Enhancers and Counteracting Polycomb Proteins","volume":"68","author":"Wang","year":"2017","journal-title":"Mol. Cell"},{"key":"10.1016\/j.celrep.2026.117813_bib58","doi-asserted-by":"crossref","DOI":"10.4028\/b-4W7Te2","article-title":"R-loops coordinate with SOX2 in regulating reprogramming to pluripotency","volume":"6","author":"Li","year":"2020","journal-title":"Sci. Adv."},{"key":"10.1016\/j.celrep.2026.117813_bib59","article-title":"Fibrillarin-GFP Facilitates the Identification of Meiotic Competent Oocytes","volume":"9","author":"Wang","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.celrep.2026.117813_bib60","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1038\/s41588-021-00820-3","article-title":"H2AK119ub1 guides maternal inheritance and zygotic deposition of H3K27me3 in mouse embryos","volume":"53","author":"Mei","year":"2021","journal-title":"Nat. Genet."},{"key":"10.1016\/j.celrep.2026.117813_bib61","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1038\/s41594-023-01125-1","article-title":"Auto-suppression of Tet dioxygenases protects the mouse oocyte genome from oxidative demethylation","volume":"31","author":"Zhang","year":"2024","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.celrep.2026.117813_bib62","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1038\/nprot.2017.003","article-title":"Spatial transcriptomic analysis of cryosectioned tissue samples with Geo-seq","volume":"12","author":"Chen","year":"2017","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.celrep.2026.117813_bib63","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1038\/s41594-023-01199-x","article-title":"Lineage regulators TFAP2C and NR5A2 function as bipotency activators in totipotent embryos","volume":"31","author":"Li","year":"2024","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.celrep.2026.117813_bib64","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1093\/bioinformatics\/bts635","article-title":"STAR: ultrafast universal RNA-seq aligner","volume":"29","author":"Dobin","year":"2013","journal-title":"Bioinformatics"},{"key":"10.1016\/j.celrep.2026.117813_bib65","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1186\/1471-2105-12-323","article-title":"RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genome","volume":"12","author":"Li","year":"2011","journal-title":"BMC Bioinf."},{"key":"10.1016\/j.celrep.2026.117813_bib66","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol."},{"key":"10.1016\/j.celrep.2026.117813_bib67","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1089\/omi.2011.0118","article-title":"clusterProfiler: an R package for comparing biological themes among gene clusters","volume":"16","author":"Yu","year":"2012","journal-title":"OMICS"},{"key":"10.1016\/j.celrep.2026.117813_bib68","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/nmeth.1923","article-title":"Fast gapped-read alignment with Bowtie 2","volume":"9","author":"Langmead","year":"2012","journal-title":"Nat. Methods"},{"key":"10.1016\/j.celrep.2026.117813_bib69","doi-asserted-by":"crossref","first-page":"2078","DOI":"10.1093\/bioinformatics\/btp352","article-title":"The Sequence Alignment\/Map format and SAMtools","volume":"25","author":"Li","year":"2009","journal-title":"Bioinformatics"},{"key":"10.1016\/j.celrep.2026.117813_bib70","doi-asserted-by":"crossref","first-page":"2032","DOI":"10.1093\/bioinformatics\/btv098","article-title":"Sambamba: fast processing of NGS alignment formats","volume":"31","author":"Tarasov","year":"2015","journal-title":"Bioinformatics"},{"key":"10.1016\/j.celrep.2026.117813_bib71","doi-asserted-by":"crossref","first-page":"W160","DOI":"10.1093\/nar\/gkw257","article-title":"deepTools2: a next generation web server for deep-sequencing data analysis","volume":"44","author":"Ram\u00edrez","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.celrep.2026.117813_bib72","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1038\/nmeth.1772","article-title":"The Human Epigenome Browser at Washington University","volume":"8","author":"Zhou","year":"2011","journal-title":"Nat. Methods"},{"key":"10.1016\/j.celrep.2026.117813_bib73","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1093\/bioinformatics\/btq033","article-title":"BEDTools: a flexible suite of utilities for comparing genomic features","volume":"26","author":"Quinlan","year":"2010","journal-title":"Bioinformatics"},{"key":"10.1016\/j.celrep.2026.117813_bib74","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.1093\/bioinformatics\/btr167","article-title":"Bismark: a flexible aligner and methylation caller for Bisulfite-Seq applications","volume":"27","author":"Krueger","year":"2011","journal-title":"Bioinformatics"}],"container-title":["Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124726008910?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124726008910?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T20:45:38Z","timestamp":1792529138000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211124726008910"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":74,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["S2211124726008910"],"URL":"https:\/\/doi.org\/10.1016\/j.celrep.2026.117813","relation":{},"ISSN":["2211-1247"],"issn-type":[{"value":"2211-1247","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The R-loop-SPT6-SETD2 axis safeguards H3K36me3 to prevent broad H3K4me3 invasion in mouse oocytes","name":"articletitle","label":"Article Title"},{"value":"Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.celrep.2026.117813","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"117813"}}