{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T23:38:49Z","timestamp":1792712329504,"version":"4.5.0"},"reference-count":63,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T00:00:00Z","timestamp":1784764800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002241","name":"Japan Science and Technology Agency","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002241","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Reports"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.celrep.2026.117824","type":"journal-article","created":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T19:20:43Z","timestamp":1786562443000},"page":"117824","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Spi-B and IRF1 activate tumor immunogenicity downstream of the Epstein-Barr virus protein LMP1"],"prefix":"10.1016","volume":"45","author":[{"given":"Keita","family":"Yamane","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yohei","family":"Kawano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shun","family":"Ohki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsuki","family":"Matayoshi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nagisa","family":"Morihara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hitoshi","family":"Azuma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusei","family":"Ota","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuo","family":"Kitajima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomohiro","family":"Asai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9997-6852","authenticated-orcid":false,"given":"Tomoharu","family":"Yasuda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.celrep.2026.117824_bib1","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1038\/ni1102-991","article-title":"Cancer immunoediting: from immunosurveillance to tumor escape","volume":"3","author":"Dunn","year":"2002","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.celrep.2026.117824_bib2","doi-asserted-by":"crossref","first-page":"1652","DOI":"10.1016\/j.cell.2023.03.006","article-title":"Immune checkpoint therapy-current perspectives and future directions","volume":"186","author":"Sharma","year":"2023","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2026.117824_bib3","doi-asserted-by":"crossref","first-page":"e419","DOI":"10.1016\/S1470-2045(20)30234-5","article-title":"Turning up the heat on non-immunoreactive tumours: opportunities for clinical development","volume":"21","author":"Ochoa de Olza","year":"2020","journal-title":"Lancet Oncol."},{"key":"10.1016\/j.celrep.2026.117824_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.eclinm.2021.101134","article-title":"The association between CD8+ tumor-infiltrating lymphocytes and the clinical outcome of cancer immunotherapy: A systematic review and meta-analysis","volume":"41","author":"Li","year":"2021","journal-title":"EClinicalMedicine"},{"key":"10.1016\/j.celrep.2026.117824_bib5","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.636568","article-title":"Cancer Immune Evasion Through Loss of MHC Class I Antigen Presentation","volume":"12","author":"Dhatchinamoorthy","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.celrep.2026.117824_bib6","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1038\/s41577-020-0390-6","article-title":"A few good peptides: MHC class I-based cancer immunosurveillance and immunoevasion","volume":"21","author":"Dersh","year":"2021","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.celrep.2026.117824_bib7","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1038\/s41571-023-00789-4","article-title":"Antigen presentation in cancer - mechanisms and clinical implications for immunotherapy","volume":"20","author":"Yang","year":"2023","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.celrep.2026.117824_bib8","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1186\/s40425-018-0479-7","article-title":"High and low mutational burden tumors versus immunologically hot and cold tumors and response to immune checkpoint inhibitors","volume":"6","author":"Maleki Vareki","year":"2018","journal-title":"J. Immunother. Cancer"},{"key":"10.1016\/j.celrep.2026.117824_bib9","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.immuni.2022.12.002","article-title":"CD8(+) T cell activation in cancer comprises an initial activation phase in lymph nodes followed by effector differentiation within the tumor","volume":"56","author":"Prokhnevska","year":"2023","journal-title":"Immunity"},{"key":"10.1016\/j.celrep.2026.117824_bib10","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1038\/s41568-024-00787-3","article-title":"Dendritic cell maturation in cancer","volume":"25","author":"Moon","year":"2025","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.celrep.2026.117824_bib11","doi-asserted-by":"crossref","first-page":"2188","DOI":"10.1016\/j.immuni.2023.09.011","article-title":"The cancer-immunity cycle: Indication, genotype, and immunotype","volume":"56","author":"Mellman","year":"2023","journal-title":"Immunity"},{"key":"10.1016\/j.celrep.2026.117824_bib12","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1038\/nrc3246","article-title":"The determinants of tumour immunogenicity","volume":"12","author":"Blankenstein","year":"2012","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.celrep.2026.117824_bib13","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1038\/nature14404","article-title":"Melanoma-intrinsic beta-catenin signalling prevents anti-tumour immunity","volume":"523","author":"Spranger","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2026.117824_bib14","doi-asserted-by":"crossref","first-page":"2218","DOI":"10.1016\/j.immuni.2023.08.014","article-title":"Dendritic cells as shepherds of T cell immunity in cancer","volume":"56","author":"Pittet","year":"2023","journal-title":"Immunity"},{"key":"10.1016\/j.celrep.2026.117824_bib15","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1016\/j.ccell.2014.09.007","article-title":"Dissecting the tumor myeloid compartment reveals rare activating antigen-presenting cells critical for T cell immunity","volume":"26","author":"Broz","year":"2014","journal-title":"Cancer Cell"},{"key":"10.1016\/j.celrep.2026.117824_bib16","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1038\/s41579-025-01181-y","article-title":"Epstein-Barr virus pathogenesis and emerging control strategies","volume":"23","author":"M\u00fcnz","year":"2025","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.celrep.2026.117824_bib17","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/j.cell.2011.12.031","article-title":"Immune surveillance and therapy of lymphomas driven by Epstein-Barr virus protein LMP1 in a mouse model","volume":"148","author":"Zhang","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2026.117824_bib18","doi-asserted-by":"crossref","first-page":"E686","DOI":"10.1073\/pnas.1713607115","article-title":"Signaling by the Epstein-Barr virus LMP1 protein induces potent cytotoxic CD4(+) and CD8(+) T cell responses","volume":"115","author":"Choi","year":"2018","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2026.117824_bib19","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1182\/blood-2008-12-194043","article-title":"CD4+ T-cell clones recognizing human lymphoma-associated antigens: generation by in vitro stimulation with autologous Epstein-Barr virus-transformed B cells","volume":"114","author":"Long","year":"2009","journal-title":"Blood"},{"key":"10.1016\/j.celrep.2026.117824_bib20","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1038\/s41586-020-03075-w","article-title":"Mechanism of EBV inducing anti-tumour immunity and its therapeutic use","volume":"590","author":"Choi","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2026.117824_bib21","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.ctrv.2017.11.007","article-title":"CXCL9, CXCL10, CXCL11\/CXCR3 axis for immune activation - A target for novel cancer therapy","volume":"63","author":"Tokunaga","year":"2018","journal-title":"Cancer Treat Rev."},{"key":"10.1016\/j.celrep.2026.117824_bib22","doi-asserted-by":"crossref","first-page":"1969","DOI":"10.1073\/pnas.0307298101","article-title":"IL-15 enhances the in vivo antitumor activity of tumor-reactive CD8+ T cells","volume":"101","author":"Klebanoff","year":"2004","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2026.117824_bib23","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1038\/nri2687","article-title":"Proteasomes in immune cells: more than peptide producers?","volume":"10","author":"Groettrup","year":"2010","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.celrep.2026.117824_bib24","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1038\/nrc3670","article-title":"Tumour antigens recognized by T lymphocytes: at the core of cancer immunotherapy","volume":"14","author":"Coulie","year":"2014","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.celrep.2026.117824_bib25","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1038\/s41568-021-00339-z","article-title":"Antigen presentation in cancer: insights into tumour immunogenicity and immune evasion","volume":"21","author":"Jhunjhunwala","year":"2021","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.celrep.2026.117824_bib26","first-page":"20.1.1","article-title":"Mouse model for pre-clinical study of human cancer immunotherapy","volume":"108","author":"Ya","year":"2015","journal-title":"Curr. Protoc. Im."},{"key":"10.1016\/j.celrep.2026.117824_bib27","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aau5516","article-title":"Noncoding regions are the main source of targetable tumor-specific antigens","volume":"10","author":"Laumont","year":"2018","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.celrep.2026.117824_bib28","doi-asserted-by":"crossref","first-page":"baw087","DOI":"10.1093\/database\/baw087","article-title":"gEVE: a genome-based endogenous viral element database provides comprehensive viral protein-coding sequences in mammalian genomes. Database 2016","volume":"2016","author":"Nakagawa","year":"2016","journal-title":"Database"},{"key":"10.1016\/j.celrep.2026.117824_bib29","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1158\/2326-6066.CIR-17-0489","article-title":"Identification of Tumoricidal TCRs from Tumor-Infiltrating Lymphocytes by Single-Cell Analysis","volume":"6","author":"Shitaoka","year":"2018","journal-title":"Cancer Immunol. Res."},{"key":"10.1016\/j.celrep.2026.117824_bib30","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2021.640207","article-title":"The Role of EBV-Encoded LMP1 in the NPC Tumor Microenvironment: From Function to Therapy","volume":"11","author":"Lo","year":"2021","journal-title":"Front. Oncol."},{"key":"10.1016\/j.celrep.2026.117824_bib31","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1146\/annurev-pathmechdis-012418-013023","article-title":"Epstein-Barr Virus and Cancer","volume":"14","author":"Farrell","year":"2019","journal-title":"Annu. Rev. Pathol."},{"key":"10.1016\/j.celrep.2026.117824_bib32","doi-asserted-by":"crossref","first-page":"3064","DOI":"10.1093\/emboj\/18.11.3064","article-title":"Latent membrane protein 1 of Epstein\u2013Barr virus interacts with JAK3 and activates STAT proteins","volume":"18","author":"Gires","year":"1999","journal-title":"EMBO J."},{"key":"10.1016\/j.celrep.2026.117824_bib33","doi-asserted-by":"crossref","first-page":"2425","DOI":"10.1084\/jem.20141207","article-title":"Limitation of immune tolerance-inducing thymic epithelial cell development by Spi-B-mediated negative feedback regulation","volume":"211","author":"Akiyama","year":"2014","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.celrep.2026.117824_bib34","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1038\/ni.2352","article-title":"The Ets transcription factor Spi-B is essential for the differentiation of intestinal microfold cells","volume":"13","author":"Kanaya","year":"2012","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.celrep.2026.117824_bib35","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/S1074-7613(01)00210-2","article-title":"Epstein-Barr virus transactivates the human endogenous retrovirus HERV-K18 that encodes a superantigen","volume":"15","author":"Sutkowski","year":"2001","journal-title":"Immunity"},{"key":"10.1016\/j.celrep.2026.117824_bib36","doi-asserted-by":"crossref","first-page":"2707","DOI":"10.1158\/2159-8290.CD-21-0506","article-title":"Endogenous Retroelements and the Viral Mimicry Response in Cancer Therapy and Cellular Homeostasis","volume":"11","author":"Chen","year":"2021","journal-title":"Cancer Discov."},{"key":"10.1016\/j.celrep.2026.117824_bib37","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2025.1597731","article-title":"T cell-mediated immune surveillance conferred by latent Epstein-Barr virus genes suppresses a broad spectrum of tumor formation through NKG2D-NKG2DL interactions","volume":"16","author":"Jin","year":"2025","journal-title":"Front. Immunol."},{"key":"10.1016\/j.celrep.2026.117824_bib38","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms11291","article-title":"Virtual memory T cells develop and mediate bystander protective immunity in an IL-15-dependent manner","volume":"7","author":"White","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2026.117824_bib39","doi-asserted-by":"crossref","first-page":"6338","DOI":"10.18632\/aging.204225","article-title":"Comprehensive pan-cancer analysis reveals the prognostic value and immunological role of SPIB","volume":"14","author":"Ding","year":"2022","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.celrep.2026.117824_bib40","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1016\/j.cell.2024.01.027","article-title":"Pan-cancer proteogenomics characterization of tumor immunity","volume":"187","author":"Petralia","year":"2024","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2026.117824_bib41","doi-asserted-by":"crossref","first-page":"6184","DOI":"10.4049\/jimmunol.174.10.6184","article-title":"Enforced expression of Spi-B reverses T lineage commitment and blocks beta-selection","volume":"174","author":"Lefebvre","year":"2005","journal-title":"J. Immunol."},{"key":"10.1016\/j.celrep.2026.117824_bib42","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1038\/nature09976","article-title":"TRIM5 is an innate immune sensor for the retrovirus capsid lattice","volume":"472","author":"Pertel","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2026.117824_bib43","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/S0959-8049(05)80024-3","article-title":"Epstein-Barr virus (EBV)-encoded membrane protein LMP1 from a nasopharyngeal carcinoma is non-immunogenic in a murine model system, in contrast to a B cell-derived homologue","volume":"30A","author":"Trivedi","year":"1994","journal-title":"Eur. J. Cancer"},{"key":"10.1016\/j.celrep.2026.117824_bib44","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.add4817","article-title":"Restoring tumor immunogenicity with dendritic cell reprogramming","volume":"8","author":"Zimmermannova","year":"2023","journal-title":"Sci. Immunol."},{"key":"10.1016\/j.celrep.2026.117824_bib45","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1158\/2159-8290.CD-21-0502","article-title":"Reprogramming Cancer into Antigen-Presenting Cells as a Novel Immunotherapy","volume":"13","author":"Linde","year":"2023","journal-title":"Cancer Discov."},{"key":"10.1016\/j.celrep.2026.117824_bib46","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1158\/2326-6066.CIR-23-0721","article-title":"Machine Learning-Directed Conversion of Glioblastoma Cells to Dendritic Cell-Like Antigen-Presenting Cells as Cancer Immunotherapy","volume":"12","author":"Liu","year":"2024","journal-title":"Cancer Immunol. Res."},{"key":"10.1016\/j.celrep.2026.117824_bib47","doi-asserted-by":"crossref","DOI":"10.1126\/science.adn9083","article-title":"In vivo dendritic cell reprogramming for cancer immunotherapy","volume":"386","author":"Ascic","year":"2024","journal-title":"Science"},{"key":"10.1016\/j.celrep.2026.117824_bib48","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1016\/j.stem.2010.08.012","article-title":"Highly efficient reprogramming to pluripotency and directed differentiation of human cells with synthetic modified mRNA","volume":"7","author":"Warren","year":"2010","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.celrep.2026.117824_bib49","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.stem.2013.06.001","article-title":"Efficient generation of human iPSCs by a synthetic self-replicative RNA","volume":"13","author":"Yoshioka","year":"2013","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.celrep.2026.117824_bib50","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1158\/2326-6066.CIR-18-0711","article-title":"IRF1 Inhibits Antitumor Immunity through the Upregulation of PD-L1 in the Tumor Cell","volume":"7","author":"Shao","year":"2019","journal-title":"Cancer Immunol. Res."},{"key":"10.1016\/j.celrep.2026.117824_bib51","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1038\/nbt1418","article-title":"Induction of pluripotent stem cells by defined factors is greatly improved by small-molecule compounds","volume":"26","author":"Huangfu","year":"2008","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.celrep.2026.117824_bib52","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1038\/ni.2418","article-title":"The cell-cycle regulator c-Myc is essential for the formation and maintenance of germinal centers","volume":"13","author":"Calado","year":"2012","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.celrep.2026.117824_bib62","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1038\/nbt.3198","article-title":"Increasing the efficiency of homology-directed repair for CRISPR-Cas9-induced precise gene editing in mammalian cells","volume":"33","author":"Chu","year":"2015","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.celrep.2026.117824_bib53","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1093\/bioinformatics\/bts635","article-title":"STAR: ultrafast universal RNA-seq aligner","volume":"29","author":"Dobin","year":"2013","journal-title":"Bioinformatics"},{"key":"10.1016\/j.celrep.2026.117824_bib54","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1186\/1471-2105-12-323","article-title":"RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genome","volume":"12","author":"Li","year":"2011","journal-title":"BMC Bioinf."},{"key":"10.1016\/j.celrep.2026.117824_bib55","article-title":"clusterProfiler 4.0: A universal enrichment tool for interpreting omics data","volume":"2","author":"Wu","year":"2021","journal-title":"Innovation"},{"key":"10.1016\/j.celrep.2026.117824_bib56","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1038\/s41592-023-02014-7","article-title":"Extending support for mouse data in the Molecular Signatures Database (MSigDB)","volume":"20","author":"Castanza","year":"2023","journal-title":"Nat. Methods"},{"key":"10.1016\/j.celrep.2026.117824_bib57","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1186\/s12859-018-2486-6","article-title":"iDEP: an integrated web application for differential expression and pathway analysis of RNA-Seq data","volume":"19","author":"Ge","year":"2018","journal-title":"BMC Bioinf."},{"key":"10.1016\/j.celrep.2026.117824_bib58","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol."},{"key":"10.1016\/j.celrep.2026.117824_bib59","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1038\/s41587-019-0201-4","article-title":"Graph-based genome alignment and genotyping with HISAT2 and HISAT-genotype","volume":"37","author":"Kim","year":"2019","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.celrep.2026.117824_bib60","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1038\/nbt.3122","article-title":"StringTie enables improved reconstruction of a transcriptome from RNA-seq reads","volume":"33","author":"Pertea","year":"2015","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.celrep.2026.117824_bib61","doi-asserted-by":"crossref","first-page":"W171","DOI":"10.1093\/nar\/gkz365","article-title":"CHOPCHOP v3: expanding the CRISPR web toolbox beyond genome editing","volume":"47","author":"Labun","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.celrep.2026.117824_bib63","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2025.125485","article-title":"Development of a messenger RNA vaccine using pH-responsive dipeptide-conjugated lipids exhibiting reduced inflammatory properties","volume":"674","author":"Matayoshi","year":"2025","journal-title":"Int. J. Pharm."}],"container-title":["Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124726009022?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124726009022?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T22:55:01Z","timestamp":1792709701000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211124726009022"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":63,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["S2211124726009022"],"URL":"https:\/\/doi.org\/10.1016\/j.celrep.2026.117824","relation":{},"ISSN":["2211-1247"],"issn-type":[{"value":"2211-1247","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Spi-B and IRF1 activate tumor immunogenicity downstream of the Epstein-Barr virus protein LMP1","name":"articletitle","label":"Article Title"},{"value":"Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.celrep.2026.117824","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"117824"}}