{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T05:03:58Z","timestamp":1789707838933,"version":"4.0.1"},"reference-count":84,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,26]],"date-time":"2026-07-26T00:00:00Z","timestamp":1785024000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["311314\/Z\/24\/Z"],"award-info":[{"award-number":["311314\/Z\/24\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["SFB 1557"],"award-info":[{"award-number":["SFB 1557"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["Project P14"],"award-info":[{"award-number":["Project P14"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["UN111\/13-2"],"award-info":[{"award-number":["UN111\/13-2"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["534725166"],"award-info":[{"award-number":["534725166"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["516911046"],"award-info":[{"award-number":["516911046"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["448135520"],"award-info":[{"award-number":["448135520"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2025YFA0923000"],"award-info":[{"award-number":["2025YFA0923000"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001839","name":"University Grants Committee","doi-asserted-by":"publisher","award":["26102725"],"award-info":[{"award-number":["26102725"]}],"id":[{"id":"10.13039\/501100001839","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001839","name":"University Grants Committee","doi-asserted-by":"publisher","award":["16103622"],"award-info":[{"award-number":["16103622"]}],"id":[{"id":"10.13039\/501100001839","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001839","name":"University Grants Committee","doi-asserted-by":"publisher","award":["16104423"],"award-info":[{"award-number":["16104423"]}],"id":[{"id":"10.13039\/501100001839","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002920","name":"Research Grants Council, University Grants Committee","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002920","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000361","name":"Diabetes UK","doi-asserted-by":"publisher","award":["22\/0006453"],"award-info":[{"award-number":["22\/0006453"]}],"id":[{"id":"10.13039\/501100000361","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005950","name":"The Hong Kong University of Science and Technology","doi-asserted-by":"publisher","award":["R9956"],"award-info":[{"award-number":["R9956"]}],"id":[{"id":"10.13039\/501100005950","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Reports"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.celrep.2026.117835","type":"journal-article","created":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T21:10:43Z","timestamp":1786569043000},"page":"117835","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Retromer mediates Ypt7-dependent lipid droplet internalization"],"prefix":"10.1016","volume":"45","author":[{"given":"Zixin","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingyan","family":"Zhi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gongcheng","family":"Qu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingyi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hei Ting","family":"Ngan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aksel J.","family":"Saukko-Paavola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusong","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Ungermann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robin W.","family":"Klemm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Langemeyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5223-6547","authenticated-orcid":false,"given":"Jieqiong","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.celrep.2026.117835_bib1","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.devcel.2016.09.030","article-title":"Lipids and Their Trafficking: An Integral Part of Cellular Organization","volume":"39","author":"Jackson","year":"2016","journal-title":"Dev. Cell"},{"key":"10.1016\/j.celrep.2026.117835_bib2","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1146\/annurev-biochem-061009-102430","article-title":"Lipid droplets and cellular lipid metabolism","volume":"81","author":"Walther","year":"2012","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.celrep.2026.117835_bib3","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1038\/s41580-018-0085-z","article-title":"Dynamics and functions of lipid droplets","volume":"20","author":"Olzmann","year":"2019","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.celrep.2026.117835_bib4","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/j.devcel.2013.01.013","article-title":"Triacylglycerol synthesis enzymes mediate lipid droplet growth by relocalizing from the ER to lipid droplets","volume":"24","author":"Wilfling","year":"2013","journal-title":"Dev. Cell"},{"key":"10.1016\/j.celrep.2026.117835_bib5","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1146\/annurev-cellbio-100616-060608","article-title":"Lipid droplet biogenesis","volume":"33","author":"Walther","year":"2017","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"10.1016\/j.celrep.2026.117835_bib6","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1007\/s11427-016-0322-x","article-title":"The size matters: regulation of lipid storage by lipid droplet dynamics","volume":"60","author":"Yu","year":"2017","journal-title":"Sci. China Life Sci."},{"key":"10.1016\/j.celrep.2026.117835_bib7","doi-asserted-by":"crossref","first-page":"3320","DOI":"10.1083\/jcb.201803153","article-title":"Lipid droplet size directs lipolysis and lipophagy catabolism in hepatocytes","volume":"218","author":"Schott","year":"2019","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.celrep.2026.117835_bib8","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1210\/en.2007-1713","article-title":"Minireview: Lipid droplets in lipogenesis and lipolysis","volume":"149","author":"Ducharme","year":"2008","journal-title":"Endocrinology"},{"key":"10.1016\/j.celrep.2026.117835_bib9","doi-asserted-by":"crossref","first-page":"2111","DOI":"10.15252\/embj.201592087","article-title":"Autophagosomes and lipid droplets: no longer just chewing the fat","volume":"34","author":"Deretic","year":"2015","journal-title":"EMBO J."},{"key":"10.1016\/j.celrep.2026.117835_bib10","first-page":"686","article-title":"Lipophagy: Molecular Mechanisms and Implications in Metabolic Disorders","volume":"43","author":"Shin","year":"2020","journal-title":"Mol. Cells"},{"key":"10.1016\/j.celrep.2026.117835_bib11","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/nrm.2017.76","article-title":"Cytosolic lipolysis and lipophagy: Two sides of the same coin","volume":"18","author":"Zechner","year":"2017","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.celrep.2026.117835_bib12","article-title":"Morphologically and Functionally Distinct Lipid Droplet Subpopulations","volume":"6","author":"Zhang","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.celrep.2026.117835_bib13","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1091\/mbc.e13-11-0634","article-title":"A phosphatidylinositol transfer protein integrates phosphoinositide signaling with lipid droplet metabolism to regulate a developmental program of nutrient stress-induced membrane biogenesis","volume":"25","author":"Ren","year":"2014","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.celrep.2026.117835_bib14","doi-asserted-by":"crossref","first-page":"4908","DOI":"10.1529\/biophysj.108.137737","article-title":"Quantitative label-free imaging of lipid composition and packing of individual cellular lipid droplets using multiplex CARS microscopy","volume":"95","author":"Rinia","year":"2008","journal-title":"Biophys. J."},{"key":"10.1016\/j.celrep.2026.117835_bib15","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1083\/jcb.201704122","article-title":"Identification of seipin-linked factors that act as determinants of a lipid droplet subpopulation","volume":"217","author":"Eisenberg-Bord","year":"2018","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.celrep.2026.117835_bib16","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1083\/jcb.201704115","article-title":"Regulation of lipid droplets by metabolically controlled Ldo isoforms","volume":"217","author":"Teixeira","year":"2018","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.celrep.2026.117835_bib17","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1016\/j.devcel.2024.01.016","article-title":"A metabolically controlled contact site between vacuoles and lipid droplets in yeast","volume":"59","author":"Diep","year":"2024","journal-title":"Dev. Cell"},{"key":"10.1016\/j.celrep.2026.117835_bib18","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/j.devcel.2024.01.014","article-title":"LDO proteins and Vac8 form a vacuole-lipid droplet contact site to enable starvation-induced lipophagy in yeast","volume":"59","author":"\u00c1lvarez-Guerra","year":"2024","journal-title":"Dev. Cell"},{"key":"10.1016\/j.celrep.2026.117835_bib19","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1083\/jcb.201209113","article-title":"RabGEFs are a major determinant for specific Rab membrane targeting","volume":"200","author":"Bl\u00fcmer","year":"2013","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.celrep.2026.117835_bib20","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1038\/nrm2728","article-title":"Rab GTPases as coordinators of vesicle traffic","volume":"10","author":"Stenmark","year":"2009","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.celrep.2026.117835_bib21","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1038\/nrm1500","article-title":"Targeting Rab GTPases to distinct membrane compartments","volume":"5","author":"Pfeffer","year":"2004","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.celrep.2026.117835_bib22","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1083\/jcb.201306010","article-title":"Rab GTPases and membrane identity: Causal or inconsequential?","volume":"202","author":"Barr","year":"2013","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.celrep.2026.117835_bib23","first-page":"3171","article-title":"Cellular functions of Rab GTPases at a glance","volume":"128","author":"Zhen","year":"2015","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.celrep.2026.117835_bib24","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1016\/j.tcb.2018.06.007","article-title":"Rab GTPase Function in Endosome and Lysosome Biogenesis","volume":"28","author":"Langemeyer","year":"2018","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.celrep.2026.117835_bib25","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1091\/mbc.e16-11-0764","article-title":"Multivalent Rab interactions determine tether-mediated membrane fusion","volume":"28","author":"L\u00fcrick","year":"2017","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.celrep.2026.117835_bib26","doi-asserted-by":"crossref","first-page":"182","DOI":"10.4161\/sgtp.2.3.16701","article-title":"Rab GTPases and tethering in the yeast endocytic pathway","volume":"2","author":"Lachmann","year":"2011","journal-title":"Small GTPases"},{"key":"10.1016\/j.celrep.2026.117835_bib27","series-title":"Who\u2019s in Control? Principles of Rab Gtpase Activation in Endolysosomal Membrane Trafficking and beyond","author":"Borchers","year":"2021"},{"key":"10.1016\/j.celrep.2026.117835_bib28","doi-asserted-by":"crossref","first-page":"1654","DOI":"10.1016\/j.cub.2010.08.002","article-title":"The Mon1-Ccz1 complex is the GEF of the late endosomal Rab7 homolog Ypt7","volume":"20","author":"Nordmann","year":"2010","journal-title":"Curr. Biol."},{"key":"10.1016\/j.celrep.2026.117835_bib29","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2121494119","article-title":"Structure of the Mon1-Ccz1 complex reveals molecular basis of membrane binding for Rab7 activation","volume":"119","author":"Klink","year":"2022","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2026.117835_bib30","first-page":"329","article-title":"Mon1-Ccz1 activates Rab7 only on late endosomes and dissociates from the lysosome in mammalian cells","volume":"129","author":"Yasuda","year":"2016","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.celrep.2026.117835_bib31","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1016\/j.cub.2014.05.005","article-title":"Protein delivery to vacuole requires SAND protein-dependent Rab GTPase conversion for MVB-vacuole fusion","volume":"24","author":"Singh","year":"2014","journal-title":"Curr. Biol."},{"key":"10.1016\/j.celrep.2026.117835_bib32","doi-asserted-by":"crossref","first-page":"2080","DOI":"10.1105\/tpc.114.123141","article-title":"Activation of the Rab7 GTPase by the MON1-CCZ1 Complex Is Essential for PVC-to-Vacuole Trafficking and Plant Growth in Arabidopsis","volume":"26","author":"Cui","year":"2014","journal-title":"Plant Cell"},{"key":"10.1016\/j.celrep.2026.117835_bib33","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.31145","article-title":"Molecular mechanism to target the endosomal Mon1-Ccz1 GEF complex to the pre-autophagosomal structure","volume":"7","author":"Gao","year":"2018","journal-title":"eLife"},{"key":"10.1016\/j.celrep.2026.117835_bib34","doi-asserted-by":"crossref","first-page":"e56090","DOI":"10.7554\/eLife.56090","article-title":"A conserved and regulated mechanism drives endosomal rab transition","volume":"9","author":"Langemeyer","year":"2020","journal-title":"eLife"},{"key":"10.1016\/j.celrep.2026.117835_bib35","doi-asserted-by":"crossref","first-page":"102915","DOI":"10.1016\/j.jbc.2023.102915","article-title":"Targeting of the Mon1-Ccz1 Rab guanine nucleotide exchange factor to distinct organelles by a synergistic protein and lipid code","volume":"299","author":"Herrmann","year":"2023","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.celrep.2026.117835_bib36","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1091\/mbc.e16-08-0582","article-title":"Retromer-driven membrane tubulation separates endosomal recycling from Rab7\/Ypt7-dependent fusion","volume":"28","author":"Purushothaman","year":"2017","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.celrep.2026.117835_bib37","doi-asserted-by":"crossref","first-page":"2378","DOI":"10.1242\/jcs.009654","article-title":"Identification of a novel conserved sorting motif required for retromer-mediated endosome-to-TGN retrieval","volume":"120","author":"Seaman","year":"2007","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.celrep.2026.117835_bib38","doi-asserted-by":"crossref","first-page":"4085","DOI":"10.1242\/jcs.071977","article-title":"The Rab GTPase Ypt7 is linked to retromer-mediated receptor recycling and fusion at the yeast late endosome","volume":"123","author":"Balderhaar","year":"2010","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.celrep.2026.117835_bib39","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a016774","article-title":"Retromer: A master conductor of endosome sorting","volume":"6","author":"Burd","year":"2014","journal-title":"Cold Spring Harbor Perspect. Biol."},{"key":"10.1016\/j.celrep.2026.117835_bib40","first-page":"4693","article-title":"The retromer complex - endosomal protein recycling and beyond","volume":"125","author":"Seaman","year":"2012","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.celrep.2026.117835_bib41","series-title":"Molecular Machinery of Lipid Droplet Degradation and Turnover in Plants","author":"Qin","year":"2023"},{"key":"10.1016\/j.celrep.2026.117835_bib42","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202401676","article-title":"Targeting Rab7-Rilp Mediated Microlipophagy Alleviates Lipid Toxicity in Diabetic Cardiomyopathy","volume":"11","author":"Ke","year":"2024","journal-title":"Adv. Sci."},{"key":"10.1016\/j.celrep.2026.117835_bib43","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1038\/s41419-022-04593-3","article-title":"The regulation, function, and role of lipophagy, a form of selective autophagy, in metabolic disorders","volume":"13","author":"Zhang","year":"2022","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.celrep.2026.117835_bib44","first-page":"435","article-title":"Lipid Droplets and the Management of Cellular Stress","volume":"92","author":"Jarc","year":"2019","journal-title":"J Biol Med."},{"key":"10.1016\/j.celrep.2026.117835_bib45","first-page":"1043","article-title":"The Mon1-Ccz1 GEF activates the Rab7 GTPase Ypt7 via a longin-fold-Rab interface and association with PI3P-positive membranes","volume":"127","author":"Cabrera","year":"2014","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.celrep.2026.117835_bib46","doi-asserted-by":"crossref","first-page":"10193","DOI":"10.1021\/acsami.6b01282","article-title":"Specific Fluorescence Probes for Lipid Droplets Based on Simple AIEgens","volume":"8","author":"Wang","year":"2016","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.celrep.2026.117835_bib47","doi-asserted-by":"crossref","first-page":"2535","DOI":"10.1091\/mbc.E15-02-0062","article-title":"Identification of a Rab GTPase-activating protein cascade that controls recycling of the Rab5 GTPase Vps21 from the vacuole","volume":"26","author":"Rana","year":"2015","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.celrep.2026.117835_bib48","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1083\/jcb.200711136","article-title":"Fld1p, a functional homologue of human seipin, regulates the size of lipid droplets in yeast","volume":"180","author":"Fei","year":"2008","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.celrep.2026.117835_bib49","doi-asserted-by":"crossref","first-page":"2699","DOI":"10.15252\/embj.201695170","article-title":"Seipin regulates ER \u2013lipid droplet contacts and cargo delivery","volume":"35","author":"Salo","year":"2016","journal-title":"EMBO J."},{"key":"10.1016\/j.celrep.2026.117835_bib50","doi-asserted-by":"crossref","first-page":"5892","DOI":"10.1038\/s41467-021-26162-6","article-title":"Mechanism of lipid droplet formation by the yeast Sei1\/Ldb16 Seipin complex","volume":"12","author":"Klug","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2026.117835_bib51","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1038\/s41594-021-00718-y","article-title":"Seipin forms a flexible cage at lipid droplet formation sites","volume":"29","author":"Arlt","year":"2022","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.celrep.2026.117835_bib52","doi-asserted-by":"crossref","first-page":"20890","DOI":"10.1073\/pnas.0704154104","article-title":"The lipodystrophy protein seipin is found at endoplasmic reticulum lipid droplet junctions and is important for droplet morphology","volume":"104","author":"Szymanski","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2026.117835_bib53","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2303750120","article-title":"Regulatory sites in the Mon1\u2013Ccz1 complex control Rab5 to Rab7 transition and endosome maturation","volume":"120","author":"Borchers","year":"2023","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2026.117835_bib54","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.devcel.2017.12.011","article-title":"Mechanism and Determinants of Amphipathic Helix-Containing Protein Targeting to Lipid Droplets","volume":"44","author":"Pr\u00e9vost","year":"2018","journal-title":"Dev. Cell"},{"key":"10.1016\/j.celrep.2026.117835_bib55","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.16988","article-title":"A filter at the entrance of the Golgi that selects vesicles according to size and bulk lipid composition","volume":"5","author":"Magdeleine","year":"2016","journal-title":"eLife"},{"key":"10.1016\/j.celrep.2026.117835_bib56","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/j.devcel.2014.10.007","article-title":"Toward a Comprehensive Map of the Effectors of Rab GTPases","volume":"31","author":"Gillingham","year":"2014","journal-title":"Dev. Cell"},{"key":"10.1016\/j.celrep.2026.117835_bib57","doi-asserted-by":"crossref","first-page":"2278","DOI":"10.1242\/jcs.164905","article-title":"The I-BAR protein Ivy1 is an effector of the Rab7 GTPase Ypt7 involved in vacuole membrane homeostasis","volume":"128","author":"Numrich","year":"2015","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.celrep.2026.117835_bib58","doi-asserted-by":"crossref","first-page":"4684","DOI":"10.1073\/pnas.1722517115","article-title":"Control of vacuole membrane homeostasis by a resident PI-3,5-kinase inhibitor","volume":"115","author":"Malia","year":"2018","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2026.117835_bib59","doi-asserted-by":"crossref","DOI":"10.1242\/jcs.260889","article-title":"Yck3 casein kinase-mediated phosphorylation determines Ivy1 localization and function at endosomes and vacuole","volume":"136","author":"Grziwa","year":"2023","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.celrep.2026.117835_bib60","first-page":"132","article-title":"Tethering complexes in the endocytic pathway: CORVET and HOPS","volume":"13","author":"Solinger","year":"2013","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.celrep.2026.117835_bib61","doi-asserted-by":"crossref","first-page":"e80901","DOI":"10.7554\/eLife.80901","article-title":"Structure of the HOPS tethering complex, a lysosomal membrane fusion machinery","volume":"11","author":"Shvarev","year":"2022","journal-title":"eLife"},{"key":"10.1016\/j.celrep.2026.117835_bib62","doi-asserted-by":"crossref","DOI":"10.1242\/jcs.263788","article-title":"Vps41 functions as a molecular ruler for HOPS tethering complex-mediated membrane fusion","volume":"138","author":"K\u00f6nig","year":"2025","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.celrep.2026.117835_bib63","doi-asserted-by":"crossref","first-page":"3670","DOI":"10.1083\/jcb.201804039","article-title":"A novel in vitro assay reveals SNARE topology and the role of Ykt6 in autophagosome fusion with vacuoles","volume":"217","author":"Gao","year":"2018","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.celrep.2026.117835_bib64","doi-asserted-by":"crossref","first-page":"2505","DOI":"10.1091\/mbc.e11-11-0915","article-title":"Rab GTPase regulation of retromer-mediated cargo export during endosome maturation","volume":"23","author":"Liu","year":"2012","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.celrep.2026.117835_bib65","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1093\/emboj\/cdg062","article-title":"Retromer and the sorting nexins Snx4\/41\/42 mediate distinct retrieval pathways from yeast endosomes","volume":"22","author":"Hettema","year":"2003","journal-title":"EMBO J."},{"key":"10.1016\/j.celrep.2026.117835_bib66","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1083\/jcb.200609161","article-title":"Grd19\/Snx3p functions as a cargo-specific adapter for retromer-dependent endocytic recycling","volume":"177","author":"Strochlic","year":"2007","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.celrep.2026.117835_bib67","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1038\/35083051","article-title":"SNX3 regulates endosomal function through its PX-domain-mediated interaction with PtdIns(3)P","volume":"3","author":"Xu","year":"2001","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.celrep.2026.117835_bib68","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1038\/ncb2281","article-title":"A SNX3-dependent retromer pathway mediates retrograde transport of the Wnt sorting receptor Wntless and is required for Wnt secretion","volume":"13","author":"Harterink","year":"2011","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.celrep.2026.117835_bib69","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abf8598","article-title":"STRUCTURAL BIOLOGY Architecture and mechanism of metazoan retromer:SNX3 tubular coat assembly","volume":"7","author":"Leneva","year":"2021","journal-title":"Sci. Adv."},{"key":"10.1016\/j.celrep.2026.117835_bib70","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1080\/15548627.2022.2072656","article-title":"Vacuole fragmentation depends on a novel Atg18-containing retromer-complex","volume":"19","author":"Marquardt","year":"2023","journal-title":"Autophagy"},{"key":"10.1016\/j.celrep.2026.117835_bib71","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1038\/s41580-024-00746-8","article-title":"Assembly and fission of tubular carriers mediating protein sorting in endosomes","volume":"25","author":"Gopaldass","year":"2024","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.celrep.2026.117835_bib72","doi-asserted-by":"crossref","DOI":"10.15252\/embj.2021109646","article-title":"CROP: a retromer-PROPPIN complex mediating membrane fission in the endo-lysosomal system","volume":"41","author":"Courtellemont","year":"2022","journal-title":"EMBO J."},{"key":"10.1016\/j.celrep.2026.117835_bib73","doi-asserted-by":"crossref","first-page":"2709","DOI":"10.1091\/mbc.E18-06-0339","article-title":"Cargo induces retromer-mediated membrane remodeling on membranes","volume":"29","author":"Purushothaman","year":"2018","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.celrep.2026.117835_bib74","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.42837","article-title":"A systematic approach to identify recycling endocytic cargo depending on the GARP complex","volume":"8","author":"Eising","year":"2019","journal-title":"eLife"},{"key":"10.1016\/j.celrep.2026.117835_bib75","doi-asserted-by":"crossref","DOI":"10.1083\/jcb.202109084","article-title":"The HOPS tethering complex is required to maintain signaling endosome identity and TORC1 activity","volume":"221","author":"Gao","year":"2022","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.celrep.2026.117835_bib76","doi-asserted-by":"crossref","first-page":"2876","DOI":"10.1083\/jcb.201901019","article-title":"A bipartite sorting signal ensures specificity of retromer complex in membrane protein recycling","volume":"218","author":"Suzuki","year":"2019","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.celrep.2026.117835_bib77","doi-asserted-by":"crossref","DOI":"10.15252\/embj.2019102586","article-title":"ESCRT machinery mediates selective microautophagy of endoplasmic reticulum in yeast","volume":"39","author":"Sch\u00e4fer","year":"2020","journal-title":"EMBO J."},{"key":"10.1016\/j.celrep.2026.117835_bib78","series-title":"ATG and ESCRT Control Multiple Modes of Microautophagy","author":"Sakai","year":"2024"},{"key":"10.1016\/j.celrep.2026.117835_bib79","first-page":"645","article-title":"Retromer and the dynamin Vps1 cooperate in the retrieval of transmembrane proteins from vacuoles","volume":"128","author":"Arlt","year":"2015","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.celrep.2026.117835_bib80","doi-asserted-by":"crossref","first-page":"D462","DOI":"10.1093\/nar\/gkae1032","article-title":"JPOST environment accelerates the reuse and reanalysis of public proteome mass spectrometry data","volume":"53","author":"Okuda","year":"2025","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.celrep.2026.117835_bib81","doi-asserted-by":"crossref","first-page":"D640","DOI":"10.1093\/nar\/gkad1045","article-title":"MetaboLights: open data repository for metabolomics","volume":"52","author":"Yurekten","year":"2024","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.celrep.2026.117835_bib82","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1002\/yea.1142","article-title":"A versatile toolbox for PCR-based tagging of yeast genes: New fluorescent proteins, more markers and promoter substitution cassettes","volume":"21","author":"Janke","year":"2004","journal-title":"Yeast"},{"key":"10.1016\/j.celrep.2026.117835_bib83","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1002\/(SICI)1097-0061(19980915)14:12<1139::AID-YEA306>3.0.CO;2-B","article-title":"New constructs and strategies for efficient PCR-based gene manipulations in yeast","volume":"14","author":"Puig","year":"1998","journal-title":"Yeast"},{"key":"10.1016\/j.celrep.2026.117835_bib84","doi-asserted-by":"crossref","DOI":"10.1016\/j.xpro.2022.101769","article-title":"Protocol for rapid and accurate quantification of phospholipids in yeast and mammalian systems using LC-MS","volume":"3","author":"Yang","year":"2022","journal-title":"STAR Protoc."}],"container-title":["Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124726009137?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124726009137?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T04:36:22Z","timestamp":1789706182000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211124726009137"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":84,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["S2211124726009137"],"URL":"https:\/\/doi.org\/10.1016\/j.celrep.2026.117835","relation":{},"ISSN":["2211-1247"],"issn-type":[{"value":"2211-1247","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Retromer mediates Ypt7-dependent lipid droplet internalization","name":"articletitle","label":"Article Title"},{"value":"Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.celrep.2026.117835","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"117835"}}