{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T21:38:25Z","timestamp":1792532305300,"version":"4.5.0"},"reference-count":72,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T00:00:00Z","timestamp":1785628800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2025YFA1804601"],"award-info":[{"award-number":["2025YFA1804601"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018537","name":"National Science and Technology Major Project","doi-asserted-by":"publisher","award":["2025ZD0214800"],"award-info":[{"award-number":["2025ZD0214800"]}],"id":[{"id":"10.13039\/501100018537","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Reports"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.celrep.2026.117877","type":"journal-article","created":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T19:29:04Z","timestamp":1787081344000},"page":"117877","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Impaired brain-gut circuit for gut motility dysfunction in mouse models of Parkinson\u2019s disease"],"prefix":"10.1016","volume":"45","author":[{"given":"Minhui","family":"Yu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianying","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Austin","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shangrong","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weitang","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yilin","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-9597-0892","authenticated-orcid":false,"given":"Qiongwei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1894-335X","authenticated-orcid":false,"given":"Jing","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7739-6857","authenticated-orcid":false,"given":"Peng","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.celrep.2026.117877_bib1","doi-asserted-by":"crossref","first-page":"2284","DOI":"10.1016\/S0140-6736(21)00218-X","article-title":"Parkinson's disease","volume":"397","author":"Bloem","year":"2021","journal-title":"Lancet"},{"key":"10.1016\/j.celrep.2026.117877_bib2","doi-asserted-by":"crossref","DOI":"10.1136\/bmj-2024-080952","article-title":"Projections for prevalence of Parkinson's disease and its driving factors in 195 countries and territories to 2050: modelling study of Global Burden of Disease Study 2021","volume":"388","author":"Su","year":"2025","journal-title":"BMJ"},{"key":"10.1016\/j.celrep.2026.117877_bib3","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/S1474-4422(21)00030-2","article-title":"Challenges in the diagnosis of Parkinson's disease","volume":"20","author":"Tolosa","year":"2021","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.celrep.2026.117877_bib4","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1002\/ana.23687","article-title":"Meta-analysis of early nonmotor features and risk factors for Parkinson disease","volume":"72","author":"Noyce","year":"2012","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.celrep.2026.117877_bib5","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/S1474-4422(25)00382-5","article-title":"The gut microbiome, systemic inflammation, and autoimmunity in Parkinson's disease","volume":"25","author":"de Castro Fonseca","year":"2026","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.celrep.2026.117877_bib6","doi-asserted-by":"crossref","first-page":"2283","DOI":"10.1093\/brain\/114.5.2283","article-title":"Ageing and Parkinson's disease: substantia nigra regional selectivity","volume":"114","author":"Fearnley","year":"1991","journal-title":"Brain"},{"key":"10.1016\/j.celrep.2026.117877_bib7","doi-asserted-by":"crossref","first-page":"2045","DOI":"10.1126\/science.276.5321.2045","article-title":"Mutation in the alpha-synuclein gene identified in families with Parkinson's disease","volume":"276","author":"Polymeropoulos","year":"1997","journal-title":"Science"},{"key":"10.1016\/j.celrep.2026.117877_bib8","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/S0140-6736(23)01478-2","article-title":"The pathogenesis of Parkinson's disease","volume":"403","author":"Morris","year":"2024","journal-title":"Lancet"},{"key":"10.1016\/j.celrep.2026.117877_bib9","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1016\/j.nbd.2011.10.014","article-title":"Pathological correlates of gastrointestinal dysfunction in Parkinson's disease","volume":"46","author":"Cersosimo","year":"2012","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.celrep.2026.117877_bib10","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.brainres.2009.05.083","article-title":"Dorsal motor nucleus of vagus protein aggregates in Lewy body disease with autonomic dysfunction","volume":"1286","author":"Miller","year":"2009","journal-title":"Brain Res."},{"key":"10.1016\/j.celrep.2026.117877_bib11","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1007\/BF00687767","article-title":"Parkinson's disease: the presence of Lewy bodies in Auerbach's and Meissner's plexuses","volume":"76","author":"Wakabayashi","year":"1988","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.celrep.2026.117877_bib12","doi-asserted-by":"crossref","DOI":"10.3390\/cells10010139","article-title":"Seeding Propensity and Characteristics of Pathogenic \u03b1Syn Assemblies in Formalin-Fixed Human Tissue from the Enteric Nervous System, Olfactory Bulb, and Brainstem in Cases Staged for Parkinson's Disease","volume":"10","author":"Fenyi","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.celrep.2026.117877_bib13","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/j.neuron.2019.05.035","article-title":"Transneuronal Propagation of Pathologic \u03b1-Synuclein from the Gut to the Brain Models Parkinson's Disease","volume":"103","author":"Kim","year":"2019","journal-title":"Neuron"},{"key":"10.1016\/j.celrep.2026.117877_bib14","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1038\/s41593-020-0589-7","article-title":"Gut-seeded \u03b1-synuclein fibrils promote gut dysfunction and brain pathology specifically in aged mice","volume":"23","author":"Challis","year":"2020","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.celrep.2026.117877_bib15","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1038\/nrgastro.2016.76","article-title":"Vagal neurocircuitry and its influence on gastric motility","volume":"13","author":"Travagli","year":"2016","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.celrep.2026.117877_bib16","doi-asserted-by":"crossref","first-page":"2106","DOI":"10.1016\/j.neuron.2021.05.004","article-title":"Highly selective brain-to-gut communication via genetically defined vagus neurons","volume":"109","author":"Tao","year":"2021","journal-title":"Neuron"},{"key":"10.1016\/j.celrep.2026.117877_bib17","first-page":"G73","article-title":"Localization of sites within dorsal motor nucleus of vagus that affect gastric motility","volume":"249","author":"Pagani","year":"1985","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.celrep.2026.117877_bib18","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1038\/s41586-024-07929-5","article-title":"A brain-to-gut signal controls intestinal fat absorption","volume":"634","author":"Lyu","year":"2024","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2026.117877_bib19","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1016\/j.stem.2025.02.016","article-title":"Vagal pathway activation links chronic stress to decline in intestinal stem cell function","volume":"32","author":"Zhang","year":"2025","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.celrep.2026.117877_bib20","doi-asserted-by":"crossref","first-page":"1494","DOI":"10.1038\/s42255-023-00866-z","article-title":"Brain regulation of gastric dysfunction induced by stress","volume":"5","author":"Dong","year":"2023","journal-title":"Nat. Metab."},{"key":"10.1016\/j.celrep.2026.117877_bib21","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-025-67765-7","article-title":"A brain-to-small intestine circuit mediates morphine-induced constipation in male mice","volume":"17","author":"Ma","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2026.117877_bib22","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abd3994","article-title":"\u03b1-Synuclein-induced Kv4 channelopathy in mouse vagal motoneurons drives nonmotor parkinsonian symptoms","volume":"7","author":"Chiu","year":"2021","journal-title":"Sci. Adv."},{"key":"10.1016\/j.celrep.2026.117877_bib23","doi-asserted-by":"crossref","first-page":"11","DOI":"10.31083\/j.jin2301011","article-title":"The Neuroprotective Effects of Electroacupuncture on Parkinson's Disease and the Underlying Molecular Mechanisms","volume":"23","author":"Han","year":"2024","journal-title":"J. Integr. Neurosci."},{"key":"10.1016\/j.celrep.2026.117877_bib24","article-title":"Anti-Inflammatory Effects of Acupuncture at ST36 Point: A Literature Review in Animal Studies","volume":"12","author":"Oh","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.celrep.2026.117877_bib25","doi-asserted-by":"crossref","first-page":"4078","DOI":"10.7150\/thno.52574","article-title":"Electroacupuncture ameliorates intestinal inflammation by activating \u03b17nAChR-mediated JAK2\/STAT3 signaling pathway in postoperative ileus","volume":"11","author":"Yang","year":"2021","journal-title":"Theranostics"},{"key":"10.1016\/j.celrep.2026.117877_bib26","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1038\/s41586-021-04001-4","article-title":"A neuroanatomical basis for electroacupuncture to drive the vagal-adrenal axis","volume":"598","author":"Liu","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2026.117877_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.neurot.2024.e00369","article-title":"Electroacupuncture improves gastrointestinal motility through a central-cholinergic pathway-mediated GDNF releasing from intestinal glial cells to protect intestinal neurons in Parkinson's disease rats","volume":"21","author":"Zhang","year":"2024","journal-title":"Neurotherapeutics"},{"key":"10.1016\/j.celrep.2026.117877_bib28","doi-asserted-by":"crossref","first-page":"3243","DOI":"10.1016\/j.neuron.2025.06.023","article-title":"Neuroanatomical organization of electroacupuncture in modulating gastric function in mice and humans","volume":"113","author":"Dong","year":"2025","journal-title":"Neuron"},{"key":"10.1016\/j.celrep.2026.117877_bib29","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/S0896-6273(02)00682-7","article-title":"Neuronal alpha-synucleinopathy with severe movement disorder in mice expressing A53T human alpha-synuclein","volume":"34","author":"Giasson","year":"2002","journal-title":"Neuron"},{"key":"10.1016\/j.celrep.2026.117877_bib30","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1186\/s40478-025-01956-7","article-title":"Assessment of gastrointestinal function and enteric nervous system changes over time in the A53T mouse model of Parkinson's disease","volume":"13","author":"Han","year":"2025","journal-title":"Acta Neuropathol. Commun."},{"key":"10.1016\/j.celrep.2026.117877_bib31","doi-asserted-by":"crossref","first-page":"20811","DOI":"10.1074\/jbc.M116.744029","article-title":"FTY720\/Fingolimod Reduces Synucleinopathy and Improves Gut Motility in A53T Mice: CONTRIBUTIONS OF PRO-BRAIN-DERIVED NEUROTROPHIC FACTOR (PRO-BDNF) AND MATURE BDNF","volume":"291","author":"Vidal-Mart\u00ednez","year":"2016","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.celrep.2026.117877_bib32","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.neuint.2018.01.006","article-title":"Genomic DNA levels of mutant alpha-synuclein correlate with non-motor symptoms in an A53T Parkinson's disease mouse model","volume":"114","author":"Wang","year":"2018","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.celrep.2026.117877_bib33","doi-asserted-by":"crossref","first-page":"1821","DOI":"10.3233\/JPD-212731","article-title":"ATH434 Reverses Colorectal Dysfunction in the A53T Mouse Model of Parkinson's Disease","volume":"11","author":"Diwakarla","year":"2021","journal-title":"J. Parkinsons Dis."},{"key":"10.1016\/j.celrep.2026.117877_bib34","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1007\/978-3-7091-0643-3_11","article-title":"The role of acetylcholine and dopamine in dementia and psychosis in Parkinson's disease","volume":"65","author":"Bosboom","year":"2003","journal-title":"J. Neural Transm. Suppl."},{"key":"10.1016\/j.celrep.2026.117877_bib35","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1186\/s13024-024-00756-2","article-title":"\u03b1-Synuclein pathology disrupts mitochondrial function in dopaminergic and cholinergic neurons at-risk in Parkinson's disease","volume":"19","author":"Geibl","year":"2024","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.celrep.2026.117877_bib36","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/S1474-4422(06)70471-9","article-title":"Epidemiology of Parkinson's disease","volume":"5","author":"de Lau","year":"2006","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.celrep.2026.117877_bib37","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/S0140-6736(23)01419-8","article-title":"The epidemiology of Parkinson's disease","volume":"403","author":"Ben-Shlomo","year":"2024","journal-title":"Lancet"},{"key":"10.1016\/j.celrep.2026.117877_bib38","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1126\/science.1227157","article-title":"Pathological \u03b1-synuclein transmission initiates Parkinson-like neurodegeneration in nontransgenic mice","volume":"338","author":"Luk","year":"2012","journal-title":"Science"},{"key":"10.1016\/j.celrep.2026.117877_bib39","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1038\/nature14547","article-title":"\u03b1-Synuclein strains cause distinct synucleinopathies after local and systemic administration","volume":"522","author":"Peelaerts","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2026.117877_bib40","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1038\/s41586-018-0104-4","article-title":"Cellular milieu imparts distinct pathological \u03b1-synuclein strains in \u03b1-synucleinopathies","volume":"557","author":"Peng","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2026.117877_bib41","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1038\/s41593-019-0541-x","article-title":"\u03b1-Synuclein strains target distinct brain regions and cell types","volume":"23","author":"Lau","year":"2020","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.celrep.2026.117877_bib42","doi-asserted-by":"crossref","first-page":"2108","DOI":"10.1016\/j.cell.2026.01.035","article-title":"Genetically encoded fluorescent reporters to visualize \u03b1-synuclein pathology in live brain","volume":"189","author":"Zhang","year":"2026","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2026.117877_bib43","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1016\/j.neuron.2020.07.015","article-title":"Somatotopic Organization and Intensity Dependence in Driving Distinct NPY-Expressing Sympathetic Pathways by Electroacupuncture","volume":"108","author":"Liu","year":"2020","journal-title":"Neuron"},{"key":"10.1016\/j.celrep.2026.117877_bib44","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1002\/j.2040-4603.2014.tb00587.x","article-title":"Central nervous system control of gastrointestinal motility and secretion and modulation of gastrointestinal functions","volume":"4","author":"Browning","year":"2014","journal-title":"Compr. Physiol."},{"key":"10.1016\/j.celrep.2026.117877_bib45","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1007\/978-1-4939-0897-4_3","article-title":"The enteric nervous system and gastrointestinal innervation: integrated local and central control","volume":"817","author":"Furness","year":"2014","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.celrep.2026.117877_bib46","first-page":"G709","article-title":"Electrophysiological identification of vagally innervated enteric neurons in guinea pig stomach","volume":"263","author":"Schemann","year":"1992","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.celrep.2026.117877_bib47","doi-asserted-by":"crossref","DOI":"10.3390\/ijerph18031189","article-title":"Nicotinic Acetylcholine Receptor Involvement in Inflammatory Bowel Disease and Interactions with Gut Microbiota","volume":"18","author":"Rueda Ruzafa","year":"2021","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"10.1016\/j.celrep.2026.117877_bib48","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1124\/jpet.102.033548","article-title":"Pharmacological properties of nicotinic acetylcholine receptors expressed by guinea pig small intestinal myenteric neurons","volume":"302","author":"Zhou","year":"2002","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.celrep.2026.117877_bib49","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1038\/sj.bjp.0706889","article-title":"Cholinergic regulation of epithelial ion transport in the mammalian intestine","volume":"149","author":"Hirota","year":"2006","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.celrep.2026.117877_bib50","article-title":"Electroacupuncture Alleviates LPS-Induced ARDS Through \u03b17 Nicotinic Acetylcholine Receptor-Mediated Inhibition of Ferroptosis","volume":"13","author":"Zhang","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.celrep.2026.117877_bib51","doi-asserted-by":"crossref","first-page":"2417","DOI":"10.1016\/j.cell.2025.02.031","article-title":"Enteric neuronal Piezo1 maintains mechanical and immunological homeostasis by sensing force","volume":"188","author":"Xie","year":"2025","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2026.117877_bib52","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/s40035-019-0146-z","article-title":"Constipation, deficit in colon contractions and alpha-synuclein inclusions within the colon precede motor abnormalities and neurodegeneration in the central nervous system in a mouse model of alpha-synucleinopathy","volume":"8","author":"Rota","year":"2019","journal-title":"Transl. Neurodegener."},{"key":"10.1016\/j.celrep.2026.117877_bib53","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1093\/hmg\/ddq038","article-title":"Extensive enteric nervous system abnormalities in mice transgenic for artificial chromosomes containing Parkinson disease-associated alpha-synuclein gene mutations precede central nervous system changes","volume":"19","author":"Kuo","year":"2010","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.celrep.2026.117877_bib54","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/S1474-4422(21)00377-X","article-title":"Cholinergic system changes in Parkinson's disease: emerging therapeutic approaches","volume":"21","author":"Bohnen","year":"2022","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.celrep.2026.117877_bib55","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/S1474-4422(15)00007-1","article-title":"Gastrointestinal dysfunction in Parkinson's disease","volume":"14","author":"Fasano","year":"2015","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.celrep.2026.117877_bib56","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1006\/exnr.2002.7882","article-title":"Behavioral and neurochemical effects of wild-type and mutated human alpha-synuclein in transgenic mice","volume":"175","author":"Richfield","year":"2002","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.celrep.2026.117877_bib57","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-019-54034-z","article-title":"Behavioural and dopaminergic changes in double mutated human A30P\u2217A53T alpha-synuclein transgenic mouse model of Parkinson\u2019s disease","volume":"9","author":"Kilpel\u00e4inen","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.celrep.2026.117877_bib58","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1523\/JNEUROSCI.0089-14.2015","article-title":"A53T human \u03b1-synuclein overexpression in transgenic mice induces pervasive mitochondria macroautophagy defects preceding dopamine neuron degeneration","volume":"35","author":"Chen","year":"2015","journal-title":"J. Neurosci."},{"key":"10.1016\/j.celrep.2026.117877_bib59","doi-asserted-by":"crossref","DOI":"10.1523\/ENEURO.0170-23.2023","article-title":"Mice Expressing A53T\/A30P Mutant Alpha-Synuclein in Dopamine Neurons Do Not Display Behavioral Deficits","volume":"11","author":"Keomanivong","year":"2024","journal-title":"eNeuro"},{"key":"10.1016\/j.celrep.2026.117877_bib60","doi-asserted-by":"crossref","first-page":"1414","DOI":"10.1038\/nn.3209","article-title":"Calcium entry induces mitochondrial oxidant stress in vagal neurons at risk in Parkinson's disease","volume":"15","author":"Goldberg","year":"2012","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.celrep.2026.117877_bib61","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1146\/annurev.physiol.68.040504.094635","article-title":"Brainstem circuits regulating gastric function","volume":"68","author":"Travagli","year":"2006","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.celrep.2026.117877_bib62","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1111\/j.1469-7793.1999.0521t.x","article-title":"Electrophysiological and morphological heterogeneity of rat dorsal vagal neurones which project to specific areas of the gastrointestinal tract","volume":"517","author":"Browning","year":"1999","journal-title":"J. Physiol."},{"key":"10.1016\/j.celrep.2026.117877_bib63","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.cmet.2011.01.010","article-title":"Melanocortin-4 receptors expressed by cholinergic neurons regulate energy balance and glucose homeostasis","volume":"13","author":"Rossi","year":"2011","journal-title":"Cell Metab."},{"key":"10.1016\/j.celrep.2026.117877_bib64","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1002\/dvg.20228","article-title":"Characterization of a mouse strain expressing Cre recombinase from the 3' untranslated region of the dopamine transporter locus","volume":"44","author":"B\u00e4ckman","year":"2006","journal-title":"Genesis"},{"key":"10.1016\/j.celrep.2026.117877_bib65","doi-asserted-by":"crossref","first-page":"3386","DOI":"10.1016\/j.cell.2023.07.006","article-title":"PIEZO2 in somatosensory neurons controls gastrointestinal transit","volume":"186","author":"Servin-Vences","year":"2023","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2026.117877_bib66","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202203020","article-title":"Ghrelin Bridges DMV Neuropathology and GI Dysfunction in the Early Stages of Parkinson's Disease","volume":"9","author":"Liu","year":"2022","journal-title":"Adv. Sci."},{"key":"10.1016\/j.celrep.2026.117877_bib67","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1016\/j.cell.2016.11.018","article-title":"Gut Microbiota Regulate Motor Deficits and Neuroinflammation in a Model of Parkinson's Disease","volume":"167","author":"Sampson","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2026.117877_bib68","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1002\/jps.3030460322","article-title":"A note on a simple apparatus for detecting neurological deficit in rats and mice","volume":"46","author":"Dunham","year":"1957","journal-title":"J. Am. Pharm. Assoc. Am. Pharm. Assoc."},{"key":"10.1016\/j.celrep.2026.117877_bib69","article-title":"Brainstem opioid peptidergic neurons regulate cough reflexes in mice","volume":"5","author":"Lu","year":"2024","journal-title":"Innovation"},{"key":"10.1016\/j.celrep.2026.117877_bib70","doi-asserted-by":"crossref","first-page":"5523","DOI":"10.1038\/s41467-025-60529-3","article-title":"A molecularly defined brain circuit module for regulating panic-like defensive state","volume":"16","author":"Zhao","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2026.117877_bib71","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1016\/j.cell.2014.05.017","article-title":"Natural neural projection dynamics underlying social behavior","volume":"157","author":"Gunaydin","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2026.117877_bib72","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1038\/s41592-019-0435-6","article-title":"High-performance calcium sensors for imaging activity in neuronal populations and microcompartments","volume":"16","author":"Dana","year":"2019","journal-title":"Nat. Methods"}],"container-title":["Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124726009551?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124726009551?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T20:42:55Z","timestamp":1792528975000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211124726009551"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":72,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["S2211124726009551"],"URL":"https:\/\/doi.org\/10.1016\/j.celrep.2026.117877","relation":{},"ISSN":["2211-1247"],"issn-type":[{"value":"2211-1247","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Impaired brain-gut circuit for gut motility dysfunction in mouse models of Parkinson\u2019s disease","name":"articletitle","label":"Article Title"},{"value":"Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.celrep.2026.117877","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"117877"}}