{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T21:38:23Z","timestamp":1792532303140,"version":"4.5.0"},"reference-count":75,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T00:00:00Z","timestamp":1785715200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82574169"],"award-info":[{"award-number":["82574169"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Reports"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.celrep.2026.117878","type":"journal-article","created":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T09:27:51Z","timestamp":1787563671000},"page":"117878","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["A single-cell transcriptomic atlas reveals the immune panorama of neonatal sepsis"],"prefix":"10.1016","volume":"45","author":[{"given":"Jie","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peicen","family":"Zou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linglong","family":"Wan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifei","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yajuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lihui","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.celrep.2026.117878_bib1","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/S0140-6736(19)32989-7","article-title":"Global, regional, and national sepsis incidence and mortality, 1990-2017: analysis for the Global Burden of Disease Study","volume":"395","author":"Rudd","year":"2020","journal-title":"Lancet"},{"key":"10.1016\/j.celrep.2026.117878_bib2","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/S2213-2600(18)30063-8","article-title":"The global burden of paediatric and neonatal sepsis: a systematic review","volume":"6","author":"Fleischmann-Struzek","year":"2018","journal-title":"Lancet Respir. Med."},{"key":"10.1016\/j.celrep.2026.117878_bib3","doi-asserted-by":"crossref","first-page":"2357","DOI":"10.1001\/jama.292.19.2357","article-title":"Neurodevelopmental and growth impairment among extremely low-birth-weight infants with neonatal infection","volume":"292","author":"Stoll","year":"2004","journal-title":"JAMA"},{"key":"10.1016\/j.celrep.2026.117878_bib4","doi-asserted-by":"crossref","first-page":"e348","DOI":"10.1542\/peds.2010-3338","article-title":"Impact of sepsis on neurodevelopmental outcome in a Swiss National Cohort of extremely premature infants","volume":"128","author":"Schlapbach","year":"2011","journal-title":"Pediatrics"},{"key":"10.1016\/j.celrep.2026.117878_bib5","doi-asserted-by":"crossref","DOI":"10.1136\/bmjgh-2017-000347","article-title":"Economic burden of neonatal sepsis in sub-Saharan Africa","volume":"3","author":"Ranjeva","year":"2018","journal-title":"BMJ Glob. Health"},{"key":"10.1016\/j.celrep.2026.117878_bib6","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1136\/archdischild-2020-320217","article-title":"Global incidence and mortality of neonatal sepsis: a systematic review and meta-analysis","volume":"106","author":"Fleischmann","year":"2021","journal-title":"Arch. Dis. Child."},{"key":"10.1016\/j.celrep.2026.117878_bib7","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1001\/jama.2016.0287","article-title":"The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)","volume":"315","author":"Singer","year":"2016","journal-title":"JAMA"},{"key":"10.1016\/j.celrep.2026.117878_bib8","doi-asserted-by":"crossref","first-page":"1770","DOI":"10.1016\/S0140-6736(17)31002-4","article-title":"Neonatal sepsis","volume":"390","author":"Shane","year":"2017","journal-title":"Lancet"},{"key":"10.1016\/j.celrep.2026.117878_bib9","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1128\/CMR.00031-13","article-title":"Early-onset neonatal sepsis","volume":"27","author":"Simonsen","year":"2014","journal-title":"Clin. Microbiol. Rev."},{"key":"10.1016\/j.celrep.2026.117878_bib10","doi-asserted-by":"crossref","DOI":"10.1002\/imt2.70121","article-title":"A large-scale single-cell transcriptomic atlas indicates the immune panorama of influenza A infection","volume":"5","author":"Wang","year":"2026","journal-title":"iMeta"},{"key":"10.1016\/j.celrep.2026.117878_bib11","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1038\/nri.2017.76","article-title":"Single-cell RNA sequencing to explore immune cell heterogeneity","volume":"18","author":"Papalexi","year":"2018","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.celrep.2026.117878_bib12","doi-asserted-by":"crossref","DOI":"10.1002\/mco2.748","article-title":"Single-cell transcriptome atlas revealed bronchoalveolar immune features related to disease severity in pediatric Mycoplasma pneumoniae pneumonia","volume":"5","author":"Shen","year":"2024","journal-title":"MedComm"},{"key":"10.1016\/j.celrep.2026.117878_bib13","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1186\/s13054-023-04378-w","article-title":"Serum-integrated omics reveal the host response landscape for severe pediatric community-acquired pneumonia","volume":"27","author":"Wang","year":"2023","journal-title":"Crit. Care"},{"key":"10.1016\/j.celrep.2026.117878_bib14","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1038\/s41392-023-01641-y","article-title":"Single-cell transcriptomic analysis reveals a systemic immune dysregulation in COVID-19-associated pediatric encephalopathy","volume":"8","author":"Wang","year":"2023","journal-title":"Signal Transduct. Targeted Ther."},{"key":"10.1016\/j.celrep.2026.117878_bib15","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1038\/s41392-024-02093-8","article-title":"A pan-immune panorama of bacterial pneumonia revealed by a large-scale single-cell transcriptome atlas","volume":"10","author":"Xiao","year":"2025","journal-title":"Signal Transduct. Targeted Ther."},{"key":"10.1016\/j.celrep.2026.117878_bib16","doi-asserted-by":"crossref","DOI":"10.1002\/imt2.226","article-title":"Single-cell landscape revealed immune characteristics associated with disease phases in brucellosis patients","volume":"3","author":"Wang","year":"2024","journal-title":"iMeta"},{"key":"10.1016\/j.celrep.2026.117878_bib17","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1016\/j.cell.2020.08.001","article-title":"Severe COVID-19 Is Marked by a Dysregulated Myeloid Cell Compartment","volume":"182","author":"Schulte-Schrepping","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2026.117878_bib18","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1016\/j.cell.2020.10.002","article-title":"Single-Cell Profiling of Ebola Virus Disease In Vivo Reveals Viral and Host Dynamics","volume":"183","author":"Kotliar","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2026.117878_bib19","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1038\/s41591-021-01329-2","article-title":"Single-cell multi-omics analysis of the immune response in COVID-19","volume":"27","author":"Stephenson","year":"2021","journal-title":"Nat. Med."},{"key":"10.1016\/j.celrep.2026.117878_bib20","article-title":"Neonatal sepsis and inflammatory mediators","volume":"2014","author":"Machado","year":"2014","journal-title":"Mediat. Inflamm."},{"key":"10.1016\/j.celrep.2026.117878_bib21","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.clp.2010.04.001","article-title":"Role of innate host defenses in susceptibility to early-onset neonatal sepsis","volume":"37","author":"Wynn","year":"2010","journal-title":"Clin. Perinatol."},{"key":"10.1016\/j.celrep.2026.117878_bib22","doi-asserted-by":"crossref","first-page":"1895","DOI":"10.1016\/j.cell.2021.01.053","article-title":"COVID-19 immune features revealed by a large-scale single-cell transcriptome atlas","volume":"184","author":"Ren","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2026.117878_bib23","doi-asserted-by":"crossref","first-page":"5304","DOI":"10.1002\/jmv.28012","article-title":"Single-cell transcriptomic atlas reveals distinct immunological responses between COVID-19 vaccine and natural SARS-CoV-2 infection","volume":"94","author":"Wang","year":"2022","journal-title":"J. Med. Virol."},{"key":"10.1016\/j.celrep.2026.117878_bib24","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1038\/nri2301","article-title":"TLR4 signalling","volume":"8","author":"Bell","year":"2008","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.celrep.2026.117878_bib25","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1164\/rccm.201209-1602OC","article-title":"Proinflammatory S100A12 can activate human monocytes via Toll-like receptor 4","volume":"187","author":"Foell","year":"2013","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.celrep.2026.117878_bib26","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.3389\/fimmu.2018.01298","article-title":"S100A8\/A9 in Inflammation","volume":"9","author":"Wang","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.celrep.2026.117878_bib27","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1003848","article-title":"DAMP molecule S100A9 acts as a molecular pattern to enhance inflammation during influenza A virus infection: role of DDX21-TRIF-TLR4-MyD88 pathway","volume":"10","author":"Tsai","year":"2014","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.celrep.2026.117878_bib28","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1038\/nri2506","article-title":"Myeloid-derived suppressor cells as regulators of the immune system","volume":"9","author":"Gabrilovich","year":"2009","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.celrep.2026.117878_bib29","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1038\/s41577-024-01098-2","article-title":"The roles of arginases and arginine in immunity","volume":"25","author":"Can\u00e8","year":"2025","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.celrep.2026.117878_bib30","doi-asserted-by":"crossref","DOI":"10.3390\/cancers15112895","article-title":"Interactions of IDO and the Kynurenine Pathway with Cell Transduction Systems and Metabolism at the Inflammation-Cancer Interface","volume":"15","author":"Stone","year":"2023","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.celrep.2026.117878_bib31","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1084\/jem.20121416","article-title":"PD-1 promotes immune exhaustion by inducing antiviral T cell motility paralysis","volume":"210","author":"Zinselmeyer","year":"2013","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.celrep.2026.117878_bib32","doi-asserted-by":"crossref","DOI":"10.1126\/scisignal.aad1884","article-title":"TGF-beta inhibits the activation and functions of NK cells by repressing the mTOR pathway","volume":"9","author":"Viel","year":"2016","journal-title":"Sci. Signal."},{"key":"10.1016\/j.celrep.2026.117878_bib33","doi-asserted-by":"crossref","first-page":"1924","DOI":"10.1158\/0008-5472.CAN-13-1504","article-title":"VISTA is an immune checkpoint molecule for human T cells","volume":"74","author":"Lines","year":"2014","journal-title":"Cancer Res."},{"key":"10.1016\/j.celrep.2026.117878_bib34","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1084\/jem.20100619","article-title":"VISTA, a novel mouse Ig superfamily ligand that negatively regulates T cell responses","volume":"208","author":"Wang","year":"2011","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.celrep.2026.117878_bib35","doi-asserted-by":"crossref","first-page":"236","DOI":"10.2174\/187152809788681038","article-title":"The role of anaphylatoxins C3a and C5a in regulating innate and adaptive immune responses","volume":"8","author":"Peng","year":"2009","journal-title":"Inflamm. Allergy - Drug Targets"},{"key":"10.1016\/j.celrep.2026.117878_bib36","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.aaf8943","article-title":"Lectin-type oxidized LDL receptor-1 distinguishes population of human polymorphonuclear myeloid-derived suppressor cells in cancer patients","volume":"1","author":"Condamine","year":"2016","journal-title":"Sci. Immunol."},{"key":"10.1016\/j.celrep.2026.117878_bib37","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1158\/0008-5472.CAN-08-1921","article-title":"Arginase I-producing myeloid-derived suppressor cells in renal cell carcinoma are a subpopulation of activated granulocytes","volume":"69","author":"Rodriguez","year":"2009","journal-title":"Cancer Res."},{"key":"10.1016\/j.celrep.2026.117878_bib38","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1038\/s41590-023-01490-5","article-title":"Neutrophils and emergency granulopoiesis drive immune suppression and an extreme response endotype during sepsis","volume":"24","author":"Kwok","year":"2023","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.celrep.2026.117878_bib39","doi-asserted-by":"crossref","first-page":"1869","DOI":"10.3389\/fimmu.2018.01869","article-title":"Natural Killer Cells: Development, Maturation, and Clinical Utilization","volume":"9","author":"Abel","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.celrep.2026.117878_bib40","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1007\/s00441-010-1023-3","article-title":"Invariant natural killer T cells: bridging innate and adaptive immunity","volume":"343","author":"Van Kaer","year":"2011","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.celrep.2026.117878_bib41","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1038\/s41392-023-01653-8","article-title":"gammadelta T cells: origin and fate, subsets, diseases and immunotherapy","volume":"8","author":"Hu","year":"2023","journal-title":"Signal Transduct. Targeted Ther."},{"key":"10.1016\/j.celrep.2026.117878_bib42","doi-asserted-by":"crossref","first-page":"1794","DOI":"10.1002\/eji.200939222","article-title":"Neonates harbour highly active gammadelta T cells with selective impairments in preterm infants","volume":"39","author":"Gibbons","year":"2009","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.celrep.2026.117878_bib43","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.4049\/jimmunol.172.3.1637","article-title":"Ontogeny of gamma delta T cells in humans","volume":"172","author":"De Rosa","year":"2004","journal-title":"J. Immunol."},{"key":"10.1016\/j.celrep.2026.117878_bib44","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.imlet.2016.03.009","article-title":"Distinct mechanisms of the newborn innate immunity","volume":"173","author":"Kumar","year":"2016","journal-title":"Immunol. Lett."},{"key":"10.1016\/j.celrep.2026.117878_bib45","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2024-009934","article-title":"Unlocking the therapeutic potential of the NKG2A-HLA-E immune checkpoint pathway in T cells and NK cells for cancer immunotherapy","volume":"12","author":"Li","year":"2024","journal-title":"J. Immunother. Cancer"},{"key":"10.1016\/j.celrep.2026.117878_bib46","doi-asserted-by":"crossref","first-page":"571","DOI":"10.4049\/jimmunol.161.2.571","article-title":"Direct binding and functional transfer of NK cell inhibitory receptors reveal novel patterns of HLA-C allotype recognition","volume":"161","author":"Winter","year":"1998","journal-title":"J. Immunol."},{"key":"10.1016\/j.celrep.2026.117878_bib47","doi-asserted-by":"crossref","first-page":"336","DOI":"10.3389\/fimmu.2012.00336","article-title":"Diverse functionality among human NK cell receptors for the C1 epitope of HLA-C: KIR2DS2, KIR2DL2, and KIR2DL3","volume":"3","author":"Moesta","year":"2012","journal-title":"Front. Immunol."},{"key":"10.1016\/j.celrep.2026.117878_bib48","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1240275","article-title":"Perspectives of targeting LILRB1 in innate and adaptive immune checkpoint therapy of cancer","volume":"14","author":"Zeller","year":"2023","journal-title":"Front. Immunol."},{"key":"10.1016\/j.celrep.2026.117878_bib49","doi-asserted-by":"crossref","first-page":"8222","DOI":"10.7150\/thno.116951","article-title":"Inhibitory leukocyte immunoglobulin-like receptors, subfamily B (LILRBs) in human diseases: structure, roles, mechanisms, and clinical applications","volume":"15","author":"Zhang","year":"2025","journal-title":"Theranostics"},{"key":"10.1016\/j.celrep.2026.117878_bib50","doi-asserted-by":"crossref","first-page":"3423","DOI":"10.1002\/(SICI)1521-4141(199811)28:11<3423::AID-IMMU3423>3.0.CO;2-2","article-title":"The MHC class I binding proteins LIR-1 and LIR-2 inhibit Fc receptor-mediated signaling in monocytes","volume":"28","author":"Fanger","year":"1998","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.celrep.2026.117878_bib51","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1002\/eji.201545897","article-title":"Monocyte infiltration into obese and fibrilized tissues is regulated by PILRalpha","volume":"46","author":"Kohyama","year":"2016","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.celrep.2026.117878_bib52","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1038\/cdd.2017.173","article-title":"CD52 inhibits Toll-like receptor activation of NF-kappaB and triggers apoptosis to suppress inflammation","volume":"25","author":"Rashidi","year":"2018","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.celrep.2026.117878_bib53","doi-asserted-by":"crossref","first-page":"7783","DOI":"10.1073\/pnas.1722056115","article-title":"CD52 glycan binds the proinflammatory B box of HMGB1 to engage the Siglec-10 receptor and suppress human T cell function","volume":"115","author":"Bandala-Sanchez","year":"2018","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2026.117878_bib54","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2024.109546","article-title":"Disruption of CD47-SIRPalpha signaling restores inflammatory function in tumor-associated myeloid-derived suppressor cells","volume":"27","author":"Zimarino","year":"2024","journal-title":"iScience"},{"key":"10.1016\/j.celrep.2026.117878_bib55","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1016\/j.immuni.2015.05.016","article-title":"E3 Ubiquitin Ligase VHL Regulates Hypoxia-Inducible Factor-1alpha to Maintain Regulatory T Cell Stability and Suppressive Capacity","volume":"42","author":"Lee","year":"2015","journal-title":"Immunity"},{"key":"10.1016\/j.celrep.2026.117878_bib56","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1038\/nature05479","article-title":"Regulatory T-cell functions are subverted and converted owing to attenuated Foxp3 expression","volume":"445","author":"Wan","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2026.117878_bib57","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2111315118","article-title":"Profound Treg perturbations correlate with COVID-19 severity","volume":"118","author":"Galv\u00e1n-Pe\u00f1a","year":"2021","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2026.117878_bib58","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1016\/j.molmed.2020.06.007","article-title":"JAK-STAT Targeting Offers Novel Therapeutic Opportunities in Sepsis","volume":"26","author":"Clere-Jehl","year":"2020","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.celrep.2026.117878_bib59","doi-asserted-by":"crossref","first-page":"811","DOI":"10.34133\/research.0811","article-title":"Decoding Sepsis: Unraveling Key Signaling Pathways for Targeted Therapies","volume":"8","author":"Tang","year":"2025","journal-title":"Research"},{"key":"10.1016\/j.celrep.2026.117878_bib60","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1007\/s00018-022-04490-0","article-title":"Metabolic reprogramming consequences of sepsis: adaptations and contradictions","volume":"79","author":"Liu","year":"2022","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.celrep.2026.117878_bib61","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/s13054-020-03424-1","article-title":"Sepsis is associated with mitochondrial DNA damage and a reduced mitochondrial mass in the kidney of patients with sepsis-AKI","volume":"25","author":"van der Slikke","year":"2021","journal-title":"Crit. Care"},{"key":"10.1016\/j.celrep.2026.117878_bib62","doi-asserted-by":"crossref","first-page":"3073","DOI":"10.1182\/blood-2016-06-725366","article-title":"Fetal and adult progenitors give rise to unique populations of CD8+ T cells","volume":"128","author":"Wang","year":"2016","journal-title":"Blood"},{"key":"10.1016\/j.celrep.2026.117878_bib63","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.abe4782","article-title":"Severely ill COVID-19 patients display impaired exhaustion features in SARS-CoV-2-reactive CD8(+) T cells","volume":"6","author":"Kusnadi","year":"2021","journal-title":"Sci. Immunol."},{"key":"10.1016\/j.celrep.2026.117878_bib64","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1016\/j.cell.2018.10.038","article-title":"Defining T Cell States Associated with Response to Checkpoint Immunotherapy in Melanoma","volume":"175","author":"Sade-Feldman","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2026.117878_bib65","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aat2004","article-title":"Shaping of infant B cell receptor repertoires by environmental factors and infectious disease","volume":"11","author":"Nielsen","year":"2019","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.celrep.2026.117878_bib66","doi-asserted-by":"crossref","first-page":"410","DOI":"10.3389\/fimmu.2016.00410","article-title":"Evaluation of the Antigen-Experienced B-Cell Receptor Repertoire in Healthy Children and Adults","volume":"7","author":"IJspeert","year":"2016","journal-title":"Front. Immunol."},{"key":"10.1016\/j.celrep.2026.117878_bib67","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1038\/s41467-023-44387-5","article-title":"Identifying immune signatures of sepsis to increase diagnostic accuracy in very preterm babies","volume":"15","author":"Das","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2026.117878_bib68","doi-asserted-by":"crossref","DOI":"10.1093\/gpbjnl\/qzaf072","article-title":"The GSA Family in 2025: A Broadened Sharing Platform for Multi-omics and Multimodal Data","volume":"23","author":"Zhang","year":"2025","journal-title":"Genom. Proteom. Bioinform."},{"key":"10.1016\/j.celrep.2026.117878_bib69","doi-asserted-by":"crossref","first-page":"D28","DOI":"10.1093\/nar\/gkaf1172","article-title":"Database resources of the National Genomics Data Center, China National Center for Bioinformation in 2026","volume":"54","year":"2026","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.celrep.2026.117878_bib70","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.jinf.2023.03.020","article-title":"Systemic immune dysregulation in severe tuberculosis patients revealed by a single-cell transcriptome atlas","volume":"86","author":"Wang","year":"2023","journal-title":"J. Infect."},{"key":"10.1016\/j.celrep.2026.117878_bib71","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1038\/s41592-019-0619-0","article-title":"Fast, sensitive and accurate integration of single-cell data with Harmony","volume":"16","author":"Korsunsky","year":"2019","journal-title":"Nat. Methods"},{"key":"10.1016\/j.celrep.2026.117878_bib72","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/s13059-017-1382-0","article-title":"SCANPY: large-scale single-cell gene expression data analysis","volume":"19","author":"Wolf","year":"2018","journal-title":"Genome Biol."},{"key":"10.1016\/j.celrep.2026.117878_bib73","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1186\/s13059-019-1663-x","article-title":"PAGA: graph abstraction reconciles clustering with trajectory inference through a topology preserving map of single cells","volume":"20","author":"Wolf","year":"2019","journal-title":"Genome Biol."},{"key":"10.1016\/j.celrep.2026.117878_bib74","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1038\/nmeth.3971","article-title":"Diffusion pseudotime robustly reconstructs lineage branching","volume":"13","author":"Haghverdi","year":"2016","journal-title":"Nat. Methods"},{"key":"10.1016\/j.celrep.2026.117878_bib75","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1136\/gutjnl-2021-325915","article-title":"Single-cell RNA sequencing reveals intrahepatic and peripheral immune characteristics related to disease phases in HBV-infected patients","volume":"72","author":"Zhang","year":"2023","journal-title":"Gut"}],"container-title":["Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124726009563?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124726009563?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T20:45:29Z","timestamp":1792529129000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211124726009563"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":75,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["S2211124726009563"],"URL":"https:\/\/doi.org\/10.1016\/j.celrep.2026.117878","relation":{},"ISSN":["2211-1247"],"issn-type":[{"value":"2211-1247","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A single-cell transcriptomic atlas reveals the immune panorama of neonatal sepsis","name":"articletitle","label":"Article Title"},{"value":"Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.celrep.2026.117878","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"117878"}}